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Technology Evaluation

Pharmaceutical development and clinical effectiveness of a novel gel technology for transdermal drug delivery

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Pages 935-950 | Published online: 16 Sep 2005

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Cindy Kristina Enggi, Mega Tri Satria, Nirmayanti Nirmayanti, Jesscia Theodor Usman, Julika Fajrika Nur, Rangga Meidianto Asri, Nana Juniarti Natsir Djide & Andi Dian Permana. (2023) Improved transdermal delivery of valsartan using combinatorial approach of polymeric transdermal hydrogels and solid microneedles: an ex vivo proof of concept investigation. Journal of Biomaterials Science, Polymer Edition 34:3, pages 334-350.
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Ahmad Shakeel, Francesca R. Lupi, Domenico Gabriele, Noemi Baldino & Bruno De Cindio. (2018) Bigels: A unique class of materials for drug delivery applications. Soft Materials 16:2, pages 77-93.
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S. S. Sagiri, B. Behera, R. R. Rafanan, C. Bhattacharya, K. Pal, I. Banerjee & D. Rousseau. (2014) Organogels as Matrices for Controlled Drug Delivery: A Review on the Current State. Soft Materials 12:1, pages 47-72.
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Umberto Leone Roberti Maggiore, Stefano Salvatore, Franco Alessandri, Valentino Remorgida, Massimo Origoni, Massimo Candiani, Pier Luigi Venturini & Simone Ferrero. (2012) Pharmacokinetics and toxicity of antimuscarinic drugs for overactive bladder treatment in females. Expert Opinion on Drug Metabolism & Toxicology 8:11, pages 1387-1408.
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Alex Gomelsky & Roger R Dmochowski. (2012) Oxybutynin gel for the treatment of overactive bladder. Expert Opinion on Pharmacotherapy 13:9, pages 1337-1343.
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Marcus J Drake. (2008) Emerging drugs for treatment of overactive bladder and detrusor overactivity. Expert Opinion on Emerging Drugs 13:3, pages 431-446.
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Amal H. El-Kamel, Iman M. Al-Fagih & Ibrahim A. Alsarra. (2007) Testosterone solid lipid microparticles for transdermal drug delivery. Formulation and physicochemical characterization. Journal of Microencapsulation 24:5, pages 457-475.
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G Willy Davila. (2006) Transdermal oxybutynin in the treatment of overactive bladder. Clinical Interventions in Aging 1:2, pages 99-105.
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Aneta Ostróżka-Cieślik, Sławomir Wilczyński & Barbara Dolińska. (2023) Hydrogel Formulations for Topical Insulin Application: Preparation, Characterization and In Vitro Permeation across the Strat-M® Membrane. Polymers 15:17, pages 3639.
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Braja Bihari Panda, Bala Krishna Kala, Ankita Parmanik, Dattatreya Kar & Anindya Bose. (2023) Formulation, Development and Evaluation of Sildenafil Citrate Oral Jelly. Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ) 5, pages 122-126.
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Nirmayanti Nirmayanti, Alhidayah Alhidayah, Jessica Theodor Usman, Julika Fajrika Nur, Muh. Nur Amir & Andi Dian Permana. (2022) Combinatorial Approach of Thermosensitive Hydrogels and Solid Microneedles to Improve Transdermal Delivery of Valsartan: an In Vivo Proof of Concept Study. AAPS PharmSciTech 24:1.
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Aneta Ostróżka-Cieślik. (2022) The Potential of Pharmaceutical Hydrogels in the Formulation of Topical Administration Hormone Drugs. Polymers 14:16, pages 3307.
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Mark S. Newman, Desmond A. Curran, Bryan P. Mayfield, Doreen Saltiel & Frank Z. Stanczyk. (2022) Assessment of estrogen exposure from transdermal estradiol gel therapy with a dried urine assay. Steroids 184, pages 109038.
