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Microenvironmental pH-modification to improve dissolution behavior and oral absorption for drugs with pH-dependent solubility

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Amina Džidić-Krivić, Jasna Kusturica, Emina Karahmet Sher, Nejra Selak, Nejra Osmančević, Esma Karahmet Farhat & Farooq Sher. (2023) Effects of intestinal flora on pharmacokinetics and pharmacodynamics of drugs. Drug Metabolism Reviews 55:1-2, pages 126-139.
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M. Dandignac, S. P. Lacerda, A. Chamayou & L. Galet. (2022) Comparison study of physicochemical and biopharmaceutics properties of hydrophobic drugs ground by two dry milling processes. Pharmaceutical Development and Technology 27:7, pages 816-828.
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Yu (Elaine) Pu, Robert Menger, Zeen Tong & Tracy Gaebele. (2022) Development of an enhanced formulation to minimize pharmacokinetic variabilities of a weakly basic drug compound. Pharmaceutical Development and Technology 27:4, pages 406-413.
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Alejandro Ruiz-Picazo, Isabel Lozoya-Agullo, Isabel González-Álvarez, Marival Bermejo & Marta González-Álvarez. (2021) Effect of excipients on oral absorption process according to the different gastrointestinal segments. Expert Opinion on Drug Delivery 18:8, pages 1005-1024.
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Flávia Lidiane Oliveira Da Silva, Maria Betânia De Freitas Marques, Kelly Cristina Kato & Guilherme Carneiro. (2020) Nanonization techniques to overcome poor water-solubility with drugs. Expert Opinion on Drug Discovery 15:7, pages 853-864.
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Ahmed Abd El-Bary, Ibrahim Al Sharabi & Balqees Saeed Haza'a. (2019) Effect of casting solvent, film-forming agent and solubilizer on orodispersible films of a polymorphic poorly soluble drug: an in vitro/in silico study. Drug Development and Industrial Pharmacy 45:11, pages 1751-1769.
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Hao Pan, Hengpan Jing, Xinggang Yang, Weisan Pan & Tianbao Chen. (2017) Synchronized and controlled release of metformin hydrochloride/glipizide from elementary osmotic delivery. Drug Development and Industrial Pharmacy 43:5, pages 780-788.
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Weiwei Sun, Bohan Wang, Penglong Wang, Boxing Liu, An Yan & Baoliang Pan. (2023) Toltrazuril alkalizer-modifying solid dispersions against Toxoplasma gondii: A pharmacotechnical strategy to improve the efficacy of the drug. European Journal of Pharmaceutical Sciences 191, pages 106613.
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Jing Zhang, Xudong Wu, Zhiyong Xing & Zhi Li. (2023) Design, synthesis and application of tetraphenylethene substituted chalcones as pH and Et3N indicators. Chemical Papers 77:8, pages 4473-4487.
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Shaolong He & Huiling Mu. (2023) Microenvironmental pH Modification in Buccal/Sublingual Dosage Forms for Systemic Drug Delivery. Pharmaceutics 15:2, pages 637.
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Shaolong He, Carsten Uhd Nielsen, Huiling Mu & Jette Jacobsen. (2022) In vitro and ex vivo evaluation of bilayered effervescent microenvironmental pH modifying buccal films with saquinavir. Journal of Drug Delivery Science and Technology 78, pages 103954.
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Bo Wang, Matthew J. Nethercott, Akshay Narula, Michael Hanrahan, Shanming Kuang, Robert M. Wenslow & Na Li. (2021) pH-Dependent supersaturation from amorphous solid dispersions of weakly basic drugs. Pharmaceutical Research 39:11, pages 2919-2936.
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Yiwang Guo & Changquan Calvin Sun. (2022) Formulation strategies for mitigating dissolution reduction of p-aminobenzoic acid by sodium lauryl sulfate through diffusion layer modulation. International Journal of Pharmaceutics 611, pages 121310.
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Shaolong He, Carmen Radeke, Jette Jacobsen, Johan Ulrik Lind & Huiling Mu. (2021) Multi-material 3D printing of programmable and stretchable oromucosal patches for delivery of saquinavir. International Journal of Pharmaceutics 610, pages 121236.
