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Expert Opinion on Drug Safety Volume 7, 2008 - Issue 5
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Safety of ceftriaxone sodium at extremes of age

Scott V Monte Clinical Assistant Professor, University at Buffalo, Director of Diabetes and Cardiovascular Research, CPL Associates, LLC, 3980 Sheridan Drive, Amherst, NY 14226, USA +1 1 011 716 839 4931 ext. 217; +1 716 713 52423; [email protected]
, PharmD,
William Allan Prescott Jr Clinical Assistant Professor University at Buffalo, 313 Cooke Hall, Amherst, NY 14260, USA
, PharmD,
Kristin K Johnson Clinical Instructor, University at Buffalo, Clinical Pharmacy Coordinator, The Women and Children's Hospital of Buffalo, 219 Bryant Street, Buffalo, NY 14222, USA
, PharmD,
Lori Kuhman Clinical Pharmacy Coordinator Kaleida Health Gates Circle Hospital, 3 Gates Circle, Buffalo, NY 14209, USA
, PharmD &
Joseph A Paladino Clinical Professor, University at Buffalo, Director, Outcomes Research, CPL Associates, LLC, 3980 Sheridan Drive, Amherst, NY 14226, USA
, PharmD
Pages 515-523 | Published online: 01 Sep 2008

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Aline Fuchs, Julia Bielicki, Shrey Mathur, Mike Sharland & Johannes N. Van Den Anker. (2018) Reviewing the WHO guidelines for antibiotic use for sepsis in neonates and children. Paediatrics and International Child Health 38:sup1, pages S3-S15.
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Alicja Bartkowska-Śniatkowska, Katarzyna Jończyk-Potoczna, Marzena Zielińska & Jowita Rosada-Kurasińska. (2015) Adverse reaction to ceftriaxone in a 28-day-old infant undergoing urgent craniotomy due to epidural hematoma: review of neonatal biliary pseudolithiasis. Therapeutics and Clinical Risk Management 11, pages 1035-1041.
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Articles from other publishers (31)

