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Expert Opinion on Drug Safety Volume 9, 2010 - Issue 1
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Drug Safety Evaluations

Clinical safety of ranibizumab in age-related macular degeneration

Ursula Schmidt-Erfurth Medical University of Vienna, Department of Ophthalmology, Waehringer Guertel 18–20, A-1090 Vienna, Austria +43 1 40400 7931; +43 1 40400 7912; [email protected]
, MD
Pages 149-165 | Published online: 15 Dec 2009

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Ciro Costagliola, Francesco Morescalchi, Sarah Duse, Davide Romano, Giuseppina Mazza, Francesco Parmeggiani, Silvia Bartollino & Francesco Semeraro. (2019) Systemic thromboembolic adverse events in patients treated with intravitreal anti-VEGF drugs for neovascular age-related macular degeneration: an update. Expert Opinion on Drug Safety 18:9, pages 803-815.
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Ron P Gallemore, Josh Wallsh, Henry L Hudson, Allen C Ho, Richard Chace & Joel Pearlman. (2017) Combination verteporfin photodynamic therapy ranibizumab-dexamethasone in choroidal neovascularization due to age-related macular degeneration: results of a phase II randomized trial. Clinical Ophthalmology 11, pages 223-231.
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Michael W Stewart. (2013) Critical appraisal of ranibizumab in the treatment of diabetic macular edema. Clinical Ophthalmology 7, pages 1257-1267.
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Daniele Tognetto, Eirini Skiadaresi, Paolo Cecchini & Giuseppe Ravalico. (2011) Subretinal recombinant tissue plasminogen activator and pneumatic displacement for the management of subretinal hemorrhage occurring after anti-VEGF injections for wet AMD. Clinical Ophthalmology 5, pages 459-463.
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Paul Mitchell. (2011) A systematic review of the efficacy and safety outcomes of anti-VEGF agents used for treating neovascular age-related macular degeneration: comparison of ranibizumab and bevacizumab. Current Medical Research and Opinion 27:7, pages 1465-1475.
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Roopa Vemala, Bhaskar Gupta & Sobha Sivaprasad. (2010) Visual outcome of ranibizumab therapy for neovascular age related macular degeneration in the black population: a report of five cases. Clinical Ophthalmology 4, pages 913-916.
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Prashanth G. Iyer & Thomas A. Albini. (2021) Drug-related adverse effects of antivascular endothelial growth factor agents. Current Opinion in Ophthalmology 32:3, pages 191-197.
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Arseniy P. Yashkin, Paul Hahn & Frank A. Sloan. (2016) Introducing Anti-Vascular Endothelial Growth Factor Therapies for AMD Did Not Raise Risk of Myocardial Infarction, Stroke, and Death. Ophthalmology 123:10, pages 2225-2231.
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Donghyun JeeMasahiro ZakoTae Yoon La. (2015) Serum D-Dimer Levels to Evaluate the Risk for Arterial Thromboembolism After Intravitreal Injection of Bevacizumab and Ranibizumab. Journal of Ocular Pharmacology and Therapeutics 31:1, pages 32-36.
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Jialiang Zhao, Xiaoxin Li, Shibo Tang, Gezhi Xu, Xun Xu, Feng Zhang, Meixia Zhang, Jila Shamsazar, Stefan Pilz & Annette Nieweg. (2014) EXTEND II: An Open-Label Phase III Multicentre Study to Evaluate Efficacy and Safety of Ranibizumab in Chinese Patients with Subfoveal Choroidal Neovascularization Secondary to Age-Related Macular Degeneration. BioDrugs 28:6, pages 527-536.
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C D Murray, D Wood, V Allgar, G Walters & R P Gale. (2014) Short-term intraocular pressure trends following intravitreal ranibizumab injections for neovascular age-related macular degeneration—the role of oral acetazolamide in protecting glaucoma patients. Eye 28:10, pages 1218-1222.
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Frank G. Holz, Steffen Schmitz-Valckenberg & Monika Fleckenstein. (2014) Recent developments in the treatment of age-related macular degeneration. Journal of Clinical Investigation 124:4, pages 1430-1438.
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Katherine A. Lyseng-Williamson & James E. Frampton. (2013) Ranibizumab: points to consider when using it to treat neovascular age-related macular degeneration according to EU labelling. Drugs & Therapy Perspectives 29:9, pages 268-274.
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Giulio Ferrari, Mohammad H. Dastjerdi, Andre Okanobo, Sheng-Fu Cheng, Francisco Amparo, Nambi Nallasamy & Reza Dana. (2013) Topical Ranibizumab as a Treatment of Corneal Neovascularization. Cornea 32:7, pages 992-997.
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Rebecca GriersonBirthe Meyer-RüsenbergFrank KunstMarc J. BernaGisbert RichardMichelle Thill. (2013) Endothelial Progenitor Cells and Plasma Vascular Endothelial Growth Factor and Stromal Cell-Derived Factor-1 During Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration. Journal of Ocular Pharmacology and Therapeutics 29:6, pages 530-538.
