321
Views
115
CrossRef citations to date
0
Altmetric
Review

Role of the aryl hydrocarbon receptor in drug metabolism

, &
Pages 9-21 | Published online: 14 Jun 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Masataka Nakano & Miki Nakajima. (2018) Current knowledge of microRNA-mediated regulation of drug metabolism in humans. Expert Opinion on Drug Metabolism & Toxicology 14:5, pages 493-504.
Read now
Prajwal P Nandekar & Abhay T Sangamwar. (2012) Cytochrome P450 1A1-mediated anticancer drug discovery: in silico findings. Expert Opinion on Drug Discovery 7:9, pages 771-789.
Read now

Articles from other publishers (112)

Tingting Wan, Yalong Wang, Kaixin He & Shu Zhu. (2023) Microbial sensing in the intestine. Protein & Cell 14:11, pages 824-860.
Crossref
Christiane A. Opitz, Pauline Holfelder, Mirja Tamara Prentzell & Saskia Trump. (2023) The complex biology of aryl hydrocarbon receptor activation in cancer and beyond. Biochemical Pharmacology 216, pages 115798.
Crossref
Walaa Abd El Naby, Cai Zong, Alzahraa Fergany, Frederick Ekuban, Saleh Ahmed, Yousra Reda, Harue Sato, Sahoko Ichihara, Natsuko Kubota, Shinya Yanagita & Gaku Ichihara. (2023) Exposure to Benzo[a]pyrene Decreases Noradrenergic and Serotonergic Axons in Hippocampus of Mouse Brain. International Journal of Molecular Sciences 24:12, pages 9895.
Crossref
Ahlem Helaoui, Sana Sfar, Najet Boudhiba, Fariba Dehghanian, Moein Dehbashi, Haifa Bouchahda, Zohreh Hojati & Abderraouf Kenani. (2022) Association of xenobiotic-metabolizing genes polymorphisms with cervical cancer risk in the Tunisian population. Molecular Biology Reports 50:2, pages 949-959.
Crossref
Susu Lin, Qiaoqiao Li, Zijin Xu, Ziwei Chen, Yi Tao, Yingpeng Tong, Ting Wang, Suhong Chen & Ping Wang. (2022) Detection of the role of intestinal flora and tryptophan metabolism involved in antidepressant-like actions of crocetin based on a multi-omics approach. Psychopharmacology 239:11, pages 3657-3677.
Crossref
Hanyi He, Yixing Huang, Yueyue Lu, Xinlu Wang, Haifeng Ni, Yihua Wu, Dajing Xia, Dong Ye, Jinwang Ding, Yanjiao Mao & Yaoshu Teng. (2022) Effect of benzo[a]pyrene on proliferation and metastasis of oral squamous cell carcinoma cells: A transcriptome analysis based on RNA ‐seq . Environmental Toxicology 37:11, pages 2589-2604.
Crossref
Dima W Alhamad, Husam Bensreti, Jennifer Dorn, William D Hill, Mark W Hamrick & Meghan E McGee-Lawrence. (2022) Aryl hydrocarbon receptor (AhR)-mediated signaling as a critical regulator of skeletal cell biology. Journal of Molecular Endocrinology 69:3, pages R109-R124.
Crossref
Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack & Tatiana Koudriakova. (2022) Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human. Drug Metabolism and Disposition 50:8, pages 1064-1076.
Crossref
Ivana Ďurovcová, Stanislav Kyzek, Jana Fabová, Jana Makuková, Eliška Gálová & Andrea Ševčovičová. (2022) Genotoxic potential of bisphenol A: A review. Environmental Pollution 306, pages 119346.
Crossref
Fatma Özlem Kargın Solmaz, Jale Akgöl, Merve Becit Kızılkaya & Ahmet Oğuz Ada. (2022) Investigation of CYP1B1*3 and CYP1B1*4 polymorphisms in a Turkish population. Health Sciences Quarterly 2:3, pages 127-138.
Crossref
Ronja Schirrmann, Michael Erkelenz, Kim Lamers, Oliver Sritharan, Milen Nachev, Bernd Sures, Sebastian Schlücker & Sven Brandau. (2022) Gold Nanorods Induce Endoplasmic Reticulum Stress and Autocrine Inflammatory Activation in Human Neutrophils. ACS Nano 16:7, pages 11011-11026.
Crossref
Julia Groestlinger, Carina Seidl, Elisabeth Varga, Giorgia Del Favero & Doris Marko. (2022) Combinatory Exposure to Urolithin A, Alternariol, and Deoxynivalenol Affects Colon Cancer Metabolism and Epithelial Barrier Integrity in vitro. Frontiers in Nutrition 9.
