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The role of aldehyde oxidase in drug metabolism

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Pages 487-503 | Published online: 16 Feb 2012

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Siva Nageswara Rao Gajula, Tanaaz Navin Nathani, Rashmi Madhukar Patil, Sasikala Talari & Rajesh Sonti. (2022) Aldehyde oxidase mediated drug metabolism: an underpredicted obstacle in drug discovery and development. Drug Metabolism Reviews 54:4, pages 427-448.
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Nikhilesh V. Dhuria, Bianka Haro, Amit Kapadia, Khadjia A. Lobo, Bernice Matusow, Mary A. Schleiff, Christina Tantoy & Jasleen K. Sodhi. (2021) Recent developments in predicting CYP-independent metabolism. Drug Metabolism Reviews 53:2, pages 188-206.
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Yasuhiro Uno, Shotaro Uehara, Norie Murayama & Hiroshi Yamazaki. (2021) Genetic variants of aldehyde oxidase (AOX) 1 in cynomolgus and rhesus macaques. Xenobiotica 51:4, pages 494-499.
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Austin C. Li, Donghui Cui, Erya Yu, Kyle Dobson, Edward T. Hellriegel & Philmore Robertson Jr. (2019) Identification and human exposure prediction of two aldehyde oxidase-mediated metabolites of a methylquinoline-containing drug candidate. Xenobiotica 49:3, pages 302-312.
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Toshito Nakagawa, Stephen Fowler, Kenji Takanashi, Kuresh Youdim, Tsuyoshi Yamauchi, Kosuke Kawashima, Mika Sato-Nakai, Li Yu & Masaki Ishigai. (2018) In vitro metabolism of alectinib, a novel potent ALK inhibitor, in human: contribution of CYP3A enzymes. Xenobiotica 48:6, pages 546-554.
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Zhengsheng Mao, Yali Wu, Qiuying Li, Xin Wang, Youping Liu & Xin Di. (2018) Aldehyde oxidase-dependent species difference in hepatic metabolism of fasudil to hydroxyfasudil. Xenobiotica 48:2, pages 170-177.
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Mohammad-Reza Rashidi & Somaieh Soltani. (2017) An overview of aldehyde oxidase: an enzyme of emerging importance in novel drug discovery. Expert Opinion on Drug Discovery 12:3, pages 305-316.
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Jun Wang, Gizem Keceli, Rui Cao, Jiangtao Su & Zhiyuan Mi. (2017) Molybdenum-containing nitrite reductases: Spectroscopic characterization and redox mechanism. Redox Report 22:1, pages 17-25.
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Tomoyuki Isobe, Masayuki Ohta, Yoshio Kaneko & Hiroyuki Kawai. (2016) Species differences in metabolism of ripasudil (K-115) are attributed to aldehyde oxidase. Xenobiotica 46:7, pages 579-590.
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Ramakrishna Nirogi, Vishwottam Kandikere, Raghava Choudary Palacharla, Gopinadh Bhyrapuneni, Vijaya Bhargava Kanamarlapudi, Ranjith Kumar Ponnamaneni & Arun Kumar Manoharan. (2014) Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions. Xenobiotica 44:3, pages 197-204.
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Li Di. (2014) The role of drug metabolizing enzymes in clearance. Expert Opinion on Drug Metabolism & Toxicology 10:3, pages 379-393.
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Enrico Garattini & Mineko Terao. (2013) Aldehyde oxidase and its importance in novel drug discovery: present and future challenges. Expert Opinion on Drug Discovery 8:6, pages 641-654.
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Maryam Hamzeh-Mivehroud, Seifullah Rahmani, Mohammad-Reza Rashidi, Mohammad-Ali Hosseinpour Feizi & Siavoush Dastmalchi. (2013) Structure-based investigation of rat aldehyde oxidase inhibition by flavonoids. Xenobiotica 43:8, pages 661-670.
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Deepak Dalvie, Cathie Xiang, Ping Kang & Sue Zhou. (2013) Interspecies variation in the metabolism of zoniporide by aldehyde oxidase. Xenobiotica 43:5, pages 399-408.
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James Matthew Hutzler, Ronald Scott Obach, Deepak Dalvie & Michael A Zientek. (2013) Strategies for a comprehensive understanding of metabolism by aldehyde oxidase. Expert Opinion on Drug Metabolism & Toxicology 9:2, pages 153-168.
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