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Recent developments in buccal and sublingual delivery systems

, MSc PhD, , PhD, , PharmD & , BPharm DPharm
Pages 615-628 | Published online: 19 Apr 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Luiz E. N. Ferreira, Michelle Franz-Montan, Bruna Benso & Harvinder S. Gill. (2023) Microneedles for oral mucosal delivery – Current trends and perspective on future directions. Expert Opinion on Drug Delivery 20:9, pages 1251-1265.
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Ízola Morais de Medeiros Ramalho, Daniel Torres Pereira, Giovanna Brunelly Lima Galvão, Danielle Teixeira Freire, Lucas Amaral-Machado, Éverton do Nascimento Alencar & Eryvaldo Socrates Tabosa do Egito. (2021) Current trends on cannabidiol delivery systems: where are we and where are we going?. Expert Opinion on Drug Delivery 18:11, pages 1577-1587.
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Sandra Lindert & Jörg Breitkreutz. (2017) Oromucosal multilayer films for tailor-made, controlled drug delivery. Expert Opinion on Drug Delivery 14:11, pages 1265-1279.
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Burak Çelik, Samet Özdemir, Aslı Barla Demirkoz & Melike Üner. (2017) Optimization of piribedil mucoadhesive tablets for efficient therapy of Parkinson’s disease: physical characterization and ex vivo drug permeation through buccal mucosa. Drug Development and Industrial Pharmacy 43:11, pages 1836-1845.
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Brunella Parodi, Eleonora Russo, Sara Baldassari, Guendalina Zuccari, Sara Pastorino, Mengying Yan, Karthik Neduri & Gabriele Caviglioli. (2017) Development and characterization of a mucoadhesive sublingual formulation for pain control: extemporaneous oxycodone films in personalized therapy. Drug Development and Industrial Pharmacy 43:6, pages 917-924.
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Anna Lisa Scaturro, Viviana De Caro, Giuseppina Campisi & Libero Italo Giannola. (2016) Potential transbuccal delivery of l-DOPA methylester prodrug: stability in the environment of the oral cavity and ability to cross the mucosal tissue. Drug Delivery 23:7, pages 2355-2362.
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Javier O. Morales & Jason T. McConville. (2014) Novel strategies for the buccal delivery of macromolecules. Drug Development and Industrial Pharmacy 40:5, pages 579-590.
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Elizabeth Ojewole, Rahul Kalhapure, Krishnacharya Akamanchi & Thirumala Govender. (2014) Novel oleic acid derivatives enhance buccal permeation of didanosine. Drug Development and Industrial Pharmacy 40:5, pages 657-668.
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Libero Italo Giannola, Flavia Maria Sutera & Viviana De Caro. (2013) Physical methods to promote drug delivery on mucosal tissues of the oral cavity. Expert Opinion on Drug Delivery 10:10, pages 1449-1462.
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Articles from other publishers (46)

Anubhav Pratap-Singh, Yigong Guo, Alberto Baldelli & Anika Singh. (2023) Concept for a Unidirectional Release Mucoadhesive Buccal Tablet for Oral Delivery of Antidiabetic Peptide Drugs Such as Insulin, Glucagon-like Peptide 1 (GLP-1), and their Analogs. Pharmaceutics 15:9, pages 2265.
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Michele Basilicata, Piergiorgio Grillo, Alvise Tancredi, Adolfo Di Fiore, Patrizio Bollero, Alessandro Stefani & Tommaso Schirinzi. (2023) Oral Health and Use of Novel Transbuccal Drug Delivery Systems in Patients with Alzheimer’s and Parkinson’s Disease: A Review. Applied Sciences 13:8, pages 4974.
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Fuat Topuz. (2022) Rapid Sublingual Delivery of Piroxicam from Electrospun Cyclodextrin Inclusion Complex Nanofibers. ACS Omega 7:39, pages 35083-35091.
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Sana Javed, Amjad Hussain, Pervaiz Akhtar Shah, Syed Atif Raza, Ubaid Ullah Anwer, Rahat Shamim, Fatima Rasool, Muhammad Ahsan Hafiz & Nadeem Irfan Bukhari. (2022) Development of Optimized Sumatriptan–Prochlorperazine Combined Orodispersible Films Without Disintegrant: in vitro, ex vivo and in vivo Characterization. AAPS PharmSciTech 23:5.
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Bharti Mangla, Shamama Javed, Muhammad H. Sultan, Waquar Ahsan, Geeta Aggarwal & Kanchan Kohli. (2022) Nanocarriers-Assisted Needle-Free Vaccine Delivery Through Oral and Intranasal Transmucosal Routes: A Novel Therapeutic Conduit. Frontiers in Pharmacology 12.
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Apipa Wanasathop, Priya B Patel, Hyojin A. Choi & S. Kevin Li. (2021) Permeability of Buccal Mucosa. Pharmaceutics 13:11, pages 1814.
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Sevda Şenel. (2021) An Overview of Physical, Microbiological and Immune Barriers of Oral Mucosa. International Journal of Molecular Sciences 22:15, pages 7821.
