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The therapeutic potential of CXCR4 antagonists in the treatment of HIV infection, cancer metastasis and rheumatoid arthritis

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Pages 1267-1282 | Published online: 21 Nov 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Shizuyo Tsujimura, Tomoko Adachi, Kazuyoshi Saito, Akio Kawabe & Yoshiya Tanaka. (2018) Relevance of P-glycoprotein on CXCR4+ B cells to organ manifestation in highly active rheumatoid arthritis. Modern Rheumatology 28:2, pages 276-286.
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Li Peng, Melissa M. Damschroder, Kimberly E. Cook, Herren Wu & William F. Dall'Acqua. (2016) Molecular basis for the antagonistic activity of an anti-CXCR4 antibody. mAbs 8:1, pages 163-175.
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Patricia Méndez-Samperio. (2014) Peptidomimetics as a new generation of antimicrobial agents: current progress. Infection and Drug Resistance 7, pages 229-237.
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Amnon Peled, Ori Wald & Jan Burger. (2012) Development of novel CXCR4-based therapeutics. Expert Opinion on Investigational Drugs 21:3, pages 341-353.
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Chiara Dell’Agnola & Arya Biragyn. (2007) Clinical utilization of chemokines to combat cancer: the double-edged sword. Expert Review of Vaccines 6:2, pages 267-283.
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Edgardo V. Ariztia, Catherine J. Lee, Radhika Gogoi & David A. Fishman. (2006) The Tumor Microenvironment: Key to Early Detection. Critical Reviews in Clinical Laboratory Sciences 43:5-6, pages 393-425.
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Articles from other publishers (42)

Manuela Leo & Lina Sabatino. (2022) Targeting CXCR4 and CD47 Receptors: An Overview of New and Old Molecules for a Biological Personalized Anticancer Therapy. International Journal of Molecular Sciences 23:20, pages 12499.
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Iman Imtiyaz Ahmed Juvale, Azzmer Azzar Abdul Hamid, Khairul Bariyyah Abd Halim & Ahmad Tarmizi Che Has. (2022) P-glycoprotein: new insights into structure, physiological function, regulation and alterations in disease. Heliyon 8:6, pages e09777.
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Ali Salimi-Jeda, Fariba Badrzadeh, Maryam Esghaei & Asghar Abdoli. (2021) The role of telomerase and viruses interaction in cancer development, and telomerase-dependent therapeutic approaches. Cancer Treatment and Research Communications 27, pages 100323.
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Rudolf A. Werner, Stefan Kircher, Takahiro Higuchi, Malte Kircher, Andreas Schirbel, Hans-Jürgen Wester, Andreas K. Buck, Martin G. Pomper, Steven P. Rowe & Constantin Lapa. (2019) CXCR4-Directed Imaging in Solid Tumors. Frontiers in Oncology 9.
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Eric M. RosenbergJr.Jr., Reed E.S. Harrison, Lun Kelvin Tsou, Natalie Drucker, Brock Humphries, Deepa Rajasekaran, Kathryn E. Luker, Chien-Huang Wu, Jen-Shin Song, Chuan-Jen Wang, James W. Murphy, Yung-Chi Cheng, Kak-Shan Shia, Gary D. Luker, Dimitrios Morikis & Elias J. Lolis. (2019) Characterization, Dynamics, and Mechanism of CXCR4 Antagonists on a Constitutively Active Mutant. Cell Chemical Biology 26:5, pages 662-673.e7.
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Tadas Penkauskas & Giulio Preta. (2019) Biological applications of tethered bilayer lipid membranes. Biochimie 157, pages 131-141.
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Huy H. Nguyen, Michelle B. Kim, Robert J. Wilson, Christopher J. Butch, Katie M. Kuo, Eric J. Miller, Yesim A. Tahirovic, Edgars Jecs, Valarie M. Truax, Tao Wang, Chi S. Sum, Mary E. Cvijic, Gretchen M. Schroeder, Lawrence J. Wilson & Dennis C. Liotta. (2018) Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties. Journal of Medicinal Chemistry 61:16, pages 7168-7188.
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Tomohiro Tanaka, Toru Aoki, Wataru Nomura & Hirokazu Tamamura. (2017) Bivalent 14-mer peptide ligands of CXCR4 with polyproline linkers with anti-chemotactic activity against Jurkat cells. Journal of Peptide Science 23:7-8, pages 574-580.
