5,401
Views
228
CrossRef citations to date
0
Altmetric
Reviews

Species differences in drug transporters and implications for translating preclinical findings to humans

, &
Pages 237-252 | Published online: 21 Dec 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (18)

Paresh P. Chothe, Masanori Nakakariya, Charles J. Rotter, Philip Sandoval & Kimio Tohyama. (2021) Recent advances in drug transporter sciences: highlights from the year 2020. Drug Metabolism Reviews 53:3, pages 321-349.
Read now
Priyanka Kulkarni. (2021) Prediction of drug-induced kidney injury in drug discovery. Drug Metabolism Reviews 53:2, pages 234-244.
Read now
Jaydeep Yadav, Mehdi El Hassani, Jasleen Sodhi, Volker M. Lauschke, Jessica H. Hartman & Laura E. Russell. (2021) Recent developments in in vitro and in vivo models for improved translation of preclinical pharmacokinetics and pharmacodynamics data. Drug Metabolism Reviews 53:2, pages 207-233.
Read now
Volker M. Lauschke. (2021) Toxicogenomics of drug induced liver injury – from mechanistic understanding to early prediction.. Drug Metabolism Reviews 53:2, pages 245-252.
Read now
Shin-ichiro Ogawa, Shotaro Uehara, Yoshihiko Tsunenari, Hiroyuki Kawai, Hiroshi Suemizu & Hiroshi Yamazaki. (2020) Prediction of circulating human metabolites of pemafibrate, a novel antidyslipidemic drug, using chimeric mice with humanized liver. Xenobiotica 50:7, pages 769-775.
Read now
Ravindra V. Alluri, Rui Li & Manthena V. S. Varma. (2020) Transporter–enzyme interplay and the hepatic drug clearance: what have we learned so far?. Expert Opinion on Drug Metabolism & Toxicology 16:5, pages 387-401.
Read now
Rui-Feng Liang, Wen-Jing Ge, Xian-Mei Song, Jun-Ping Zhang, Wei-Feng Cui, She-Feng Zhang & Geng-Sheng Li. (2020) Involvement of organic anion-transporting polypeptides and organic cation transporter in the hepatic uptake of jatrorrhizine. Xenobiotica 50:4, pages 479-487.
Read now
Mingxiang Liao, Qing Zhu, Andy Zhu, Christopher Gemski, Bingli Ma, Emily Guan, Albert P. Li, Guangqing Xiao & Cindy Q. Xia. (2019) Comparison of uptake transporter functions in hepatocytes in different species to determine the optimal model for evaluating drug transporter activities in humans. Xenobiotica 49:7, pages 852-862.
Read now
Chunyong He & Hong Wan. (2018) Drug metabolism and metabolite safety assessment in drug discovery and development. Expert Opinion on Drug Metabolism & Toxicology 14:10, pages 1071-1085.
Read now
Donna A. Volpe & Hisham Qosa. (2018) Challenges with the precise prediction of ABC-transporter interactions for improved drug discovery. Expert Opinion on Drug Discovery 13:8, pages 697-707.
Read now
Donna A. Volpe. (2016) Transporter assays as useful in vitro tools in drug discovery and development. Expert Opinion on Drug Discovery 11:1, pages 91-103.
Read now
Darren Michael Moss, Catia Marzolini, Rajith KR Rajoli & Marco Siccardi. (2015) Applications of physiologically based pharmacokinetic modeling for the optimization of anti-infective therapies. Expert Opinion on Drug Metabolism & Toxicology 11:8, pages 1203-1217.
Read now
Keigo Kosaka, Tomoko Watanabe, Takeshi Susukida, Shigeki Aoki, Shuichi Sekine, Toshiyuki Kume & Kousei Ito. (2015) Key determinants of the circulatory exposure of organic anions: differences in hepatic uptake between multidrug resistance-associated protein 2 (Mrp2)-deficient rats and wild-type rats. Xenobiotica 45:6, pages 556-562.
Read now
Swati Jaiswal, Abhisheak Sharma, Mahendra Shukla, Kalpesh Vaghasiya, Nagarjun Rangaraj & Jawahar Lal. (2014) Novel pre-clinical methodologies for pharmacokinetic drug–drug interaction studies: spotlight on “humanized” animal models. Drug Metabolism Reviews 46:4, pages 475-493.
