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Review

Therapeutic potential of target of rapamycin inhibitors

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Pages 551-564 | Published online: 25 Feb 2005

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R.L. Tiwari, V. Singh & M.K. Barthwal. (2007) Macrophages: An elusive yet emerging therapeutic target of atherosclerosis. Medicinal Research Reviews 28:4, pages 483-544.
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Wim Martinet & Guido R. Y. De Meyer. (2008) Autophagy in atherosclerosis. Current Atherosclerosis Reports 10:3, pages 216-223.
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Crossref
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Crossref
Marie-Emmanuelle Legrier, Chia-Ping Huang Yang, Han-Guang Yan, Lluis Lopez-Barcons, Steven M. Keller, Roman Pérez-Soler, Susan Band Horwitz & Hayley M. McDaid. (2007) Targeting Protein Translation in Human Non–Small Cell Lung Cancer via Combined MEK and Mammalian Target of Rapamycin Suppression. Cancer Research 67:23, pages 11300-11308.
Crossref
J.R. Chapman, H. Valantine, J. Albanell, W.A. Arns, J.M. Campistol, H. Eisen, M. Frigerio, H. Lehmkuhl, R. Marcen, R. Morris, B. Nashan, J. Pascual, E. Pohanka, J. Segovia & A. Zuckermann. (2007) Proliferation Signal Inhibitors in Transplantation: Questions at the Cutting Edge of Everolimus Therapy. Transplantation Proceedings 39:10, pages 2937-2950.
Crossref
Wim Martinet, Michiel W.M. Knaapen, Mark M. Kockx & Guido R.Y. De Meyer. (2007) Autophagy in cardiovascular disease. Trends in Molecular Medicine 13:11, pages 482-491.
Crossref
Michael J. Clemens. 2005. The Cancer Handbook. The Cancer Handbook.
Marlene L. Rose. (2007) Interferon-γ and Intimal Hyperplasia. Circulation Research 101:6, pages 542-544.
Crossref
Hugo Bonatti, Felix Aigner, Eric De Clercq, Claudia Boesmueller, Andreas Widschwendner, Clara Larcher, Raimund Margreiter & Stefan Schneeberger. (2007) Local administration of cidofovir for human papilloma virus associated skin lesions in transplant recipients. Transplant International 20:3, pages 238-246.
Crossref
Sreenath V. Sharma, Daphne W. Bell, Jeffrey Settleman & Daniel A. Haber. (2007) Epidermal growth factor receptor mutations in lung cancer. Nature Reviews Cancer 7:3, pages 169-181.
Crossref
Maximilian Zeyda, René Geyeregger, Marko Poglitsch, Thomas Weichhart, Gerhard J Zlabinger, Shigeo Koyasu, Walter H Hörl, Thomas M Stulnig, Bruno Watschinger & Marcus D Saemann. (2007) Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-κB in immunological synapse formation. Journal of Leukocyte Biology 81:1, pages 319-327.
Crossref
Mouna El-Salem, Puthiyaveettil N Raghunath, Michal Marzec, Pawel Wlodarski, Donald Tsai, Eric Hsi & Mariusz A Wasik. (2007) Constitutive activation of mTOR signaling pathway in post-transplant lymphoproliferative disorders. Laboratory Investigation 87:1, pages 29-39.
Crossref
María G. Crespo Leiro, Luis Almenar Bonet, Luis Alonso-Pulpón, Marta Campreciós, José J. Cuenca Castillo, Luis de la Fuente Galván, Juan Delgado Jiménez, Luis García Guereta, Nicolás Manito Lorite, Carlos Maroto, Jesús Palomo, Domingo Pascual Figal, Ernesto Lage Gallé, José L. Rodríguez Lambert, Eulàlia Roig i Minguell, María L. Sanz Julve & José A. Vázquez de Prada. (2007) Conferencia de Consenso de los Grupos Españoles de Trasplante Cardiaco. Revista Española de Cardiología Suplementos 7:2, pages 4B-54B.
Crossref
J Adam van der Vliet, Martine C.M. Willems, Ben M. de Man, Roger M.L.M. Lomme & Thijs Hendriks. (2006) Everolimus Interferes With Healing of Experimental Intestinal Anastomoses. Transplantation 82:11, pages 1477-1483.
Crossref
Silvia Mateo-Lozano, Prafulla C. Gokhale, Viatcheslav A. Soldatenkov, Anatoly Dritschilo, Oscar M. Tirado & Vicente Notario. (2006) Combined Transcriptional and Translational Targeting of EWS/FLI-1 in Ewing's Sarcoma. Clinical Cancer Research 12:22, pages 6781-6790.
Crossref
M Marderosian, A Sharma, A P Funk, R Vartanian, J Masri, O D Jo & J F Gera. (2006) Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling. Oncogene 25:47, pages 6277-6290.
Crossref
Marcin Jankiewicz, Bernd Groner & Sylvane Desrivières. (2006) Mammalian Target of Rapamycin Regulates the Growth of Mammary Epithelial Cells through the Inhibitor of Deoxyribonucleic Acid Binding Id1 and Their Functional Differentiation through Id2. Molecular Endocrinology 20:10, pages 2369-2381.
Crossref
Manzar Shojaiefard & Florian Lang. (2006) Stimulation of the intestinal phosphate transporter SLC34A2 by the protein kinase mTOR. Biochemical and Biophysical Research Communications 345:4, pages 1611-1614.
Crossref
Qi-Wen Fan, Zachary A. Knight, David D. Goldenberg, Wei Yu, Keith E. Mostov, David Stokoe, Kevan M. Shokat & William A. Weiss. (2006) A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell 9:5, pages 341-349.
Crossref
Ken Inoki & Kun-Liang Guan. (2006) Complexity of the TOR signaling network. Trends in Cell Biology 16:4, pages 206-212.
Crossref
Manzar Shojaiefard, David L. Christie & Florian Lang. (2006) Stimulation of the creatine transporter SLC6A8 by the protein kinase mTOR. Biochemical and Biophysical Research Communications 341:4, pages 945-949.
Crossref
Paul S. Gaynon. (2005) Childhood acute lymphoblastic leukaemia and relapse. British Journal of Haematology 131:5, pages 579-587.
Crossref
R-H Xu, H Pelicano, H Zhang, F J Giles, M J Keating & P Huang. (2005) Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells. Leukemia 19:12, pages 2153-2158.
Crossref

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