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K Ghasemi Falavarjani & Q D Nguyen. (2013) Adverse events and complications associated with intravitreal injection of anti-VEGF agents: a review of literature. Eye 27:7, pages 787-794.
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J. Gambrelle, G. Missotten, S. Delhoum & L. Desjardins. (2013) Intravitreal injection of anti-VEGF and diagnosis of primary intraocular central nervous system lymphoma. Journal Fran?ais d'Ophtalmologie 36:5, pages 431-434.
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James E. Frampton. (2013) Ranibizumab: A Review of Its Use in the Treatment of Neovascular Age-Related Macular Degeneration. Drugs & Aging 30:5, pages 331-358.
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David Xu & Peter K Kaiser. (2013) Intravitreal aflibercept for neovascular age-related macular degeneration. Immunotherapy 5:2, pages 121-130.
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Noemi Lois, Vikki Mcbain, Ehab Abdelkader, Neil W. Scott & Reena Kumari. (2013) RETINAL PIGMENT EPITHELIAL ATROPHY IN PATIENTS WITH EXUDATIVE AGE-RELATED MACULAR DEGENERATION UNDERGOING ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY. Retina 33:1, pages 13-22.
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Mark S. Blumenkranz, Loh-Shan Leung, Daniel F. Martin, Philip J. Rosenfeld & Marco A. Zarbin. 2013. Retina. Retina 1213 1255 .
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Simon E. Skalicky, Ivan Ho, Ashish Agar & Allan Bank. (2012) Glaucoma Filtration Surgery Following Sustained Elevation of Intraocular Pressure Secondary to Intravitreal Anti-VEGF Injections. Ophthalmic Surgery, Lasers and Imaging Retina 43:4, pages 328-334.
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L. García-López, R. Coloma Peral & M.T. Criado Illana. (2012) Tratamiento antiangiogénico de degeneración macular asociada a la edad en pacientes con riesgo cerebrovascular previo. Farmacia Hospitalaria 36:3, pages 169-170.
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Victor Chong. (2012) Biological, Preclinical and Clinical Characteristics of Inhibitors of Vascular Endothelial Growth Factors. Ophthalmologica 227:s1, pages 2-10.
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Raafay Sophie, Abeer Akhtar, Yasir J. Sepah, Mohamed Ibrahim, Millena Bittencourt, Diana V. Do & Quan Dong Nguyen. (2012) Aflibercept: a Potent Vascular Endothelial Growth Factor Antagonist for Neovascular Age-Related Macular Degeneration and Other Retinal Vascular Diseases. Biologics in Therapy 2:1.
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Anna MachalińskaEdyta PaczkowskaTomasz PabinKrzysztof SafranowDanuta KarczewiczBoguslaw Machaliński. (2011) Influence of Ranibizumab on Vascular Endothelial Growth Factor Plasma Level and Endothelial Progenitor Cell Mobilization in Age-Related Macular Degeneration Patients: Safety of Intravitreal Treatment for Vascular Homeostasis. Journal of Ocular Pharmacology and Therapeutics 27:5, pages 471-475.
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Laurence S. Lim, Chui Ming Gemmy Cheung, Paul Mitchell & Tien Y. Wong. (2011) Emerging Evidence Concerning Systemic Safety of Anti-VEGF Agents – Should Ophthalmologists Be Concerned?. American Journal of Ophthalmology 152:3, pages 329-331.
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C H Meyer & F G Holz. (2011) Preclinical aspects of anti-VEGF agents for the treatment of wet AMD: ranibizumab and bevacizumab. Eye 25:6, pages 661-672.
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W M Amoaku. (2011) Ranibizumab: a medical treatment that requires surgical administration. Eye 25:4, pages 399-401.
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Jos? Manuel Real Campa?a, Patricia Carrera Lafuentes, Clemencia Torr?n Fern?ndez-Blanco, Rafael Huarte Lacunza, Isabel Varela Mart?nez & M. Jos? Rabanaque Hern?ndez. (2011) Efectividad y seguridad de ranibizumab en degeneraci?n macular neovascular asociada a la edad. Medicina Cl?nica 136:11, pages 471-477.
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Michael Stur. (2011) Leitlinien zur Behandlung der feuchten Makuladegeneration. Spektrum der Augenheilkunde 25:1, pages 51-55.
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An Truong, Tien Y. Wong & Levon M. Khachigian. (2010) Emerging therapeutic approaches in the management of retinal angiogenesis and edema. Journal of Molecular Medicine 89:4, pages 343-361.
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Th. Dietlein, G. K. Krieglstein & P. WiedemannKatrin Engelmann & Klio Ai Becker. 2012. Glaukom und Makula 2010. Glaukom und Makula 2010 143 154 .
Jose S. Pulido. (2010) Monitoring systemic complications of intraocular medications. Canadian Journal of Ophthalmology 45:3, pages 215-217.
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Tien Y. Wong. (2010) Age-Related Macular Degeneration. Stroke 41:4, pages 575-576.
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