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Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology

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Robert L Katona. (2015) Human artificial chromosomes for future biomedicine. Cell Cycle 14:10, pages 1494-1494.
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Mikhail Liskovykh, Sergey Ponomartsev, Elena Popova, Michael Bader, Natalay Kouprina, Vladimir Larionov, Natalia Alenina & Alexey Tomilin. (2015) Stable maintenance of de novo assembled human artificial chromosomes in embryonic stem cells and their differentiated progeny in mice. Cell Cycle 14:8, pages 1268-1273.
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Vítor Gaspar, Duarte de Melo-Diogo, Elisabete Costa, André Moreira, João Queiroz, Chantal Pichon, Ilídio Correia & Fani Sousa. (2015) Minicircle DNA vectors for gene therapy: advances and applications. Expert Opinion on Biological Therapy 15:3, pages 353-379.
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Articles from other publishers (50)

Narumi Uno, Hiroyuki Satofuka, Hitomaru Miyamoto, Kazuhisa Honma, Teruhiko Suzuki, Kyotaro Yamazaki, Ryota Ito, Takashi Moriwaki, Shusei Hamamichi, Kazuma Tomizuka, Mitsuo Oshimura & Yasuhiro Kazuki. (2023) Treatment of CHO cells with Taxol and reversine improves micronucleation and microcell-mediated chromosome transfer efficiency. Molecular Therapy - Nucleic Acids 33, pages 391-403.
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Mikhail Liskovykh, Nikolai S. Petrov, Vladimir N. Noskov, Hiroshi Masumoto, William C. Earnshaw, David Schlessinger, Svetlana A. Shabalina, Vladimir Larionov & Natalay Kouprina. (2023) Actively transcribed rDNA and distal junction (DJ) sequence are involved in association of NORs with nucleoli. Cellular and Molecular Life Sciences 80:5.
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S.P. Simna & Zongchao Han. (2022) Prospects of Non-Coding Elements in Genomic DNA Based Gene Therapy. Current Gene Therapy 22:2, pages 89-103.
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Narumi Uno, Shuta Takata, Shinya Komoto, Hitomaru Miyamoto, Yuji Nakayama, Mitsuhiko Osaki, Ryota Mayuzumi, Natsumi Miyazaki, Chiaki Hando, Satoshi Abe, Tetsushi Sakuma, Takashi Yamamoto, Teruhiko Suzuki, Yoshihiro Nakajima, Mitsuo Oshimura, Kazuma Tomizuka & Yasuhiro Kazuki. (2022) Panel of human cell lines with human/mouse artificial chromosomes. Scientific Reports 12:1.
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Pankaj Singh, Pradeep Kumar Singh & Ram Lakhan Singh. 2022. Emerging Issues in Climate Smart Livestock Production. Emerging Issues in Climate Smart Livestock Production 171 208 .
Nicholas C. O. Lee, Nikolai S. Petrov, Vladimir Larionov & Natalay Kouprina. (2021) Assembly of Multiple Full‐Size Genes or Genomic DNA Fragments on Human Artificial Chromosomes Using the Iterative Integration System. Current Protocols 1:12.
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Hesam Babahosseini, Darawalee Wangsa, Mani Pabba, Thomas Ried, Tom Misteli & Don L DeVoe. (2021) Deterministic assembly of chromosome ensembles in a programmable membrane trap array. Biofabrication 13:4, pages 045005.
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Mikhail Liskovykh, Vladimir Larionov & Natalay Kouprina. (2021) Highly Efficient Microcell‐Mediated Transfer of HACs Containing a Genomic Region of Interest into Mammalian Cells. Current Protocols 1:9.
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Kai K. Ewert, Pablo Scodeller, Lorena Simón-Gracia, Victoria M. Steffes, Emily A. Wonder, Tambet Teesalu & Cyrus R. Safinya. (2021) Cationic Liposomes as Vectors for Nucleic Acid and Hydrophobic Drug Therapeutics. Pharmaceutics 13:9, pages 1365.
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Manisha Singh, Surinder P. Singh, Deepshikha Yadav, Mugdha Agarwal, Shriya Agarwal, Vinayak Agarwal, Geeta Swargiary, Sahil Srivastava, Sakshi Tyagi, Ramneek Kaur & Shalini Mani. (2021) Targeted Delivery for Neurodegenerative Disorders Using Gene Therapy Vectors: Gene Next Therapeutic Goals. Current Gene Therapy 21:1, pages 23-42.