Crossref
Masataka Nakano & Miki Nakajima. (2022) Adenosine-to-Inosine RNA Editing and N 6 -Methyladenosine Modification Modulating Expression of Drug Metabolizing Enzymes . Drug Metabolism and Disposition 50:5, pages 624-633.
Crossref
Chun-Hua Lin, Chia-Cheng Chou, Yi-Hsuan Lee & Chia-Chi Hung. (2022) Curcumin Facilitates Aryl Hydrocarbon Receptor Activation to Ameliorate Inflammatory Astrogliosis. Molecules 27:8, pages 2507.
Crossref
Zhentian Wei, Feng Li & Guofu Pi. (2022) Association Between Gut Microbiota and Osteoarthritis: A Review of Evidence for Potential Mechanisms and Therapeutics. Frontiers in Cellular and Infection Microbiology 12.
Crossref
Martin Krkoška, Jana Nekvindová, Kateřina Nevědělová, Veronika Zubáňová, Lenka Radová, Jan Vondráček, Jarmila Herůdková, Ondřej Slabý, Igor Kiss, Lucia Bohovicová, Pavel Fabian, Zuzana Tylichová, Zdeněk Kala, Petr Kysela, Lenka Ostřížková, Vladimír Palička & Alena Hyršlová Vaculová. (2021) Role of miR-653 and miR-29c in downregulation of CYP1A2 expression in hepatocellular carcinoma. Pharmacological Reports 74:1, pages 148-158.
Crossref
Jessie King, Victoria H. Woolner, Robert A. Keyzers & Rhonda J. Rosengren. (2022) Characterization of marine-derived halogenated indoles as ligands of the aryl hydrocarbon receptor. Toxicology Reports 9, pages 1198-1203.
Crossref
Jimmy Alarcan, Georges de Sousa, Efrosini S. Katsanou, Anastasia Spyropoulou, Petros Batakis, Kyriaki Machera, Roger Rahmani, Alfonso Lampen, Albert Braeuning & Dajana Lichtenstein. (2021) Investigating the in vitro steatotic mixture effects of similarly and dissimilarly acting test compounds using an adverse outcome pathway-based approach. Archives of Toxicology 96:1, pages 211-229.
Crossref
Khursheed Iqbal, Stephen H. Pierce, Keisuke Kozai, Pramod Dhakal, Regan L. Scott, Katherine F. Roby, Carrie A. Vyhlidal & Michael J. Soares. (2021) Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure. Environmental Health Perspectives 129:11.
Crossref
Kelsey Dawes, Luke Sampson, Rachel Reimer, Shelly Miller, Robert Philibert & Allan Andersen. (2021) Epigenetic Analyses of Alcohol Consumption in Combustible and Non-Combustible Nicotine Product Users. Epigenomes 5:3, pages 18.
Crossref
Matteo Puccetti, Larissa Gomes dos Reis, Marilena Pariano, Claudio Costantini, Giorgia Renga, Maurizio Ricci, Daniela Traini & Stefano Giovagnoli. (2021) Development and in vitro-in vivo performances of an inhalable indole-3-carboxaldehyde dry powder to target pulmonary inflammation and infection. International Journal of Pharmaceutics 607, pages 121004.
Crossref
Hevna Dhulkifle, Abdelali Agouni, Asad Zeidan, Mohammed Saif Al-Kuwari, Aijaz Parray, Mohamed Tolefat & Hesham M. Korashy. (2021) Influence of the Aryl Hydrocarbon Receptor Activating Environmental Pollutants on Autism Spectrum Disorder. International Journal of Molecular Sciences 22:17, pages 9258.
Crossref
Keane Lim, Max Lam, Clement Zai, Jenny Tay, Nina Karlsson, Smita N. Deshpande, B. K. Thelma, Norio Ozaki, Toshiya Inada, Kang Sim, Siow-Ann Chong, Todd Lencz, Jianjun Liu & Jimmy Lee. (2021) Genome wide study of tardive dyskinesia in schizophrenia. Translational Psychiatry 11:1.
Crossref
Younes Aftabi, Zahra Khoshkam, Amir Amiri-Sadeghan, Yeganeh Khalili & Gaku Ichihara. (2020) An introduction to EpiPol (Epigenetic affecting Polymorphism) concept with an in silico identification of CpG-affecting SNPs in the upstream regulatory sequences of human AHR gene. Meta Gene 26, pages 100805.
Crossref
Claudio Costantini, Matteo Puccetti, Marilena Pariano, Giorgia Renga, Claudia Stincardini, Fiorella D’Onofrio, Marina M. Bellet, Barbara Cellini, Stefano Giovagnoli & Luigina Romani. (2020) Selectively targeting key inflammatory pathways in cystic fibrosis. European Journal of Medicinal Chemistry 206, pages 112717.