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Kalle Sigfridsson, Theresa Andreasson, Britt-Marie Fihn, Martin Kearns & Sara Lindblom. (2021) Supersaturated formulations of poorly soluble weak acid drugs evaluated in rodents; a case study. International Journal of Pharmaceutics 606, pages 120883.
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Shaolong He, Jette Jacobsen, Carsten Uhd Nielsen, Natalja Genina, Jesper Østergaard & Huiling Mu. (2021) Exploration of in vitro drug release testing methods for saquinavir microenvironmental pH modifying buccal films. European Journal of Pharmaceutical Sciences 163, pages 105867.
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Surendra Poudel & Dong Wuk Kim. (2021) Developing pH-Modulated Spray Dried Amorphous Solid Dispersion of Candesartan Cilexetil with Enhanced In Vitro and In Vivo Performance. Pharmaceutics 13:4, pages 497.
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Ava M. Vargason, Aaron C. Anselmo & Samir Mitragotri. (2021) The evolution of commercial drug delivery technologies. Nature Biomedical Engineering 5:9, pages 951-967.
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Taddese Mekonnen Ambay, Philipp Schick, Michael Grimm, Maximilian Sager, Felix Schneider, Mirko Koziolek, Werner Siegmund, Franziska Schindele, Rainer Haas & Werner Weitschies. (2021) Design and Optimization of a Novel Strategy for the Local Treatment of Helicobacter pylori Infections. Journal of Pharmaceutical Sciences 110:3, pages 1302-1309.
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Bhupendra Raj Giri, Jaewook Kwon, Anh Q. Vo, Ajinkya M. Bhagurkar, Suresh Bandari & Dong Wuk Kim. (2021) Hot-Melt Extruded Amorphous Solid Dispersion for Solubility, Stability, and Bioavailability Enhancement of Telmisartan. Pharmaceuticals 14:1, pages 73.
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Vishwas P. Pardhi & Swaran Flora. (2020) Stable solid dispersion of lurasidone hydrochloride with augmented physicochemical properties for the treatment of schizophrenia and bipolar disorder. Biopharmaceutics & Drug Disposition 41:8-9, pages 334-351.
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Hibah M. Aldawsari & Shaimaa M. Badr-Eldin. (2020) Enhanced pharmacokinetic performance of dapoxetine hydrochloride via the formulation of instantly-dissolving buccal films with acidic pH modifier and hydrophilic cyclodextrin: Factorial analysis, in vitro and in vivo assessment. Journal of Advanced Research 24, pages 281-290.
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Shaolong He, Jesper Østergaard, Madina Ashna, Carsten Uhd Nielsen, Jette Jacobsen & Huiling Mu. (2020) Microenvironmental pH modifying films for buccal delivery of saquinavir: Effects of organic acids on pH and drug release in vitro. International Journal of Pharmaceutics 585, pages 119567.
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Deanna M. Mudie, Nasim Samiei, Derrick J. Marshall, Gregory E. Amidon & Christel A.S. Bergström. (2020) Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties. The AAPS Journal 22:2.
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Luning Dong, Yaping Mai, Qiang Liu, Wannian Zhang & Jianhong Yang. (2020) Mechanism and Improved Dissolution of Glycyrrhetinic Acid Solid Dispersion by Alkalizers. Pharmaceutics 12:1, pages 82.
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Chunhui Hu, Zhengsheng Liu, Chengyu Liu, Jianhua Li, Zhixin Wang, Liuting Xu, Cen Chen, Haining Fan & Feng Qian. (2019) Enhanced Oral Bioavailability and Anti-Echinococcosis Efficacy of Albendazole Achieved by Optimizing the “Spring” and “Parachute”. Molecular Pharmaceutics 16:12, pages 4978-4986.
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Joao A.C. Barbosa, Malaz S.E. Abdelsadig, Barbara R. Conway & Hamid A. Merchant. (2019) Using zeta potential to study the ionisation behaviour of polymers employed in modified-release dosage forms and estimating their pKa. International Journal of Pharmaceutics: X 1, pages 100024.