Read now
Bo Feng, Manthena V Varma, Chester Costales, Hui Zhang & Larry Tremaine. (2014) In vitro and in vivo approaches to characterize transporter-mediated disposition in drug discovery. Expert Opinion on Drug Discovery 9:8, pages 873-890.
Read now
Alessandro Polini, Ljupcho Prodanov, Nupura S Bhise, Vijayan Manoharan, Mehmet R Dokmeci & Ali Khademhosseini. (2014) Organs-on-a-chip: a new tool for drug discovery. Expert Opinion on Drug Discovery 9:4, pages 335-352.
Read now

Articles from other publishers (210)

Ke Fang, Shaoyu Ren & Qian Zhang. (2023) Identification and characterization of the metabolites of sinomenine using liquid chromatography combined with benchtop Orbitrap mass spectrometry and nuclear magnetic resonance spectroscopy. Rapid Communications in Mass Spectrometry 38:3.
Crossref
Dimosthenis A. Sarigiannis, Antonios K. Stratidakis & Spyridon P. Karakitsios. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 159 169 .
Lawrence Harold Lash. (2023) A Novel Approach to Predicting Organic Anion Transporting Polypeptide Function in Human Hepatic Drug Disposition and Biliary Clearance. Journal of Pharmacology and Experimental Therapeutics 387:2, pages 131-134.
Crossref
Taiji Miyake, Haruka Tsutsui, Manabu Hirabayashi & Tatsuhiko Tachibana. (2023) Quantitative Prediction of OATP-Mediated Disposition and Biliary Clearance Using Human Liver Chimeric Mice. Journal of Pharmacology and Experimental Therapeutics 387:2, pages 135-149.
Crossref
Kenji Matsui, Shuichiro Yamanaka, Sandy Chen, Naoto Matsumoto, Keita Morimoto, Yoshitaka Kinoshita, Yuka Inage, Yatsumu Saito, Tsuyoshi Takamura, Toshinari Fujimoto, Susumu Tajiri, Kei Matsumoto, Eiji Kobayashi & Takashi Yokoo. (2023) Long-term viable chimeric nephrons generated from progenitor cells are a reliable model in cisplatin-induced toxicity. Communications Biology 6:1.
Crossref
Annelies Noorlander, Sebastiaan Wesseling, Ivonne M.C.M. Rietjens & Bennard van Ravenzwaay. (2023) Predicting acute paraquat toxicity using physiologically based kinetic modelling incorporating in vitro active renal excretion via the OCT2 transporter. Toxicology Letters 388, pages 30-39.
Crossref
Siyu Liu & Yohei Kosugi. (2023) Human Brain Penetration Prediction Using Scaling Approach from Animal Machine Learning Models. The AAPS Journal 25:5.
Crossref
Raymond K. Hau, Stephen H. Wright & Nathan J. Cherrington. (2023) In Vitro and In Vivo Models for Drug Transport Across the Blood-Testis Barrier. Drug Metabolism and Disposition 51:9, pages 1157-1168.
Crossref
Manasi Jiwankar & Vidya Sabale. (2023) Potential of nanostructured lipid carriers in oral delivery of the poorly soluble drugs. Journal of Nanoparticle Research 25:9.
Crossref
Jessica Chu, Erika Panfen, Linna Wang, Anthony Marino, Xue-Qing Chen, R. Marcus Fancher, Raviraj Landage, Omprakash Patil, Salil Dileep Desai, Devang Shah, Yongjun Xue, Michael Sinz & Hong Shen. (2023) Evaluation of Encequidar as An Intestinal P-gp and BCRP Specific Inhibitor to Assess the Role of Intestinal P-gp and BCRP in Drug-Drug Interactions. Pharmaceutical Research.
Crossref
Chrisna Matthee, Andrew Ross Brown, Anke Lange & Charles R. Tyler. (2023) Factors Determining the Susceptibility of Fish to Effects of Human Pharmaceuticals. Environmental Science & Technology 57:24, pages 8845-8862.
Crossref
Melissa Chassé & Neil Vasdev. (2023) Synthesis and Preclinical Positron Emission Tomography Imaging of the p38 MAPK Inhibitor [ 11 C]Talmapimod: Effects of Drug Efflux and Sex Differences . ACS Chemical Neuroscience 14:11, pages 2193-2200.
