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Drug Evaluations

Deferasirox: pharmacokinetics and clinical experience

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Pages 123-134 | Published online: 19 Dec 2011

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Vip Viprakasit, Sarayuth Rodmai & Somdet Srichairatanakool. (2014) Deferiprone for transfusional iron overload and its roles in developing countries. Expert Opinion on Orphan Drugs 2:2, pages 189-200.
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Ali T Taher, Sally Temraz & M Domenica Cappellini. (2013) Deferasirox for the treatment of iron overload in non-transfusion-dependent thalassemia. Expert Review of Hematology 6:5, pages 495-509.
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Articles from other publishers (21)

Michele Malagù, Federico Marchini, Alessio Fiorio, Paolo Sirugo, Stefano Clò, Elisa Mari, Maria Rita Gamberini, Claudio Rapezzi & Matteo Bertini. (2022) Atrial Fibrillation in β-Thalassemia: Overview of Mechanism, Significance and Clinical Management. Biology 11:1, pages 148.
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Imre Nagy, Gergő Ferenczik, Linda Bíró, Etelka Farkas, Attila Cs. Bényei & Péter Buglyó. (2020) Metal complexation of deferasirox derivatives: A solid state and equilibrium study. Polyhedron 190, pages 114780.
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Chun-Chi Wang, Po-Tsang Huang, Hwang- Shang Kou & Shou-Mei Wu. (2020) Cu2+-induced quenching and recovery of the luminescence of dopamine-conjugated carbon dots for sensing deferasirox in plasma. Sensors and Actuators B: Chemical 311, pages 127916.
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Coralea Stephanou, Stella Tamana, Anna Minaidou, Panayiota Papasavva, Marina Kleanthous & Petros Kountouris. (2019) Genetic Modifiers at the Crossroads of Personalised Medicine for Haemoglobinopathies. Journal of Clinical Medicine 8:11, pages 1927.
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Upendra Bulbake, Alka Singh, Abraham J. Domb & Wahid Khan. (2019) Therapeutic Macromolecular Iron Chelators. Current Medicinal Chemistry 26:2, pages 323-334.
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Mark A. Westwood & Dudley J. Pennell. 2019. Cardiovascular Magnetic Resonance. Cardiovascular Magnetic Resonance 400 409.e4 .
Natalia Maximova, Massimo Gregori, Roberto Simeone, Aurelio Sonzogni, Giulia Boz, Carmen Fucile, Valeria Marini, Antonietta Martelli & Francesca Mattioli. (2017) Safety and tolerability of deferasirox in pediatric hematopoietic stem cell transplant recipients: one facility's five years’ experience of chelation treatment. Oncotarget 8:38, pages 63177-63186.
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Min Dong, Tomoyuki Mizuno & Alexander A. Vinks. (2017) Opportunities for model-based precision dosing in the treatment of sickle cell anemia. Blood Cells, Molecules, and Diseases 67, pages 143-147.
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Jasmine L Hamilton & Jayachandran N Kizhakkedathu. (2015) Polymeric nanocarriers for the treatment of systemic iron overload. Molecular and Cellular Therapies 3:1.
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Francesca Mattioli, Matteo Puntoni, Valeria Marini, Carmen Fucile, Giulia Milano, Luigi Robbiano, Silverio Perrotta, Valeria Pinto, Antonietta Martelli & Gian Luca Forni. (2015) Determination of deferasirox plasma concentrations: do gender, physical and genetic differences affect chelation efficacy?. European Journal of Haematology 94:4, pages 310-317.
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Jasmine L. Hamilton, Azadeh Hatef, Muhammad Imran ul-haq, Neelima Nair, Suraj Unniappan & Jayachandran N. Kizhakkedathu. (2014) Clinically Approved Iron Chelators Influence Zebrafish Mortality, Hatching Morphology and Cardiac Function. PLoS ONE 9:10, pages e109880.
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Maria Marsella & Caterina Borgna-Pignatti. (2014) Transfusional Iron Overload and Iron Chelation Therapy in Thalassemia Major and Sickle Cell Disease. Hematology/Oncology Clinics of North America 28:4, pages 703-727.
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Joerg J Meerpohl, Lisa K Schell, Gerta Rücker, Edith Motschall, Nigel Fleeman, Charlotte M Niemeyer & Dirk Bassler. (2014) Deferasirox for managing transfusional iron overload in people with sickle cell disease. Cochrane Database of Systematic Reviews 2017:6.
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Matt Shirley & Greg L. Plosker. (2014) Deferasirox: A Review of Its Use for Chronic Iron Overload in Patients with Non-Transfusion-Dependent Thalassaemia. Drugs 74:9, pages 1017-1027.
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Zvi RappoportLi‐June Ming. 2010. Patai's Chemistry of Functional Groups. Patai's Chemistry of Functional Groups 1 154 .
Annalisa Dean, Maria Grazia Ferlin, Mirjana Cvijovic, Predrag Djurdjevic, Francesco Dotto, Denis Badocco, Paolo Pastore, Alfonso Venzo & Valerio B. Di Marco. (2014) Evaluation of 1,2-dimethyl-3-hydroxy-4-pyridinecarboxylic acid and of other 3-hydroxy-4-pyridinecarboxylic acid derivatives for possible application in iron and aluminium chelation therapy. Polyhedron 67, pages 520-528.
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SALVATORE IMPROTA, MARIA ROSARIA VILLA, ANTONIO VOLPE, ANGELA LOMBARDI, PAOLA STIUSO, NICOLA CANTORE & LUCIA MASTRULLO. (2013) Transfusion-dependent low-risk myelodysplastic patients receiving deferasirox: Long-term follow-up. Oncology Letters 6:6, pages 1774-1778.
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Dudley J. Pennell, James E. Udelson, Andrew E. Arai, Biykem Bozkurt, Alan R. Cohen, Renzo Galanello, Timothy M. Hoffman, Michael S. Kiernan, Stamatios Lerakis, Antonio Piga, John B. Porter, John Malcolm Walker & John Wood. (2013) Cardiovascular Function and Treatment in β-Thalassemia Major. Circulation 128:3, pages 281-308.
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Dae-Hyoung Lee, Pil Sang Jang, Nack Gyun Chung, Bin Cho, Dae Chul Jeong & Hack Ki Kim. (2013) Deferasirox shows in vitro and in vivo antileukemic effects on murine leukemic cell lines regardless of iron status. Experimental Hematology 41:6, pages 539-546.
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Annalisa Dean, Éva Sija, Éva Zsigó, Maria Grazia Ferlin, Daniele Marton, Valentina Gandin, Cristina Marzano, Denis Badocco, Paolo Pastore, Alfonso Venzo, Roberta Bertani, Tamás Kiss & Valerio Di Marco. (2013) Possible Chelating Agents for Iron and Aluminium – 4‐Hydroxy‐5‐methyl‐ and 4‐Hydroxy‐1,5‐dimethyl‐3‐pyridinecarboxylic Acid. European Journal of Inorganic Chemistry 2013:8, pages 1310-1319.
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Ramakrishna Nirogi, Devender Reddy Ajjala, Vishwottam Kandikere, Raghupathi Aleti, SuryaRao Srikakolapu & Himabindu Vurimindi. (2012) Dried blood spot analysis of an iron chelator – Deferasirox and its potential application to therapeutic drug monitoring. Journal of Chromatography B 907, pages 65-73.
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