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Original Research

Novel nanostructured lipid carrier-based inserts for controlled ocular drug delivery: evaluation of corneal bioavailability and treatment efficacy in bacterial keratitis

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Read on this site (9)

Ece Özcan Bülbül, Neslihan Üstündağ Okur, Duygu Mısırlı, Erdal Cevher, Vasilios Tsanaktsis, Özlem Bingöl Özakpınar & Panoraia I. Siafaka. (2023) Applying quality by design approach for the determination of potent paclitaxel loaded poly(lactic acid) based implants for localized tumor drug delivery. International Journal of Polymeric Materials and Polymeric Biomaterials 72:12, pages 968-983.
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Heidi M. Abdel-Mageed, Amira E. Abd El Aziz, Saleh A. Mohamed & Nermeen Z. AbuelEzz. (2022) The tiny big world of solid lipid nanoparticles and nanostructured lipid carriers: an updated review. Journal of Microencapsulation 39:1, pages 72-94.
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İpek Erol, Neslihan Üstündağ Okur, Duygu Orak, Hande Sipahi, Ahmet Aydın & Özgen Özer. (2020) Tazarotene-loaded in situ gels for potential management of psoriasis: biocompatibility, anti-inflammatory and analgesic effect. Pharmaceutical Development and Technology 25:8, pages 909-918.
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Girdhari Roy, Rohini Devi Galigama, Veda Suresh Thorat, Prashant Garg & Venkata Vamsi Krishna Venuganti. (2020) Microneedle ocular patch: fabrication, characterization, and ex-vivo evaluation using pilocarpine as model drug. Drug Development and Industrial Pharmacy 46:7, pages 1114-1122.
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Zahra Mohtashami, Zahra Esmaili, Molood Alsadat Vakilinezhad, Ehsan Seyedjafari & Hamid Akbari Javar. (2020) Pharmaceutical implants: classification, limitations and therapeutic applications. Pharmaceutical Development and Technology 25:1, pages 116-132.
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Prashant Garg, Venkata Vamsi Krishna Venuganti, Aravind Roy & Girdhari Roy. (2019) Novel drug delivery methods for the treatment of keratitis: moving away from surgical intervention. Expert Opinion on Drug Delivery 16:12, pages 1381-1391.
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Aashu Gupta, Kritika Nayak & Manju Misra. (2019) Cow ghee fortified ocular topical microemulsion; in vitro, ex vivo, and in vivo evaluation. Journal of Microencapsulation 36:7, pages 603-621.
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Tian Fu, Jinglin Yi, Songyi Lv & Bing Zhang. (2017) Ocular amphotericin B delivery by chitosan-modified nanostructured lipid carriers for fungal keratitis-targeted therapy. Journal of Liposome Research 27:3, pages 228-233.
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Mária Budai-Szű cs, Gabriella Horvát, Benjámin Gyarmati, Barnabás Áron Szilágyi, András Szilágyi, Tímea Csihi, Szilvia Berkó, Piroska Szabó-Révész, Michela Mori, Giuseppina Sandri, Maria Cristina Bonferoni, Carla Caramella & Erzsébet Csányi. (2016) In vitro testing of thiolated poly(aspartic acid) from ophthalmic formulation aspects. Drug Development and Industrial Pharmacy 42:8, pages 1241-1246.
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Articles from other publishers (43)

Abhishek Tiwari, Varsha Tiwari, Binita Palaria, Ramsha Aslam, Manish Kumar & Neeraj Kumar. (2023) Network pharmacology, molecular docking-driven, Qbd-Engineered antifungal in-situ gel loaded with voriconazole nanostructured lipid carriers . Journal of Biomolecular Structure and Dynamics, pages 1-20.
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Vildan Yozgatlı, Neslihan Üstündağ Okur, Mehmet Evren Okur, Hande Sipahi, Mohammad Charehsaz, Ahmet Aydın & Timuçin Uğurlu. (2023) Managing allergic conjunctivitis via ophthalmic microemulsions: Formulation, characterization, in vitro irritation studies based on EpiOcular ™ eye irritation assay and in vivo studies in rabbit eye . Journal of Surfactants and Detergents 26:6, pages 853-866.