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Mohammad A. Altamimi, Ehab M. Elzayat, Wajhul Qamar, Sultan M. Alshehri, Abdelrahman Y. Sherif, Nazrul Haq & Faiyaz Shakeel. (2019) Evaluation of the bioavailability of hydrocortisone when prepared as solid dispersion. Saudi Pharmaceutical Journal 27:5, pages 629-636.
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Shudong Zhang, Qiang Wan, Xiaolin Xu, Yidan Xing, Jiafeng Ding, Shizhuang Yang, Weiwei Sun, Mengmeng Lu & Baoliang Pan. (2019) A novel oil-based suspension of a micro-environmental, pH-modifying solid dispersion for parenteral delivery: Formulation and stability evaluation. Colloids and Surfaces B: Biointerfaces 179, pages 382-392.
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Marius Monschke & Karl G. Wagner. (2019) Amorphous solid dispersions of weak bases with pH-dependent soluble polymers to overcome limited bioavailability due to gastric pH variability – An in-vitro approach. International Journal of Pharmaceutics 564, pages 162-170.
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Shudong Zhang, Qiang Wan, Yidan Xing, Jiafeng Ding, Shizhuang Yang, Weiwei Sun, Mengmeng Lu & Baoliang Pan. (2019) Formulation and Evaluation of a Novel Oral Oil-Based Suspension Using Micro-environmental pH-Modifying Solid Dispersion. AAPS PharmSciTech 20:2.
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Haley McFall, Sandeep Sarabu, Vijaykumar Shankar, Suresh Bandari, S. Narasimha Murthy, Karl Kolter, Nigel Langley, Dong Wuk Kim & Michael A. Repka. (2019) Formulation of aripiprazole-loaded pH-modulated solid dispersions via hot-melt extrusion technology: In vitro and in vivo studies. International Journal of Pharmaceutics 554, pages 302-311.
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Anh Q. Vo, Xin Feng, Jiaxiang Zhang, Feng Zhang & Michael A. Repka. (2018) Dual mechanism of microenvironmental pH modulation and foam melt extrusion to enhance performance of HPMCAS based amorphous solid dispersion. International Journal of Pharmaceutics 550:1-2, pages 216-228.
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Masashi Mizoguchi, Makoto Kataoka, Kazutoshi Yokoyama, Risa Aihara, Koichi Wada & Shinji Yamashita. (2018) Application of an In Vitro Dissolution/Permeation System to Early Screening of Oral Formulations of Poorly Soluble, Weakly Basic Drugs Containing an Acidic pH-Modifier. Journal of Pharmaceutical Sciences 107:9, pages 2404-2410.
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Tatyana Shabatina, Olga Vernaya, Vladimir Shabatin, Iuliia Evseeva, Michail Melnikov, Andrew Fitch & Vladimir Chernyshev. (2018) Cryochemically Obtained Nanoforms of Antimicrobial Drug Substance Dioxidine and Their Physico-chemical and Structural Properties. Crystals 8:7, pages 298.
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Jinheng Huang, Huaqing Lin, Bingxin Peng, Qianfeng Huang, Fangzhou Shuai & Yanxian Xie. (2018) Design and Evaluation of Hydrophilic Matrix System for pH-Independent Sustained Release of Weakly Acidic Poorly Soluble Drug. AAPS PharmSciTech 19:5, pages 2144-2154.
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Shimul Halder, Aiko Tabata, Yoshiki Seto, Hideyuki Sato & Satomi Onoue. (2018) Amorphous solid dispersions of carvedilol along with pH‐modifiers improved pharmacokinetic properties under hypochlorhydoria. Biopharmaceutics & Drug Disposition 39:4, pages 232-242.
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Shaolong He, Carsten Uhd Nielsen, Huiling Mu & Jette Jacobsen. (2022) <i>In Vitro</i> and <i>Ex Vivo</i> Evaluation of Bi-Layered Effervescent Microenvironmental PH Modifying Buccal Films with Saquinavir. SSRN Electronic Journal.
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