Crossref
Johanna Weiss, Gzona Bajraktari-Sylejmani & Walter E. Haefeli. (2020) Interaction of Hydroxychloroquine with Pharmacokinetically Important Drug Transporters. Pharmaceutics 12:10, pages 919.
Crossref
Anna Wajda, Joanna Łapczuk-Romańska & Agnieszka Paradowska-Gorycka. (2020) Epigenetic Regulations of AhR in the Aspect of Immunomodulation. International Journal of Molecular Sciences 21:17, pages 6404.
Crossref
Bárbara G. Postal, Sara Ghezzal, Doriane Aguanno, Sébastien André, Kevin Garbin, Laurent Genser, Edith Brot-Laroche, Christine Poitou, Hédi Soula, Armelle Leturque, Karine Clément & Véronique Carrière. (2020) AhR activation defends gut barrier integrity against damage occurring in obesity. Molecular Metabolism 39, pages 101007.
Crossref
Chien-Lin Lu, Chun-Hou Liao, Kuo-Cheng Lu & Ming-Chieh Ma. (2020) TRPV1 Hyperfunction Involved in Uremic Toxin Indoxyl Sulfate-Mediated Renal Tubular Damage. International Journal of Molecular Sciences 21:17, pages 6212.
Crossref
David Bovard, Albert Giralt, Keyur Trivedi, Laurent Neau, Petros Kanellos, Anita Iskandar, Athanasios Kondylis, Karsta Luettich, Stefan Frentzel, Julia Hoeng & Manuel C. Peitsch. (2020) Comparison of the basic morphology and function of 3D lung epithelial cultures derived from several donors. Current Research in Toxicology 1, pages 56-69.
Crossref
Kai Guo, Jing Ge, Cong Zhang, Mei-Wei Lv, Qi Zhang, Milton Talukder & Jin-Long Li. (2020) `Cadmium induced cardiac inflammation in chicken (Gallus gallus) via modulating cytochrome P450 systems and Nrf2 mediated antioxidant defense. Chemosphere 249, pages 125858.
Crossref
Dajana Lichtenstein, Claudia Luckert, Jimmy Alarcan, Georges de Sousa, Michail Gioutlakis, Efrosini S. Katsanou, Parthena Konstantinidou, Kyriaki Machera, Emanuela S. Milani, Ad Peijnenburg, Roger Rahmani, Deborah Rijkers, Anastasia Spyropoulou, Marianna Stamou, Geert Stoopen, Shana J. Sturla, Bernd Wollscheid, Nathalie Zucchini-Pascal, Albert Braeuning & Alfonso Lampen. (2020) An adverse outcome pathway-based approach to assess steatotic mixture effects of hepatotoxic pesticides in vitro. Food and Chemical Toxicology 139, pages 111283.
Crossref
Shogo Nakajima, Koichi Watashi, Kento Fukano, Senko Tsukuda, Kousho Wakae, Hideki Aizaki, Masamichi Muramatsu, Takaji Wakita & Tetsuya Toyoda. (2019) Non-nucleoside hepatitis B virus polymerase inhibitors identified by an in vitro polymerase elongation assay. Journal of Gastroenterology 55:4, pages 441-452.
Crossref
Askhi M. Valodara & Kaid Johar SR. (2020) Sexual Dimorphism in Drug Metabolism and Pharmacokinetics. Current Drug Metabolism 20:14, pages 1154-1166.
Crossref
Bidisha Dutta, Chitrine Biswas, Rakesh K. Arya & Shaik O. Rahaman. 2020. Gut Microbiome and Its Impact on Health and Diseases. Gut Microbiome and Its Impact on Health and Diseases 167 186 .
Afsaneh Ghaedi, Majid Keshavarzi, Ali Ghafarian Bahraman & Afshin Mohammadi‐Bardbori. (2019) Selective cytochrome P450 1A1 but not 1B1 promoterCpG island DNA methylation by 6‐formylindolo[3,2‐b]carbazole (FICZ). Journal of Biochemical and Molecular Toxicology 34:1.
Crossref
Joseph L. Dempsey & Julia Yue Cui. (2019) Microbiome Is a Functional Modifier of P450 Drug Metabolism. Current Pharmacology Reports 5:6, pages 481-490.
Crossref
Klara Hercog, Sara Maisanaba, Metka Filipič, Marija Sollner-Dolenc, Lidija Kač & Bojana Žegura. (2019) Genotoxic activity of bisphenol A and its analogues bisphenol S, bisphenol F and bisphenol AF and their mixtures in human hepatocellular carcinoma (HepG2) cells. Science of The Total Environment 687, pages 267-276.