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Zoltán Szekanecz & Alisa E. Koch. 2017. Kelley and Firestein's Textbook of Rheumatology. Kelley and Firestein's Textbook of Rheumatology 384 395.e5 .
Francesca Chiarini, Annalisa Lonetti, Camilla Evangelisti, Francesca Buontempo, Ester Orsini, Cecilia Evangelisti, Alessandra Cappellini, Luca M. Neri, James A. McCubrey & Alberto M. Martelli. (2016) Advances in understanding the acute lymphoblastic leukemia bone marrow microenvironment: From biology to therapeutic targeting. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:3, pages 449-463.
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Sanjukta Chakraborty, David C. Zawieja, Michael J. Davis & Mariappan Muthuchamy. (2015) MicroRNA signature of inflamed lymphatic endothelium and role of miR-9 in lymphangiogenesis and inflammation. American Journal of Physiology-Cell Physiology 309:10, pages C680-C692.
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Guillaume Pierre Charles George, Federica Pisaneschi, Quang-Dé Nguyen & Eric Ofori Aboagye. (2015) Positron Emission Tomographic Imaging of CXCR4 in Cancer: Challenges and Promises. Molecular Imaging 14:1, pages 7290.2014.00041.
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Philipp Ermert, Kerstin Moehle & Daniel Obrecht. 2014. Macrocycles in Drug Discovery. Macrocycles in Drug Discovery 283 338 .
Susan Costantini, Raffaele Raucci, Giovanni Colonna, Flavia Anna Mercurio, Anna Maria Trotta, Ringhieri Paola, Marilisa Leone, Filomena Rossi, Carmela Pellegrino, Giuseppe Castello & Stefania Scala. (2014) Peptides targeting chemokine receptor CXCR4: structural behavior and biological binding studies. Journal of Peptide Science 20:4, pages 270-278.
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Stephanie Hummel, Hugo Van Aken & Alexander Zarbock. (2014) Inhibitors of CXC chemokine receptor type 4. Current Opinion in Hematology 21:1, pages 29-36.
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Oliver Demmer, Andreas O. Frank, Franz Hagn, Margret Schottelius, Luciana Marinelli, Sandro Cosconati, Ruth Brack‐Werner, Stephan Kremb, Hans‐Jürgen Wester & Horst Kessler. (2012) A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti‐HIV Activity. Angewandte Chemie International Edition 51:32, pages 8110-8113.
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Oliver Demmer, Andreas O. Frank, Franz Hagn, Margret Schottelius, Luciana Marinelli, Sandro Cosconati, Ruth Brack‐Werner, Stephan Kremb, Hans‐Jürgen Wester & Horst Kessler. (2012) Erhöhte CXCR4‐Affinität und Anti‐HIV‐Aktivität eines Peptoids durch Konformationsfixierung. Angewandte Chemie 124:32, pages 8234-8237.
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Sylvie Delhalle, Jean-Claude Schmit & Andy Chevigné. (2012) Phages and HIV-1: From Display to Interplay. International Journal of Molecular Sciences 13:4, pages 4727-4794.
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Won-Tak Choi, Srinivas Duggineni, Yan Xu, Ziwei Huang & Jing An. (2011) Drug Discovery Research Targeting the CXC Chemokine Receptor 4 (CXCR4). Journal of Medicinal Chemistry 55:3, pages 977-994.
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Shayne Cox GadZoltán Szekanecz & Alisa E. Koch. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Oliver Demmer, Ingrid Dijkgraaf, Udo Schumacher, Luciana Marinelli, Sandro Cosconati, Eleni Gourni, Hans-Jürgen Wester & Horst Kessler. (2011) Design, Synthesis, and Functionalization of Dimeric Peptides Targeting Chemokine Receptor CXCR4. Journal of Medicinal Chemistry 54:21, pages 7648-7662.
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Mohd W. Nasser, Zahida Qamri, Yadwinder S. Deol, Diane Smith, Konstantin Shilo, Xianghong Zou & Ramesh K. Ganju. (2011) Crosstalk between Chemokine Receptor CXCR4 and Cannabinoid Receptor CB2 in Modulating Breast Cancer Growth and Invasion. PLoS ONE 6:9, pages e23901.
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Sameer P Kawatkar, Maocai Yan, Harsukh Gevariya, Mi Youn Lim, Steven Eisold, Xuejun Zhu, Ziwei Huang & Jing An. (2011) Computational analysis of the structural mechanism of inhibition of chemokine receptor CXCR4 by small molecule antagonists. Experimental Biology and Medicine 236:7, pages 844-850.