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Rubens T. Monteiro, Thamyres F. Da Silva, RaimundoN.F. Moreira Filho, Niédja F. Vasconcelos, KarinaA.B. Nogueira, Raquel Petrilli, Fabia K. Andrade & Rodrigo S. Vieira. (2023) Simvastatin-loaded alginate bilayer membranes for wound dressing applications. Journal of Drug Delivery Science and Technology 86, pages 104701.
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Jing Wei, Jinyu Mu, Yong Tang, Dalian Qin, Junguo Duan & Anguo Wu. (2023) Next-generation nanomaterials: advancing ocular anti-inflammatory drug therapy. Journal of Nanobiotechnology 21:1.
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Muhammet Davut Arpa, Neslihan Üstündağ Okur, Mehmet Koray Gök, Saadet Özgümüş & Erdal Cevher. (2023) Chitosan-based buccal mucoadhesive patches to enhance the systemic bioavailability of tizanidine. International Journal of Pharmaceutics 642, pages 123168.
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Binita Palaria, Varsha Tiwari, Abhishek Tiwari, Ramsha Aslam, Ashok Kumar, Biswa Mohan Sahoo, Manish Kumar, Sunil Singh & Suresh Kumar. (2023) Nanostructured Lipid Carriers: A Promising Carrier in Targeted Drug Delivery System. Current Nanomaterials 8:1, pages 23-43.
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Lional Raj Daniel Raj Ponniah. 2023. Keratitis - Current Perspectives [Working Title]. Keratitis - Current Perspectives [Working Title].
Jasjeet Kaur Narang, Kiranjeet Kaur, Gurpreet Kaur, Anmol Dogra & Deepti Pandita. 2023. Nanotechnology in Ophthalmology. Nanotechnology in Ophthalmology 151 179 .
Biswarup Das, Amit Kumar Nayak & Subrata Mallick. (2022) Lipid-based nanocarriers for ocular drug delivery: An updated review. Journal of Drug Delivery Science and Technology 76, pages 103780.
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Lidawani Lambuk, Nurfatihah Azlyna Ahmad Suhaimi, Muhammad Zulfiqah Sadikan, Azliana Jusnida Ahmad Jafri, Suhana Ahmad, Nurul Alimah Abdul Nasir, Vuk Uskoković, Ramlah Kadir & Rohimah Mohamud. (2022) Nanoparticles for the treatment of glaucoma-associated neuroinflammation. Eye and Vision 9:1.
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Stephen Tuft, Tobi F. Somerville, Ji-Peng Olivia Li, Timothy Neal, Surjo De, Malcolm J. Horsburgh, Joanne L. Fothergill, Daniel Foulkes & Stephen Kaye. (2022) Bacterial keratitis: identifying the areas of clinical uncertainty. Progress in Retinal and Eye Research 89, pages 101031.
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Heybet Kerem PolatNihat Kurt, Eren AytekinSibel Bozdağ PehlivanSema Çalış. (2022) Novel Drug Delivery Systems to Improve the Treatment of Keratitis. Journal of Ocular Pharmacology and Therapeutics.
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Aravind Roy, Venkata V. Krishna Venuganti, Shreya S. Chauhan & Prashant Garg. (2022) Polymeric Drug Delivery Devices: Role in Cornea and External Disease. Eye & Contact Lens: Science & Clinical Practice 48:3, pages 119-126.
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Lawson Ung & James Chodosh. (2021) Foundational concepts in the biology of bacterial keratitis. Experimental Eye Research 209, pages 108647.
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Jason W. Lee, Tobi Somerville, Stephen B. Kaye & Vito Romano. (2021) Staphylococcus aureus Keratitis: Incidence, Pathophysiology, Risk Factors and Novel Strategies for Treatment. Journal of Clinical Medicine 10:4, pages 758.
