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Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics

, PharmD PhD, &
Pages 29-46 | Published online: 19 Dec 2011

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Read on this site (6)

Lisa Chedik, Dominique Mias-Lucquin, Olivier Fardel, Olivier Delalande & Arnaud Bruyere. (2022) Interactions of organophosphorus pesticides with ATP-binding cassette (ABC) drug transporters. Xenobiotica 52:6, pages 644-652.
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Nelly Guéniche, Arnaud Bruyere, Mélanie Ringeval, Elodie Jouan, Antoine Huguet, Ludovic Le Hégarat & Olivier Fardel. (2020) Differential interactions of carbamate pesticides with drug transporters. Xenobiotica 50:11, pages 1380-1392.
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Lisa Chedik, Arnaud Bruyere & Olivier Fardel. (2019) Interactions of organophosphorus pesticides with solute carrier (SLC) drug transporters. Xenobiotica 49:3, pages 363-374.
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Lisa Chedik, Arnaud Bruyere, Astrid Bacle, Sophie Potin, Marc Le Vée & Olivier Fardel. (2018) Interactions of pesticides with membrane drug transporters: implications for toxicokinetics and toxicity. Expert Opinion on Drug Metabolism & Toxicology 14:7, pages 739-752.
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V. Prachayasittikul, A. Worachartcheewan, A. P. Toropova, A. A. Toropov, N. Schaduangrat, V. Prachayasittikul & C. Nantasenamat. (2017) Large-scale classification of P-glycoprotein inhibitors using SMILES-based descriptors. SAR and QSAR in Environmental Research 28:1, pages 1-16.
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Olivier Fardel, Marc Le Vee, Elodie Jouan, Claire Denizot & Yannick Parmentier. (2015) Nature and uses of fluorescent dyes for drug transporter studies. Expert Opinion on Drug Metabolism & Toxicology 11:8, pages 1233-1251.
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Valentin Tastet, Marc Le Vée, Marie Kerhoas, Anna Zerdoug, Elodie Jouan, Arnaud Bruyère & Olivier Fardel. (2023) Interactions of organophosphate flame retardants with human drug transporters. Ecotoxicology and Environmental Safety 263, pages 115348.
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Valentin Tastet, Marc Le Vée, Arnaud Bruyère & Olivier Fardel. (2023) Interactions of human drug transporters with chemical additives present in plastics: Potential consequences for toxicokinetics and health. Environmental Pollution 331, pages 121882.
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Nada Ben Halima, Laura Álvarez-Fernández, Esther Blanco-Paniagua, Salwa Abid-Essefi, Yosra Guedri & Gracia Merino. (2023) In vitro interaction of the pesticides flupyradifurone, bupirimate and its metabolite ethirimol with the ATP-binding cassette transporter G2 (ABCG2). Toxicology Letters 380, pages 23-30.
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Matteo Rosellini, Petri Turunen & Thomas Efferth. (2023) Impact of Plastic-Related Compounds on P-Glycoprotein and Breast Cancer Resistance Protein In Vitro. Molecules 28:6, pages 2710.
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Yajuan Bi, Xue Wang, Hui Ding, Feng He, Lifeng Han & Youcai Zhang. (2022) Transporter-mediated Natural Product-Drug Interactions. Planta Medica 89:02, pages 119-133.
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Paratpar Sarkar, Mustafa A. Alheety & Vivek Srivastava. (2023) Molecular Docking and ADMET Study of Spice‐Derived Potential Phytochemicals against Human DNA Topoisomerase III Alpha. Macromolecular Symposia 407:1.
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Maryam Alehashem, Steven Mamet, Natacha Hogan, Markus Hecker, Dimitra Florou, Aristidis Tsatsakis & Steven Siciliano. (2022) Correlation between in vitro toxicity of pesticides and in vivo risk guidelines in support of complex operating site risk management: A meta-analysis. Food and Chemical Toxicology 170, pages 113502.
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Shuyi Zhang, Xianwang Lu, Xin Fang, Zihao Wang, Shihao Cheng & Jue Song. (2022) Cigarette smoke extract combined with LPS reduces ABCA3 expression in chronic pulmonary inflammation may be related to PPARγ/ P38 MAPK signaling pathway. Ecotoxicology and Environmental Safety 244, pages 114086.
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Francisco Alejandro Lagunas‐Rangel, Jenni Viivi Linnea‐Niemi, Błażej Kudłak, Michael J. Williams, Jörgen Jönsson & Helgi B. Schiöth. (2022) Role of the Synergistic Interactions of Environmental Pollutants in the Development of Cancer. GeoHealth 6:4.
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Anastasia Weyrich, Markus Frericks, Michael Eichenlaub, Steffen Schneider, Thomas Hofmann, Steven Van Cruchten & Bennard van Ravenzwaay. (2022) Ontogeny of renal, hepatic, and placental expression of ATP-binding cassette and solute carrier transporters in the rat and the rabbit. Reproductive Toxicology 107, pages 1-9.
