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Drug Evaluations

The role of glimepiride in the treatment of type 2 diabetes mellitus

, PhD, , MD & , MD
Pages 225-235 | Published online: 07 Jan 2010

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Yehuda Handelsman, Brett Lauring, Ira Gantz, Carol Iredale, Edward A. O’Neill, Ziwen Wei, Shailaja Suryawanshi, Keith D. Kaufman, Samuel S. Engel & Eseng Lai. (2017) A randomized, double-blind, non-inferiority trial evaluating the efficacy and safety of omarigliptin, a once-weekly DPP-4 inhibitor, or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy. Current Medical Research and Opinion 33:10, pages 1861-1868.
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. (2014) Glucose control: Non-insulin therapies. South African Family Practice 56:1, pages 21-30.
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Abdul Basit, Musarrat Riaz & Asher Fawwad. (2012) Glimepiride: evidence-based facts, trends, and observations. Vascular Health and Risk Management 8, pages 463-472.
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. (2012) The 2012 SEMDSA Guideline for the Management of Type 2 Diabetes (Revised). Journal of Endocrinology, Metabolism and Diabetes of South Africa 17:2, pages S1-S95.
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. (2012) The 2012 SEMDSA Guideline for the Management of type 2 Diabetes. Journal of Endocrinology, Metabolism and Diabetes of South Africa 17:1, pages S1-S94.
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Articles from other publishers (21)