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Mahvash Shokrollahi, S. Hajir Bahrami, Masoumeh Haghbin Nazarpak & Atefeh Solouk. (2020) Biomimetic double-sided polypropylene mesh modified by DOPA and ofloxacin loaded carboxyethyl chitosan/polyvinyl alcohol-polycaprolactone nanofibers for potential hernia repair applications. International Journal of Biological Macromolecules 165, pages 902-917.
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Hamdy Abdelkader, David Wertheim, Barbara Pierscionek & Raid G. Alany. (2020) Curcumin In Situ Gelling Polymeric Insert with Enhanced Ocular Performance. Pharmaceutics 12:12, pages 1158.
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Tanvi Kadam & Surendra Agrawal. (2020) A Short Review on the Important Aspects Involved in Preparation, Characterization and Application of Nanostructured Lipid Carriers for Drug Delivery. Current Nanomedicine 10:3, pages 188-207.
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Matheus Aparecido dos Santos Ramos, Karen Cristina dos Santos, Patrícia Bento da Silva, Luciani Gaspar de Toledo, Gabriel Davi Marena, Camila Fernanda Rodero, Bruna Almeida Furquim de Camargo, Giovanna Capaldi Fortunato, Taís Maria Bauab & Marlus Chorilli. (2020) Nanotechnological strategies for systemic microbial infections treatment: A review. International Journal of Pharmaceutics 589, pages 119780.
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Neslihan Üstündağ Okur, Ayşe Pınar Yağcılar & Panoraia I. Siafaka. (2020) Promising Polymeric Drug Carriers for Local Delivery: The Case of in situ Gels. Current Drug Delivery 17:8, pages 675-693.
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Marcela Gómez-Garzón, M. Alejandra Martínez-Ceballos, Arley Gómez-López & Adriana Rojas-Villarraga. (2020) Aplicaciones de la nanotecnología en el campo de la oftalmología: ¿dónde estamos?. Revista Mexicana de Oftalmología 94:5S, pages 221-233.
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Neslihan Üstündağ Okur, Vildan Yozgatli & Mehmet Evren Okur. (2020) In vitro–in vivo evaluation of tetrahydrozoline‐loaded ocular in situ gels on rabbits for allergic conjunctivitis management. Drug Development Research 81:6, pages 716-727.
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Alexandra Zamboulis, Stavroula Nanaki, Georgia Michailidou, Ioanna Koumentakou, Maria Lazaridou, Nina Maria Ainali, Eleftheria Xanthopoulou & Dimitrios N. Bikiaris. (2020) Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments. Polymers 12:7, pages 1519.
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Junaid Qureshi, Furqan Muhammad Iqbal, Farwa Hussain, Hira Ijaz, Muhammad Fakhruddin Aamir & Mehreen Afzal. (2020) Fabrication and evaluation of Olopatadine hydrochloride ocular inserts. Journal of Plastic Film & Sheeting 36:3, pages 243-259.
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Neslihan Üstündağ OkurEmre Şefik ÇağlarPanoraia I. Siafaka. (2020) Novel Ocular Drug Delivery Systems: An Update on Microemulsions. Journal of Ocular Pharmacology and Therapeutics 36:6, pages 342-354.
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H. Kerem Polat, Sibel Bozdağ Pehlivan, Ceren Özkul, Semih Çalamak, Naile Öztürk, Eren Aytekin, Ayşegül Fırat, Kezban Ulubayram, Sibel Kocabeyoğlu, Murat İrkeç & Sema Çalış. (2020) Development of besifloxacin HCl loaded nanofibrous ocular inserts for the treatment of bacterial keratitis: In vitro, ex vivo and in vivo evaluation. International Journal of Pharmaceutics 585, pages 119552.
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Shahrzad Ghafoorianfar, Adel Ghorani-Azam, Seyed Ahmad Mohajeri & Davood Farzin. (2020) Efficiency of nanoparticles for treatment of ocular infections: Systematic literature review. Journal of Drug Delivery Science and Technology 57, pages 101765.
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Anmol Dogra, Kuljeet Kaur, Javed Ali, Sanjula Baboota, Ramandeep Singh Narang & Jasjeet Kaur Narang. (2020) Nanoformulations for Ocular Delivery of Drugs - A Patent Perspective. Recent Patents on Drug Delivery & Formulation 13:4, pages 255-272.