Crossref
Vadim Osadchiy, Clair R. Martin & Emeran A. Mayer. (2019) The Gut–Brain Axis and the Microbiome: Mechanisms and Clinical Implications. Clinical Gastroenterology and Hepatology 17:2, pages 322-332.
Crossref
Allan M. Andersen, Man-Kit Lei, Robert A. Philibert & Steven R. H. Beach. (2018) Methylation of MTHFR Moderates the Effect of Smoking on Genomewide Methylation Among Middle Age African Americans. Frontiers in Genetics 9.
Crossref
Ying-Zhi Zhang, Yu-Zhu Zuo, Zheng-Hai Du, Jun Xia, Cong Zhang, Hui Wang, Xue-Nan Li & Jin-Long Li. (2018) Di (2-ethylhexyl) phthalate (DEHP)-induced hepatotoxicity in quails (Coturnix japonica) via triggering nuclear xenobiotic receptors and modulating cytochrome P450 systems. Food and Chemical Toxicology 120, pages 287-293.
Crossref
Xue-Nan Li, Yu-Zhu Zuo, Lei Qin, Wei Liu, Yan-Hua Li & Jin-Long Li. (2018) Atrazine-xenobiotic nuclear receptor interactions induce cardiac inflammation and endoplasmic reticulum stress in quail (Coturnix coturnix coturnix). Chemosphere 206, pages 549-559.
Crossref
Joseph T. Madak, Christine R. Cuthbertson, Yoshinari Miyata, Shuzo Tamura, Elyse M. Petrunak, Jeanne A. Stuckey, Yanyan Han, Miao He, Duxin Sun, Hollis D. Showalter & Nouri Neamati. (2018) Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase. Journal of Medicinal Chemistry 61:12, pages 5162-5186.
Crossref
Othman Soufan, Wail Ba-alawi, Arturo Magana-Mora, Magbubah Essack & Vladimir B. Bajic. (2018) DPubChem: a web tool for QSAR modeling and high-throughput virtual screening. Scientific Reports 8:1.
Crossref
Gaston Otarola, Hector Castillo & Sylvain Marcellini. (2018) Aryl hydrocarbon receptor-based bioassays for dioxin detection: Thinking outside the box. Journal of Applied Toxicology 38:4, pages 437-449.
Crossref
Gabriele D'Uva, Denisa Baci, Adriana Albini & Douglas M. Noonan. (2018) Cancer chemoprevention revisited: Cytochrome P450 family 1B1 as a target in the tumor and the microenvironment. Cancer Treatment Reviews 63, pages 1-18.
Crossref
Masataka Nakano & Miki Nakajima. (2018) Significance of A-to-I RNA editing of transcripts modulating pharmacokinetics and pharmacodynamics. Pharmacology & Therapeutics 181, pages 13-21.
Crossref
X. Ding & Q-Y. Zhang. 2018. Comprehensive Toxicology. Comprehensive Toxicology 8 44 .
Kazuhiro Shiizaki, Masanobu Kawanishi & Takashi Yagi. (2017) Modulation of benzo[a]pyrene–DNA adduct formation by CYP1 inducer and inhibitor. Genes and Environment 39:1.
Crossref
Ryeo-Eun Go, Kyung-A Hwang, Cho-Won Kim, Yong-Sub Byun, Ki-Hoan Nam & Kyung-Chul Choi. (2017) Effect of dioxin and 17β-estradiol on the expression of cytochrome P450 1A1 gene via an estrogen receptor dependent pathway in cellular and xenografted models. Environmental Toxicology 32:10, pages 2225-2233.
Crossref
Steven R. H. Beach, Man Kit Lei, Mei Ling Ong, Gene H. Brody, Meeshanthini V. Dogan & Robert A. Philibert. (2017) MTHFR methylation moderates the impact of smoking on DNA methylation at AHRR for African American young adults. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 174:6, pages 608-618.
Crossref
Karolina Zajda, Anna Ptak, Agnieszka Rak, Elżbieta Fiedor, Adam Grochowalski, Tomasz Milewicz & Ewa L. Gregoraszczuk. (2017) Effects of human blood levels of two PAH mixtures on the AHR signalling activation pathway and CYP1A1 and COMT target genes in granulosa non-tumor and granulosa tumor cell lines. Toxicology 389, pages 1-12.
Crossref
Jimmy Alarcan, Estelle Dubreil, Antoine Huguet, Dominique Hurtaud-Pessel, Stefanie Hessel-Pras, Alfonso Lampen, Valérie Fessard & Ludovic Le Hegarat. (2017) Metabolism of the Marine Phycotoxin PTX-2 and Its Effects on Hepatic Xenobiotic Metabolism: Activation of Nuclear Receptors and Modulation of the Phase I Cytochrome P450. Toxins 9:7, pages 212.
