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Cardiovascular risks associated with low-dose ibuprofen and diclofenac as used OTC

, MD PhD, , MD PhD, , PharmD, , MD & , MD PhD

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Mandeep Kaur, Pramodkumar P. Gupta, Anmol Jain, Gurmeet Kaur, Amandeep Kaur & Manisha Bansal. (2023) Investigating multifaceted action of ibuprofen derivatives towards cox isozymes and interleukin-6 (IL-6) site correlating with various target sites. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-14.
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Francesco Salvo, Stefania Antoniazzi, Mai Duong, Mathieu Molimard, Fabienne Bazin, Annie Fourrier-Réglat, Antoine Pariente & Nicholas Moore. (2014) Cardiovascular events associated with the long-term use of NSAIDs: a review of randomized controlled trials and observational studies. Expert Opinion on Drug Safety 13:5, pages 573-585.
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Deepak Ahire, Scott Heyward & Bhagwat Prasad. (2023) Intestinal Metabolism of Diclofenac by Polymorphic UGT2B17 Correlates with its Highly Variable Pharmacokinetics and Safety across Populations . Clinical Pharmacology & Therapeutics 114:1, pages 161-172.
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Alessandra Bettiol, Ettore Marconi, Alfredo Vannacci, Monica Simonetti, Alberto Magni, Claudio Cricelli & Francesco Lapi. (2021) Effectiveness of ibuprofen plus paracetamol combination on persistence of acute musculoskeletal disorders in primary care patients. International Journal of Clinical Pharmacy.
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Nicholas Moore. (2020) Coronary Risks Associated with Diclofenac and Other NSAIDs: An Update. Drug Safety 43:4, pages 301-318.
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Olga D Ostroumova & Mariia I Kulikova. (2019) Drug-induced arterial hypertension. Systemic Hypertension 16:2, pages 32-41.
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Mai Duong, Abdelilah Abouelfath, Regis Lassalle, Cécile Droz, Patrick Blin & Nicholas Moore. (2018) Coronary Events After Dispensing of Ibuprofen: A Propensity Score-Matched Cohort Study Versus Paracetamol in the French Nationwide Claims Database Sample. Drug Safety 41:11, pages 1049-1058.
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Chun-Shuo Shan, Qing-Qing Xu, Yi-Hua Shi, Yong Wang, Zhang-Xin He & Guo-Qing Zheng. (2018) Chuanxiong Formulae for Migraine: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials. Frontiers in Pharmacology 9.
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Jeff Taylor. (2017) Over-the-Counter Medicines and Diabetes Care. Canadian Journal of Diabetes 41:6, pages 551-557.
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Dominick J. Angiolillo & Steven M. Weisman. (2016) Clinical Pharmacology and Cardiovascular Safety of Naproxen. American Journal of Cardiovascular Drugs 17:2, pages 97-107.
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Nina Dippold & Ludger Klimek. (2017) Leitliniengerechte Therapie von Schnupfen und SinusitisRhinosinusitis — diagnosis and guideline-based therapy. MMW - Fortschritte der Medizin 159:1, pages 37-43.
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Paola Avetta, Debora Fabbri, Marco Minella, Marcello Brigante, Valter Maurino, Claudio Minero, Marco Pazzi & Davide Vione. (2016) Assessing the phototransformation of diclofenac, clofibric acid and naproxen in surface waters: Model predictions and comparison with field data. Water Research 105, pages 383-394.
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L. Bendtsen, S. Ashina, A. Moore & T. J. Steiner. (2016) Muscles and their role in episodic tension-type headache: implications for treatment. European Journal of Pain 20:2, pages 166-175.
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Carmelo Scarpignato & Corrado Blandizzi. 2016. NSAIDs and Aspirin. NSAIDs and Aspirin 61 89 .
R Andrew Moore, Sheena Derry, Dominic Aldington & Philip J Wiffen. (2015) Adverse events associated with single dose oral analgesics for acute postoperative pain in adults - an overview of Cochrane reviews. Cochrane Database of Systematic Reviews.
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R.A. Moore, S. Derry, P.J. Wiffen, S. Straube & D.J. Aldington. (2014) Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions. European Journal of Pain 19:9, pages 1213-1223.
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R Andrew Moore, Sheena Derry, Dominic Aldington, Peter Cole & Philip J Wiffen. (2015) Amitriptyline for fibromyalgia in adults. Cochrane Database of Systematic Reviews 2019:5.
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M. Lantéri-Minet, M. Cucherat & A. Benkhelil. (2015) Sécurité d’emploi de l’ibuprofène en prescription médicale facultative chez l’adulte : méta-analyse comparative ibuprofène versus placebo et paracétamolThe safe use of ibuprofen on facultative medical prescription in adults: a comparative meta-analysis of ibuprofen versus placebo and paracetamol. Douleur et Analgésie 28:2, pages 100-115.
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R. A. Moore. (2015) Analgesic safety - myths, mysteries and misconceptions. International Journal of Clinical Practice 69, pages 24-27.
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Waheed Asghar & Fakhreddin Jamali. (2014) The effect of COX-2-selective meloxicam on the myocardial, vascular and renal risks: a systematic review. Inflammopharmacology 23:1, pages 1-16.
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Venkata S.K. Indurthi, Estelle Leclerc & Stefan W. Vetter. (2014) Calorimetric investigation of diclofenac drug binding to a panel of moderately glycated serum albumins. European Journal of Pharmaceutical Sciences 59, pages 58-68.
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R Andrew Moore, Philip J Wiffen, Sheena Derry & Andrew SC Rice. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.

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