Ashok Kumar Das, Banshi Saboo, Rajeev Chawla, S. R. Aravind, Rajesh Rajput, Awadhesh K. Singh, J. J. Mukherjee, Ashok Jhingan, Parag Shah, Vaishali Deshmukh, Shailaja Kale, Shalini Jaggi, G. R. Sridhar, Rajnish Dhediya & Kumar Gaurav. (2023) Time to reposition sulfonylureas in type 2 diabetes management in Indian context: A pragmatic practical approach. International Journal of Diabetes in Developing Countries 43:6, pages 856-874.
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Mohamed Kh. ElMahdy, Mennatallah O. Zaki, Ahmed A. Al-Karmalawy, Walied Abdo, Sulaiman Mohammed Alnasser & Samar A. Antar. (2022) Glimepiride ameliorates renal toxicity induced by cadmium in mice: Modulation of Jun N terminal kinase (JNK)/nuclear factor kappa B (NF-κB) and phosphatidylinositol 3-kinases (PI3K)/protein kinase (AKT) pathways. Life Sciences 311, pages 121184.
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Umme Farwa & Muhammad Asam Raza. (2022) Heterocyclic compounds as a magic bullet for diabetes mellitus: a review. RSC Advances 12:35, pages 22951-22973.
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Linling Que, Kai Huang, Xuemei Xiang, Ying Ding, Nannan Chu & Qing He. (2022) No apparent pharmacokinetic interactions were found between henagliflozin: A novel sodium‐glucose co‐transporter 2 inhibitor and glimepiride in healthy Chinese male subjects. Journal of Clinical Pharmacy and Therapeutics 47:8, pages 1225-1231.
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Hyunkoo Kang, Sungmin Lee, Kyeongmin Kim, Jaewan Jeon, Seok-Gu Kang, HyeSook Youn, Hae Yu Kim & BuHyun Youn. (2021) Downregulated CLIP3 induces radioresistance by enhancing stemness and glycolytic flux in glioblastoma. Journal of Experimental & Clinical Cancer Research 40:1.
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Huiwen Sun, Dongyan Guan, Jiting Wang, Zhen Wang, Yang Li, Haojun Han, Xiang Li & Tingting Fang. (2021) Effects of glimepiride on growth, glucose metabolism and expression of p38MAPK, JNK in skeletal muscles of GIFT tilapia. Aquaculture Reports 21, pages 100873.
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Debashish Mondol, Md. Nahinul Islam, Sonchita Biswas, Protic Jodder, Samiron Sana, Md. Abu Saleh & Md. Rafiqul Islam. (2020) Investigation of the synergistic effect of glimepiride and rosuvastatin on alloxan-induced diabetic rat. Journal of Diabetes & Metabolic Disorders 19:2, pages 1415-1422.
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Kritika Singh, Praveen Kumar Tripathi, Vinay Kumar Singh, Ashok Kumar Patel, O. N. Srivastava, S. K. Singh & Arvind M. Kayastha. (2019) In Silico Analysis of New Potent Anti-hyperglycemic Molecule for Diabetes Type 2 Management. International Journal of Peptide Research and Therapeutics 26:2, pages 1031-1042.
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Sanjay Kalra, Silver Bahendeka, Rakesh Sahay, Sujoy Ghosh, Fariduddin Md, Abbas Orabi, Kaushik Ramaiya, Sameer Al Shammari, Dina Shrestha, Khalid Shaikh, Sachitha Abhayaratna, PradeepK Shrestha, Aravinthan Mahalingam, Mazen Askheta, AlyAhmed A. Rahim, Fatimah Eliana, HariK Shrestha, Sandeep Chaudhary, Nancy Ngugi, JeanClaude Mbanya, ThanThan Aye, TintSwe Latt, ZhanayA Akanov, AbbasRaza Syed, Nikhil Tandon, AG Unnikrishnan, SV Madhu, Ali Jawa, Subhankar Chowdhury, Sarita Bajaj & AshokKumar Das. (2018) Consensus recommendations on sulfonylurea and sulfonylurea combinations in the management of Type 2 diabetes mellitus – International Task Force. Indian Journal of Endocrinology and Metabolism 22:1, pages 132.
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Charles E. Leonard, Sean Hennessy, Xu Han, David S. Siscovick, James H. Flory & Rajat Deo. (2017) Pro- and Antiarrhythmic Actions of Sulfonylureas: Mechanistic and Clinical Evidence. Trends in Endocrinology & Metabolism 28:8, pages 561-586.
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C.S. Harrell, C.F. Gillespie & G.N. Neigh. (2016) Energetic stress: The reciprocal relationship between energy availability and the stress response. Physiology & Behavior 166, pages 43-55.
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Yu Dong, Yi-Tao Chen, Yuan-Xiao Yang, Dan Shou & Chang-Yu Li. (2016) Urinary Metabolomic Profiling in Zucker Diabetic Fatty Rats with Type 2 Diabetes Mellitus Treated with Glimepiride, Metformin, and Their Combination. Molecules 21:11, pages 1446.
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Eusebio ChiefariCarmelo CapulaAda VeroRosa OliverioLuigi PuccioRossella LiguoriVittorio PullanoManfredi GrecoDaniela FotiDomenico TirinatoRaffaella VeroAntonio Brunetti. (2015) Add-On Treatment with Liraglutide Improves Glycemic Control in Patients with Type 2 Diabetes on Metformin Therapy. Diabetes Technology & Therapeutics 17:7, pages 468-474.
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JM. Amate, T. Lopez‐Cuadrado, N. Almendro, C. Bouza, Z. Saz‐Parkinson, R. Rivas‐Ruiz & J. Gonzalez‐Canudas. (2015) Effectiveness and safety of glimepiride and iDPP4, associated with metformin in second line pharmacotherapy of type 2 diabetes mellitus: systematic review and meta‐analysis. International Journal of Clinical Practice 69:3, pages 292-304.
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Katiucia Marques Capiotti, R?gis AntonioliJuniorJunior, Luiza Wilges Kist, Maur?cio Reis Bogo, Carla Denise Bonan & Rosane Souza Da Silva. (2014) Persistent impaired glucose metabolism in a zebrafish hyperglycemia model. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 171, pages 58-65.
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Anat Levit, Stefanie Nowak, Maximilian Peters, Ayana Wiener, Wolfgang Meyerhof, Maik Behrens & Masha Y. Niv. (2013) The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14. The FASEB Journal 28:3, pages 1181-1197.
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Lyudmila Alexandrovna Ruyatkina & Maksim Yur'evich Sorokin. (2012) Modern antihyperglycemic therapy: safety and efficacy of glimepiride. Diabetes mellitus 15:2, pages 89-97.
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. (2012) Russian Association of Endocrinologists reports commencement of Amaril clinical use. Diabetes mellitus 15:1, pages 99-101.
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Sreeraj Macha, Michaela Mattheus, Sabine Pinnetti, Leo Seman & Hans J Woerle. (2012) Pharmacokinetics of Empagliflozin, a Sodium Glucose Cotransporter 2 Inhibitor, and Glimepiride Following Co-administration in Healthy Volunteers: A Randomised, Open-label, Crossover Study. Journal of Diabetes Research and Clinical Metabolism 1:1, pages 14.
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Chun Fa Huang, Ya Wen Chen, Ching Yao Yang, Hui Yi Lin, Tzong Der Way, Wenchang Chiang & Shing Hwa Liu. (2011) Extract of Lotus Leaf (Nelumbo nucifera) and Its Active Constituent Catechin with Insulin Secretagogue Activity. Journal of Agricultural and Food Chemistry 59:4, pages 1087-1094.
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Aviva Levina & Peter A. Lay. (2011) Metal-based anti-diabetic drugs: advances and challenges. Dalton Transactions 40:44, pages 11675.
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