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Review

The use of accelerator mass spectrometry to obtain early human ADME/PK data

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Pages 23-31 | Published online: 14 Jun 2005

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Angus N.R. Nedderman, Gordon J. Dear, Stephanie North, R. Scott Obach & David Higton. (2011) From definition to implementation: a cross-industry perspective of past, current and future MIST strategies. Xenobiotica 41:8, pages 605-622.
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Hongbin Yu, Daniel Bischoff & Donald Tweedie. (2010) Challenges and solutions to metabolites in safety testing: impact of the International Conference on Harmonization M3(R2) guidance. Expert Opinion on Drug Metabolism & Toxicology 6:12, pages 1539-1549.
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Graham Lappin & R Colin Garner. (2008) The utility of microdosing over the past 5 years. Expert Opinion on Drug Metabolism & Toxicology 4:12, pages 1499-1506.
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Graham Lappin & Lloyd Stevens. (2008) Biomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics. Expert Opinion on Drug Metabolism & Toxicology 4:8, pages 1021-1033.
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Michael Kiffe, DietmarG. Schmid & GerardJ. M. Bruin. (2008) Radioactivity Detectors for High-Performance Liquid Chromatography in Drug Metabolism Studies. Journal of Liquid Chromatography & Related Technologies 31:11-12, pages 1593-1619.
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Graham Lappin, Malcolm Rowland & R Colin Garner. (2006) The use of isotopes in the determination of absolute bioavailability of drugs in humans. Expert Opinion on Drug Metabolism & Toxicology 2:3, pages 419-427.
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Mirei Takeyama, Toru Moriya, Hisako Saitoh, Hiroko Miyahara, Fusa Miyake, Motonari Ohyama, Rimi Sato, Rie Shitara, Hirohisa Sakurai & Fuyuki Tokanai. (2023) Present status of the YU-AMS system and its operation over the past 10 years. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 538, pages 30-35.
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Simon G. Wong & Shuguang Ma. 2023. Overcoming Obstacles in Drug Discovery and Development. Overcoming Obstacles in Drug Discovery and Development 137 174 .
Paul Erhardt, Kenneth BachmannDonald BirkettMichael BobergNicholas BodorGordon GibsonDavid HawkinsGabrielle HawksworthJack HinsonDaniel KoehlerBrian KressAmarjit LuniwalHiroshi MasumotoRaymond NovakPhillip PortogheseJeffrey SarverM. Teresa SerafiniChristopher TrabbicNico VermeulenSteven Wrighton. (2021) Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report). Pure and Applied Chemistry 93:3, pages 273-403.
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Fuyuki Tokanai, Toru Moriya, Mirei Takeyama, Hirohisa Sakurai, Toyoharu Umebayashi, Hiroko Miyahara, Motonari Ohyama, Hisako Saitoh & Yasushi Okada. (2020) Review of Application of Compact AMS System at Yamagata University. Review of Application of Compact AMS System at Yamagata University.
Andrew McEwen. 2020. Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Drug Discovery and Evaluation: Methods in Clinical Pharmacology 773 806 .
Toru Moriya, Mirei Takeyama, Hirohisa Sakurai, Toyoharu Umebayashi, Teiko Toyoguchi, Tadashi Shiraishi, Hiroko Miyahara, Motonari Ohyama, Kohei Nozawa, Satoshi Ito, Shigeru Itoh, Masashi Hirota & Fuyuki Tokanai. (2019) Status of the AMS system at Yamagata University. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 439, pages 94-99.
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Nicholas R. Hum, Kelly A. Martin, Michael A. Malfatti, Kurt Haack, Bruce A. Buchholz & Gabriela G. Loots. (2018) Tracking Tumor Colonization in Xenograft Mouse Models Using Accelerator Mass Spectrometry. Scientific Reports 8:1.
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Frédéric Lozac'h, Simon Fahrni, Daniele De Maria, Caroline Welte, Joël Bourquin, Hans-Arno Synal, David Pearson, Markus Walles & Gian Camenisch. (2018) Evaluation of cAMS for 14 C microtracer ADME studies: opportunities to change the current drug development paradigm . Bioanalysis 10:5, pages 321-339.
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Andrew McEwen. 2017. Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Drug Discovery and Evaluation: Methods in Clinical Pharmacology 1 34 .
A. Daniel McCartt, Ted J. Ognibene, Graham Bench & Kenneth W. Turteltaub. (2016) Quantifying Carbon-14 for Biology Using Cavity Ring-Down Spectroscopy. Analytical Chemistry 88:17, pages 8714-8719.
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Gordon J. Dear & Andrew McEwen. 2016. Metabolite Safety in Drug Development. Metabolite Safety in Drug Development 45 85 .
Le Thuy Vuong, Qi Song, Hee Joo Lee, Ad F Roffel, Seok-Ho Shin, Young G Shin & Stephen R Dueker. (2016) Opportunities in low-level radiocarbon microtracing: applications and new technology. Future Science OA 2:1.
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Kamla Pathak & Smita Raghuvanshi. (2015) Oral Bioavailability: Issues and Solutions via Nanoformulations. Clinical Pharmacokinetics 54:4, pages 325-357.
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Doo-Yeoun Cho, Soo Hyeon Bae, Ji-Hong Shon & Soo Kyung Bae. (2013) High-sensitive LC-MS/MS method for the simultaneous determination of mirodenafil and its major metabolite, SK-3541, in human plasma: Application to microdose clinical trials of mirodenafil. Journal of Separation Science 36:5, pages 840-848.
