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Assessment of in silico models for fraction of unbound drug in human liver microsomes

, PhD (Associate Research Fellow) , , PhD (Associate Research Fellow) , , PhD (Principal Scientist) & , PhD (Senior Principal Scientist)
Pages 533-542 | Published online: 16 Mar 2010

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Iain Gardner, Mandy Xu, Chunyan Han, Yi Wang, Xingjin Jiao, Masoud Jamei, Hiba Khalidi, Peter Kilford, Sibylle Neuhoff, Roz Southall, David B. Turner, Helen Musther, Barry Jones & Simon Taylor. (2022) Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models. Xenobiotica 52:8, pages 943-956.
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Michael H. Abraham & Rupert P. Austin. (2012) The effect of ionized species on microsomal binding. European Journal of Medicinal Chemistry 47, pages 202-205.
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Patrick Poulin & Sami Haddad. (2011) Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomes. Journal of Pharmaceutical Sciences 100:10, pages 4501-4517.
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