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Expert Opinion on Drug Delivery Volume 3, 2006 - Issue 5
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Technology Evaluation

Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET™

Thomas W Leonard VP and Chief Scientific Officer, Merrion Pharmaceuticals USA, 219 Racine Drive, Suite D, Wilmington, NC 28403, USA. [email protected]
,
John Lynch Chief Operating Officer, Merrion Pharmaceuticals, Ireland, Biotechnology Building, Trinity College, Dublin 2, Ireland
,
Michael J McKenna Chief Executive Officer, Merrion Pharmaceuticals USA, Wilmington, NC, USA
&
David J Brayden Associate Professor, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Pages 685-692 | Published online: 01 Sep 2006

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Sam Maher, Caroline Geoghegan & David J. Brayden. (2021) Intestinal permeation enhancers to improve oral bioavailability of macromolecules: reasons for low efficacy in humans. Expert Opinion on Drug Delivery 18:2, pages 273-300.
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Juber Akhtar, Hefazat Hussain Siddiqui, Sheeba Fareed, Badruddeen, Mohammad Khalid & Mohammed Aqil. (2016) Nanoemulsion: for improved oral delivery of repaglinide. Drug Delivery 23:6, pages 2026-2034.
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Fiona McCartney, John P. Gleeson & David J. Brayden. (2016) Safety concerns over the use of intestinal permeation enhancers: A mini-review. Tissue Barriers 4:2.
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Christian Tscheik, Ingolf E. Blasig & Lars Winkler. (2013) Trends in drug delivery through tissue barriers containing tight junctions. Tissue Barriers 1:2.
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Jerry R Colca. (2012) Discontinued drugs 2011: endocrine and metabolic. Expert Opinion on Investigational Drugs 21:11, pages 1619-1624.
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Ping Li, Hanne Mørck Nielsen & Anette Müllertz. (2012) Oral delivery of peptides and proteins using lipid-based drug delivery systems. Expert Opinion on Drug Delivery 9:10, pages 1289-1304.
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Taslim A. Al-Hilal, Farzana Alam & Youngro Byun. (2013) Oral drug delivery systems using chemical conjugates or physical complexes. Advanced Drug Delivery Reviews 65:6, pages 845-864.
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Elisabeth V. Giger, Bastien Castagner & Jean-Christophe Leroux. (2013) Biomedical applications of bisphosphonates. Journal of Controlled Release 167:2, pages 175-188.
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Pius Fasinu, Yahya E. Choonara, Riaz A. Khan, Lisa C. Du Toit, Pradeep Kumar, Valence M. K. Ndesendo & Viness Pillay. (2013) Flavonoids and Polymer Derivatives as CYP3A4 Inhibitors for Improved Oral Drug Bioavailability. Journal of Pharmaceutical Sciences 102:2, pages 541-555.
Crossref
Louise Rosenmayr-Templeton. (2013) The oral delivery of peptides and proteins: established versus recently patented approaches. Pharmaceutical Patent Analyst 2:1, pages 125-145.
Crossref
Lyn H. Jones & David A. Price. 2013. 45 96 .
Lars Hovgaard, Sven Frokjaer & Marco van de WeertUlrik Rahbek, František Hubálek & Simon Bjerregaard. 2012. Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition. Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition 269 296 .
Francisca Araújo, Pedro Fonte, Hélder A. Santos & Bruno Sarmento. (2012) Oral Delivery of Glucagon-like Peptide-1 and Analogs: Alternatives for Diabetes Control?. Journal of Diabetes Science and Technology 6:6, pages 1486-1497.
Crossref
G. Del Vecchio, C. Tscheik, K. Tenz, H. C. Helms, L. Winkler, R. Blasig & I. E. Blasig. (2012) Sodium Caprate Transiently Opens Claudin-5-Containing Barriers at Tight Junctions of Epithelial and Endothelial Cells. Molecular Pharmaceutics 9:9, pages 2523-2533.
Crossref
Sam Maher, Katie B. Ryan, Tauseef Ahmad, Caitriona M. O'driscoll & David J. Brayden*. 2012. Nanostructured Biomaterials for Overcoming Biological Barriers. Nanostructured Biomaterials for Overcoming Biological Barriers 39 62 .
Sam Maher & David J. Brayden. (2012) Overcoming poor permeability: translating permeation enhancers for oral peptide delivery. Drug Discovery Today: Technologies 9:2, pages e113-e119.