Crossref
Zheng-Hai Du, Jun Xia, Xiao-Chen Sun, Xue-Nan Li, Cong Zhang, Hua-Shan Zhao, Shi-Yong Zhu & Jin-Long Li. (2017) A novel nuclear xenobiotic receptors (AhR/PXR/CAR)-mediated mechanism of DEHP-induced cerebellar toxicity in quails ( Coturnix japonica ) via disrupting CYP enzyme system homeostasis. Environmental Pollution 226, pages 435-443.
Crossref
Zheng-Hai Du, Lei Qin, Jia Lin, Yan-Chun Sun, Jun Xia, Cong Zhang, Xue-Nan Li & Jin-Long Li. (2017) Activating nuclear xenobiotic receptors and triggering ER stress and hepatic cytochromes P450 systems in quails ( Coturnix C. coturnix ) during atrazine exposure . Environmental Toxicology 32:6, pages 1813-1822.
Crossref
Ryeo-Eun Go, Cho-Won Kim, So-Ye Jeon, Yong-Sub Byun, Eui-Bae Jeung, Ki-Hoan Nam & Kyung-Chul Choi. (2017) Fludioxonil induced the cancer growth and metastasis via altering epithelial-mesenchymal transition via an estrogen receptor-dependent pathway in cellular and xenografted breast cancer models. Environmental Toxicology 32:4, pages 1439-1454.
Crossref
Jun Xia, Lei Qin, Zheng-Hai Du, Jia Lin, Xue-Nan Li & Jin-Long Li. (2017) Performance of a novel atrazine-induced cerebellar toxicity in quail (Coturnix C. coturnix): Activating PXR/CAR pathway responses and disrupting cytochrome P450 homeostasis. Chemosphere 171, pages 259-264.
Crossref
Damian Brauze, Piotr Zawierucha, Katarzyna Kiwerska, Kinga Bednarek, Martyna Oleszak, Malgorzata Rydzanicz & Malgorzata Jarmuz-Szymczak. (2016) Induction of expression of aryl hydrocarbon receptor-dependent genes in human HepaRG cell line modified by shRNA and treated with β-naphthoflavone. Molecular and Cellular Biochemistry 425:1-2, pages 59-75.
Crossref
Othman Soufan, Wail Ba-Alawi, Moataz Afeef, Magbubah Essack, Panos Kalnis & Vladimir B. Bajic. (2016) DRABAL: novel method to mine large high-throughput screening assays using Bayesian active learning. Journal of Cheminformatics 8:1.
Crossref
Claire L. Boulangé, Ana Luisa Neves, Julien Chilloux, Jeremy K. Nicholson & Marc-Emmanuel Dumas. (2016) Impact of the gut microbiota on inflammation, obesity, and metabolic disease. Genome Medicine 8:1.
Crossref
Tonya Ellis & Bryan Crawford. (2016) Experimental Dissection of Metalloproteinase Inhibition-Mediated and Toxic Effects of Phenanthroline on Zebrafish Development. International Journal of Molecular Sciences 17:9, pages 1503.
Crossref
Karina Orlowska, Tomasz Molcan, Sylwia Swigonska, Agnieszka Sadowska, Monika Jablonska, Anna Nynca, Jan P. Jastrzebski & Renata E. Ciereszko. (2016) The tertiary structures of porcine AhR and ARNT proteins and molecular interactions within the TCDD/AhR/ARNT complex. Journal of Molecular Graphics and Modelling 67, pages 119-126.
Crossref
Candy Chuah, Malcolm K. Jones, Donald P. McManus, Sujeevi K. Nawaratna, Melissa L. Burke, Helen C. Owen, Grant A. Ramm & Geoffrey N. Gobert. (2016) Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica. International Journal for Parasitology 46:4, pages 239-252.
Crossref
Masataka Nakano, Tatsuki Fukami, Saki Gotoh, Masataka Takamiya, Yasuhiro Aoki & Miki Nakajima. (2016) RNA Editing Modulates Human Hepatic Aryl Hydrocarbon Receptor Expression by Creating MicroRNA Recognition Sequence. Journal of Biological Chemistry 291:2, pages 894-903.
Crossref
Nadja Förster, Inga Mewis, Hansruedi Glatt, Michael Haack, Regina Brigelius-Flohé, Monika Schreiner & Christian Ulrichs. (2016) Characteristic single glucosinolates from Moringa oleifera: Induction of detoxifying enzymes and lack of genotoxic activity in various model systems. Food & Function 7:11, pages 4660-4674.
Crossref
K.H. Dittmann, M.C. Rothmund, A. Paasch, C. Mayer, B. Fehrenbacher, M. Schaller, K. Frauenstein, E. Fritsche, T. Haarmann-Stemmann, A. Braeuning & H.P. Rodemann. (2016) The nuclear aryl hydocarbon receptor is involved in regulation of DNA repair and cell survival following treatment with ionizing radiation. Toxicology Letters 240:1, pages 122-129.