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Larissa Carine Pünnel & Dominique Jasmin Lunter. (2021) Film-Forming Systems for Dermal Drug Delivery. Pharmaceutics 13:7, pages 932.
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Mahgol Tajbakhsh, Majid Saeedi, Jafar Akbari, Katayoun Morteza-Semnani, Ali Nokhodchi & Akbar Hedayatizadeh-Omran. (2020) An investigation on parameters affecting the optimization of testosterone enanthate loaded solid nanoparticles for enhanced transdermal delivery. Colloids and Surfaces A: Physicochemical and Engineering Aspects 589, pages 124437.
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Katherine A. Lyseng-Williamson. (2019) Testosterone 2% gel (Testavan®, Testarzon®) in adult male hypogonadism: a profile of its use. Drugs & Therapy Perspectives 35:5, pages 209-218.
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Qianwen Wang, Zhong Zuo, Cheuk Kit Chucky Cheung & Sharon Shui Yee Leung. (2019) Updates on thermosensitive hydrogel for nasal, ocular and cutaneous delivery. International Journal of Pharmaceutics 559, pages 86-101.
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Joshua A. Cohn, Elizabeth T. Brown, W. Stuart Reynolds, Melissa R. Kaufman, Douglas F. Milam & Roger R. Dmochowski. (2016) An update on the use of transdermal oxybutynin in the management of overactive bladder disorder. Therapeutic Advances in Urology 8:2, pages 83-90.
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Ju-Young Kim, Joon-Ho Jun, Sang-Joon Kim, Kyu-Mok Hwang, Sung Rak Choi, Sang Duk Han, Mi-Won Son & Eun-Seok Park. (2014) Wound healing efficacy of a chitosan-based film-forming gel containing tyrothricin in various rat wound models. Archives of Pharmacal Research 38:2, pages 229-238.
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Håkan Olsson, Rikard Sandström, Anders Neijber, Dario Carrara & Lars Grundemar. (2014) Pharmacokinetics and bioavailability of a new testosterone gel formulation in comparison to Testogel® in healthy men. Clinical Pharmacology in Drug Development 3:5, pages 358-364.
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Christina Wang, Niloufar Ilani, Stefan Arver, Robert I. McLachlan, Tina Soulis & Adam Watkinson. (2011) Efficacy and safety of the 2% formulation of testosterone topical solution applied to the axillae in androgen-deficient men. Clinical Endocrinology 75:6, pages 836-843.
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Ruiwei Guo, Xiaoyan Du, Rui Zhang, Liandong Deng, Anjie Dong & Jianhua Zhang. (2011) Bioadhesive film formed from a novel organic–inorganic hybrid gel for transdermal drug delivery system. European Journal of Pharmaceutics and Biopharmaceutics 79:3, pages 574-583.
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. (2010) Topical Oxybutynin (Gelnique) for Overactive Bladder. Obstetrics & Gynecology 115:5, pages 1078-1079.
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G. Popken. (2010) TestosteronsubstitutionTestosterone replacement. Der Urologe 49:1, pages 37-42.
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Biancamaria Baroli. (2010) Penetration of nanoparticles and nanomaterials in the skin: Fiction or reality?. Journal of Pharmaceutical Sciences 99:1, pages 21-50.
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U. Paasch, H.-J. Glander & J.-U. Stolzenburg. (2009) Andrologische TestosteronersatztherapieAndrological testosterone replacement therapy. Der Urologe 48:1, pages 79-87.
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Dolores D. Mruk, Bruno Silvestrini & C. Yan Cheng. (2008) Anchoring Junctions As Drug Targets: Role in Contraceptive Development. Pharmacological Reviews 60:2, pages 146-180.
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M. de Sèze, A. Ruffion & E. Chartier-Kastler. (2007) Chapitre C-l A - Traitement pharmacologique de l’hyperactivité détrusorienne neurologique : per os, en patch, en instillation endo-vésicale. Progrès en Urologie 17:3, pages 559-563.
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