Crossref
Xiaodan An, Jingqi Wang, Linjiang Tong, Xiaojun Zhang, Hualong Fu, Jinming Zhang, Hua Xie, Yiyun Huang & Hongmei Jia. (2023) 18F-Labeled o‑aminopyridyl alkynyl radioligands targeting colony-stimulating factor 1 receptor for neuroinflammation imaging. Bioorganic & Medicinal Chemistry 83, pages 117233.
Crossref
Sheena Sharma, Dilip K. Singh, Vijay S. Mettu, Guihua Yue, Deepak Ahire, Abdul Basit, Scott Heyward & Bhagwat Prasad. (2023) Quantitative Characterization of Clinically Relevant Drug-Metabolizing Enzymes and Transporters in Rat Liver and Intestinal Segments for Applications in PBPK Modeling. Molecular Pharmaceutics 20:3, pages 1737-1749.
Crossref
Anthony J. Roecker, Kathy M. Schirripa, H. Marie Loughran, Ling Tong, Tao Liang, Kerry L. Fillgrove, Yuhsin Kuo, Kelly Bleasby, Hannah Collier, Michael D. Altman, Melissa C. Ford, Robert E. Drolet, Mali Cosden, Sarah Jinn, Nathan G. Hatcher, Lihang Yao, Monika Kandebo, Joshua D. Vardigan, Rosemarie B. Flick, Xiaomei Liu, Christina Minnick, Laura A. Price, Marla L. Watt, Wei Lemaire, Christine Burlein, Gregory C. Adam, Lauren A. Austin, Jacob N. Marcus, Sean M. Smith & Mark E. Fraley. (2023) Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson’s Disease. ACS Medicinal Chemistry Letters 14:2, pages 146-155.
Crossref
Rachel S. Perkins, Abigail Davis, Olivia Campagne, Thandranese S. Owens & Clinton F. Stewart. (2023) CNS penetration of methotrexate and its metabolite 7-hydroxymethotrexate in mice bearing orthotopic Group 3 medulloblastoma tumors and model-based simulations for children. Drug Metabolism and Pharmacokinetics 48, pages 100471.
Crossref
Caitlin Krause, Kinga Suwada, Eric A. G. Blomme, Kenneth Kowalkowski, Michael J. Liguori, Prathap Kumar Mahalingaiah, Scott Mittelstadt, Richard Peterson, Lauren Rendino, Andy Vo & Terry R. Van Vleet. (2023) Preclinical species gene expression database: Development and meta-analysis. Frontiers in Genetics 13.
Crossref
Markus Karlsson, Christian Simonsson, Nils Dahlström, Gunnar Cedersund & Peter Lundberg. (2023) Mathematical models for biomarker calculation of drug-induced liver injury in humans and experimental models based on gadoxetate enhanced magnetic resonance imaging. PLOS ONE 18:1, pages e0279168.
Crossref
Jinping Gan, Kan He & W. Griffith Humphreys. 2023. Overcoming Obstacles in Drug Discovery and Development. Overcoming Obstacles in Drug Discovery and Development 107 121 .
David A. Candito, Vladimir Simov, Anmol Gulati, Solomon Kattar, Ryan W. Chau, Blair T. Lapointe, Joey L. Methot, Duane E. DeMong, Thomas H. Graham, Ravi Kurukulasuriya, Mitchell H. Keylor, Ling Tong, Gregori J. Morriello, John J. Acton, Barbara Pio, Weiguo Liu, Jack D. Scott, Michael J. Ardolino, Theodore A. Martinot, Matthew L. Maddess, Xin Yan, Hakan Gunaydin, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Hongshi Yu, Ellen C. Minnihan, Charles A. Lesburg, Ping Liu, Jing Su, Laxminarayan G. Hegde, Lily Y. Moy, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul Ciaccio, Jennifer A. Piesvaux, Karin M. Otte, Matthew E. Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew J. Fell, Santhosh Neelamkavil, Harold B. Wood, Peter H. Fuller & J. Michael Ellis. (2022) Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease . Journal of Medicinal Chemistry 65:24, pages 16801-16817.