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Akel F. Kanaan, Ana P. Piedade, Hermínio C. de Sousa & Ana M.A. Dias. (2021) Semi-interpenetrating chitosan/ionic liquid polymer networks as electro-responsive biomaterials for potential wound dressings and iontophoretic applications. Materials Science and Engineering: C 121, pages 111798.
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Stephany Di Carla Santos, Nádia Cristina Fávaro-Moreira, Henrique Ballassin Abdalla, Gabriela Gama Xavier Augusto, Yuri Martins Costa, Maria Cristina Volpato, Francisco Carlos Groppo, Harvinder Singh Gill & Michelle Franz-Montan. (2021) A crossover clinical study to evaluate pain intensity from microneedle insertion in different parts of the oral cavity. International Journal of Pharmaceutics 592, pages 120050.
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You Xu, Xiaojuan Zhang, Nana Wang, Xing Pei, Yiyue Guo, Jianxin Wang, Stefan Barth, Fei Yu, Seung Jin Lee, Huining He & Victor C. Yang. (2020) Cell-penetrating peptide enhanced insulin buccal absorption. International Journal of Pharmaceutics 584, pages 119469.
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Yasmin A El-Feky, Dalia A Mostafa, Majid M Al-Sawahli, Rania Farag A El-Telbany, Sherin Zakaria, Ahmed M Fayez, Kawkab A Ahmed, Ebtesam M Alolayan & Dalia Farag A El-Telbany. (2020) Reduction of intraocular pressure using timolol orally dissolving strips in the treatment of induced primary open-angle glaucoma in rabbits. Journal of Pharmacy and Pharmacology 72:5, pages 682-698.
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Jenny K.W. Lam, Chucky C.K. Cheung, Michael Y.T. Chow, Emily Harrop, Susie Lapwood, Stephen I.G. Barclay & Ian C.K. Wong. (2020) Transmucosal drug administration as an alternative route in palliative and end-of-life care during the COVID-19 pandemic. Advanced Drug Delivery Reviews 160, pages 234-243.
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Alhussain Aodah, Mohamad Rawas-Qalaji, Rawan Bafail & Mutasem Rawas-Qalaji. (2019) Effect of Fast-Disintegrating Tablets’ Characteristics on the Sublingual Permeability of Atropine Sulfate for the Potential Treatment of Organophosphates Toxicity. AAPS PharmSciTech 20:6.
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Gülçin Akca, Ayşe Özdemir, Z. Gülşen Öner & Sevda Şenel. (2018) Comparison of different types and sources of chitosan for the treatment of infections in the oral cavity. Research on Chemical Intermediates 44:8, pages 4811-4825.
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Bruno Fonseca-Santos & Marlus Chorilli. (2018) An overview of polymeric dosage forms in buccal drug delivery: State of art, design of formulations and their in vivo performance evaluation. Materials Science and Engineering: C 86, pages 129-143.
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Ka Lun Lai, Yuan Fang, Hao Han, Qingqing Li, Shuai Zhang, Ho Yin Li, Shing Fung Chow, Tai Ning Lam & Wai Yip Thomas Lee. (2018) Orally-dissolving film for sublingual and buccal delivery of ropinirole. Colloids and Surfaces B: Biointerfaces 163, pages 9-18.
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Viviana De Caro, Flavia Maria Sutera & Libero Italo Giannola. (2017) In situ delivery of corticosteroids for treatment of oral diseases . Therapeutic Delivery 8:10, pages 899-914.
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Ivana d’Angelo, Aurore Fraix, Francesca Ungaro, Fabiana Quaglia & Agnese Miro. (2017) Poly(ethylene oxide)/hydroxypropyl-β-cyclodextrin films for oromucosal delivery of hydrophilic drugs. International Journal of Pharmaceutics 531:2, pages 606-613.
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Alhussain Aodah, Rawan S. Bafail & Mutasem Rawas-Qalaji. (2016) Formulation and Evaluation of Fast-Disintegrating Sublingual Tablets of Atropine Sulfate: the Effect of Tablet Dimensions and Drug Load on Tablet Characteristics. AAPS PharmSciTech 18:5, pages 1624-1633.
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Javier O. Morales, Kristin R. Fathe, Ashlee Brunaugh, Silvia Ferrati, Song Li, Miguel Montenegro-Nicolini, Zeynab Mousavikhamene, Jason T. McConville, Mark R. Prausnitz & Hugh D. C. Smyth. (2017) Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes. The AAPS Journal 19:3, pages 652-668.
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Alan Talevi, Luis Blanch & Guillermo Castro. 2017. Drug Delivery. Drug Delivery 13 46 .
Soledad Montero-Padilla, Sitaram Velaga & Javier O. Morales. (2016) Buccal Dosage Forms: General Considerations for Pediatric Patients. AAPS PharmSciTech 18:2, pages 273-282.
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Narinder Singh, Anjali Joshi, Amrit Pal Toor & Gaurav Verma. 2017. Nanostructures for Drug Delivery. Nanostructures for Drug Delivery 865 886 .
Sandra J. Morantes, Diana M. Buitrago, José F. Ibla, Yenny M. García, Gloria I. Lafaurie & Jenny E. Parraga. 2017. Biopolymer-Based Composites. Biopolymer-Based Composites 107 138 .
