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Drug Evaluations

Azithromycin plus chloroquine: combination therapy for protection against malaria and sexually transmitted infections in pregnancy

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Pages 1153-1167 | Published online: 07 Jul 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Mondher Toumi, Malgorzata Biernikiewicz, Shuyao Liang, Yitong Wang, Tingting Qiu & Ru Han. (2020) A critical analysis and review of Lancet COVID-19 hydroxychloroquine study. Journal of Market Access & Health Policy 8:1.
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Brioni R. Moore & Timothy M. E. Davis. (2018) Pharmacotherapy for the prevention of malaria in pregnant women: currently available drugs and challenges. Expert Opinion on Pharmacotherapy 19:16, pages 1779-1796.
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Timothy M. E. Davis, Brioni R. Moore, Sam Salman, Madhu Page-Sharp, Kevin T. Batty & Laurens Manning. (2016) Use of quantitative pharmacology tools to improve malaria treatments. Expert Review of Clinical Pharmacology 9:2, pages 303-316.
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R Matthew Chico, Berkin B Hack, Melanie J Newport, Enesia Ngulube & Daniel Chandramohan. (2013) On the pathway to better birth outcomes? A systematic review of azithromycin and curable sexually transmitted infections. Expert Review of Anti-infective Therapy 11:12, pages 1303-1332.
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Articles from other publishers (35)

Ahmed E. Abou Warda, Mahmoud Tammam, Rabab A. El-Gazar, Rania M. Sarhan & Sayed Gaber. (2022) Hydroxychloroquine and Azithromycin Combination in the Management of COVID-19 Infection: Safety and Effectiveness Challenges. Current Drug Safety 17:2, pages 143-151.
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Vong Sok, Florence Marzan, David Gingrich, Francesca Aweeka & Liusheng Huang. (2021) Development and validation of an LC-MS/MS method for determination of hydroxychloroquine, its two metabolites, and azithromycin in EDTA-treated human plasma. PLOS ONE 16:3, pages e0247356.
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Guillaume HacheJean Marc RolainPhilippe GautretJean-Claude DeharoPhilippe BrouquiDidier RaoultStéphane Honoré. (2021) Combination of Hydroxychloroquine Plus Azithromycin As Potential Treatment for COVID-19 Patients: Safety Profile, Drug Interactions, and Management of Toxicity. Microbial Drug Resistance 27:3, pages 281-290.
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Serge Henri Zango, Moussa Lingani, Innocent Valea, Ouindpanga Sékou Samadoulougou, Biebo Bihoun, Toussaint Rouamba, Karim Derra, Eli Rouamba, Phillipe Donnen, Michele Dramaix, Halidou Tinto & Annie Robert. (2020) Malaria and curable sexually transmitted infections in pregnant women: A two-years observational study in rural Burkina Faso. PLOS ONE 15:11, pages e0242368.
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Carmen Riggioni, Pasquale Comberiati, Mattia Giovannini, Ioana Agache, Mübeccel Akdis, Magna Alves‐Correia, Josep M. Antó, Alessandra Arcolaci, Ahmet Kursat Azkur, Dilek Azkur, Burcin Beken, Cristina Boccabella, Jean Bousquet, Heimo Breiteneder, Daniela Carvalho, Leticia De las Vecillas, Zuzana Diamant, Ibon Eguiluz‐Gracia, Thomas Eiwegger, Stefanie Eyerich, Wytske Fokkens, Ya‐dong Gao, Farah Hannachi, Sebastian L. Johnston, Marek Jutel, Aspasia Karavelia, Ludger Klimek, Beatriz Moya, Kari C. Nadeau, Robyn O'Hehir, Liam O'Mahony, Oliver Pfaar, Marek Sanak, Jürgen Schwarze, Milena Sokolowska, María J. Torres, Willem van de Veen, Menno C. van Zelm, De Yun Wang, Luo Zhang, Rodrigo Jiménez‐Saiz & Cezmi A. Akdis. (2020) A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2. Allergy 75:10, pages 2503-2541.
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Nathalie Cristina Crivelari, Gisele Queiroz de Oliveira, Clarice Hyesuk Lee Park, Gregorio da Cruz Riemma, Isabela Bispo Santos da Silva Costa, Marcus Vinícius Guimarães de Lacerda, Glaucia Maria Moraes de Oliveira, Francisco Carlos da Costa Darrieux, Luciana Sacilotto & Ludhmila Abrahão Hajjar. (2020) Severe Cardiovascular Complications of COVID-19: a Challenge for the Physician. International Journal of Cardiovascular Sciences 33:5, pages 572-581.
