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Multifunctional coprocessed excipients for improved tabletting performance

& , PhD
Pages 197-208 | Published online: 24 Feb 2009

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Read on this site (13)

Natalia Veronica, Paul Wan Sia Heng & Celine Valeria Liew. (2023) Alginate-based matrix tablets for drug delivery. Expert Opinion on Drug Delivery 20:1, pages 115-130.
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Daniel Zakowiecki, Peter Edinger, Markos Papaioannou, Tobias Hess, Bartlomiej Kubiak & Anna Terlecka. (2022) Exploiting synergistic effects of brittle and plastic excipients in directly compressible formulations of sitagliptin phosphate and sitagliptin hydrochloride. Pharmaceutical Development and Technology 27:6, pages 702-713.
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Prashantkumar K. Parmar, Srilaxmi G. Rao & Arvind K. Bansal. (2021) Co-processing of small molecule excipients with polymers to improve functionality. Expert Opinion on Drug Delivery 18:7, pages 907-928.
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Dhaval Mori, Punit Rathod, Ramesh Parmar, Kiran Dudhat & Jayant Chavda. (2020) Preparation and optimization of multi-functional directly compressible excipient: an integrated approach of principal component analysis and design of experiments. Drug Development and Industrial Pharmacy 46:12, pages 2010-2021.
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Punit Rathod, Dhaval Mori, Ramesh Parmar, Moinuddin Soniwala & Jayant Chavda. (2019) Co-processing of cefuroxime axetil by spray drying technique for improving compressibility and flow property. Drug Development and Industrial Pharmacy 45:5, pages 767-774.
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Jitka Mužíková, Alena Srbová & Petra Svačinová. (2017) A study of a novel coprocessed dry binder composed of α-lactose monohydrate, microcrystalline cellulose and corn starch. Pharmaceutical Development and Technology 22:8, pages 964-971.
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Simay Yıldız, Eren Aytekin, Burçin Yavuz, Sibel Bozdağ Pehlivan & Nurşen Ünlü. (2016) Formulation studies for mirtazapine orally disintegrating tablets. Drug Development and Industrial Pharmacy 42:6, pages 1008-1017.
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Payal Sharma, Sameer R. Modi & Arvind K. Bansal. (2015) Co-processing as a tool to improve aqueous dispersibility of cellulose ethers. Drug Development and Industrial Pharmacy 41:11, pages 1745-1758.
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Oluwatomide Adeoye & Gbenga Alebiowu. (2014) Flow, packing and compaction properties of novel coprocessed multifunctional directly compressible excipients prepared from tapioca starch and mannitol. Pharmaceutical Development and Technology 19:8, pages 901-910.
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Ines Saniocki, Albrecht Sakmann & Claudia S. Leopold. (2013) How suitable is the measurement of take-off forces for detection of sticking during direct compression of various ibuprofen tablet formulations?. Pharmaceutical Development and Technology 18:1, pages 257-265.
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Mohammad Zaki Ahmad, Sohail Akhter, Ishita Dhiman, Poonam Sharma & Reena Verma. (2013) Evaluation of material properties and compression characteristics of Assam Bora rice flours as a directly compressible vehicle in tablet formulation. Expert Opinion on Drug Delivery 10:2, pages 163-171.
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C. M. Hentzschel, A. Sakmann & C. S. Leopold. (2012) Comparison of traditional and novel tableting excipients: Physical and compaction properties. Pharmaceutical Development and Technology 17:6, pages 649-653.
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John Rojas, Ira Buckner & Vijay Kumar. (2012) Co-proccessed excipients with enhanced direct compression functionality for improved tableting performance. Drug Development and Industrial Pharmacy 38:10, pages 1159-1170.
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Articles from other publishers (65)

Kaushalendra Chaturvedi, Pasaorn Pongkulapa, Xiaoyi Ding, Harsh S. Shah, San Kiang & Veeran Kadajji. (2023) Enhancement of material attributes of poorly compressible metformin hydrochloride through coprocessing with hydroxypropyl cellulose (HPC-L) using coprecipitation (CPT). AAPS Open 9:1.
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Karnkamol Trisopon, Nisit Kittipongpatana & Ornanong Suwannapakul Kittipongpatana. (2023) Performance study of cross-linked carboxymethyl rice starch, co-processed with sodium silicate as a direct compression excipient using SeDeM expert system. Journal of Drug Delivery Science and Technology 89, pages 105056.