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Sergey A. Sinenko, Sergey V. Ponomartsev & Alexey N. Tomilin. (2020) Pluripotent stem cell-based gene therapy approach: human de novo synthesized chromosomes. Cellular and Molecular Life Sciences 78:4, pages 1207-1220.
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Simona Grazioli & Gianluca Petris. 2021. Curing Genetic Diseases Through Genome Reprogramming. Curing Genetic Diseases Through Genome Reprogramming 477 520 .
Elisa Pesenti, Mikhail Liskovykh, Koei Okazaki, Alessio Mallozzi, Caitlin Reid, Maria Alba Abad, A. Arockia Jeyaprakash, Natalay Kouprina, Vladimir Larionov, Hiroshi Masumoto & William C. Earnshaw. (2020) Analysis of Complex DNA Rearrangements during Early Stages of HAC Formation. ACS Synthetic Biology 9:12, pages 3267-3287.
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Tomoya Terashima, Shuhei Kobashi, Yasuhiro Watanabe, Mami Nakanishi, Naoto Honda, Miwako Katagi, Natsuko Ohashi & Hideto Kojima. (2020) Enhancing the Therapeutic Efficacy of Bone Marrow-Derived Mononuclear Cells with Growth Factor-Expressing Mesenchymal Stem Cells for ALS in Mice. iScience 23:11, pages 101764.
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Sergey V. Ponomartsev, Sergey A. Sinenko, Elena V. Skvortsova, Mikhail A. Liskovykh, Ivan N. Voropaev, Maria M. Savina, Andrey A. Kuzmin, Elena Yu. Kuzmina, Alexandra M. Kondrashkina, Vladimir Larionov, Natalay Kouprina & Alexey N. Tomilin. (2020) Human AlphoidtetO Artificial Chromosome as a Gene Therapy Vector for the Developing Hemophilia A Model in Mice. Cells 9:4, pages 879.
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Sergey A. Sinenko, Sergey V. Ponomartsev & Alexey N. Tomilin. (2020) Human artificial chromosomes for pluripotent stem cell-based tissue replacement therapy. Experimental Cell Research 389:1, pages 111882.
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Mikhail Liskovykh, Nikolay V. Goncharov, Nikolai Petrov, Vasilisa Aksenova, Gianluca Pegoraro, Laurent L. Ozbun, William C. Reinhold, Sudhir Varma, Mary Dasso, Vadim Kumeiko, Hiroshi Masumoto, William C. Earnshaw, Vladimir Larionov & Natalay Kouprina. (2019) A novel assay to screen siRNA libraries identifies protein kinases required for chromosome transmission. Genome Research 29:10, pages 1719-1732.
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Natalay Kouprina & Vladimir Larionov. (2019) TAR Cloning: Perspectives for Functional Genomics, Biomedicine, and Biotechnology. Molecular Therapy - Methods & Clinical Development 14, pages 16-26.
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Sergey Sinenko, Elena Skvortsova, Mikhail Liskovykh, Sergey Ponomartsev, Andrey Kuzmin, Aleksandr Khudiakov, Anna Malashicheva, Natalia Alenina, Vladimir Larionov, Natalay Kouprina & Alexey Tomilin. (2018) Transfer of Synthetic Human Chromosome into Human Induced Pluripotent Stem Cells for Biomedical Applications. Cells 7:12, pages 261.
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Hee-Sheung Lee, Mar Carmena, Mikhail Liskovykh, Emma Peat, Jung-Hyun Kim, Mitsuo Oshimura, Hiroshi Masumoto, Marie-Paule Teulade-Fichou, Yves Pommier, William C. Earnshaw, Vladimir Larionov & Natalay Kouprina. (2018) Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy. Cancer Research 78:21, pages 6282-6296.
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Natalay Kouprina, Nikolai Petrov, Oscar Molina, Mikhail Liskovykh, Elisa Pesenti, Jun-ichirou Ohzeki, Hiroshi Masumoto, William C. Earnshaw & Vladimir Larionov. (2018) Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies. ACS Synthetic Biology 7:9, pages 1974-1989.
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Martin P. Stewart, Robert Langer & Klavs F. Jensen. (2018) Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts. Chemical Reviews 118:16, pages 7409-7531.