Crossref
Ana Luisa Neves, Julien Chilloux, Magali H Sarafian, Mohd Badrin Abdul Rahim, Claire L Boulangé & Marc-Emmanuel Dumas. (2015) The microbiome and its pharmacological targets: therapeutic avenues in cardiometabolic diseases. Current Opinion in Pharmacology 25, pages 36-44.
Crossref
Ryeo-Eun Go, Cho-Won Kim & Kyung-Chul Choi. (2015) Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metastasis-related genes via an estrogen receptor-dependent pathway in cellular and xenografted ovarian cancer models. Toxicology and Applied Pharmacology 289:1, pages 48-57.
Crossref
C. Lisa Kurtz, Emily E. Fannin, Cynthia L. Toth, Daniel S. Pearson, Kasey C. Vickers & Praveen Sethupathy. (2015) Inhibition of miR-29 has a significant lipid-lowering benefit through suppression of lipogenic programs in liver. Scientific Reports 5:1.
Crossref
Limin Zhang, Emmanuel Hatzakis, Robert G. Nichols, Ruixin Hao, Jared Correll, Philip B. Smith, Christopher R. Chiaro, Gary H. Perdew & Andrew D. Patterson. (2015) Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice. Environmental Science & Technology 49:13, pages 8067-8077.
Crossref
Bhagavatula Moorthy, Chun Chu & Danielle J. Carlin. (2015) Polycyclic Aromatic Hydrocarbons: From Metabolism to Lung Cancer. Toxicological Sciences 145:1, pages 5-15.
Crossref
Ryeo-Eun Go, Kyung-A Hwang & Kyung-Chul Choi. (2015) Cytochrome P450 1 family and cancers. The Journal of Steroid Biochemistry and Molecular Biology 147, pages 24-30.
Crossref
Damian Brauze, Katarzyna Fijalkiewicz, Marcin Szaumkessel, Katarzyna Kiwerska, Kinga Bednarek, Malgorzata Rydzanicz, Julia Richter, Reidar Grenman & Malgorzata Jarmuz-Szymczak. (2014) Diversified expression of aryl hydrocarbon receptor dependent genes in human laryngeal squamous cell carcinoma cell lines treated with β-naphthoflavone. Toxicology Letters 231:1, pages 99-107.
Crossref
Kaarthik John, Tejas S. Lahoti, Kelly Wagner, Jarod M. Hughes & Gary H. Perdew. (2014) The Ah receptor regulates growth factor expression in head and neck squamous cell carcinoma cell lines. Molecular Carcinogenesis 53:10, pages 765-776.
Crossref
Evan G. Williams, Laurent Mouchiroud, Michael Frochaux, Ashutosh Pandey, Pénélope A. Andreux, Bart Deplancke & Johan Auwerx. (2014) An Evolutionarily Conserved Role for the Aryl Hydrocarbon Receptor in the Regulation of Movement. PLoS Genetics 10:9, pages e1004673.
Crossref
Pekka K. Poutiainen, Tuulia Huhtala, Tiina Jääskeläinen, Aleksanteri Petsalo, Jenni Küblbeck, Sanna Kaikkonen, Jorma J. Palvimo, Hannu Raunio, Ale Närvänen, Mikael Peräkylä, Risto O. Juvonen, Paavo Honkakoski, Reino Laatikainen & Juha T. Pulkkinen. (2014) Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator. Molecular and Cellular Endocrinology 387:1-2, pages 8-18.
Crossref
Meili Gao, Yongfei Li, Xiaochang Xue, Jiangang Long, Lan Chen, Walayat Shah & Yu Kong. (2014) Impact of AhR, CYP1A1 and GSTM1 Genetic Polymorphisms on TP53 R273G Mutations in Individuals Exposed to Polycyclic Aromatic Hydrocarbons. Asian Pacific Journal of Cancer Prevention 15:6, pages 2699-2705.
Crossref
Brigitta StockingerPaola Di MeglioManolis GialitakisJoão H. Duarte. (2014) The Aryl Hydrocarbon Receptor: Multitasking in the Immune System. Annual Review of Immunology 32:1, pages 403-432.
Crossref
David Druzd, Alba de Juan & Christoph Scheiermann. (2014) Circadian rhythms in leukocyte trafficking. Seminars in Immunopathology.
Crossref
Maike Gährs, Robert Roos, Patrik L. Andersson & Dieter Schrenk. (2013) Role of the nuclear xenobiotic receptors CAR and PXR in induction of cytochromes P450 by non-dioxinlike polychlorinated biphenyls in cultured rat hepatocytes. Toxicology and Applied Pharmacology 272:1, pages 77-85.