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Zhenda Liu, Chuting Shi, Ying Fang, Haiyue Zhao, Yingying Mu, Lijie Zhao & Lan Shen. (2023) A comprehensive understanding of disintegrants and disintegration quantification techniques: From the perspective of tablet microstructure. Journal of Drug Delivery Science and Technology 88, pages 104891.
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Chonticha Amornrojvaravut & Jomjai Peerapattana. (2023) Application of co-precipitated glutinous rice starch as a multifunctional excipient in direct compression tablets. Heliyon 9:9, pages e19904.
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Ana Baumgartner & Odon Planinšek. (2023) Effect of process parameters in high shear granulation on characteristics of a novel co-processed mesoporous silica material. European Journal of Pharmaceutical Sciences 188, pages 106528.
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Chuting Shi, Haiyue Zhao, Ying Fang, Lan Shen & Lijie Zhao. (2023) Lactose in tablets: Functionality, critical material attributes, applications, modifications and co-processed excipients. Drug Discovery Today 28:9, pages 103696.
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Darshan R. Telange, Neha M. Bhaktani, Atul T. Hemke, Anil M. Pethe, Surendra S. Agrawal, Nilesh R. Rarokar & Shirish P. Jain. (2023) Development and Characterization of Pentaerythritol-EudragitRS100 Co-processed Excipients as Solid Dispersion Carriers for Enhanced Aqueous Solubility, In Vitro Dissolution, and Ex Vivo Permeation of Atorvastatin . ACS Omega 8:28, pages 25195-25208.
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Cheng Jin, Fei Wu, Yanlong Hong, Lan Shen, Xiao Lin, Lijie Zhao & Yi Feng. (2023) Updates on applications of low-viscosity grade Hydroxypropyl methylcellulose in coprocessing for improvement of physical properties of pharmaceutical powders. Carbohydrate Polymers 311, pages 120731.
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DARSHAN R. TELANGE, SURENDRA S. AGRAWAL, ANIL M. PETHE & ANKITA V. HADKE. (2023) ENHANCED AQUEOUS SOLUBILITY AND IN VITRO DISSOLUTION OF THE ANTI-HYPERLIPIDEMIC AGENT USING SYNTHESIZED SOLID DISPERSION CARRIER. International Journal of Applied Pharmaceutics, pages 121-130.
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Sajal Jain, Ritu Rathi, Upendra Nagaich & Inderbir Singh. (2023) Co-processed tablet excipient composition, its preparation and use: US10071059 B2: patent spotlight. Pharmaceutical Patent Analyst 12:1, pages 19-25.
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Sandesh Narayan Somnache, K. Vasantakumar Pai, Ajeet Madhukar Godbole, Pankaj Sadashiv Gajare & Arti Shashikant Pednekar. (2022) Development of M3 as Improved Functionality Composite Excipient for Direct Compression. International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15:5, pages 6111-6120.
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Qiuhua Luo, Qianying Zhang & Puxiu Wang. (2022) Hydrochlorothiazide/Losartan Potassium Tablet Prepared by Direct Compression. Pharmaceutics 14:8, pages 1741.
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Amber Nawab, Sehar Iqtidar, Dr. Subia Jamil & Javeria Shiekh. (2022) Co-processed excipients-A step towards better drug product performance. Co-processed excipients-A step towards better drug product performance.
Slobodanka Ćirin-Varađan, Jelena Đuriš, Miljana Mirković, Marija Ivanović, Jelena Parojčić & Ivana Aleksić. (2022) Comparative evaluation of mechanical properties of lactose-based excipients co-processed with lipophilic glycerides as meltable binders. Journal of Drug Delivery Science and Technology 67, pages 102981.
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Djordje Medarević, Jelena Djuriš, Mirjana Krkobabić & Svetlana Ibrić. (2021) Improving Tableting Performance of Lactose Monohydrate by Fluid-Bed Melt Granulation Co-Processing. Pharmaceutics 13:12, pages 2165.
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Ilyasu Salim, Adeniji Kehinde Olowosulu, Abdulrahman Abdulsamad, Mahmud Sani Gwarzo, Garba Mohammed Khalid, Naimatu Tijjani Ahmad, Florence Egbomonjiade Eichie & Fatima Shuaibu Kurfi. (2021) Application of SeDeM Expert System in the development of novel directly compressible co-processed excipients via co-processing. Future Journal of Pharmaceutical Sciences 7:1.
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Navpreet Kaur & Raj Suryanarayanan. (2021) Levothyroxine Sodium Pentahydrate Tablets – Formulation Considerations. Journal of Pharmaceutical Sciences 110:12, pages 3743-3756.
