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Expert Opinion on Drug Metabolism & Toxicology Volume 8, 2012 - Issue 1
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Mitochondrial toxicity of antiepileptic drugs and their tolerability in mitochondrial disorders

Josef Finsterer Danube University Krems, Krankenanstalt Rudolfstiftung, Postfach 20, 1180 Vienna, Krems Austria, Europe+43 1 71165 92085; +43 1 4781711; [email protected]
, MD PhD (University Professor) &
Sinda Zarrouk MahjoubResearch Unit ‘Human Nutrition & Metabolic Disorders', Faculty of Medicine Monastir, Biochemistry Laboratory, Avenue Avicenne 5019 Monastir, Tunisie, Afrique
, PhD
Pages 71-79 | Published online: 07 Dec 2011

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Sophie Dorsey & Fayyaz Ahmed. (2021) Developments in distinguishing secondary vascular headache from primary headache disorders in clinical practice. Expert Review of Neurotherapeutics 21:12, pages 1357-1369.
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Josef Finsterer. (2019) Pharmacotherapeutic management of epilepsy in MERRF syndrome. Expert Opinion on Pharmacotherapy 20:10, pages 1289-1297.
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Gabriel C Quintero. (2017) Review about gabapentin misuse, interactions, contraindications and side effects. Journal of Experimental Pharmacology 9, pages 13-21.
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Josef Finsterer & Sinda Zarrouk-Mahjoub. (2016) Managing seizures in mitochondrial disorders. Expert Opinion on Orphan Drugs 4:2, pages 197-204.
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. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 303 337 .
Harold A. Coleman & Helena C. Parkington. 2016. Prenatal and Postnatal Determinants of Development. Prenatal and Postnatal Determinants of Development 203 219 .
Josef Finsterer. 2017. Pharmacology of Mitochondria. Pharmacology of Mitochondria 473 488 .
Rodrigo Furtado Madeiro da CostaMichelle Louise KormannAntonio GalinaStevens Kastrup Rehen. (2015) Valproate Disturbs Morphology and Mitochondrial Membrane Potential in Human Neural Cells. Applied In Vitro Toxicology 1:4, pages 254-261.
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Davide Germano, Marianne Uteng, Francois Pognan, Salah-Dine Chibout & Armin Wolf. (2015) Determination of liver specific toxicities in rat hepatocytes by high content imaging during 2-week multiple treatment. Toxicology in Vitro 30:1, pages 79-94.
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Paulo José Lorenzoni, Lineu Cesar Werneck, Cláudia Suemi Kamoi Kay, Carlos Eduardo Soares Silvado & Rosana Herminia Scola. (2015) When should MELAS (Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes) be the diagnosis?. Arquivos de Neuro-Psiquiatria 73:11, pages 959-967.
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Eylert Brodtkorb. 2015. The Treatment of Epilepsy. The Treatment of Epilepsy 193 204 .
Josef Finsterer & Sinda Zarrouk-Mahjoub. (2015) Focal and Generalized Seizures May Occur in Mitochondrial Encephalomyopathy, Lactic Acidosis, and Strokelike Episodes (MELAS) Patients. Journal of Child Neurology 30:11, pages 1553-1554.
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Ayman W. El-Hattab, Adekunle M. Adesina, Jeremy Jones & Fernando Scaglia. (2015) MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options. Molecular Genetics and Metabolism 116:1-2, pages 4-12.
Crossref
Tomomi Imamura, Shingo Konno, Masashi Inoue, Mayumi Murata, Hiroshi Nakazora, Hideki Sugimoto & Toshiki Fujioka. (2015) Convulsion and cerebellar ataxia associated with maternally inherited diabetes and deafness: a case report. Clinical Case Reports 3:7, pages 656-659.
Crossref
Shengbiao Li, Jingyi Guo, Zhongfu Ying, Shen Chen, Liang Yang, Keshi Chen, Qi Long, Dajiang Qin, Duanqing Pei & Xingguo Liu. (2015) Valproic acid‐induced hepatotoxicity in alpers syndrome is associated with mitochondrial permeability transition pore opening‐dependent apoptotic sensitivity in an induced pluripotent stem cell model. Hepatology 61:5, pages 1730-1739.
Crossref
Josef Finsterer & Parayil Sankaran Bindu. (2015) Therapeutic Strategies for Mitochondrial Disorders. Pediatric Neurology 52:3, pages 302-313.
Crossref
Ronald J. Sokol. 2014. Liver Disease in Children. Liver Disease in Children 603 630 .
Steve S. Chung & Courtney Schusse. 2014. A worldwide yearly survey of new data in adverse drug reactions and interactions. A worldwide yearly survey of new data in adverse drug reactions and interactions 133 169 .
Simon Horslen. 2014. Diseases of the Liver in Children. Diseases of the Liver in Children 107 131 .
Andreas Hermann. 2014. Chorea. Chorea 31 55 .
Katrin Hayess, Christian Riebeling, Ralph Pirow, Matthias Steinfath, Dana Sittner, Birgitta Slawik, Andreas Luch & Andrea E.M. Seiler. (2013) The DNT-EST: A predictive embryonic stem cell-based assay for developmental neurotoxicity testing in vitro. Toxicology 314:1, pages 135-147.
Crossref
Manuela G. Neuman, Radu M. Nanau, Tawfeeq Shekh-Ahmad, Boris Yagen & Meir Bialer. (2013) Valproic acid derivatives signal for apoptosis and repair in vitro. Clinical Biochemistry 46:15, pages 1532-1537.
Crossref
Radu M. Nanau & Manuela G. Neuman. (2013) Adverse drug reactions induced by valproic acid. Clinical Biochemistry 46:15, pages 1323-1338.
Crossref
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Crossref
Divya S. Khurana, Ignacio Valencia, Michael J. Goldenthal & Agustín Legido. (2013) Mitochondrial Dysfunction in Epilepsy. Seminars in Pediatric Neurology 20:3, pages 176-187.
Crossref
Josef Finsterer & Sinda Zarrouk Mahjoub. (2013) Presentation of adult mitochondrial epilepsy. Seizure 22:2, pages 119-123.
Crossref
Iris E. Martínez-Juárez, Laura Elena Hernández-Vanegas, Nayelli Rodríguez y Rodríguez, Jorge Alfredo León-Aldana & Antonio V. Delgado-Escueta. 2013. Pharmacoresistance in Epilepsy. Pharmacoresistance in Epilepsy 11 25 .
Hu Chen, Svetlana Dzitoyeva & Hari Manev. (2012) Effect of valproic acid on mitochondrial epigenetics. European Journal of Pharmacology 690:1-3, pages 51-59.
Crossref
Josef Finsterer & Sinda Zarrouk Mahjoub. (2012) Epilepsy in mitochondrial disorders. Seizure 21:5, pages 316-321.
Crossref

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