Crossref
E. Mitchell Seymour, Maurice R. Bennink & Steven F. Bolling. (2013) Diet-relevant phytochemical intake affects the cardiac AhR and nrf2 transcriptome and reduces heart failure in hypertensive rats. The Journal of Nutritional Biochemistry 24:9, pages 1580-1586.
Crossref
Kazuhiro Shiizaki, Masanobu Kawanishi & Takashi Yagi. (2013) Dioxin suppresses benzo[a]pyrene-induced mutations and DNA adduct formation through cytochrome P450 1A1 induction and (±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide inactivation in human hepatoma cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 750:1-2, pages 77-85.
Crossref
Damian Brauze & Agnieszka Anna Rawłuszko. (2012) The effect of aryl hydrocarbon receptor ligands on the expression of polymerase (DNA directed) kappa (Polκ), polymerase RNA II (DNA directed) polypeptide A (PolR2a), CYP1B1 and CYP1A1 genes in rat liver. Environmental Toxicology and Pharmacology 34:3, pages 819-825.
Crossref
Ying Ding, Keshar Prasain, Thi D.T. Nguyen, Duy H. Hua & Thu Annelise Nguyen. (2012) The effect of the PQ1 anti-breast cancer agent on normal tissues. Anti-Cancer Drugs 23:9, pages 897-905.
Crossref
Aihua Gu, Guixiang Ji, Tao Jiang, Ailin Lu, Yongping You, Ning Liu, Chengzhang Luo, Wei Yan & Peng Zhao. (2012) Contributions of Aryl Hydrocarbon Receptor Genetic Variants 
to the Risk of Glioma and PAH-DNA Adducts. Toxicological Sciences 128:2, pages 357-364.
Crossref
Kevin A. Lanham, Richard E. Peterson & Warren Heideman. (2012) Sensitivity to Dioxin Decreases as Zebrafish Mature. Toxicological Sciences 127:2, pages 360-370.
Crossref
Yuki Oda, Miki Nakajima, Takuya Mohri, Masataka Takamiya, Yasuhiro Aoki, Tatsuki Fukami & Tsuyoshi Yokoi. (2012) Aryl hydrocarbon receptor nuclear translocator in human liver is regulated by miR-24. Toxicology and Applied Pharmacology 260:3, pages 222-231.
Crossref
Adrian J. Fretland, Anshul Gupta, Peijuan Zhu & Catherine L. Booth‐Genthe. 2012. ADME‐Enabling Technologies in Drug Design and Development. ADME‐Enabling Technologies in Drug Design and Development 233 251 .
Yakun Chen, Yong Tang, Changxiong Guo, Jiuhui Wang, Debasish Boral & Daotai Nie. (2012) Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters. Biochemical Pharmacology 83:8, pages 1112-1126.
Crossref
Xinsheng Gu & Jose E. Manautou. (2012) Molecular mechanisms underlying chemical liver injury. Expert Reviews in Molecular Medicine 14.
Crossref
Anders Sonesson & Birgitte Buur Rasmussen. (2011) In Vitro Studies Investigating the Interactions between Degarelix, a Decapeptide Gonadotropin-Releasing Hormone Blocker, and Cytochrome P450. Basic & Clinical Pharmacology & Toxicology 109:3, pages 195-202.
Crossref
Steve Wiseman & Mathilakath M. Vijayan. (2011) Aroclor 1254 disrupts liver glycogen metabolism and enhances acute stressor-mediated glycogenolysis in rainbow trout. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 154:3, pages 254-260.
Crossref
Anieta M Sieuwerts, Marleen Ansems, Maxime P Look, Paul N Span, Vanja de Weerd, Anne van Galen, John A Foekens, Gosse J Adema & John WM Martens. (2010) Clinical significance of the nuclear receptor co-regulator DC-SCRIPT in breast cancer: an independent retrospective validation study. Breast Cancer Research 12:6.
Crossref
Subodh Kumar, Bharti Jaiswal, Sanjay Kumar, Seema Negi & Rakesh K. Tyagi. (2010) Cross-talk between androgen receptor and pregnane and xenobiotic receptor reveals existence of a novel modulatory action of anti-androgenic drugs. Biochemical Pharmacology 80:7, pages 964-976.
Crossref
Antonia H. Tolson & Hongbing Wang. (2010) Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR. Advanced Drug Delivery Reviews 62:13, pages 1238-1249.
Crossref
Thomas Haarmann-Stemmann, Jandirk Sendker, Christine Götz, Nathalie Krug, Hanno Bothe, Ellen Fritsche, Peter Proksch & Josef Abel. (2010) Regulation of dioxin receptor function by different beta-carboline alkaloids. Archives of Toxicology 84:8, pages 619-629.
