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Original Research

Optimization of self-nanoemulsifying systems for the enhancement of in vivo hypoglycemic efficacy of glimepiride transdermal patches

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Elsaied H. Elsaied, Hamdy M. Dawaba, El Sherbini A. Ibrahim & Mohsen I. Afouna. (2023) Spanlastics gel-A novel drug carrier for transdermal delivery of glimepiride. Journal of Liposome Research 33:1, pages 102-114.
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Nabil A. Alhakamy, Gamal A. Mohamed, Usama A. Fahmy, Basma G. Eid, Mohammed W. Al-Rabia, Amgad I. M. Khedr, Mohammed Z. Nasrullah, Sabrin R. M. Ibrahim, Ashraf B. Abdel-Naim, Osama A. A. Ahmed & Shadab Md. (2022) Thioctamer: a novel thioctic acid–glatiramer acetate nanoconjugate expedites wound healing in diabetic rats. Drug Delivery 29:1, pages 1776-1784.
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Haiying Li, Jiajia Wang, Qianru Xu, Shuya Tian & Wenzhi Yang. (2022) Design and evaluation of glimepiride hydrogel for transdermal delivery. Drug Development and Industrial Pharmacy 48:8, pages 397-405.
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Nabil A. Alhakamy, Usama A. Fahmy, Osama A. A. Ahmed, Enas A. Almohammadi, Shahad A. Alotaibi, Raghad A. Aljohani, Waleed S. Alharbi, Mohamed A. Alfaleh & Mohammad Y. Alfaifi. (2020) Development of an optimized febuxostat self-nanoemulsified loaded transdermal film: in-vitro, ex-vivo and in-vivo evaluation. Pharmaceutical Development and Technology 25:3, pages 326-331.
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Khalid M El-Say, Osama AA Ahmed, Amir I Mohamed, Martin K Safo & Abdelsattar M Omar. (2019) Zein-alpha lipoic acid-loaded nanoparticles to enhance the oral bioavailability of dapoxetine: optimization and clinical pharmacokinetic evaluation. International Journal of Nanomedicine 14, pages 7461-7473.
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Osama AA Ahmed, Khalid M El-Say, Bader M Aljaeid, Shaimaa M Badr-Eldin & Tarek A Ahmed. (2019) Optimized vinpocetine-loaded vitamin E D-α-tocopherol polyethylene glycol 1000 succinate-alpha lipoic acid micelles as a potential transdermal drug delivery system: in vitro and ex vivo studies. International Journal of Nanomedicine 14, pages 33-43.
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Maha K. A. Khalifa, Hoda A. Salem, Seham M. Shawky, Heba A. Eassa & Asmaa M. Elaidy. (2019) Enhancement of zaleplon oral bioavailability using optimized self-nano emulsifying drug delivery systems and its effect on sleep quality among a sample of psychiatric patients. Drug Delivery 26:1, pages 1243-1253.
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Osama AA Ahmed & Waleed Y Rizq. (2018) Finasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach. Drug Design, Development and Therapy 12, pages 2259-2265.
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Tarek A. Ahmed, Mohammad A. A. Suhail, Khaled M. Hosny & Fathy I. Abd-Allah. (2018) Clinical pharmacokinetic study for the effect of glimepiride matrix tablets developed by quality by design concept. Drug Development and Industrial Pharmacy 44:1, pages 66-81.
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Shaimaa M Badr-Eldin & Osamaa AA Ahmed. (2016) Optimized nano-transfersomal films for enhanced sildenafil citrate transdermal delivery: ex vivo and in vivo evaluation. Drug Design, Development and Therapy 10, pages 1323-1333.
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Mallesh Kurakula, Osama A. A. Ahmed, Usama A. Fahmy & Tarek A. Ahmed. (2016) Solid lipid nanoparticles for transdermal delivery of avanafil: optimization, formulation, in-vitro and ex-vivo studies. Journal of Liposome Research 26:4, pages 288-296.
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Vineet Kumar Rai, Nidhi Mishra, Ashish Kumar Agrawal, Sanyog Jain & Narayan Prasad Yadav. (2016) Novel drug delivery system: an immense hope for diabetics. Drug Delivery 23:7, pages 2371-2390.
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Osama A. Ahmed, Amal K. Hussein & Fatma M. Mady. (2016) Optimisation of microstructured biodegradable finasteride formulation for depot parenteral application. Journal of Microencapsulation 33:3, pages 229-238.
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Kunika Saini & Smriti Sharma. (2023) Nanomedicine’s transformative impact on anti-diabetic drug discovery: an appraisal. Journal of Nanoparticle Research 25:11.
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Saleh A. Al-Suwayeh, Mohamed M. Badran, Ghada O. Alhumoud, Ehab I. Taha, Lubna Y. Ashri & Mohsin Kazi. (2023) Design and dermatokinetic appraisal of lornoxicam-loaded ultrafine self-nanoemulsion hydrogel for the management of inflammation: In vitro and in vivo studies. Saudi Pharmaceutical Journal 31:6, pages 889-903.
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Tahani S. Basahih, Abdullah A. Alamoudi, Khalid M. El-Say, Nabil A. Alhakamy & Osama A. A. Ahmed. (2020) Improved Transmucosal Delivery of Glimepiride via Unidirectional Release Buccal Film Loaded With Vitamin E TPGS-Based Nanocarrier. Dose-Response 18:3, pages 155932582094516.
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Siddharth Uppal, Kishan S. Italiya, Deepak Chitkara & Anupama Mittal. (2018) Nanoparticulate-based drug delivery systems for small molecule anti-diabetic drugs: An emerging paradigm for effective therapy. Acta Biomaterialia 81, pages 20-42.
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Osama A. A. Ahmed, Khalid M. El-Say & Abdulrahman M. Alahdal. (2017) A PLGA-reinforced PEG in situ gel formulation for improved sustainability of hypoglycaemic activity of glimepiride in streptozotocin-induced diabetic rats. Scientific Reports 7:1.
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Tarek A. Ahmed & Khalid M. El-Say. (2016) Transdermal film-loaded finasteride microplates to enhance drug skin permeation: Two-step optimization study. European Journal of Pharmaceutical Sciences 88, pages 246-256.
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Tarek A. Ahmed, Khalid M. El-Say, Bader M. Aljaeid, Usama A. Fahmy & Fathy I. Abd-Allah. (2016) Transdermal glimepiride delivery system based on optimized ethosomal nano-vesicles: Preparation, characterization, in vitro , ex vivo and clinical evaluation. International Journal of Pharmaceutics 500:1-2, pages 245-254.
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Osama Abdelhakim Aly Ahmed, Mallesh Kurakula, Zainy Mohamed Banjar, Mohsen Ibrahim Afouna & Ahmed Samir Zidan. (2015) Quality by Design Coupled with Near Infrared in Formulation of Transdermal Glimepiride Liposomal Films. Journal of Pharmaceutical Sciences 104:6, pages 2062-2075.
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Usama A. Fahmy, Osama A. A. Ahmed & Khaled M. Hosny. (2014) Development and Evaluation of Avanafil Self-nanoemulsifying Drug Delivery System with Rapid Onset of Action and Enhanced Bioavailability. AAPS PharmSciTech 16:1, pages 53-58.
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