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Ophthalmic preservatives: focus on polyquaternium-1

, MD, , PhD & , MD
Pages 1425-1438 | Published online: 09 Sep 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Sowmya Andole & Sirisha Senthil. (2023) Ocular Surface Disease and Anti-Glaucoma Medications: Various features, Diagnosis, and Management Guidelines. Seminars in Ophthalmology 38:2, pages 158-166.
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Renee Garofalo, Carolina Kunnen, Rekha Rangarajan, Venkiteshwar Manoj & Howard Ketelson. (2021) Relieving the symptoms of dry eye disease: update on lubricating eye drops containing hydroxypropyl-guar. Clinical and Experimental Optometry 104:8, pages 826-834.
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Karen Walsh & Lyndon Jones. (2019) The use of preservatives in dry eye drops. Clinical Ophthalmology 13, pages 1409-1425.
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Alison Ng, Adam Keech & Lyndon Jones. (2018) Tear osmolarity changes after use of hydroxypropyl-guar-based lubricating eye drops. Clinical Ophthalmology 12, pages 695-700.
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Majid Moshirfar, Kasey Pierson, Kamalani Hanamaikai, Luis Santiago-Caban, Valliammai Muthappan & Samuel F Passi. (2014) Artificial tears potpourri: a literature review. Clinical Ophthalmology 8, pages 1419-1433.
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Articles from other publishers (19)

Mariantonia Ferrara, Francesca Gatti, David Lockington, Antonio Iaria, Stephen Kaye, Gianni Virgili, Pasquale Aragona, Francesco Semeraro & Vito Romano. (2023) Antimicrobials and antiseptics: Lowering effect on ocular surface bacterial flora – A systematic review. Acta Ophthalmologica.
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Chih-Chiun Jamie Chang & Bryan J. Winn. (2023) Perturbations of the ocular surface microbiome and their effect on host immune function. Current Opinion in Ophthalmology 34:2, pages 181-188.
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Judy Weng, Michael K. Fink & Ajay Sharma. (2023) A Critical Appraisal of the Physicochemical Properties and Biological Effects of Artificial Tear Ingredients and Formulations. International Journal of Molecular Sciences 24:3, pages 2758.
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Katarzyna Asendrych-Wicik, Jakub Zarczuk, Katarzyna Walaszek, Tomasz Ciach & Magdalena Markowicz-Piasecka. (2023) Trends in development and quality assessment of pharmaceutical formulations - F2α analogues in the glaucoma treatment. European Journal of Pharmaceutical Sciences 180, pages 106315.
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Jens Boventer, Irene Krämer & Julia Reichhold. 2023. Practical Pharmaceutics. Practical Pharmaceutics 377 403 .
Chih-Chiun J. Chang, Karina Somohano, Christine Zemsky, Anne-Catrin Uhlemann, Jeffrey Liebmann, George A. Cioffi, Lama A. Al-Aswad, Susan V. Lynch & Bryan J. Winn. (2022) Topical Glaucoma Therapy Is Associated With Alterations of the Ocular Surface Microbiome. Investigative Opthalmology & Visual Science 63:9, pages 32.
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Michael H. Goldstein, Fabiana Q. Silva, Nysha Blender, Trung Tran & Srilatha Vantipalli. (2021) Ocular benzalkonium chloride exposure: problems and solutions. Eye 36:2, pages 361-368.
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Omer Ersin Muz, Kenan Dagdelen, Tuncay Pirdal & Mete Guler. (2021) Comparison of BAK-preserved latanoprost and polyquad-preserved travoprost on ocular surface parameters in patients with glaucoma and ocular hypertension. International Ophthalmology 41:11, pages 3825-3835.
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Avani Kathuria, Kiumars Shamloo, Vishal Jhanji & Ajay Sharma. (2021) Categorization of Marketed Artificial Tear Formulations Based on Their Ingredients: A Rational Approach for Their Use. Journal of Clinical Medicine 10:6, pages 1289.
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Marisa Meloni, Silvia Balzaretti & Laura Ceriotti. (2019) Medical devices biocompatibility assessment on HCE: Evidences of delayed cytotoxicity of preserved compared to preservative free eye drops. Regulatory Toxicology and Pharmacology 106, pages 81-89.
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Angela Verkade & Alice Y. Matoba. (2019) Polyquaternium-1–Associated Dendritiform Keratopathy. Cornea 38:4, pages 502-503.
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Daniel L. Krinsky, Stefanie P. Ferreri, Brian Hemstreet, Anne L. Hume, Gail D. Newton, Carol J. Rollins & Karen J. TietzeAleda M. H. Chen & Andrew M. Straw. 2017. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 19th Edition. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 19th Edition.
Alice Y. Matoba, Jeff R. Peterson & Kirk R. Wilhelmus. (2016) Dendritiform Keratopathy Associated with Exposure to Polyquarternium-1, a Common Ophthalmic Preservative. Ophthalmology 123:3, pages 451-456.
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Thirumurthy Velpandian. 2016. Pharmacology of Ocular Therapeutics. Pharmacology of Ocular Therapeutics 419 430 .
Aleda M.H. Chen & Tracy R. Frame. 2015. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 18th Edition. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 18th Edition.
Annick Ludwig & Holger Reimann. 2015. Practical Pharmaceutics. Practical Pharmaceutics 163 188 .
Elmer Y. Tu. (2014) Balancing antimicrobial efficacy and toxicity of currently available topical ophthalmic preservatives. Saudi Journal of Ophthalmology 28:3, pages 182-187.
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Anastasios G. P. Konstas, Irini C. Voudouragkaki, Kostantinos G. Boboridis, Anna-Bettina Haidich, Eleni Paschalinou, Theodoros Giannopoulos, Nikolaos D. Dragoumis, Alexandros K. Makridis & Malik Y. Kahook. (2014) 24-Hour Efficacy of Travoprost/Timolol BAK-Free Versus Latanoprost/Timolol Fixed Combinations in Patients Insufficiently Controlled with Latanoprost. Advances in Therapy 31:6, pages 592-603.
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Murat Irkec, Banu Bozkurt & Mehmet Cem Mocan. (2013) Are preservatives necessary to improve efficacy of some glaucoma drops?. British Journal of Ophthalmology 97:12, pages 1493-1494.
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