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Subh Naman, Nupur Madhavi, Bhupendra Singh, Jitendra Madan & Ashish Baldi. (2021) Implementing risk-based quality by design for development and optimization of flavored oral disintegrating mini tablets. Journal of Drug Delivery Science and Technology 66, pages 102799.
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Muhammad Sohail Arshad, Saman Zafar, Bushra Yousef, Yasmine Alyassin, Radeyah Ali, Ali AlAsiri, Ming-Wei Chang, Zeeshan Ahmad, Amal Ali Elkordy, Ahmed Faheem & Kendal Pitt. (2021) A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing. Advanced Drug Delivery Reviews 178, pages 113840.
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Kondamodugula Tejaswi, Pusukuri Navya, Kothamasi Priyarini & Prasanthi D. (2021) COPROCESSED EXCIPIENTS-PREPARATION AND FUNCTIONALITIES. PARIPEX INDIAN JOURNAL OF RESEARCH, pages 52-54.
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Karnkamol Trisopon, Nisit Kittipongpatana, Phanphen Wattanaarsakit & Ornanong Suwannapakul Kittipongpatana. (2021) Formulation Study of a Co-Processed, Rice Starch-Based, All-in-One Excipient for Direct Compression Using the SeDeM-ODT Expert System. Pharmaceuticals 14:10, pages 1047.
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Martin Dominik, Barbora Vraníková, Petra Svačinová, Jan Elbl, Sylvie Pavloková, Barbora Blahová Prudilová, Zdeňka Šklubalová & Aleš Franc. (2021) Comparison of Flow and Compression Properties of Four Lactose-Based Co-Processed Excipients: Cellactose® 80, CombiLac®, MicroceLac® 100, and StarLac®. Pharmaceutics 13:9, pages 1486.
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Nobel O. Sierra-Vega, Krizia M. Karry, Rodolfo J. Romañach & Rafael Méndez. (2021) Monitoring of high-load dose formulations based on co-processed and non co-processed excipients. International Journal of Pharmaceutics 606, pages 120910.
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Srilaxmi G. Rao, Prashantkumar K. Parmar, Katangur Vishruth Reddy & Arvind K. Bansal. (2021) Preparation and Characterization of Co-Processed Mannitol and Sorbitol Using NanoCrySP Technology. AAPS PharmSciTech 22:5.
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Nailla Jiwa, Yildiz Ozalp, Gizem Yegen & Buket Aksu. (2021) Critical Tools in Tableting Research: Using Compaction Simulator and Quality by Design (QbD) to Evaluate Lubricants’ Effect in Direct Compressible Formulation. AAPS PharmSciTech 22:4.
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Carl Allenspach, Peter Timmins, Geoffroy Lumay, James Holman & Tamara Minko. (2021) Loss-in-weight feeding, powder flow and electrostatic evaluation for direct compression hydroxypropyl methylcellulose (HPMC) to support continuous manufacturing. International Journal of Pharmaceutics 596, pages 120259.
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Nizar Al-Zoubi, Shadi Gharaibeh, Ahmad Aljaberi & Ioannis Nikolakakis. (2021) Spray Drying for Direct Compression of Pharmaceuticals. Processes 9:2, pages 267.
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Nasser N. Nyamweya. (2021) Applications of polymer blends in drug delivery. Future Journal of Pharmaceutical Sciences 7:1.
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Liang Chen, Zizhou He, Kuriakose Kunnath, Kai Zheng, Sangah Kim & Rajesh N. Davé. (2020) Fine grade engineered microcrystalline cellulose excipients for direct compaction: Assessing suitability of different dry coating processes. European Journal of Pharmaceutical Sciences 151, pages 105408.
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Noelia M. Sanchez-Ballester, Bernard Bataille, Rihab Benabbas, Bruno Alonso & Ian Soulairol. (2020) Development of alginate esters as novel multifunctional excipients for direct compression. Carbohydrate Polymers 240, pages 116280.
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Karnkamol Trisopon, Nisit Kittipongpatana & Ornanong Suwannapakul Kittipongpatana. (2020) A Spray-Dried, Co-Processed Rice Starch as a Multifunctional Excipient for Direct Compression. Pharmaceutics 12:6, pages 518.
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Sudarshan Singh, Ozioma F. Nwabor, Julalak C. Ontong & Supayang P. Voravuthikunchai. (2020) Characterization and assessment of compression and compactibility of novel spray-dried, co-processed bio-based polymer. Journal of Drug Delivery Science and Technology 56, pages 101526.
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Anis Yohana Chaerunisaa, Sriwidodo Sriwidodo & Marline Abdassah. 2020. Pharmaceutical Formulation Design - Recent Practices. Pharmaceutical Formulation Design - Recent Practices.