Crossref
Payal Rana, Sanaa Khan, Seda Arat, David Potter & Nasir Khan. (2022) Nonclinical Safety Signals in PharmaPendium Improve the Predictability of Human Drug-Induced Liver Injury. Chemical Research in Toxicology 35:11, pages 2133-2144.
Crossref
Surabhi Talele, Wenjuan Zhang, Jiajia Chen, Shiv K. Gupta, Danielle M. Burgenske, Jann N. Sarkaria & William F. Elmquist. (2022) Central Nervous System Distribution of the Ataxia-Telangiectasia Mutated Kinase Inhibitor AZD1390: Implications for the Treatment of Brain Tumors. Journal of Pharmacology and Experimental Therapeutics 383:1, pages 91-102.
Crossref
Flavia Storelli, Mengyue Yin, Aditya R. Kumar, Mayur K. Ladumor, Raymond Evers, Paresh P. Chothe, Osatohanmwen J. Enogieru, Xiaomin Liang, Yurong Lai & Jashvant D. Unadkat. (2022) The next frontier in ADME science: Predicting transporter-based drug disposition, tissue concentrations and drug-drug interactions in humans. Pharmacology & Therapeutics 238, pages 108271.
Crossref
Bernhard Blank-Landeshammer, Gerald Klanert, Lisa Mitter, Sophia Turisser, Nicolas Nusser, Alice König, Marcus Iken & Julian Weghuber. (2022) Improved Bioavailability and Bioaccessibility of Lutein and Isoflavones in Cultured Cells In Vitro through Interaction with Ginger, Curcuma and Black Pepper Extracts. Antioxidants 11:10, pages 1917.
Crossref
Eleanor Luce, Clara Steichen, Soumeya Abed, Anne Weber, Philippe Leboulch, Leila Maouche-Chrétien & Anne Dubart-Kupperschmitt. (2022) Successful Derivation of Hepatoblasts, Cholangiocytes and Hepatocytes from Simian Induced Pluripotent Stem Cells. International Journal of Molecular Sciences 23:18, pages 10861.
Crossref
Raymond K. Hau, Joseph S. Tash, Gunda I. Georg, Stephen H. Wright & Nathan J. Cherrington. (2022) Physiological Characterization of the Transporter-Mediated Uptake of the Reversible Male Contraceptive H2-Gamendazole Across the Blood-Testis Barrier. Journal of Pharmacology and Experimental Therapeutics 382:3, pages 299-312.
Crossref
Yan Weng, Kari R. Fonseca, Yi-an Bi, Sumathy Mathialagan, Keith Riccardi, Elaine Tseng, Andrew J. Bessire, Mathew A. Cerny, David A. Tess, A. David Rodrigues, Amit S. Kalgutkar, John Litchfield, Li Di & Manthena V. S. Varma. (2022) Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, a First-In-Class Ketohexokinase Inhibitor for Metabolic Disorders and Nonalcoholic Fatty Liver Disease. Drug Metabolism and Disposition 50:9, pages 1312-1321.
Crossref
Anna Zerdoug, Marc Le Vée, Shotaro Uehara, Béatrice Lopez, Christophe Chesné, Hiroshi Suemizu & Olivier Fardel. (2022) Contribution of Humanized Liver Chimeric Mice to the Study of Human Hepatic Drug Transporters: State of the Art and Perspectives. European Journal of Drug Metabolism and Pharmacokinetics 47:5, pages 621-637.
Crossref
Marcus Baaz, Tim Cardilin, Floriane Lignet & Mats Jirstrand. (2022) Optimized scaling of translational factors in oncology: from xenografts to RECIST. Cancer Chemotherapy and Pharmacology 90:3, pages 239-250.
Crossref
Kim L.R. Brouwer, Raymond Evers, Elizabeth Hayden, Shuiying Hu, Cindy Yanfei Li, Henriette E. Meyer zu Schwabedissen, Sibylle Neuhoff, Stefan Oswald, Micheline Piquette‐Miller, Chitra Saran, Noora Sjöstedt, Jason A. Sprowl, Simone H. Stahl & Wei Yue. (2022) Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium. Clinical Pharmacology & Therapeutics 112:3, pages 461-484.