Zon-Min Lee, Ling-Sai Chang, Kuang-Che Kuo, Meng-Chiao Lin & Hong-Ren Yu. (2023) Impact of Protein Binding Capacity and Daily Dosage of a Drug on Total Serum Bilirubin Levels in Susceptible Infants. Children 10:6, pages 926.
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Mustafa AKÇALI, Hüseyin ŞİMŞEK, Ferda ÖZLÜ, Hacer YAPICIOĞLU & Mehmet SATAR. (2022) Yenidoğanlarda seftriakson kullanımının yan etkilerinin değerlendirilmesiEvaluation of side effects of ceftriaxone use in newborns. Cukurova Medical Journal 47:4, pages 1641-1649.
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Zon-Min Lee, Yao-Hsu Yang, Ling-Sai Chang, Chih-Cheng Chen, Hong-Ren Yu & Kuang-Che Kuo. (2022) Increased Total Serum Bilirubin Level Post-Ibuprofen Use Is Inversely Correlated with Neonates’ Body Weight. Children 9:8, pages 1184.
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Soichi Arakawa, Masashi Kasai, Shin Kawai, Hiroshi Sakata & Toshihiko Mayumi. (2021) The JAID/JSC guidelines for management of infectious diseases 2017 – Sepsis and catheter-related bloodstream infection. Journal of Infection and Chemotherapy 27:5, pages 657-677.
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Anthony Martin Mena, Morgane Masse, Laura Négrier, Thu Huong Nguyen, Bruno Ladam, Laurent Storme, Christine Barthélémy, Pascal Odou, Stéphanie Genay & Bertrand Décaudin. (2021) Optimising an Infusion Protocol Containing Cefepime to Limit Particulate Load to Newborns in a Neonatal Intensive Care Unit. Pharmaceutics 13:3, pages 351.
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Garrett B. Hile, Kaitlin L. Musick, Adam J. Dugan, Abby M. Bailey & Gavin T. Howington. (2021) Occurrence of Hyperbilirubinemia in Neonates Given a Short-term Course of Ceftriaxone versus Cefotaxime for Sepsis. The Journal of Pediatric Pharmacology and Therapeutics 26:1, pages 99-103.
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Ophélie Maison, Cléa Tardy, Delphine Cabelguenne, Stéphanie Parat, Sophie Ducastelle, Vincent Piriou, Alain Lepape & Laure Lalande. (2018) Drug incompatibilities in intravenous therapy: evaluation and proposition of preventive tools in intensive care and hematology units. European Journal of Clinical Pharmacology 75:2, pages 179-187.
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. (2018) JAID/JSC 感染症治療ガイドライン2017 ―敗血症およびカテーテル関連血流感染症―. Kansenshogaku Zasshi 92:1, pages 10-45.
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Pieter A. J. G. De Cock, Karel Allegaert, Matthew W. Linakis & Catherine M. T. Sherwin. 2018. Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill. Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill 239 263 .
Elizabeth M. Molyneux, Queen Dube, Francis M. Banda, Msandeni Chiume, Isaac Singini, Macpherson Mallewa, Edward C. Schwalbe & Robert S. Heyderman. (2017) The Treatment of Possible Severe Infection in Infants. Pediatric Infectious Disease Journal 36:12, pages e328-e333.
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Caroline Fonzo-Christe, Lucie Bouchoud & Riccardo Pfister. (2017) Incompatibilités médicamenteuses et nutrition parentérale en néonatologie. Nutrition Clinique et Métabolisme 31:1, pages 24-27.
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Patrick C. Donnelly, Rebecca M. Sutich, Ryan Easton, Oluwatunmise A. Adejumo, Todd A. Lee & Latania K. Logan. (2016) Ceftriaxone-Associated Biliary and Cardiopulmonary Adverse Events in Neonates: A Systematic Review of the Literature. Pediatric Drugs 19:1, pages 21-34.
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Maxime Perez, Aurélie Maiguy-Foinard, Christine Barthélémy, Bertrand Décaudin & Pascal Odou. (2016) Particulate Matter in Injectable Drugs: Evaluation of Risks to Patients. Pharmaceutical Technology in Hospital Pharmacy 1:2.
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Young R. Lee, Danni McMahan, Catherine McCall & Gregory K. Perry. (2015) Complicated Intra-Abdominal Infections: The Old Antimicrobials and the New Players. Drugs 75:18, pages 2097-2117.
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David Isaacs. 2013. Evidence-Based Neonatal Infections. Evidence-Based Neonatal Infections 269 290 .
Conan MacDougall, B. Joseph Guglielmo & Jeanine Wiener-Kronish. 2011. Anesthetic Pharmacology. Anesthetic Pharmacology 963 986 .
Eman F. Badran, Hamdi A. Battah, Kamal F Akl, Raida W. Khalil & Iyad Al Amori. (2013) Detection of novel LAMA3 mutation in Herlitz junctional epidermolysis bullosa in a Jordanian family . Australasian Journal of Dermatology 54:3, pages 218-221.
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Cuneyt TaymanMaisa Rayyan & Karel Allegaert. (2011) Neonatal Pharmacology: Extensive Interindividual Variability Despite Limited Size. The Journal of Pediatric Pharmacology and Therapeutics 16:3, pages 170-184.
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John S. Esterly, Emily Steadman & Marc H. Scheetz. (2011) Impact of the FDA warning of potential ceftriaxone and calcium interactions on drug use policy in clinical practice. International Journal of Clinical Pharmacy 33:3, pages 537-542.
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Hans-Rudolf Schmutz, Pascal Detampel, Theo Bühler, André Büttler, Benjamin Gygax & Jörg Huwyler. (2011) In Vitro Assessment of the Formation of Ceftriaxone–Calcium Precipitates in Human Plasma. Journal of Pharmaceutical Sciences 100:6, pages 2300-2310.
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Tore Midtvedt. 2011. A worldwide yearly survey of new data in adverse drug reactions. A worldwide yearly survey of new data in adverse drug reactions 491 508 .
Yohannes Hagos & Natascha A. Wolff. (2010) Assessment of the Role of Renal Organic Anion Transporters in Drug-Induced Nephrotoxicity. Toxins 2:8, pages 2055-2082.
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Isabella Giorgi, Bertrand Guignard, Caroline Fonzo-Christe & Pascal Bonnabry. (2010) Evaluation of tools to prevent drug incompatibilities in paediatric and neonatal intensive care units. Pharmacy World & Science 32:4, pages 520-529.
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Emily Steadman, Dennis W. Raisch, Charles L. Bennett, John S. Esterly, Tischa Becker, Michael Postelnick, June M. McKoy, Steve Trifilio, Paul R. Yarnold & Marc H. Scheetz. (2010) Evaluation of a Potential Clinical Interaction between Ceftriaxone and Calcium. Antimicrobial Agents and Chemotherapy 54:4, pages 1534-1540.
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Hartmut Lode. (2010) Safety and Tolerability of Commonly Prescribed Oral Antibiotics for the Treatment of Respiratory Tract Infections. The American Journal of Medicine 123:4, pages S26-S38.
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David Greenwood. 2010. Antibiotic and Chemotherapy. Antibiotic and Chemotherapy 170 199 .
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Susana Chavez-Bueno & Terrence L. Stull. (2009) Antibacterial Agents in Pediatrics. Infectious Disease Clinics of North America 23:4, pages 865-880.
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