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Anne‐Margarethe Enge, Florian Kaltner, Christoph Gottschalk, Angelina Kin, Michael Kirstgen, Joachim Geyer, Anja These, Helen Hammer, Oliver Pötz, Albert Braeuning & Stefanie Hessel‐Pras. (2021) Organic Cation Transporter I and Na + /taurocholate Co‐Transporting Polypeptide are Involved in Retrorsine‐ and Senecionine‐Induced Hepatotoxicity in HepaRG cells . Molecular Nutrition & Food Research 66:2.
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Juliane I. Beier & Gavin E. Arteel. (2021) Environmental exposure as a risk-modifying factor in liver diseases: Knowns and unknowns. Acta Pharmaceutica Sinica B 11:12, pages 3768-3778.
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Sascha C.T. Nicklisch, Amara K. Pouv, Steven D. Rees, Aaron P. McGrath, Geoffrey Chang & Amro Hamdoun. (2021) Transporter-interfering chemicals inhibit P-glycoprotein of yellowfin tuna (Thunnus albacares). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 248, pages 109101.
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Stephen A Pearson & J A Cowan. (2021) Glutathione-coordinated metal complexes as substrates for cellular transporters. Metallomics 13:5.
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Tristan Furnary, Rolando Garcia-Milian, Zeyan Liew, Shannon Whirledge & Vasilis Vasiliou. (2021) In Silico Exploration of the Potential Role of Acetaminophen and Pesticides in the Etiology of Autism Spectrum Disorder. Toxics 9:5, pages 97.
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Jing Li, Xiangfei Sun, Jun Xu, Hongli Tan, Eddy Y. Zeng & Da Chen. (2020) Transplacental Transfer of Environmental Chemicals: Roles of Molecular Descriptors and Placental Transporters. Environmental Science & Technology 55:1, pages 519-528.
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Allan Peter Davis, Thomas C. Wiegers, Jolene Wiegers, Cynthia J. Grondin, Robin J. Johnson, Daniela Sciaky & Carolyn J. Mattingly. (2021) CTD anatomy: Analyzing chemical-induced phenotypes and exposures from an anatomical perspective, with implications for environmental health studies. Current Research in Toxicology 2, pages 128-139.
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Mohammed A. Aboktifa & Duraid A. Abbas. (2020) Interaction Toxicity Study between P-glycoprotein Inhibitor (Captopril) and Inducer (Spironolactone) with Their Substrate (Lovastatin) in Male Rats. The Iraqi Journal of Veterinary Medicine 44:(E0), pages 106-112.
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Manuel Pristner & Benedikt Warth. (2020) Drug–Exposome Interactions: The Next Frontier in Precision Medicine. Trends in Pharmacological Sciences 41:12, pages 994-1005.
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Sascha C.T. Nicklisch & Amro Hamdoun. (2020) Disruption of small molecule transporter systems by Transporter‐Interfering Chemicals (TICs). FEBS Letters 594:23, pages 4158-4185.
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Stephen A Pearson, Christine Wachnowsky & J A Cowan. (2020) Defining the mechanism of the mitochondrial Atm1p [2Fe–2S] cluster exporter. Metallomics 12:6, pages 902-915.
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K. Darney, L. Turco, F.M. Buratti, E. Di Consiglio, S. Vichi, A.C. Roudot, C. Béchaux, E. Testai, J.L.C.M. Dorne & L.S. Lautz. (2020) Human variability in influx and efflux transporters in relation to uncertainty factors for chemical risk assessment. Food and Chemical Toxicology 140, pages 111305.
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Riann Jenay Egusquiza, Maria Elena Ambrosio, Shuyi Gin Wang, Kaelen Marie Kay, Chunyun Zhang, Hans-Joachim Lehmler & Bruce Blumberg. (2020) Evaluating the Role of the Steroid and Xenobiotic Receptor (SXR/PXR) in PCB-153 Metabolism and Protection against Associated Adverse Effects during Perinatal and Chronic Exposure in Mice. Environmental Health Perspectives 128:4.
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Gentao Li, Ruicong Ma, Yufeng Xing, Jing Wei, Yajuan Bi, Caiyu Li, Hui Xiong, Kim K. Baldridge, Jianhui Huang, Jay S. Siegel & Youcai Zhang. (2020) Involvement of aryl hydrocarbon receptor in the cytotoxicity of corannulene and its derivatives. Toxicology Letters 321, pages 114-121.
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Nelly Guéniche, Arnaud Bruyere, Marc Le Vée & Olivier Fardel. (2019) Implication of human drug transporters to toxicokinetics and toxicity of pesticides. Pest Management Science 76:1, pages 18-25.
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Marc Le Vée, Astrid Bacle, Arnaud Bruyere & Olivier Fardel. (2019) Neonicotinoid pesticides poorly interact with human drug transporters. Journal of Biochemical and Molecular Toxicology 33:10.