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Fuyuki Tokanai, Kazuhiro Kato, Minoru Anshita, Hirohisa Sakurai, Akihiro Izumi, Teiko Toyoguchi, Takeshi Kobayashi, Hiroko Miyahara, Motonari Ohyama & Yasuharu Hoshino. (2016) Present Status of YU-AMS System. Radiocarbon 55:2, pages 251-259.
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Natalia Penner, Lin Xu & Chandra Prakash. (2012) Radiolabeled Absorption, Distribution, Metabolism, and Excretion Studies in Drug Development: Why, When, and How?. Chemical Research in Toxicology 25:3, pages 513-531.
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Soo Kyung Bae & Ji-Hong Shon. (2011) Microdosing studies using accelerated mass spectrometry as exploratory investigational new drug trials. Archives of Pharmacal Research 34:11, pages 1789-1798.
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Anne-Françoise Aubry. (2011) LC–MS/MS bioanalytical challenge: ultra-high sensitivity assays. Bioanalysis 3:16, pages 1819-1825.
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Lan Gao, Jing Li, Claudia Kasserra, Qi Song, Ali Arjomand, David Hesk & Swapan K Chowdhury. (2011) Precision and Accuracy in the Quantitative Analysis of Biological Samples by Accelerator Mass Spectrometry: Application in Microdose Absolute Bioavailability Studies. Analytical Chemistry 83:14, pages 5607-5616.
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Shuguang Ma & Swapan K. Chowdhury. (2011) Analytical Strategies for Assessment of Human Metabolites in Preclinical Safety Testing. Analytical Chemistry 83:13, pages 5028-5036.
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Sarah Adler, David Basketter, Stuart Creton, Olavi Pelkonen, Jan van Benthem, Valérie Zuang, Klaus Ejner Andersen, Alexandre Angers-Loustau, Aynur Aptula, Anna Bal-Price, Emilio Benfenati, Ulrike Bernauer, Jos Bessems, Frederic Y. Bois, Alan Boobis, Esther Brandon, Susanne Bremer, Thomas Broschard, Silvia Casati, Sandra Coecke, Raffaella Corvi, Mark Cronin, George Daston, Wolfgang Dekant, Susan Felter, Elise Grignard, Ursula Gundert-Remy, Tuula Heinonen, Ian Kimber, Jos Kleinjans, Hannu Komulainen, Reinhard Kreiling, Joachim Kreysa, Sofia Batista Leite, George Loizou, Gavin Maxwell, Paolo Mazzatorta, Sharon Munn, Stefan Pfuhler, Pascal Phrakonkham, Aldert Piersma, Albrecht Poth, Pilar Prieto, Guillermo Repetto, Vera Rogiers, Greet Schoeters, Michael Schwarz, Rositsa Serafimova, Hanna Tähti, Emanuela Testai, Joost van Delft, Henk van Loveren, Mathieu Vinken, Andrew Worth & José-Manuel Zaldivar. (2011) Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010. Archives of Toxicology 85:5, pages 367-485.
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Claudia C. Wagner, Marie Simpson, Markus Zeitlinger, Martin Bauer, Rudolf Karch, Aiman Abrahim, Thomas Feurstein, Matthias Schütz, Kurt Kletter, Markus Müller, Graham Lappin & Oliver Langer. (2011) A Combined Accelerator Mass Spectrometry-Positron Emission Tomography Human Microdose Study with 14C- and 11C-Labelled Verapamil. Clinical Pharmacokinetics 50:2, pages 111-120.
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Graham Lappin. 2011. Pharmacokinetics in Drug Development. Pharmacokinetics in Drug Development 115 130 .
J Chen, R C Garner, L S Lee, M Seymour, E J Fuchs, W C Hubbard, T L Parsons, G E Pakes, C V Fletcher & C Flexner. (2010) Accelerator Mass Spectrometry Measurement of Intracellular Concentrations of Active Drug Metabolites in Human Target Cells In Vivo. Clinical Pharmacology & Therapeutics 88:6, pages 796-800.
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Benjamin J. Stewart, Ali Navid, Kenneth W. Turteltaub & Graham Bench. (2010) Yeast Dynamic Metabolic Flux Measurement in Nutrient-Rich Media by Hplc and Accelerator Mass Spectrometry. Analytical Chemistry 82:23, pages 9812-9817.
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Shayne Cox GadShulamit Levin. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
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Jinsong Ni, Hui Ouyang, Carmai Seto, Takeo Sakuma, Robert Ellis, Josh Rowe, Andrew Acheampong, Devin Welty & Gabriella Szekely-Klepser. (2010) Sensitivity and proportionality assessment of metabolites from microdose to high dose in rats using LC–MS/MS. Bioanalysis 2:3, pages 407-419.
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Ali Arjomand. (2010) Accelerator mass spectrometry-enabled studies: current status and future prospects. Bioanalysis 2:3, pages 519-541.
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Stuart Creton, Richard Billington, Will Davies, Matthew P. Dent, Gabrielle M. Hawksworth, Simon Parry & Kim Z. Travis. (2009) Application of toxicokinetics to improve chemical risk assessment: Implications for the use of animals. Regulatory Toxicology and Pharmacology 55:3, pages 291-299.
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Thomas N. Thompson. 2009. Annual Reports in Medicinal Chemistry Volume 44. Annual Reports in Medicinal Chemistry Volume 44 459 474 .
Wing W. Lam, Cho‐Ming Loi, Angus Nedderman & Don Walker. 2008. Mass Spectrometry in Drug Metabolism and Pharmacokinetics. Mass Spectrometry in Drug Metabolism and Pharmacokinetics 253 273 .
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