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Elisa Pesenti, Natalay Kouprina, Mikhail Liskovykh, Joan Aurich-Costa, Vladimir Larionov, Hiroshi Masumoto, William C. Earnshaw & Oscar Molina. (2018) Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies. ACS Synthetic Biology 7:4, pages 1116-1130.
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Sara Benedetti, Narumi Uno, Hidetoshi Hoshiya, Martina Ragazzi, Giulia Ferrari, Yasuhiro Kazuki, Louise Anne Moyle, Rossana Tonlorenzi, Angelo Lombardo, Soraya Chaouch, Vincent Mouly, Marc Moore, Linda Popplewell, Kanako Kazuki, Motonobu Katoh, Luigi Naldini, George Dickson, Graziella Messina, Mitsuo Oshimura, Giulio Cossu & Francesco Saverio Tedesco. (2017) Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next‐generation human artificial chromosomes for Duchenne muscular dystrophy. EMBO Molecular Medicine 10:2, pages 254-275.
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Narumi Uno, Satoshi Abe, Mitsuo Oshimura & Yasuhiro Kazuki. (2017) Combinations of chromosome transfer and genome editing for the development of cell/animal models of human disease and humanized animal models. Journal of Human Genetics 63:2, pages 145-156.
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Nicholas C. O. Lee, Jung-Hyun Kim, Nikolai S. Petrov, Hee-Sheung Lee, Hiroshi Masumoto, William C. Earnshaw, Vladimir Larionov & Natalay Kouprina. (2017) Method to Assemble Genomic DNA Fragments or Genes on Human Artificial Chromosome with Regulated Kinetochore Using a Multi-Integrase System. ACS Synthetic Biology 7:1, pages 63-74.
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Zongchao Han. 2018. Gene Therapy in Neurological Disorders. Gene Therapy in Neurological Disorders 63 80 .
Oscar Molina, Natalay Kouprina, Hiroshi Masumoto, Vladimir Larionov & William C. Earnshaw. (2017) Using human artificial chromosomes to study centromere assembly and function. Chromosoma 126:5, pages 559-575.
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Rachel E. DinerChari M. Noddings, Nathan C. Lian, Anthony K. Kang, Jeffrey B. McQuaidJelena JablanovicJosh L. EspinozaNgocquynh A. Nguyen, Miguel A. AnzelmattiJr.Jr., Jakob Jansson, Vincent A. Bielinski, Bogumil J. Karas, Christopher L. DupontAndrew E. AllenPhilip D. Weyman. (2017) Diatom centromeres suggest a mechanism for nuclear DNA acquisition. Proceedings of the National Academy of Sciences 114:29.
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Kathleen Plona, Taehyun Kim, Katherine Halloran & Anthony Wynshaw-Boris. (2016) Chromosome therapy: Potential strategies for the correction of severe chromosome aberrations. American Journal of Medical Genetics Part C: Seminars in Medical Genetics 172:4, pages 422-430.
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Daniel G. Booth, Alison J. Beckett, Oscar Molina, Itaru Samejima, Hiroshi Masumoto, Natalay Kouprina, Vladimir Larionov, Ian A. Prior & William C. Earnshaw. (2016) 3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin. Molecular Cell 64:4, pages 790-802.
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Andrea MartellaSteven M. PollardJunbiao Dai & Yizhi Cai. (2016) Mammalian Synthetic Biology: Time for Big MACs. ACS Synthetic Biology 5:10, pages 1040-1049.
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Natalay Kouprina & Vladimir Larionov. (2016) Transformation-associated recombination (TAR) cloning for genomics studies and synthetic biology. Chromosoma 125:4, pages 621-632.
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Teruhiko Suzuki, Yasuhiro Kazuki, Mitsuo Oshimura & Takahiko Hara. (2016) Highly Efficient Transfer of Chromosomes to a Broad Range of Target Cells Using Chinese Hamster Ovary Cells Expressing Murine Leukemia Virus-Derived Envelope Proteins. PLOS ONE 11:6, pages e0157187.
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Jung-Hyun Kim, Hee-Sheung Lee, Nicholas C. O. Lee, Nikolay V. Goncharov, Vadim Kumeiko, Hiroshi Masumoto, William C. Earnshaw, Natalay Kouprina & Vladimir Larionov. (2016) Development of a novel HAC-based “gain of signal” quantitative assay for measuring chromosome instability (CIN) in cancer cells. Oncotarget 7:12, pages 14841-14856.