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Vânia Vilas-Boas, Eva Gijbels, Axelle Cooreman, Raf Van Campenhout, Emma Gustafson, Kaat Leroy & Mathieu Vinken. (2019) Industrial, Biocide, and Cosmetic Chemical Inducers of Cholestasis. Chemical Research in Toxicology 32:7, pages 1327-1334.
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Laure-Alix Clerbaux, Alicia Paini, Annie Lumen, Hanan Osman-Ponchet, Andrew P. Worth & Olivier Fardel. (2019) Membrane transporter data to support kinetically-informed chemical risk assessment using non-animal methods: Scientific and regulatory perspectives. Environment International 126, pages 659-671.
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Laure-Alix Clerbaux, Sandra Coecke, Annie Lumen, Tomas Kliment, Andrew P. Worth & Alicia Paini. (2018) Capturing the applicability of in vitro-in silico membrane transporter data in chemical risk assessment and biomedical research. Science of The Total Environment 645, pages 97-108.
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Vincenzo Tumiatti, Carmela Fimognari, Andrea Milelli & Davide Manucra. 2018. Clinical Handbook of Air Pollution-Related Diseases. Clinical Handbook of Air Pollution-Related Diseases 215 230 .
Lisa Chedik, Dominique Mias-Lucquin, Arnaud Bruyere & Olivier Fardel. (2017) In Silico Prediction for Intestinal Absorption and Brain Penetration of Chemical Pesticides in Humans. International Journal of Environmental Research and Public Health 14:7, pages 708.
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Arnaud Bruyere, Céline Hubert, Marc Le Vee, Lisa Chedik, Katia Sayyed, Bruno Stieger, Claire Denizot, Yannick Parmentier & Olivier Fardel. (2017) Inhibition of SLC drug transporter activities by environmental bisphenols. Toxicology in Vitro 40, pages 34-44.
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Lisa Chedik, Arnaud Bruyere, Marc Le Vee, Bruno Stieger, Claire Denizot, Yannick Parmentier, Sophie Potin & Olivier Fardel. (2017) Inhibition of Human Drug Transporter Activities by the Pyrethroid Pesticides Allethrin and Tetramethrin. PLOS ONE 12:1, pages e0169480.
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Frédérique Rodieux, Verena Gotta, Marc Pfister & Johannes N. van den Anker. (2016) Causes and Consequences of Variability in Drug Transporter Activity in Pediatric Drug Therapy. The Journal of Clinical Pharmacology 56, pages S173-S192.
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Yan Li, Kai Wang, Qing-Yun Zou, Chi Zhou, Ronald R. Magness & Jing Zheng. (2015) A possible role of aryl hydrocarbon receptor in spontaneous preterm birth. Medical Hypotheses 84:5, pages 494-497.
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Marc Le Vee, Elodie Jouan, Bruno Stieger, Valérie Lecureur & Olivier Fardel. (2015) Regulation of Human Hepatic Drug Transporter Activity and Expression by Diesel Exhaust Particle Extract. PLOS ONE 10:3, pages e0121232.
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Jerome Henri, Antoine Huguet, Jean-Michel Delmas, Aurore Besson, Pascal Sanders & Valerie Fessard. (2014) Low in vitro permeability of the cyanotoxin microcystin-LR across a Caco-2 monolayer: With identification of the limiting factors using modelling. Toxicon 91, pages 5-14.
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Yuanyuan Zhang, Zhiqiang Jia, Shutong Yin, Anshan Shan, Rui Gao, Zhe Qu, Min Liu & Shaoping Nie. (2014) Toxic Effects of Maternal Zearalenone Exposure on Uterine Capacity and Fetal Development in Gestation Rats. Reproductive Sciences 21:6, pages 743-753.
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Simon Bucher, Marc Le Vee, Elodie Jouan & Olivier Fardel. (2014) Regulation of Hepatic Drug Transporter Activity and Expression by Organochlorine Pesticides. Journal of Biochemical and Molecular Toxicology 28:3, pages 119-128.
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Douglas B. Kell. (2013) Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it. FEBS Journal 280:23, pages 5957-5980.
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Lenka Šmerdová, Jiří Neča, Jana Svobodová, Jan Topinka, Jana Schmuczerová, Alois Kozubík, Miroslav Machala & Jan Vondráček. (2013) Inflammatory mediators accelerate metabolism of benzo[a]pyrene in rat alveolar type II cells: The role of enhanced cytochrome P450 1B1 expression. Toxicology 314:1, pages 30-38.
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Qi Yu & Jing-Fei Huang. (2013) The DEER database: A bridge connecting drugs, environmental effects, and regulations. Gene 520:2, pages 98-105.
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Douglas B. Kell, Paul D. Dobson, Elizabeth Bilsland & Stephen G. Oliver. (2013) The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so. Drug Discovery Today 18:5-6, pages 218-239.
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