Crossref
Louise Breuil, Sébastien Goutal, Solène Marie, Antonio Del Vecchio, Davide Audisio, Amélie Soyer, Maud Goislard, Wadad Saba, Nicolas Tournier & Fabien Caillé. (2022) Comparison of the Blood–Brain Barrier Transport and Vulnerability to P-Glycoprotein-Mediated Drug–Drug Interaction of Domperidone versus Metoclopramide Assessed Using In Vitro Assay and PET Imaging. Pharmaceutics 14:8, pages 1658.
Crossref
Gergely Gyimesi & Matthias A. Hediger. (2022) Systematic in silico discovery of novel solute carrier-like proteins from proteomes. PLOS ONE 17:7, pages e0271062.
Crossref
Golestan Salimbeigi, Nihal E. Vrana, Amir M. Ghaemmaghami, Pinar Y. Huri & Garrett B. McGuinness. (2022) Basement membrane properties and their recapitulation in organ-on-chip applications. Materials Today Bio 15, pages 100301.
Crossref
Zhicheng Duan, Tingting Yang, Lin Li, Xue Wang, Chujing Wei, Ziyin Xia, Yuanyuan Chai, Xin Huang, Luyong Zhang & Zhenzhou Jiang. (2022) Comparison of bile acids profiles in the enterohepatic circulation system of mice and rats. The Journal of Steroid Biochemistry and Molecular Biology 220, pages 106100.
Crossref
Marleen J. Meyer, Pascale C.F. Schreier, Mert Basaran, Stefaniia Vlasova, Tina Seitz, Jürgen Brockmöller, Barbara Zdrazil & Mladen V. Tzvetkov. (2022) Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1. Journal of Biological Chemistry 298:6, pages 101974.
Crossref
Yoo-Kyung Song, Min-Ju Kim, Min-Soo Kim, Ji Hun Lee, Suk-Jae Chung, Jin Sook Song, Yoon-Jee Chae & Kyeong-Ryoon Lee. (2022) Role of the efflux transporters Abcb1 and Abcg2 in the brain distribution of olaparib in mice. European Journal of Pharmaceutical Sciences 173, pages 106177.
Crossref
Kenta Haraya, Haruka Tsutsui, Yasunori Komori & Tatsuhiko Tachibana. (2022) Recent Advances in Translational Pharmacokinetics and Pharmacodynamics Prediction of Therapeutic Antibodies Using Modeling and Simulation. Pharmaceuticals 15:5, pages 508.
Crossref
Michela Cantiello, Monica Carletti, Mery Giantin, Giulia Gardini, Francesca Capolongo, Paolo Cascio, Marianna Pauletto, Flavia Girolami, Mauro Dacasto & Carlo Nebbia. (2022) Induction by Phenobarbital of Phase I and II Xenobiotic-Metabolizing Enzymes in Bovine Liver: An Overall Catalytic and Immunochemical Characterization. International Journal of Molecular Sciences 23:7, pages 3564.
Crossref
M.L. Lawrence, M. Elhendawi, M. Morlock, W. Liu, S. Liu, A. Palakkan, L.F. Seidl, P. Hohenstein, A.K. Sjögren & J.A. Davies. (2022) Human iPSC-derived renal organoids engineered to report oxidative stress can predict drug-induced toxicity. iScience 25:3, pages 103884.
Crossref
Amrendra K. Ajay. (2022) Functional Drug Screening using Kidney Cells On-A-Chip: Advances in Disease Modeling and Development of Biomarkers. Kidney360 3:2, pages 194-198.
Crossref
Pei Zhao, Jianchun Wang, Chengmin Chen, Jianmei Wang, Guangxia Liu, Krishnaswamy Nandakumar, Yan Li & Liqiu Wang. (2022) Microfluidic Applications in Drug Development: Fabrication of Drug Carriers and Drug Toxicity Screening. Micromachines 13:2, pages 200.
Crossref
Sonia Youhanna, Aurino M. Kemas, Lena Preiss, Yitian Zhou, Joanne X. Shen, Selgin D. Cakal, Francesco S. Paqualini, Sravan K. Goparaju, Reza Zandi Shafagh, Johan Ulrik Lind, Carl M. Sellgren & Volker M. Lauschke. (2022) Organotypic and Microphysiological Human Tissue Models for Drug Discovery and Development—Current State-of-the-Art and Future Perspectives. Pharmacological Reviews 74:1, pages 141-206.