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Jelena Stojkovic‐Filipovic & Martina Bosic. (2020) Treatment of COVID 19—Repurposing drugs commonly used in dermatology. Dermatologic Therapy 33:5.
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Ehud Chorin, Lalit Wadhwani, Silvia Magnani, Matthew Dai, Eric Shulman, Charles Nadeau-Routhier, Robert Knotts, Roi Bar-Cohen, Edward Kogan, Chirag Barbhaiya, Anthony Aizer, Douglas Holmes, Scott Bernstein, Michael Spinelli, David S. Park, Carugo Stefano, Larry A. Chinitz & Lior Jankelson. (2020) QT interval prolongation and torsade de pointes in patients with COVID-19 treated with hydroxychloroquine/azithromycin. Heart Rhythm 17:9, pages 1425-1433.
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JM. Scherrmann. (2020) Intracellular ABCB1 as a Possible Mechanism to Explain the Synergistic Effect of Hydroxychloroquine-Azithromycin Combination in COVID-19 Therapy. The AAPS Journal 22:4.
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Isabel Lasheras & Javier Santabárbara. (2020) Uso de antipalúdicos en el tratamiento del COVID-19: ¿una ventana de oportunidad?. Medicina Clínica 155:1, pages 23-25.
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Isabel Lasheras & Javier Santabárbara. (2020) Use of antimalarial drugs in the treatment of COVID-19: A window of opportunity?. Medicina Clínica (English Edition) 155:1, pages 23-25.
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Bruno Mégarbane & Jean‐Michel Scherrmann. (2020) Hydroxychloroquine and Azithromycin to Treat Patients With COVID‐19: Both Friends and Foes?. The Journal of Clinical Pharmacology 60:7, pages 808-814.
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Moussa Saleh, James Gabriels, David Chang, Beom Soo KimAmtul Mansoor, Eitezaz MahmoodParth Makker, Haisam IsmailBruce Goldner, Jonathan WillnerStuart BeldnerRaman Mitra, Roy JohnJason ChinitzNicholas Skipitaris, Stavros MountantonakisLaurence M. Epstein. (2020) Effect of Chloroquine, Hydroxychloroquine, and Azithromycin on the Corrected QT Interval in Patients With SARS-CoV-2 Infection. Circulation: Arrhythmia and Electrophysiology 13:6.
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Л. В. Хіміон. (2020) Coronavirus Disease: New Humans Challenge and Known Approaches to Treatment. Family medicine:1-2, pages 18-21.
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Raman L. Mitra, Steven A. Greenstein & Laurence M. Epstein. (2020) An algorithm for managing QT prolongation in coronavirus disease 2019 (COVID-19) patients treated with either chloroquine or hydroxychloroquine in conjunction with azithromycin: Possible benefits of intravenous lidocaine. HeartRhythm Case Reports 6:5, pages 244-248.
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Brioni R. Moore, John M. Benjamin, Roselyn Tobe, Maria Ome-Kaius, Gumul Yadi, Bernadine Kasian, Charles Kong, Leanne J. Robinson, Moses Laman, Ivo Mueller, Stephen Rogerson & Timothy M. E. Davis. (2019) A Randomized Open-Label Evaluation of the Antimalarial Prophylactic Efficacy of Azithromycin-Piperaquine versus Sulfadoxine-Pyrimethamine in Pregnant Papua New Guinean Women. Antimicrobial Agents and Chemotherapy 63:10.
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Lidija Senerovic, Dejan Opsenica, Ivana Moric, Ivana Aleksic, Marta Spasić & Branka Vasiljevic. 2020. Advances in Microbiology, Infectious Diseases and Public Health. Advances in Microbiology, Infectious Diseases and Public Health 37 69 .
Lotta HallamaaYin Bun CheungKenneth MaletaMari LuntamoUlla AshornMelissa Gladstone, Teija KulmalaCharles ManganiPer Ashorn. (2018) Child Health Outcomes After Presumptive Infection Treatment in Pregnant Women: A Randomized Trial. Pediatrics 141:3.
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Mitali Mishra, Vikash K. Mishra, Varsha Kashaw, Arun K. Iyer & Sushil Kumar Kashaw. (2017) Comprehensive review on various strategies for antimalarial drug discovery. European Journal of Medicinal Chemistry 125, pages 1300-1320.