. 2016. Drug Delivery. Drug Delivery 201 214 .
Vibhuti Agrahari, Vivek Agrahari & Ashim K Mitra. (2016) Nanocarrier fabrication and macromolecule drug delivery: challenges and opportunities. Therapeutic Delivery 7:4, pages 257-278.
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Javier Morales. 2015. Handbook of Encapsulation and Controlled Release. Handbook of Encapsulation and Controlled Release 1225 1253 .
Branca M.A. Silva, Ana Filipa Borges, Cláudia Silva, Jorge F.J. Coelho & Sérgio Simões. (2015) Mucoadhesive oral films: The potential for unmet needs. International Journal of Pharmaceutics 494:1, pages 537-551.
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Thiago Caon, Liang Jin, Cláudia M. O. Simões, Raymond S. Norton & Joseph A. Nicolazzo. (2014) Enhancing the Buccal Mucosal Delivery of Peptide and Protein Therapeutics. Pharmaceutical Research 32:1, pages 1-21.
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Michael John Rathbone, Sevda Şenel & Indiran Pather. 2015. Oral Mucosal Drug Delivery and Therapy. Oral Mucosal Drug Delivery and Therapy 149 167 .
L. I. Giannola, V. De Caro & F. M. Sutera. 2015. Oral Mucosal Drug Delivery and Therapy. Oral Mucosal Drug Delivery and Therapy 89 124 .
Michael John Rathbone, Indiran Pather & Sevda Şenel. 2015. Oral Mucosal Drug Delivery and Therapy. Oral Mucosal Drug Delivery and Therapy 17 29 .
Thomas P. Johnston. 2015. Oral Mucosal Drug Delivery and Therapy. Oral Mucosal Drug Delivery and Therapy 1 15 .
Celia L. McNeilly, Michael L. Crichton, Clare A. Primiero, Ian H. Frazer, Michael S. Roberts & Mark A.F. Kendall. (2014) Microprojection arrays to immunise at mucosal surfaces. Journal of Controlled Release 196, pages 252-260.
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Libero Italo Giannola, Viviana De Caro & Flavia Maria Sutera. (2014) Buccal drug delivery: what's new and what does the future hold?. Therapeutic Delivery 5:9, pages 965-968.
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Samir Mitragotri, Paul A. Burke & Robert Langer. (2014) Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies. Nature Reviews Drug Discovery 13:9, pages 655-672.
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Zhijun Wang & Moses SS Chow. (2014) Overview and appraisal of the current concept and technologies for improvement of sublingual drug delivery. Therapeutic Delivery 5:7, pages 807-816.
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Jenny K.W. Lam, Yingying Xu, Alan Worsley & Ian C.K. Wong. (2014) Oral transmucosal drug delivery for pediatric use. Advanced Drug Delivery Reviews 73, pages 50-62.
Crossref
Thiago Caon, Yijun Pan, Cláudia M.O. Simões & Joseph A. Nicolazzo. (2014) Exploiting the Buccal Mucosa as an Alternative Route for the Delivery of Donepezil Hydrochloride. Journal of Pharmaceutical Sciences 103:6, pages 1643-1651.
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Prashanth Manda, Muralikrishnan Angamuthu, Shobharani R. Hiremath, Vijayasankar Raman & S. Narasimha Murthy. (2014) Iontophoretic Drug Delivery for the Treatment of Scars. Journal of Pharmaceutical Sciences 103:6, pages 1638-1642.
Crossref
J. Hao. (2014) Topical iontophoresis for local therapeutic effects. Journal of Drug Delivery Science and Technology 24:3, pages 255-258.
Crossref
Sevda Şenel, Merve Cansız & Michael J. Rathbone. 2014. Mucosal Delivery of Biopharmaceuticals. Mucosal Delivery of Biopharmaceuticals 149 168 .
Camilla Sander, Katrine Dragsbæk Madsen, Birgitte Hyrup, Hanne Mørck Nielsen, Jukka Rantanen & Jette Jacobsen. (2013) Characterization of spray dried bioadhesive metformin microparticles for oromucosal administration. European Journal of Pharmaceutics and Biopharmaceutics 85:3, pages 682-688.
Crossref
Agnese Miro, Ivana d?Angelo, Antonella Nappi, Pietro La Manna, Marco Biondi, Laura Mayol, Pellegrino Musto, Roberto Russo, Maria Immacolata La Rotonda, Francesca Ungaro & Fabiana Quaglia. (2013) Engineering poly(ethylene oxide) buccal films with cyclodextrin: A novel role for an old excipient?. International Journal of Pharmaceutics 452:1-2, pages 283-291.
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Marcello Iriti & Elena Varoni. (2013) Chemopreventive Potential of Flavonoids in Oral Squamous Cell Carcinoma in Human Studies. Nutrients 5:7, pages 2564-2576.
Crossref
Edward A. Shipton. (2012) Advances in delivery systems and routes for local anaesthetics. Trends in Anaesthesia and Critical Care 2:5, pages 228-233.
Crossref

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