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How is sesamin metabolised in the human liver to show its biological effects?

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Pages 93-102 | Published online: 19 Nov 2011

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Amin F. Majdalawieh, Sarah M. Yousef, Imad A. Abu-Yousef & Gheyath K. Nasrallah. (2022) Immunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions. Critical Reviews in Food Science and Nutrition 62:18, pages 5081-5112.
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Ali-Mohammad Rousta, Seyed-Mohamad-Sadegh Mirahmadi, Alireza Shahmohammadi, Davood Nourabadi, Mohammad-Reza Khajevand-Khazaei, Tourandokht Baluchnejadmojarad & Mehrdad Roghani. (2018) Protective effect of sesamin in lipopolysaccharide-induced mouse model of acute kidney injury via attenuation of oxidative stress, inflammation, and apoptosis. Immunopharmacology and Immunotoxicology 40:5, pages 423-429.
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Articles from other publishers (16)

Mohammad Amin Ghaderi, Seyed Ahmad Emami, Mahla Daliri Beirak Olia & Behjat Javadi. (2023) The Role of Sesamin in Targeting Neurodegenerative Disorders: A Systematic Review. Mini-Reviews in Medicinal Chemistry 23:6, pages 756-770.
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Keith W. Singletary. (2022) Sesame. Nutrition Today 57:5, pages 271-287.
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Daiki Oikawa, Satoshi Yamashita, Seiji Takahashi, Toshiyuki Waki, Koichi Kikuchi, Takaaki Abe, Takane Katayama & Toru Nakayama. (2022) (+)-Sesamin, a sesame lignan, is a potent inhibitor of gut bacterial tryptophan indole-lyase that is a key enzyme in chronic kidney disease pathogenesis. Biochemical and Biophysical Research Communications 590, pages 158-162.
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Amin F. Majdalawieh, Sarah Dalibalta & Sarah M. Yousef. (2020) Effects of sesamin on fatty acid and cholesterol metabolism, macrophage cholesterol homeostasis and serum lipid profile: A comprehensive review. European Journal of Pharmacology 885, pages 173417.
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Dilipkumar Pal, Phool Chandra & Neetu Sachan. 2020. Nuts and Seeds in Health and Disease Prevention. Nuts and Seeds in Health and Disease Prevention 183 210 .
Rhian B. Cope. 2019. Nutraceuticals in Veterinary Medicine. Nutraceuticals in Veterinary Medicine 711 727 .
Chitra Rajagopal, Manendra Babu Lankadasari, Jesil Mathew Aranjani & K.B. Harikumar. (2018) Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy. Pharmacological Research 130, pages 273-291.
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Toshiyuki Sakaki, Kaori Yasuda, Miyu Nishikawa & Shinichi Ikushiro. (2018) Metabolism of Sesamin and Drug-Sesamin Interactionセサミンの代謝及び医薬品との相互作用. YAKUGAKU ZASSHI 138:3, pages 357-363.
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Hisashi Takeda, Kazuki Ishikawa, Hinaka Yoshida, Daisuke Kasai, Daigo Wakana, Masao Fukuda, Fumihiko Sato & Tomoo Hosoe. (2017) Common origin of methylenedioxy ring degradation and demethylation in bacteria. Scientific Reports 7:1.
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Amin F. Majdalawieh, Mariam Massri & Gheyath K. Nasrallah. (2017) A comprehensive review on the anti-cancer properties and mechanisms of action of sesamin, a lignan in sesame seeds (Sesamum indicum). European Journal of Pharmacology 815, pages 512-521.
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Namino Tomimori, Tomohiro Rogi & Hiroshi Shibata. (2017) Absorption, distribution, metabolism, and excretion of [ 14 C]sesamin in rats . Molecular Nutrition & Food Research 61:8, pages 1600844.
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Kristýna Schneiderová & Karel Šmejkal. (2014) Phytochemical profile of Paulownia tomentosa (Thunb). Steud.. Phytochemistry Reviews 14:5, pages 799-833.
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Kaori Yasuda, Sera Ueno, Erika Ueda, Miyu Nishikawa, Kie Takeda, Masaki Kamakura, Shinichi Ikushiro & Toshiyuki Sakaki. (2015) Influence of sesamin on CYP 2C‐mediated diclofenac metabolism: in vitro and in vivo analysis . Pharmacology Research & Perspectives 3:5.
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Yukie Yaguchi, Tomomi Komura, Noriko Kashima, Miho Tamura, Eriko Kage-Nakadai, Shigeru Saeki, Keiji Terao & Yoshikazu Nishikawa. (2014) Influence of oral supplementation with sesamin on longevity of Caenorhabditis elegans and the host defense. European Journal of Nutrition 53:8, pages 1659-1668.
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Yi-Shin Huang. (2014) Open, sesame! The gateway to mitigate hepatic injury using sesamin. Journal of the Chinese Medical Association 77:5, pages 219-220.
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Nikhil Taxak, Bhargav Patel & Prasad V. Bharatam. (2013) Carbene Generation by Cytochromes and Electronic Structure of Heme-Iron-Porphyrin-Carbene Complex: A Quantum Chemical Study. Inorganic Chemistry 52:9, pages 5097-5109.
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