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Metalloproteinases: their role in arthritis and potential as therapeutic targets

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Pages 19-34 | Published online: 02 Mar 2005

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Himadri Shekhar Roy, Gurudutt Dubey, Vishnu Kumar Sharma, Prasad V. Bharatam & Deepa Ghosh. (2022) Molecular docking and molecular dynamics to identify collagenase inhibitors as lead compounds to address osteoarthritis. Journal of Biomolecular Structure and Dynamics 40:5, pages 2339-2351.
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Edward A Lin & Chuan-ju Liu. (2009) The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases. Open Access Rheumatology: Research and Reviews 1, pages 121-131.
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Helmtrud I Roach. (2008) Potential directions for drug development for osteoarthritis. Expert Opinion on Drug Discovery 3:5, pages 475-486.
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E. R. Garvican, A. Vaughan-Thomas, C. Redmond & P. D. Clegg. (2008) MT3-MMP (MMP-16) is Downregulated by In Vitro Cytokine Stimulation of Cartilage, but Unaltered in Naturally Occurring Equine Osteoarthritis and Osteochondrosis. Connective Tissue Research 49:2, pages 62-67.
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Haoyu Yu, Rongyao Gao, Yuxin Liu, Limin Fu, Jing Zhou & Luoyuan Li. (2023) Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy. Advanced Science.
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Qi Jiang & Shufang Zhang. (2023) Stimulus‐Responsive Drug Delivery Nanoplatforms for Osteoarthritis Therapy. Small 19:23.
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Taeheon Lee, Chae-Bin Na, Dasom Kim, Hae Jung Han, Jongbok Yun, Sun Kyu Park & Eunhae Cho. (2022) Osteoarthritis improvement effect of Chrysanthemum zawadskii var. latilobum extract in relation to genotype . International Journal for Vitamin and Nutrition Research.
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Guangshuai Zhang, Lixue Ma, Lijun Bai, Mo Li, Tiange Guo, Baocheng Tian, Zhonggui He & Qiang Fu. (2021) Inflammatory microenvironment-targeted nanotherapies. Journal of Controlled Release 334, pages 114-126.
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Takashi Ohtsuki, Akira Shinaoka, Kanae Kumagishi-Shinaoka, Keiichi Asano, Omer Faruk Hatipoglu, Junko Inagaki, Ken Takahashi, Toshitaka Oohashi, Keiichiro Nishida, Keiji Naruse & Satoshi Hirohata. (2019) Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1. Experimental Cell Research 383:2, pages 111556.
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P. Yeung, W. Zhang, X.N. Wang, C.H. Yan & B.P. Chan. (2018) A human osteoarthritis osteochondral organ culture model for cartilage tissue engineering. Biomaterials 162, pages 1-21.
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Thomas Fischer & Rainer Riedl. (2017) Development of a Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-7/-13 Inhibitor. Molecules 22:9, pages 1548.
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Yan Ma, Xuewu Sun, Kangmao Huang, Shuying Shen, Xianfeng Lin, Ziang Xie, Jiying Wang, Shunwu Fan, Jianjun Ma & Xing Zhao. (2017) Sanguinarine protects against osteoarthritis by suppressing the expression of catabolic proteases. Oncotarget 8:38, pages 62900-62913.
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Thomas Fischer & Rainer Riedl. (2017) Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor. ChemistryOpen 6:2, pages 192-195.
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John S. Mort, Yeqing Geng, William D. Fisher & Peter J. Roughley. (2016) Aggrecan heterogeneity in articular cartilage from patients with osteoarthritis. BMC Musculoskeletal Disorders 17:1.
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Peter J Roughley & John S Mort. (2014) The role of aggrecan in normal and osteoarthritic cartilage. Journal of Experimental Orthopaedics 1:1.
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Antonella Di PizioAntonio LaghezzaPaolo TortorellaMariangela Agamennone. (2013) Probing the S1′ Site for the Identification of Non‐Zinc‐Binding MMP‐2 Inhibitors. ChemMedChem 8:9, pages 1475-1482.
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Satoko MatsukawaMiki TanimuraTomoko Toyosaki-MaedaAkihiro NodaMika KobayashiAkira YamauchiJunji OnodaToshinaga TsujiTatsuya TakahashiYoshiyuki MatsuoNaoshi Fukui. (2013) CIINE Reflects Collagenase-Specific CII Breakdown in Cartilage Explant and Whole Body of Canine. Biomarker Insights 8, pages BMI.S11627.
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Antonella Di Pizio, Mariangela Agamennone & Massimiliano Aschi. (2012) An Integrated Computational Approach to Rationalize the Activity of Non-Zinc-Binding MMP-2 Inhibitors. PLoS ONE 7:11, pages e47774.
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Jonathan D. Tugwood, Janet Kelsall, Lucy C. Coverley, F. Russell Westwood, Kemal Haque & Russell D. J. Huby. (2012) Fibrodysplasia Induced in Dog Skin by a Matrix Metalloproteinase (MMP) Inhibitor—A Mechanistic Analysis. Toxicological Sciences 127:1, pages 236-245.
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Rui Sun, Zheng-yu Li, Han-jiang He, Jie Wei, Juan Wang, Qi-xian Zhang, Jia Zhao, Xi-mei Zhan & Zhong-dao Wu. (2011) Molecular cloning and characterization of a matrix metalloproteinase, from Caenorhabditis elegans: employed to identify homologous protein from Angiostrongylus cantonensis. Parasitology Research 110:5, pages 2001-2012.
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Hanwei Li, Noel Davison, Lorenzo Moroni, Felicia Feng, Joshua Crist, Erin Salter, Clifton O. Bingham & Jennifer Elisseeff. (2012) Evaluating Osteoarthritic Chondrocytes through a Novel 3-Dimensional In Vitro System for Cartilage Tissue Engineering and Regeneration . CARTILAGE 3:2, pages 128-140.