Crossref
Iain A. Murray, Colin A. Flaveny, Brett C. DiNatale, Chris R. Chairo, Jennifer C. Schroeder, Ann Kusnadi & Gary H. Perdew. (2010) Antagonism of Aryl Hydrocarbon Receptor Signaling by 6,2′,4′-Trimethoxyflavone. Journal of Pharmacology and Experimental Therapeutics 332:1, pages 135-144.
Crossref
X. Ding & Q.-Y. Zhang. 2010. Comprehensive Toxicology. Comprehensive Toxicology 9 29 .
E.J. Dougherty & R.S. Pollenz. 2010. Comprehensive Toxicology. Comprehensive Toxicology 231 252 .
David J. Waxman & Minita G. Holloway. (2009) Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes. Molecular Pharmacology 76:2, pages 215-228.
Crossref
Stefan Balaz. (2009) Modeling Kinetics of Subcellular Disposition of Chemicals. Chemical Reviews 109:5, pages 1793-1899.
Crossref
Vikram D. Kekatpure, Andrew J. Dannenberg & Kotha Subbaramaiah. (2009) HDAC6 Modulates Hsp90 Chaperone Activity and Regulates Activation of Aryl Hydrocarbon Receptor Signaling. Journal of Biological Chemistry 284:12, pages 7436-7445.
Crossref
Simone Kobe de Oliveira & Albert Smolenski. (2009) Phosphodiesterases link the aryl hydrocarbon receptor complex to cyclic nucleotide signaling. Biochemical Pharmacology 77:4, pages 723-733.
Crossref
Tobias Stoeger, Shinji Takenaka, Birgit Frankenberger, Baerbel Ritter, Erwin Karg, Konrad Maier, Holger Schulz & Otmar Schmid. (2009) Deducing in Vivo Toxicity of Combustion-Derived Nanoparticles from a Cell-Free Oxidative Potency Assay and Metabolic Activation of Organic Compounds . Environmental Health Perspectives 117:1, pages 54-60.
Crossref
Duncan Hughes, Joseph B. Guttenplan, Craig B. Marcus, Kotha Subbaramaiah & Andrew J. Dannenberg. (2008) Heat Shock Protein 90 Inhibitors Suppress Aryl Hydrocarbon Receptor–Mediated Activation of CYP1A1 and CYP1B1 Transcription and DNA Adduct Formation . Cancer Prevention Research 1:6, pages 485-493.
Crossref
Iain A. Murray & Gary H. Perdew. (2008) Omeprazole Stimulates the Induction of Human Insulin-Like Growth Factor Binding Protein-1 through Aryl Hydrocarbon Receptor Activation. Journal of Pharmacology and Experimental Therapeutics 324:3, pages 1102-1110.
Crossref
Jean-Marc PascussiSabine Gerbal-ChaloinCédric DuretMartine Daujat-ChavanieuMarie-José VilaremPatrick Maurel. (2008) The Tangle of Nuclear Receptors that Controls Xenobiotic Metabolism and Transport: Crosstalk and Consequences. Annual Review of Pharmacology and Toxicology 48:1, pages 1-32.
Crossref
Daniela Schuster, Theodora M. Steindl & Thierry Langer. 2008. Antitargets. Antitargets 317 339 .
Bo Chen, Yunping Hu, Taiyi Jin, Daru Lu, Minhua Shao, Lixing Zheng, Qiangyi Wang, Yue Shen, Hongliang Liu, Yanhong Liu & Yuanfen Zhou. (2007) The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Science of The Total Environment 381:1-3, pages 38-46.
Crossref
Thierry Claudel, Gaspard Cretenet, Anne Saumet & Frédéric Gachon. (2007) Crosstalk between xenobiotics metabolism and circadian clock. FEBS Letters 581:19, pages 3626-3633.
Crossref
Simone Kobe de Oliveira, Meike Hoffmeister, Stepan Gambaryan, Werner Müller-Esterl, Jorge A. Guimaraes & Albert P. Smolenski. (2007) Phosphodiesterase 2A Forms a Complex with the Co-chaperone XAP2 and Regulates Nuclear Translocation of the Aryl Hydrocarbon Receptor. Journal of Biological Chemistry 282:18, pages 13656-13663.
Crossref
Damian Brauze, Magdalena Widerak, Joanna Cwykiel, Krzysztof Szyfter & Wanda Baer-Dubowska. (2006) The effect of aryl hydrocarbon receptor ligands on the expression of AhR, AhRR, ARNT, Hif1α, CYP1A1 and NQO1 genes in rat liver. Toxicology Letters 167:3, pages 212-220.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.