Jaime Conceição, Oluwatomide Adeoye, Helena Cabral-Marques, Angel Concheiro, Carmen Alvarez-Lorenzo & José Manuel Sousa Lobo. (2020) Orodispersible Carbamazepine/Hydroxypropyl-β-Cyclodextrin Tablets Obtained by Direct Compression with Five-in-One Co-processed Excipients. AAPS PharmSciTech 21:2.
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Sudarshan Singh, Ozioma F. Nwabor, Julalak C. Ontong, Nattha Kaewnopparat & Supayang P. Voravuthikunchai. (2020) Characterization of a novel, co-processed bio-based polymer, and its effect on mucoadhesive strength. International Journal of Biological Macromolecules 145, pages 865-875.
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Dian Eka Ermawati, Bimar Putri Andini, Fea Prihapsara, Yeni Farida, Sholichah Rohmani, Wisnu Kundarto & Estu Retnaningtyas Nugraheni. Optimization of Suweg starch (Amorphophallus paeoniifolius (Dennst.) Nicolson) and lactose as co-processed excipient of Ibuprofen-PEG 6000 solid dispersion of effervescent tablet. Optimization of Suweg starch (Amorphophallus paeoniifolius (Dennst.) Nicolson) and lactose as co-processed excipient of Ibuprofen-PEG 6000 solid dispersion of effervescent tablet.
Ard Lura, Oliver Luhn, Javier Suarez Gonzales & Jörg Breitkreutz. (2019) New orodispersible mini-tablets for paediatric use – A comparison of isomalt with a mannitol based co-processed excipient. International Journal of Pharmaceutics 572, pages 118804.
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Petra Svačinová, Barbora Vraníková, Martin Dominik, Jan Elbl, Sylvie Pavloková, Roman Kubalák, Pavlína Kopecká & Aleš Franc. (2019) Comprehensive study of co-processed excipients F- Melts®: Flow, viscoelastic and compacts properties. Powder Technology 355, pages 675-687.
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Domínguez-Robles, Stewart, Rendl, González, Donnelly & Larrañeta. (2019) Lignin and Cellulose Blends as Pharmaceutical Excipient for Tablet Manufacturing via Direct Compression. Biomolecules 9:9, pages 423.
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Emmanuel Reginald Jacques & Paschalis Alexandridis. (2019) Tablet Scoring: Current Practice, Fundamentals, and Knowledge Gaps. Applied Sciences 9:15, pages 3066.
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Yonni Eshovo Apeji, Olubunmi Jumoke Olayemi, Sophie Nock Anyebe, Chinyere Oparaeche, Oluwaseun Adenike Orugun, Adeniji Kehinde Olowosulu & Avosuahi Rukayat Oyi. (2019) Impact of binder as a formulation variable on the material and tableting properties of developed co-processed excipients. SN Applied Sciences 1:6.
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Karnkamol Trisopon & Ornanong S. Kittipongpatana. (2019) Development of a Direct Compression Excipient from Epichlorohydrin-Crosslinked Carboxymethyl Rice Starch with Sodium Silicate Using a Coprocessing Technique. Starch - Stärke, pages 1800220.
Crossref
Gerald A. Hebbink & Bastiaan H.J. Dickhoff. 2019. Lactose. Lactose 175 229 .
Hesham M. Tawfeek, Matthew Roberts, Mohamed A. El Hamd, Ahmed A. H. Abdellatif & Mahmoud A. Younis. (2018) Glibenclamide Mini-tablets with an Enhanced Pharmacokinetic and Pharmacodynamic Performance. AAPS PharmSciTech 19:7, pages 2948-2960.
Crossref
Suhair S. Al-Nimry & Khouloud A. Alkhamis. (2018) Effect of Moisture Content of Chitin-Calcium Silicate on Rate of Degradation of Cefotaxime Sodium. AAPS PharmSciTech 19:3, pages 1337-1343.
Crossref
Yonni E. Apeji, Avosuahi R. Oyi, Adamu B. Isah, Teryila S. Allagh, Sameer R. Modi & Arvind K. Bansal. (2017) Development and Optimization of a Starch-Based Co-processed Excipient for Direct Compression Using Mixture Design. AAPS PharmSciTech 19:2, pages 866-880.
Crossref
Pavlína Vodáčková, Barbora Vraníková, Petra Svačinová, Aleš Franc, Jan Elbl, Jan Muselík, Roman Kubalák & Tomaš Solný. (2018) Evaluation and Comparison of Three Types of Spray Dried Coprocessed Excipient Avicel® for Direct Compression. BioMed Research International 2018, pages 1-15.