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Naida Omerović & Edina Vranić. (2019) Application of nanoparticles in ocular drug delivery systems. Health and Technology 10:1, pages 61-78.
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Neslihan Üstündağ Okur, Nesrin Hökenek, Mehmet Evren Okur, Şule Ayla, Ayşegül Yoltaş, Panoraia I. Siafaka & Erdal Cevher. (2019) An alternative approach to wound healing field; new composite films from natural polymers for mupirocin dermal delivery. Saudi Pharmaceutical Journal 27:5, pages 738-752.
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Neslihan Üstündağ Okur, Vildan Yozgatlı, Mehmet Evren Okur, Aysegül Yoltaş & Panoraia I. Siafaka. (2019) Improving therapeutic efficacy of voriconazole against fungal keratitis: Thermo-sensitive in situ gels as ophthalmic drug carriers. Journal of Drug Delivery Science and Technology 49, pages 323-333.
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Panoraia Siafaka, Mehmet Evren Okur, Şule Ayla, Sevda Er, Emre Şefik Cağlar & Neslihan Üstündağ Okur. (2019) Design and characterization of nanocarriers loaded with Levofloxacin for enhanced antimicrobial activity; physicochemical properties, in vitro release and oral acute toxicity. Brazilian Journal of Pharmaceutical Sciences 55.
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Jan Sobczyński & Gabriela Bielecka. 2019. Nanoparticles in Pharmacotherapy. Nanoparticles in Pharmacotherapy 275 309 .
Archana Khosa, Satish Reddi & Ranendra N. Saha. (2018) Nanostructured lipid carriers for site-specific drug delivery. Biomedicine & Pharmacotherapy 103, pages 598-613.
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Sharma T. Sanjay, Wan Zhou, Maowei Dou, Hamed Tavakoli, Lei Ma, Feng Xu & XiuJun Li. (2018) Recent advances of controlled drug delivery using microfluidic platforms. Advanced Drug Delivery Reviews 128, pages 3-28.
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Marion Dubald, Sandrine Bourgeois, Véronique Andrieu & Hatem Fessi. (2018) Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review. Pharmaceutics 10:1, pages 10.
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Lida Lalu, Vishakha Tambe, Deepak Pradhan, Kritika Nayak, Suchandra Bagchi, Rahul Maheshwari, Kiran Kalia & Rakesh Kumar Tekade. (2017) Novel nanosystems for the treatment of ocular inflammation: Current paradigms and future research directions. Journal of Controlled Release 268, pages 19-39.
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Ajay Sharma & Jonathan Taniguchi. (2017) Review: Emerging strategies for antimicrobial drug delivery to the ocular surface: Implications for infectious keratitis. The Ocular Surface 15:4, pages 670-679.
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Loïc Bugnicourt & Catherine Ladavière. (2017) A close collaboration of chitosan with lipid colloidal carriers for drug delivery applications. Journal of Controlled Release 256, pages 121-140.
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Ragwa M. Farid, Noha S. El-Salamouni, Amal H. El-Kamel & Safaa S. El-Gamal. 2017. Nanostructures for Drug Delivery. Nanostructures for Drug Delivery 495 522 .
Slavomira Doktorovová, Andjelka B. Kovačević, Maria L. Garcia & Eliana B. Souto. (2016) Preclinical safety of solid lipid nanoparticles and nanostructured lipid carriers: Current evidence from in vitro and in vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics 108, pages 235-252.
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Panoraia Siafaka, Neslihan Üstündağ Okur, Evangelos Karavas & Dimitrios Bikiaris. (2016) Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses. International Journal of Molecular Sciences 17:9, pages 1440.
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Panoraia I. Siafaka, Alexandra Titopoulou, Emmanuel N. Koukaras, Margaritis Kostoglou, Efthimios Koutris, Evangelos Karavas & Dimitrios N. Bikiaris. (2015) Chitosan derivatives as effective nanocarriers for ocular release of timolol drug. International Journal of Pharmaceutics 495:1, pages 249-264.
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