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Expert Opinion on Drug Safety Volume 5, 2006 - Issue 2
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Review

Adult and paediatric poor metabolisers of desloratadine: an assessment of pharmacokinetics and safety

Bruce Prenner President, Principal Investigator, Allergy Associates Medical Group, 6386 Alvarado Court, San Diego, CA 92120, USA. [email protected]
,
Kenneth Kim CEO, West Coast Clinical Trials, 2600 Redondo Avenue, Suite 400, Long Beach, CA, 90806, USA
,
Samir Gupta Senior Research Fellow, Schering-Plough Research Institute, Department of Drug Metabolism and Pharmacokinetics, 2015 Galloping Hill Road, Kenilworth, NJ, USA
,
Sauzanne Khalilieh Director, Clinical Trials, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, USA
,
Bhavna Kantesaria Schering-Plough Research Institute, Department of Drug Metabolism and Pharmacokinetics, 2015 Galloping Hill Road, Kenilworth, NJ, USA
,
Prasarn Manitpisitkul [Formerly] Senior Principle Scientist, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, USA
,
Richard Lorber Senior Director, Allergy Clinical Research, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, USA
,
Zaiqi Wang Director of Clinical Research, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, USA
&
Barry Lutsky Director, Schering-Plough Research Institute, Department of Allergy/Respiratory Medicine, 2015 Galloping Hill Road, Kenilworth, NJ, USA
 show all
Pages 211-223 | Published online: 27 Feb 2006

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Vanesa González-Núñez, Antonio Valero & Joaquim Mullol. (2013) Safety evaluation of desloratadine in allergic rhinitis. Expert Opinion on Drug Safety 12:3, pages 445-453.
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Jean-Marie Nicolas, Pascal Espie & Mathieu Molimard. (2009) Gender and interindividual variability in pharmacokinetics. Drug Metabolism Reviews 41:3, pages 408-421.
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Margherita Strolin Benedetti, Rhys Whomsley, Italo Poggesi, Willi Cawello, François-Xavier Mathy, Marie-Laure Delporte, Peggy Papeleu & Jean-Baptiste Watelet. (2009) Drug metabolism and pharmacokinetics. Drug Metabolism Reviews 41:3, pages 344-390.
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R. Ramanathan, L. Reyderman, A.-D. Su, N. Alvarez, S. K. Chowdhury, K. B. Alton, M. A. Wirth, R. P. Clement, P. Statkevich & J. E. Patrick. (2007) Disposition of desloratadine in healthy volunteers. Xenobiotica 37:7, pages 770-787.
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Articles from other publishers (19)

Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi & Janne T. Backman. (2019) Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans. Drug Metabolism and Disposition 47:4, pages 377-385.
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Jörg Täubel, Georg Ferber, Sara Fernandes, Ulrike Lorch, Eva Santamaría & Iñaki Izquierdo. (2016) Pharmacokinetics, Safety and Cognitive Function Profile of Rupatadine 10, 20 and 40 mg in Healthy Japanese Subjects: A Randomised Placebo-Controlled Trial. PLOS ONE 11:9, pages e0163020.
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. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 870 872 .
Ari Murad, Constance H. Katelaris & Garry G. Graham. 2016. Compendium of Inflammatory Diseases. Compendium of Inflammatory Diseases 87 97 .
Ting Wang, Kun Zhang, Tingting Li, Lin He, Huiru Xie, Xuehua Jiang & Ling Wang. (2015) Prevalence of Desloratadine Slow-metabolizer Phenotype and Food-dependent Pharmacokinetics of Desloratadine in Healthy Chinese Volunteers. Clinical Drug Investigation 35:12, pages 807-813.
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Faraz Kazmi, Phyllis Yerino, Joanna E. Barbara & Andrew Parkinson. (2015) Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor. Drug Metabolism and Disposition 43:9, pages 1294-1302.
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Faraz Kazmi, Joanna E. Barbara, Phyllis Yerino & Andrew Parkinson. (2015) A Long-Standing Mystery Solved: The Formation of 3-Hydroxydesloratadine Is Catalyzed by CYP2C8 But Prior Glucuronidation of Desloratadine by UDP-Glucuronosyltransferase 2B10 Is an Obligatory Requirement. Drug Metabolism and Disposition 43:4, pages 523-533.
Crossref
Natasha Penner. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
Ari Murad, Constance H. Katelaris & Garry G. Graham. 2016. Encyclopedia of Inflammatory Diseases. Encyclopedia of Inflammatory Diseases 1 11 .
Nancy Hakooz & Isam I. Salem. (2012) Prevalence of desloratadine poor metabolizer phenotype in healthy Jordanian males. Biopharmaceutics & Drug Disposition 33:1, pages 15-21.
Crossref
Garry M. Walsh. 2010. Side Effects of Drugs Annual 32 - A worldwide yearly survey of new data and trends in adverse drug reactions and interactions. Side Effects of Drugs Annual 32 - A worldwide yearly survey of new data and trends in adverse drug reactions and interactions 305 310 .
Garry M. Walsh. 2009. 297 303 .
F. Estelle, R. Simons & Cezmi A. Akdis. 2009. Middleton's Allergy: Principles and Practice. Middleton's Allergy: Principles and Practice 1517 1547 .
Evrim Alyamac Dizdar, Bulent Enis Sekerel & Ayfer Tuncer. (2008) Desloratadine: a review of pharmacology and clinical efficacy in allergic rhinitis and urticaria. Therapy 5:6, pages 817-828.
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Anna Solans, Iñaki Izquierdo, Esther Donado, Rosa Antonijoan, Juana Peña, Teresa Nadal, Marcel-lí Carbó, Manuel Merlos & Manel Barbanoj. (2008) Pharmacokinetic and safety profile of rupatadine when coadministered with azithromycin at steady-state levels: a randomized, open-label, two-way, crossover, Phase I study. Clinical Therapeutics 30:9, pages 1639-1650.
Crossref
N G Astaf'eva. (2008) Allergicheskiy rinit i ego vliyaniena astmu: rol' an tigistaminn ykhpreparatov v lechenii i profilaktike. Russian Journal of Allergy 5:1, pages 37-48.
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Philippe Devillier, Nicolas Roche & Christophe Faisy. (2008) Clinical Pharmacokinetics and Pharmacodynamics of Desloratadine, Fexofenadine and Levocetirizine. Clinical Pharmacokinetics 47:4, pages 217-230.
Crossref
Samir K. Gupta, Bhavna Kantesaria, Christopher Banfield & Zaiqi Wang. (2007) Desloratadine dose selection in children aged 6 months to 2 years: comparison of population pharmacokinetics between children and adults. British Journal of Clinical Pharmacology 64:2, pages 174-184.
Crossref
Lawrence DuBuske. (2007) Desloratadine for Chronic Idiopathic Urticaria. American Journal of Clinical Dermatology 8:5, pages 271-283.
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