Crossref
Anastasia Weyrich, Markus Frericks, Michael Eichenlaub, Steffen Schneider, Thomas Hofmann, Steven Van Cruchten & Bennard van Ravenzwaay. (2022) Ontogeny of renal, hepatic, and placental expression of ATP-binding cassette and solute carrier transporters in the rat and the rabbit. Reproductive Toxicology 107, pages 1-9.
Crossref
Gretchen J. Mahler & Stephanie Zhang. 2022. Regenerative Nephrology. Regenerative Nephrology 353 366 .
Lauren E. Himmel, Kristin Lewis Wilson, Sara F. Santagostino & Brad Bolon. 2022. Haschek and Rousseaux's Handbook of Toxicologic Pathology. Haschek and Rousseaux's Handbook of Toxicologic Pathology 859 924 .
Surat Parvatam & Pavithra L. Chavali. 2022. Microfluidics and Multi Organs on Chip. Microfluidics and Multi Organs on Chip 557 588 .
Daisy Arora & Bharat Khurana. 2022. Computer Aided Pharmaceutics and Drug Delivery. Computer Aided Pharmaceutics and Drug Delivery 189 215 .
Janine Hussner, Annalise Foletti, Isabell Seibert, Anja Fuchs, Eveline Schuler, Vanessa Malagnino, Markus Grube & Henriette E. Meyer zu Schwabedissen. (2021) Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1). Drug Metabolism and Pharmacokinetics 41, pages 100418.
Crossref
L. J. Stevens, A. Z. X. Zhu, P. P. Chothe, S. K. Chowdhury, J. M. Donkers, W. H. J. Vaes, C. A. J. Knibbe, I. P. J. Alwayn & E. van de Steeg. (2021) Evaluation of Normothermic Machine Perfusion of Porcine Livers as a Novel Preclinical Model to Predict Biliary Clearance and Transporter-Mediated Drug-Drug Interactions Using Statins. Drug Metabolism and Disposition 49:9, pages 780-789.
Crossref
Amira Sayed Hanafy, Dirk Dietrich, Gert Fricker & Alf Lamprecht. (2021) Blood-brain barrier models: Rationale for selection. Advanced Drug Delivery Reviews 176, pages 113859.
Crossref
Birthe Gericke, Saskia Borsdorf, Inka Wienböker, Andreas Noack, Sandra Noack & Wolfgang Löscher. (2021) Similarities and differences in the localization, trafficking, and function of P-glycoprotein in MDR1-EGFP-transduced rat versus human brain capillary endothelial cell lines. Fluids and Barriers of the CNS 18:1.
Crossref
Justin Q. Ly, Susan Wong, Liling Liu, Ruina Li, Kirsten Messick & Jae H. Chang. (2021) Investigating the Utility of Humanized Pregnane X Receptor-Constitutive Androstane Receptor-CYP3A4/7 Mouse Model to Assess CYP3A-Mediated Induction. Drug Metabolism and Disposition 49:7, pages 540-547.
Crossref
Aditya R. Kumar, Bhagwat Prasad, Deepak Kumar Bhatt, Sumathy Mathialagan, Manthena V. S. Varma & Jashvant D. Unadkat. (2021) In Vitro–to–In Vivo Extrapolation of Transporter-Mediated Renal Clearance: Relative Expression Factor Versus Relative Activity Factor Approach. Drug Metabolism and Disposition 49:6, pages 470-478.
Crossref
Theresa Balber & Markus Mitterhauser. (2021) Perspektiven und Methoden der Experimentellen Nuklearmedizin. Der Nuklearmediziner 44:02, pages 113-119.
Crossref
Annelies Noorlander, Sebastiaan Wesseling, Ivonne M.C.M. Rietjens & Bennard van Ravenzwaay. (2021) Incorporating renal excretion via the OCT2 transporter in physiologically based kinetic modelling to predict in vivo kinetics of mepiquat in rat. Toxicology Letters 343, pages 34-43.
Crossref
Raymond K Hau, Siennah R Miller & Nathan J Cherrington. (2021) ToxPoint: Implications of Species Differences in Function and Localization of Transporters at the Blood–Testis Barrier. Toxicological Sciences 181:1, pages 1-2.