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Hanwei Li, Felicia Feng, Clifton O. BinghamIIIIII & Jennifer H. Elisseeff. (2012) Matrix metalloproteinases and inhibitors in cartilage tissue engineering. Journal of Tissue Engineering and Regenerative Medicine 6:2, pages 144-154.
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Christian Gege, Bagna Bao, Harald Bluhm, Jürgen Boer, Brian M. GallagherJr.Jr., Brian Korniski, Timothy S. Powers, Christoph Steeneck, Arthur G. Taveras & Vijaykumar M. Baragi. (2012) Discovery and Evaluation of a Non-Zn Chelating, Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitor for Potential Intra-articular Treatment of Osteoarthritis. Journal of Medicinal Chemistry 55:2, pages 709-716.
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Priyanka Verma & Krishna Dalal. (2011) ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis. Journal of Cellular Biochemistry 112:12, pages 3507-3514.
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Paola Vicini, Lucia Crascì, Matteo Incerti, Simone Ronsisvalle, Venera Cardile & Anna Maria Panico. (2011) Benzisothiazolyliminothiazolidin-4-ones with Chondroprotective Properties: Searching for Potent and Selective Inhibitors of MMP-13. ChemMedChem 6:7, pages 1199-1202.
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Guo-Xin Ni, Li-Qiong Zhan, Mei-Qin Gao, Lei Lei, Yue-Zhu Zhou & Yan-Xia Pan. (2011) Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats. Arthritis Research & Therapy 13:6, pages R192.
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Marc Fajardo, Chuan-Ju Liu, Kirill Ilalov & Kenneth A Egol. (2010) Matrix Metalloproteinases That Associate With and Cleave Bone Morphogenetic Protein-2 In Vitro Are Elevated in Hypertrophic Fracture Nonunion Tissue. Journal of Orthopaedic Trauma 24:9, pages 557-563.
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Donghong Amy Gao, Zhaoming Xiong, Alexander Heim-Riether, Laura Amodeo, E. Michael August, Xianhua Cao, Leonard Ciccarelli, Brandon K. Collins, Kyle Harrington, Kathleen Haverty, Melissa Hill-Drzewi, Xiang Li, Shuang Liang, Steluta Mariana Margarit, Neil Moss, Nelamangala Nagaraja, John Proudfoot, Rene Roman, Sabine Schlyer, Lana Smith Keenan, Steven Taylor, Bernd Wellenzohn, Dieter Wiedenmayer, Jun Li & Neil A. Farrow. (2010) SAR studies of non-zinc-chelating MMP-13 inhibitors: Improving selectivity and metabolic stability. Bioorganic & Medicinal Chemistry Letters 20:17, pages 5039-5043.
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Dorothea Piecha, Jürgen Weik, Heike Kheil, Gabriele Becher, Andreas Timmermann, Andreas Jaworski, Maren Burger & Michael W. Hofmann. (2009) Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants. Inflammation Research 59:5, pages 379-389.
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H. Li & J.H. Elisseeff. 2010. Regenerative Medicine and Biomaterials for the Repair of Connective Tissues. Regenerative Medicine and Biomaterials for the Repair of Connective Tissues 301 329 .
Edward A. Lin & Chuan-Ju Liu. (2010) The role of ADAMTSs in arthritis. Protein & Cell 1:1, pages 33-47.
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Tim E. Cawston & David A. Young. (2009) Proteinases involved in matrix turnover during cartilage and bone breakdown. Cell and Tissue Research 339:1, pages 221-235.
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Russell Westwood, Robert C. Scott, Rebecca L. Somers, Michelle Coulson & Rose A. Maciewicz. (2009) Characterization of Fibrodysplasia in the Dog Following Inhibition of Metalloproteinases. Toxicologic Pathology 37:7, pages 860-872.
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Alison K Surridge, Ursula R Rodgers, Tracey E Swingler, Rose K Davidson, Lara Kevorkian, Rosemary Norton, Jasmine G Waters, Mary B Goldring, Andrew E Parker & Ian M Clark. (2009) Characterization and regulation of ADAMTS-16. Matrix Biology 28:7, pages 416-424.
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Alexander Heim-Riether, Steven J. Taylor, Shuang Liang, Donghong Amy Gao, Zhaoming Xiong, E. Michael August, Brandon K. Collins, Bennett T. FarmerIIII, Kathleen Haverty, Melissa Hill-Drzewi, Hans-Dieter Junker, S. Mariana Margarit, Neil Moss, Thomas Neumann, John R. Proudfoot, Lana Smith Keenan, Renate Sekul, Qiang Zhang, Jun Li & Neil A. Farrow. (2009) Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors. Bioorganic & Medicinal Chemistry Letters 19:18, pages 5321-5324.
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Vijaykumar M. Baragi, Gabriel Becher, Alison M. Bendele, Ralf Biesinger, Harald Bluhm, Jürgen Boer, Hongbo Deng, Rory Dodd, Michael Essers, Tim Feuerstein, Brian M. GallagherJr.Jr., Christian Gege, Matthias Hochgürtel, Michael Hofmann, Andreas Jaworski, Lixia Jin, Andrew Kiely, Brian Korniski, Heiko Kroth, Darrell Nix, Bert Nolte, Dorothea Piecha, Timothy S. Powers, Frank Richter, Matthias Schneider, Christoph Steeneck, Irving Sucholeiki, Arthur Taveras, Andreas Timmermann, Joshua Van Veldhuizen, Juergen Weik, Xinyuan Wu & Bing Xia. (2009) A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models. Arthritis & Rheumatism 60:7, pages 2008-2018.
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