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Mariana Loperfido, Susan Jarmin, Sumitava Dastidar, Mario Di Matteo, Ilaria Perini, Marc Moore, Nisha Nair, Ermira Samara-Kuko, Takis Athanasopoulos, Francesco Saverio Tedesco, George Dickson, Maurilio Sampaolesi, Thierry VandenDriessche & Marinee K. Chuah. (2016) piggyBac transposons expressing full-length human dystrophin enable genetic correction of dystrophic mesoangioblasts . Nucleic Acids Research 44:2, pages 744-760.
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Mikhail Liskovykh, Nicholas CO Lee, Vladimir Larionov & Natalay Kouprina. (2016) Moving toward a higher efficiency of microcell-mediated chromosome transfer. Molecular Therapy - Methods & Clinical Development 3, pages 16043.
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Narumi Uno, Yasuhiro Kazuki & Mitsuo Oshimura. 2016. Gene Therapy and Cell Therapy Through the Liver. Gene Therapy and Cell Therapy Through the Liver 75 83 .
Marianna Paulis, Alessandra Castelli, Lucia Susani, Michela Lizier, Irina Lagutina, Maria Luisa Focarelli, Camilla Recordati, Paolo Uva, Francesca Faggioli, Tui Neri, Eugenio Scanziani, Cesare Galli, Franco Lucchini, Anna Villa & Paolo Vezzoni. (2015) Chromosome transplantation as a novel approach for correcting complex genomic disorders. Oncotarget 6:34, pages 35218-35230.
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S. Pérez-Luz, A. Gimenez-Cassina, I. Fernández-Frías, R. Wade-Martins & J. Díaz-Nido. (2015) Delivery of the 135 kb human frataxin genomic DNA locus gives rise to different frataxin isoforms. Genomics 106:2, pages 76-82.
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Artem V. Kononenko, Nicholas C.O. Lee, Mikhail Liskovykh, Hiroshi Masumoto, William C. Earnshaw, Vladimir Larionov & Natalay Kouprina. (2015) Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette. Nucleic Acids Research 43:9, pages e57-e57.
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Nicholas C.O. Lee, Vladimir Larionov & Natalay Kouprina. (2015) Highly efficient CRISPR/Cas9-mediated TAR cloning of genes and chromosomal loci from complex genomes in yeast. Nucleic Acids Research 43:8, pages e55-e55.
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Natalay Kouprina & Vladimir Larionov. (2015) Recent advances in chromosome engineering. Chromosome Research 23:1, pages 1-5.
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Francesco Saverio Tedesco. (2015) Human artificial chromosomes for Duchenne muscular dystrophy and beyond: challenges and hopes. Chromosome Research 23:1, pages 135-141.
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Mitsuo Oshimura, Narumi Uno, Yasuhiro Kazuki, Motonobu Katoh & Toshiaki Inoue. (2015) A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges. Chromosome Research 23:1, pages 111-133.
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Robert L. Katona. (2015) De novo formed satellite DNA-based mammalian artificial chromosomes and their possible applications. Chromosome Research 23:1, pages 143-157.
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Daniela Moralli & Zoia L. Monaco. (2015) Developing de novo human artificial chromosomes in embryonic stem cells using HSV-1 amplicon technology. Chromosome Research 23:1, pages 105-110.
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Narumi Uno, Katsuhiro Uno, Shinya Komoto, Teruhiko Suzuki, Masaharu Hiratsuka, Mitsuhiko Osaki, Yasuhiro Kazuki & Mitsuo Oshimura. (2015) Development of a Safeguard System Using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy. Molecular Therapy - Nucleic Acids 4, pages e272.
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Artem V. Kononenko, Ruchi Bansal, Nicholas C.O. Lee, Brenda R. Grimes, Hiroshi Masumoto, William C. Earnshaw, Vladimir Larionov & Natalay Kouprina. (2014) A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function. Nucleic Acids Research 42:21, pages e164-e164.
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Teruhiko Suzuki, Yasuhiro Kazuki, Mitsuo Oshimura & Takahiko Hara. (2014) A Novel System for Simultaneous or Sequential Integration of Multiple Gene-Loading Vectors into a Defined Site of a Human Artificial Chromosome. PLoS ONE 9:10, pages e110404.
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