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Review

Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs

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Pages 97-110 | Published online: 22 Dec 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (20)

Eesha Shukla, Divya Dhatri Kara, Tanvi Katikala & Mahalaxmi Rathnanand. (2023) Self-nanoemulsifying drug delivery systems (SNEDDS) of anti-cancer drugs: a multifaceted nanoplatform for the enhancement of oral bioavailability. Drug Development and Industrial Pharmacy 49:1, pages 1-16.
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Ožbej Zupančič, Martin Spoerk & Amrit Paudel. (2022) Lipid-based solubilization technology via hot melt extrusion: promises and challenges. Expert Opinion on Drug Delivery 19:9, pages 1013-1032.
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Fiza Ur Rehman, Kifayat Ullah Shah, Shefaat Ullah Shah, Ikram Ullah Khan, Gul Majid Khan & Amjad Khan. (2017) From nanoemulsions to self-nanoemulsions, with recent advances in self-nanoemulsifying drug delivery systems (SNEDDS). Expert Opinion on Drug Delivery 14:11, pages 1325-1340.
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Gurinder Singh & Roopa S. Pai. (2016) In vitro and in vivo performance of supersaturable self-nanoemulsifying system of trans-resveratrol. Artificial Cells, Nanomedicine, and Biotechnology 44:2, pages 510-516.
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Milica Vukićević, Anne Bee Hegge, Predrag Vulić & Hanne Hjorth Tønnesen. (2015) Poloxamer-based curcumin solid dispersions for ex tempore preparation of supersaturated solutions intended for antimicrobial photodynamic therapy. Pharmaceutical Development and Technology 20:7, pages 863-871.
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Bing Shao, Chao Cui, Hongyu Ji, Jingling Tang, Zhiyong Wang, Hongmei Liu, Mengnan Qin, Xin Li & Linhua Wu. (2015) Enhanced oral bioavailability of piperine by self-emulsifying drug delivery systems: in vitro, in vivo and in situ intestinal permeability studies. Drug Delivery 22:6, pages 740-747.
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Shambhu Dokania & Amita K. Joshi. (2015) Self-microemulsifying drug delivery system (SMEDDS) – challenges and road ahead. Drug Delivery 22:6, pages 675-690.
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Haiyan Li, Yonggang Tan, Lixia Yang, Lijun Gao, Tao Wang, Xi Yang & Dongqin Quan. (2015) Dissolution evaluation in vitro and bioavailability in vivo of self-microemulsifying drug delivery systems for pH-sensitive drug loratadine. Journal of Microencapsulation 32:2, pages 175-180.
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Shantanu Bandyopadhyay, OP Katare & Bhupinder Singh. (2014) Development of optimized supersaturable self-nanoemulsifying systems of ezetimibe: effect of polymers and efflux transporters. Expert Opinion on Drug Delivery 11:4, pages 479-492.
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Takatsune Yoshida, Ippei Kurimoto, Keiichi Yoshihara, Hiroyuki Umejima, Naoki Ito, Shunsuke Watanabe, Kazuhiro Sako & Akihiko Kikuchi. (2013) Effect of aminoalkyl methacrylate copolymer E/ HCl on in vivo absorption of poorly water-soluble drug. Drug Development and Industrial Pharmacy 39:11, pages 1698-1705.
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Zhi-Qiang Chen, Ying Liu, Ji-Hui Zhao, Lan Wang & Nian-Ping Feng. (2012) Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system. International Journal of Nanomedicine 7, pages 1115-1125.
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Abdul Wadood Khan, Sabna Kotta, Shahid H Ansari, Rakesh Kumar Sharma & Javed Ali. (2012) Potentials and challenges in self-nanoemulsifying drug delivery systems. Expert Opinion on Drug Delivery 9:10, pages 1305-1317.
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Saumitra Bagchi, Tusharmouli Mukherjee & Fotios Plakogiannis. (2012) Re-evaluation of in vitro dissolution techniques for supersaturating drug delivery systems. Pharmaceutical Development and Technology 17:4, pages 477-482.
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Nan Zhang, Weidong Zhang, Yinghua Jin & Dong-qin Quan. (2011) Studies on preparation of carbamazepine (CBZ) supersaturatable self-microemulsifying (S-SMEDDS) formulation and relative bioavailability in beagle dogs. Pharmaceutical Development and Technology 16:4, pages 415-421.
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Dallas B. Warren, Hassan Benameur, Christopher J.H. Porter & Colin W. Pouton. (2010) Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility. Journal of Drug Targeting 18:10, pages 704-731.
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James C. DiNunzio, Justin R. Hughey, Chris Brough, Dave A. Miller, Robert O. Williams III & James W. McGinity. (2010) Production of advanced solid dispersions for enhanced bioavailability of itraconazole using KinetiSol® Dispersing. Drug Development and Industrial Pharmacy 36:9, pages 1064-1078.
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Cai-Xia He, Zhong-Gui He & Jian-Qing Gao. (2010) Microemulsions as drug delivery systems to improve the solubility and the bioavailability of poorly water-soluble drugs. Expert Opinion on Drug Delivery 7:4, pages 445-460.
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Seshadri Neervannan. (2006) Preclinical formulations for discovery and toxicology: physicochemical challenges. Expert Opinion on Drug Metabolism & Toxicology 2:5, pages 715-731.
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