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Review

Tyrosine kinases as targets in cancer therapy – successes and failures

Pages 215-234 | Published online: 02 Mar 2005

Keep up to date with the latest research on this topic with citation updates for this article.

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Ali S. Alqahtani, Mostafa M. Ghorab, Fahd A. Nasr, Mohammad Z. Ahmed, Abdullah A. Al-Mishari & Sabry M. Attia. (2022) Novel sulphonamide-bearing methoxyquinazolinone derivatives as anticancer and apoptosis inducers: synthesis, biological evaluation and in silico studies. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 86-99.
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Farrhat F. Mohammed, Mohamad Hagar, Shazia Parveen, Rua B. Alnoman, Hoda A. Ahmed, El Sayed H. El Ashry & Hanaa A. Rasheed. (2022) 2-(Alkylthio)-3-(Naphthalen-1-yl)Quinazolin-4(3H)-Ones: Ultrasonic Synthesis, DFT and Molecular Docking Aspects. Polycyclic Aromatic Compounds 42:7, pages 4034-4048.
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Marwa F. Ahmed, Eman Y. Santali & Radwan El-Haggar. (2021) Novel piperazine–chalcone hybrids and related pyrazoline analogues targeting VEGFR-2 kinase; design, synthesis, molecular docking studies, and anticancer evaluation. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 308-319.
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Fatih M Uckun & Sanjive Qazi. (2010) Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity. Expert Opinion on Therapeutic Patents 20:11, pages 1457-1470.
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Bin Shi, James Hardwick, Brett Connolly, Xianzhi Mao, Rosemary McFall, Susan Hill, Kenneth A. Thomas, Nancy E. Kohl & Laura Sepp-Lorenzino. (2010) Immunohistochemical Detection of Antitumor, Antimetastasis, and Antiangiogenesis Effects of a Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor in an Orthotopic Breast Cancer Metastasis Model. Journal of Histotechnology 33:1, pages 15-24.
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Yong Jia, Xiang-ju Gu, Achim Brinker & Markus Warmuth. (2008) Measuring the tyrosine kinase activity: a review of biochemical and cellular assay technologies. Expert Opinion on Drug Discovery 3:8, pages 959-978.
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Julie A Spicer. (2008) New small-molecule inhibitors of mitogen-activated protein kinase kinase. Expert Opinion on Drug Discovery 3:7, pages 801-817.
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Fatih M. Uckun. (2008) Clinical Potential of Targeting Bruton's Tyrosine Kinase. International Reviews of Immunology 27:1-2, pages 43-69.
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PKS Sarma, Ruchi Tandon, Praful Gupta, Sunanda G Dastidar, Abhijit Ray, Biswajit Das & Ian A Cliffe. (2007) Progress in the development of small molecule inhibitors of insulin-like growth factor-1 receptor kinase. Expert Opinion on Therapeutic Patents 17:1, pages 25-35.
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Keykavous Parang & Gongqin Sun. (2005) Recent advances in the discovery of Src kinase inhibitors. Expert Opinion on Therapeutic Patents 15:9, pages 1183-1207.
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Peter M Fischer & Athos Gianella-Borradori. (2005) Recent progress in the discovery and development of cyclin-dependent kinase inhibitors. Expert Opinion on Investigational Drugs 14:4, pages 457-477.
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Ariane Söling & Nikolai G Rainov. (2003) Bioluminescence imaging in vivo – application to cancer research. Expert Opinion on Biological Therapy 3:7, pages 1163-1172.
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