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Massod Rahimi, Theodore A. Toth & Careen K. Tang. (2011) CXCR4 suppression attenuates EGFRvIII-mediated invasion and induces p38 MAPK-dependent protein trafficking and degradation of EGFRvIII in breast cancer cells. Cancer Letters 306:1, pages 43-51.
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Mikhail A. Zhukovsky, Stéphane Basmaciogullari, Beatriz Pacheco, Liping Wang, Navid Madani, Hillel Haim & Joseph Sodroski. (2010) Thermal Stability of the Human Immunodeficiency Virus Type 1 (HIV-1) Receptors, CD4 and CXCR4, Reconstituted in Proteoliposomes. PLoS ONE 5:10, pages e13249.
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Tsutomu Murakami & Naoki Yamamoto. (2010) Role of CXCR4 in HIV infection and its potential as a therapeutic target. Future Microbiology 5:7, pages 1025-1039.
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Sarah M. Eck, Jessica S. Blackburn, Adam C. Schmucker, Peter S. Burrage & Constance E. Brinckerhoff. (2009) Matrix metalloproteinase and G protein coupled receptors: Co-conspirators in the pathogenesis of autoimmune disease and cancer. Journal of Autoimmunity 33:3-4, pages 214-221.
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Zoltán Szekanecz & Alisa E. Koch. 2009. New Therapeutic Targets in Rheumatoid Arthritis. New Therapeutic Targets in Rheumatoid Arthritis 129 153 .
Hirokazu Tamamura, Tomohiro Tanaka, Hiroshi Tsutsumi, Nami Ohashi, Kenichi Hiramatsu, Takanobu Araki, Akio Ojida, Itaru Hamachi, Zixuan Wang, Stephen C. Peiper, John O. Trent, Satoshi Ueda, Shinya Oishi & Nobutaka Fujii. 2009. Peptides for Youth. Peptides for Youth 145 146 .
Gebhard Thoma, Markus B. Streiff, Jiri Kovarik, Fraser Glickman, Trixie Wagner, Christian Beerli & Hans-Günter Zerwes. (2008) Orally Bioavailable Isothioureas Block Function of the Chemokine Receptor CXCR4 In Vitro and In Vivo. Journal of Medicinal Chemistry 51:24, pages 7915-7920.
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Catherine Labbaye, Isabella Spinello, Maria Teresa Quaranta, Elvira Pelosi, Luca Pasquini, Eleonora Petrucci, Mauro Biffoni, Eugenia Rosa Nuzzolo, Monia Billi, Robin Foà, Ercole Brunetti, Francesco Grignani, Ugo Testa & Cesare Peschle. (2008) A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis. Nature Cell Biology 10:7, pages 788-801.
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O. Demmer, I. Dijkgraaf, M. Schottelius, H.-J. Wester & H. Kessler. (2008) Introduction of Functional Groups into Peptides via N -Alkylation . Organic Letters 10:10, pages 2015-2018.
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Thomas Dittmar, Christoph Heyder, Eva Gloria-Maercker, Wolfgang Hatzmann & Kurt S. Zänker. (2007) Adhesion molecules and chemokines: the navigation system for circulating tumor (stem) cells to metastasize in an organ-specific manner. Clinical & Experimental Metastasis 25:1, pages 11-32.
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Hirokazu TamamuraHiroshi TsutsumiWataru NomuraNobutaka Fujii. (2008) Exploratory Studies on Development of the Chemokine Receptor CXCR4 Antagonists toward Downsizing. Perspectives in Medicinal Chemistry 2, pages PMC.S422.
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Michal Abraham, Katia Biyder, Michal Begin, Hanna Wald, Ido D. Weiss, Eithan Galun, Arnon Nagler & Amnon Peled. (2007) Enhanced Unique Pattern of Hematopoietic Cell Mobilization Induced by the CXCR4 Antagonist 4F-Benzoyl-TN14003. Stem Cells 25:9, pages 2158-2166.
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Faisal Yusuf, Rizwan Rehimi, Gabriela Moroşan‐Puopolo, Fangping Dai, Xiaobing Zhang & Beate Brand‐Saberi. (2006) Inhibitors of CXCR4 affect the migration and fate of CXCR4 + progenitors in the developing limb of chick embryos . Developmental Dynamics 235:11, pages 3007-3015.
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