Crossref
. (2017) Comparative analysis of co-processed starches prepared by three different methods. British Journal of Pharmacy 2:1.
Crossref
Sohil I. Chauhan, Sandeep V. Nathwani, Moinuddin M. Soniwala & Jayant R. Chavda. (2016) Development and Characterization of Multifunctional Directly Compressible Co-processed Excipient by Spray Drying Method. AAPS PharmSciTech 18:4, pages 1293-1301.
Crossref
Zhe Li, Xiao Lin, Lan Shen, YanLong Hong & Yi Feng. (2017) Composite particles based on particle engineering for direct compaction. International Journal of Pharmaceutics 519:1-2, pages 272-286.
Crossref
Suhair S. Al-Nimry, Khouloud A. Alkhamis & Kawthar Z. Alzarieni. (2017) The Effect of Specific Surface Area of Chitin–Metal Silicate Coprocessed Excipient on the Chemical Decomposition of Cefotaxime Sodium. Journal of Pharmaceutical Sciences 106:2, pages 570-578.
Crossref
Rizki Awaluddin, Arif Widya Prasetya, Yayan Nugraha, Mohammad Fahmi Suweleh, Aris Perdana Kusuma & Oktavia Indrati. Physical modification and characterization of starch using pregelatinization and co-process of various tubers from Yogyakarta as an excipient. Physical modification and characterization of starch using pregelatinization and co-process of various tubers from Yogyakarta as an excipient.
Li Qu, Peter J. Stewart, Karen P. Hapgood, Satu Lakio, David A.V. Morton & Qi (Tony) Zhou. (2017) Single-step Coprocessing of Cohesive Powder via Mechanical Dry Coating for Direct Tablet Compression. Journal of Pharmaceutical Sciences 106:1, pages 159-167.
Crossref
Karl Kolter & Felicitas Guth. 2016. Pharmaceutical Excipients. Pharmaceutical Excipients 269 301 .
D Kumar. 2015. Herbal Bioactives and Food Fortification. Herbal Bioactives and Food Fortification 147 172 .
Sharad Mangal, Ian Larson, Felix Meiser & David AV Morton. 2015. Handbook of Polymers for Pharmaceutical Technologies. Handbook of Polymers for Pharmaceutical Technologies 1 31 .
Payal Sharma, Sameer R. Modi & Arvind K. Bansal. (2015) Co-processing of hydroxypropyl methylcellulose (HPMC) for improved aqueous dispersibility. International Journal of Pharmaceutics 485:1-2, pages 348-356.
Crossref
Kothiya Madhvi, Kuldeep Mehta, K. R. Vadalia, Chavda Jay & Kapadiya Sandip. (2014) Design and development of co-processed excipients for fast dissolving tablets of Irbesartan by melt agglomeration technique. Journal of Pharmaceutical Investigation 45:2, pages 163-186.
Crossref
Sharad Mangal, Felix Meiser, Satu Lakio, David Morton & Ian Larson. (2015) The role of physico-chemical and bulk characteristics of co-spray dried l-leucine and polyvinylpyrrolidone on glidant and binder properties in interactive mixtures. International Journal of Pharmaceutics 479:2, pages 338-348.
Crossref
John Rojas. 2015. Excipient Applications in Formulation Design and Drug Delivery. Excipient Applications in Formulation Design and Drug Delivery 589 612 .
Ravikiran Panakanti & Ajit S. Narang. 2015. Excipient Applications in Formulation Design and Drug Delivery. Excipient Applications in Formulation Design and Drug Delivery 273 310 .
Hesham M. Tawfeek, Imran Y. Saleem & Matthew Roberts. (2014) Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets. Journal of Pharmaceutical Sciences 103:8, pages 2470-2483.
Crossref
Rehab N. Shamma & Mona Basha. (2013) Soluplus®: A novel polymeric solubilizer for optimization of Carvedilol solid dispersions: Formulation design and effect of method of preparation. Powder Technology 237, pages 406-414.
Crossref
Ravikiran Panakanti & Ajit S. Narang. (2012) Impact of Excipient Interactions on Drug Bioavailability from Solid Dosage Forms. Pharmaceutical Research 29:10, pages 2639-2659.
Crossref
I. Stoltenberg & J. Breitkreutz. (2011) Orally disintegrating mini-tablets (ODMTs) – A novel solid oral dosage form for paediatric use. European Journal of Pharmaceutics and Biopharmaceutics 78:3, pages 462-469.
Crossref

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