Crossref
Rishi Paliwal, Shivani R. Paliwal, Govind P. Agrawal & Suresh P. Vyas. (2011) Recent advances in search of oral heparin therapeutics. Medicinal Research Reviews 32:2, pages 388-409.
Crossref
Emanuel Calenoff. (2012) Interplaying Factors That Effect Multiple Sclerosis Causation and Sustenance. ISRN Neurology 2012, pages 1-27.
Crossref
Edwin G Walsh, Bozena E Adamczyk, Kishore B Chalasani, Sam Maher, Edel B O’Toole, John S Fox, Thomas W Leonard & David J Brayden. (2011) Oral delivery of macromolecules: rationale underpinning Gastrointestinal Permeation Enhancement Technology (GIPET ® ) . Therapeutic Delivery 2:12, pages 1595-1610.
Crossref
BT Griffin & CM O’Driscoll. (2011) Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies. Therapeutic Delivery 2:12, pages 1633-1653.
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Rabea Parveen, Sanjula Baboota, Javed Ali, Alka Ahuja, Suruchi S. Vasudev & Sayeed Ahmad. (2011) Oil based nanocarrier for improved oral delivery of silymarin: In vitro and in vivo studies. International Journal of Pharmaceutics 413:1-2, pages 245-253.
Crossref
Pius Fasinu, Viness Pillay, Valence M. K. Ndesendo, Lisa C. du Toit & Yahya E. Choonara. (2011) Diverse approaches for the enhancement of oral drug bioavailability. Biopharmaceutics & Drug Disposition 32:4, pages 185-209.
Crossref
Jian Meng & Liandong Hu. (2011) Positively-charged microemulsion for improving the oral bioavailability of alendronate: in-vitro and in-vivo assessment. Journal of Pharmacy and Pharmacology 63:3, pages 400-408.
Crossref
Xuexuan Wang, Sam Maher & David J Brayden. (2010) Restoration of rat colonic epithelium after in situ intestinal instillation of the absorption promoter, sodium caprate . Therapeutic Delivery 1:1, pages 75-82.
Crossref
Kyung-Hee Roh, Ki-Jong Lee, Jong-Sug Park, Hyun-Uk Kim, Kyeong-Ryeol Lee & Jong-Bum Kim. (2010) Production of Medium-chain Fatty Acids in Brassica napus by Biotechnology. Journal of Applied Biological Chemistry 53:2, pages 65-70.
Crossref
Shayne Cox GadLuis Granero & Ana Polache. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
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Crossref
Sam Maher, Xuexuan Wang, Victoria Bzik, Siobhan McClean & David J. Brayden. (2009) Evaluation of intestinal absorption and mucosal toxicity using two promoters. II. Rat instillation and perfusion studies. European Journal of Pharmaceutical Sciences 38:4, pages 301-311.
Crossref
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Crossref
Kathryn Whitehead & Samir Mitragotri. (2008) Mechanistic Analysis of Chemical Permeation Enhancers for Oral Drug Delivery. Pharmaceutical Research 25:6, pages 1412-1419.
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Linda M. Feighery, Sean W. Cochrane, Teresa Quinn, Alan W. Baird, Daniel O’Toole, Sian-Eleri Owens, Diarmuid O’Donoghue, Randall J. Mrsny & David J. Brayden. (2007) Myosin Light Chain Kinase Inhibition: Correction of Increased Intestinal Epithelial Permeability In Vitro. Pharmaceutical Research 25:6, pages 1377-1386.
Crossref
Sam Maher & Siobh?n McClean. (2008) Melittin exhibits necrotic cytotoxicity in gastrointestinal cells which is attenuated by cholesterol. Biochemical Pharmacology 75:5, pages 1104-1114.
Crossref
Alyssa B. Cox, Lee-Anne Rawlinson, Alan W. Baird, Victoria Bzik & David J. Brayden. (2007) In vitro Interactions Between the Oral Absorption Promoter, Sodium Caprate (C10) and S. typhimurium in Rat Intestinal Ileal Mucosae. Pharmaceutical Research 25:1, pages 114-122.
Crossref
Sam Maher, Linda Feighery, David J. Brayden & Siobhán McClean. (2007) Melittin as an Epithelial Permeability Enhancer I: Investigation of Its Mechanism of Action in Caco-2 Monolayers. Pharmaceutical Research 24:7, pages 1336-1345.
Crossref
Sam Maher, Linda Feighery, David J. Brayden & Siobhán McClean. (2007) Melittin as a Permeability Enhancer II: In Vitro Investigations in Human Mucus Secreting Intestinal Monolayers and Rat Colonic Mucosae. Pharmaceutical Research 24:7, pages 1346-1356.
Crossref
J.H. HammanP.H. DemanaE.I. Olivier. (2017) Targeting Receptors, Transporters and Site of Absorption to Improve Oral Drug Delivery. Drug Target Insights 2, pages 117739280700200.
Crossref

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