Expert Opinion on Drug Metabolism & Toxicology, Volume 1, Issue 1 (2005)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 1, Issue 1 (2005)

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Editorial

Article
From in vivo to in vitro/in silico ADME: progress and challenges
Han Van de Waterbeemd
Pages: 1-4
Published online: 14 Jun 2005
AbstractforFrom in vivo to in vitro/in silico ADME: progress and challenges | References | PDF (56.8 KB)
  • 177 Views
  • 28 CrossRef citations
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Perspective

Article
Human P450s in the metabolism of drugs: molecular modelling of enzyme–substrate interactions
David FV Lewis
Pages: 5-8
Published online: 14 Jun 2005
AbstractforHuman P450s in the metabolism of drugs: molecular modelling of enzyme–substrate interactions | References | PDF (50 KB)
  • 75 Views
  • 11 CrossRef citations
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Review

Article
Role of the aryl hydrocarbon receptor in drug metabolism
Preeti Ramadoss, Craig Marcus & Gary H Perdew
Pages: 9-21
Published online: 14 Jun 2005
AbstractforRole of the aryl hydrocarbon receptor in drug metabolism | References | PDF (154.8 KB)
  • 320 Views
  • 115 CrossRef citations
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Article
The use of accelerator mass spectrometry to obtain early human ADME/PK data
Graham Lappin & R Colin Garner
Pages: 23-31
Published online: 14 Jun 2005
AbstractforThe use of accelerator mass spectrometry to obtain early human ADME/PK data | References | PDF (134.6 KB)
  • 238 Views
  • 43 CrossRef citations
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Article
Pharmacokinetic dosage guidelines for elderly subjects
Klaus Turnheim
Pages: 33-48
Published online: 14 Jun 2005
AbstractforPharmacokinetic dosage guidelines for elderly subjects | References | PDF (170.7 KB)
  • 236 Views
  • 19 CrossRef citations
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Article
In vitro screening of drug metabolism during drug development: can we trust the predictions?
Olavi Pelkonen & Hannu Raunio
Pages: 49-59
Published online: 14 Jun 2005
AbstractforIn vitro screening of drug metabolism during drug development: can we trust the predictions? | References | PDF (116.9 KB)
  • 147 Views
  • 35 CrossRef citations
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Article
Generation of human hepatocytes by stem cell technology: definition of the hepatocyte
Jan G Hengstler, Marc Brulport, Wiebke Schormann, Alexander Bauer, Matthias Hermes, Andreas K Nussler, Fred Fandrich, Maren Ruhnke, Hendrik Ungefroren, Louise Griffin, Ernesto Bockamp, Franz Oesch & Marc-Alexander von Mach
Pages: 61-74
Published online: 14 Jun 2005
AbstractforGeneration of human hepatocytes by stem cell technology: definition of the hepatocyte | References | PDF (178.7 KB)
  • 371 Views
  • 101 CrossRef citations
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Article
Cell-based models to study hepatic drug metabolism and enzyme induction in humans
Marc Vermeir, Pieter Annaert, Rao NVS Mamidi, Dirk Roymans, Willem Meuldermans & Geert Mannens
Pages: 75-90
Published online: 14 Jun 2005
AbstractforCell-based models to study hepatic drug metabolism and enzyme induction in humans | References | PDF (178.9 KB)
  • 272 Views
  • 64 CrossRef citations
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Article
Minimising the potential for metabolic activation in drug discovery
Amit S Kalgutkar & John R Soglia
Pages: 91-142
Published online: 14 Jun 2005
AbstractforMinimising the potential for metabolic activation in drug discovery | References | PDF (548.5 KB)
  • 1119 Views
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Drug Evaluation

Article
New drugs for chemotherapy-induced nausea and vomiting: focus on palonosetron
Giuseppe Tonini, Bruno Vincenzi & Daniele Santini
Pages: 143-149
Published online: 14 Jun 2005
AbstractforNew drugs for chemotherapy-induced nausea and vomiting: focus on palonosetron | References | PDF (82.5 KB)
  • 66 Views
  • 16 CrossRef citations
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Article
Clinical pharmacology of bimatoprost
Louis B Cantor
Pages: 151-157
Published online: 14 Jun 2005
AbstractforClinical pharmacology of bimatoprost | References | PDF (83.6 KB)
  • 147 Views
  • 12 CrossRef citations
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Technology Evaluation

Article
From physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools
Stefan Willmann, Jörg Lippert & Walter Schmitt
Pages: 159-168
Published online: 14 Jun 2005
AbstractforFrom physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools | References | PDF (237.7 KB)
  • 550 Views
  • 110 CrossRef citations
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