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Kamija Phiri, Joshua Kimani, George A. Mtove, Qinying Zhao, Ricardo Rojo, Jeffery Robbins, Stephan Duparc, Ayman Ayoub & Pol Vandenbroucke. (2016) Parasitological Clearance Rates and Drug Concentrations of a Fixed Dose Combination of Azithromycin-Chloroquine in Asymptomatic Pregnant Women with Plasmodium Falciparum Parasitemia: An Open-Label, Non-Comparative Study in Sub-Saharan Africa. PLOS ONE 11:11, pages e0165692.
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Brioni R. Moore, John M. Benjamin, Siu On Auyeung, Sam Salman, Gumul Yadi, Suzanne Griffin, Madhu Page-Sharp, Kevin T. Batty, Peter M. Siba, Ivo Mueller, Stephen J. Rogerson & Timothy ME Davis. (2016) Safety, tolerability and pharmacokinetic properties of coadministered azithromycin and piperaquine in pregnant Papua New Guinean women. British Journal of Clinical Pharmacology 82:1, pages 199-212.
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Joshua Kimani, Kamija Phiri, Steve Kamiza, Stephan Duparc, Ayman Ayoub, Ricardo Rojo, Jeffery Robbins, Russell Orrico & Pol Vandenbroucke. (2016) Efficacy and Safety of Azithromycin-Chloroquine versus Sulfadoxine-Pyrimethamine for Intermittent Preventive Treatment of Plasmodium falciparum Malaria Infection in Pregnant Women in Africa: An Open-Label, Randomized Trial. PLOS ONE 11:6, pages e0157045.
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Sam Salman, Timothy M. E. Davis, Madhu Page-Sharp, Bully Camara, Claire Oluwalana, Abdoulie Bojang, Umberto D'Alessandro & Anna Roca. (2016) Pharmacokinetics of Transfer of Azithromycin into the Breast Milk of African Mothers. Antimicrobial Agents and Chemotherapy 60:3, pages 1592-1599.
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Holger W Unger, Maria Ome-Kaius, Regina A Wangnapi, Alexandra J Umbers, Sarah Hanieh, Connie SN Li Wai Suen, Leanne J Robinson, Anna Rosanas-Urgell, Johanna Wapling, Elvin Lufele, Charles Kongs, Paula Samol, Desmond Sui, Dupain Singirok, Azucena Bardaji, Louis Schofield, Clara Menendez, Inoni Betuela, Peter Siba, Ivo Mueller & Stephen J Rogerson. (2015) Sulphadoxine-pyrimethamine plus azithromycin for the prevention of low birthweight in Papua New Guinea: a randomised controlled trial. BMC Medicine 13:1.
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Daisuke Shibahara, Takeshi Kinjo, Naoya Nishiyama, Wakaki Kami, Daijiro Nabeya, Shusaku Haranaga, Futoshi Higa, Masao Tateyama, Takashi Shinzato, Hiromu Toma, Hidehiro Kishimoto & Jiro Fujita. (2015) Falciparum Malaria Incidentally Pretreated with Azithromycin. Internal Medicine 54:19, pages 2513-2516.
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Letícia S Castro-Filice, Bellisa F Barbosa, Mariana B Angeloni, Neide M Silva, Angelica O Gomes, Celene M O S Alves, Deise A O Silva, Olindo A Martins-Filho, Maria C Santos, José R Mineo & Eloisa A V Ferro. (2014) Azithromycin is able to control Toxoplasma gondii infection in human villous explants. Journal of Translational Medicine 12:1.
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Jules C. Hancox, Mehrul Hasnain, W. Victor R. Vieweg, Ericka L. Breden Crouse & Adrian Baranchuk. (2013) Azithromycin, cardiovascular risks, QTc interval prolongation, torsade de pointes , and regulatory issues: A narrative review based on the study of case reports . Therapeutic Advances in Infectious Disease 1:5, pages 155-165.
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Graham Freimanis, Mary Sedegah, Shirley Owusu-Ofori, Sanjai Kumar & Jean-Pierre Allain. (2013) Investigating the prevalence of transfusion transmission of Plasmodium within a hyperendemic blood donation system . Transfusion 53:7, pages 1429-1441.
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Mari Luntamo, Teija Kulmala, Yin Bun Cheung, Kenneth Maleta & Per Ashorn. (2013) The effect of antenatal monthly sulphadoxine–pyrimethamine, alone or with azithromycin, on foetal and neonatal growth faltering in M alawi: a randomised controlled trial . Tropical Medicine & International Health 18:4, pages 386-397.
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