Crossref
Heather Eng, Yi-an Bi, Mark A. West, Sangwoo Ryu, Emi Yamaguchi, Rachel E. Kosa, David A. Tess, David A. Griffith, John Litchfield, Amit S. Kalgutkar & Manthena V. S. Varma. (2021) Organic Anion–Transporting Polypeptide 1B1/1B3–Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro–In Vivo Evaluation in Cynomolgus Monkey. Journal of Pharmacology and Experimental Therapeutics 377:1, pages 169-180.
Crossref
Bo Feng, Rachel Pemberton, Wojciech Dworakowski, Zhengqi Ye, Craig Zetterberg, Guanyu Wang, Yoshio Morikawa & Sanjeev Kumar. (2021) Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Polypeptide Transporter Substrates. Drug Metabolism and Disposition 49:3, pages 254-264.
Crossref
Nihan Izat & Selma Sahin. (2021) Hepatic transporter‐mediated pharmacokinetic drug–drug interactions: Recent studies and regulatory recommendations. Biopharmaceutics & Drug Disposition 42:2-3, pages 45-77.
Crossref
Karine Tadevosyan, Olalla Iglesias-García, Manuel M. Mazo, Felipe Prósper & Angel Raya. (2021) Engineering and Assessing Cardiac Tissue Complexity. International Journal of Molecular Sciences 22:3, pages 1479.
Crossref
Kristin M. Bircsak, Richard DeBiasio, Mark Miedel, Alaa Alsebahi, Ryan Reddinger, Anthony Saleh, Tongying Shun, Lawrence A. Vernetti & Albert Gough. (2021) A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®. Toxicology 450, pages 152667.
Crossref
Kinga K. Borowicz-Reutt & Monika Banach. (2021) Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice. Pharmacology Biochemistry and Behavior 201, pages 173110.
Crossref
Mohammed A. A. Saleh & Elizabeth C. M. de Lange. (2021) Impact of CNS Diseases on Drug Delivery to Brain Extracellular and Intracellular Target Sites in Human: A “WHAT-IF” Simulation Study. Pharmaceutics 13:1, pages 95.
Crossref
Sonia Youhanna & Volker M. Lauschke. (2021) The Past, Present and Future of Intestinal In Vitro Cell Systems for Drug Absorption Studies. Journal of Pharmaceutical Sciences 110:1, pages 50-65.
Crossref
Priyanka R. Kulkarni, Amir S. Youssef & Aneesh A. Argikar. 2021. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism 369 417 .
Vladimir Shalgunov, Mengfei Xiong, Elina T. L’Estrade, Nakul R. Raval, Ida V. Andersen, Fraser G. Edgar, Nikolaj R. Speth, Simone L. Baerentzen, Hanne D. Hansen, Lene L. Donovan, Arafat Nasser, Siv T. Peitersen, Andreas Kjaer, Gitte M. Knudsen, Stina Syvänen, Mikael Palner & Matthias M. Herth. (2020) Blocking of efflux transporters in rats improves translational validation of brain radioligands. EJNMMI Research 10:1.
Crossref
Seyed Hamidreza Mahmoudpour, Luca Valerio, Jonathan Douxfils, Charles E. Mahan, Marius Jankowski, Kurt Quitzau, Stavros V. Konstantinides & Stefano Barco. (2020) Potential Drug Interactions between Recombinant Interleukin-2 and Direct Oral Anticoagulants: Indirect Evidence from In Vivo Animal Studies. Hämostaseologie 40:05, pages 679-686.
Crossref
Sascha C.T. Nicklisch & Amro Hamdoun. (2020) Disruption of small molecule transporter systems by Transporter‐Interfering Chemicals (TICs). FEBS Letters 594:23, pages 4158-4185.
Crossref
Brielle Rosa. (2020) Equine Drug Transporters: A Mini-Review and Veterinary Perspective. Pharmaceutics 12:11, pages 1064.
Crossref
Raymond K. Hau, Siennah R. Miller, Stephen H. Wright & Nathan J. Cherrington. (2020) Generation of a hTERT-Immortalized Human Sertoli Cell Model to Study Transporter Dynamics at the Blood-Testis Barrier. Pharmaceutics 12:11, pages 1005.
Crossref
David A. Tess, Heather Eng, Amit S. Kalgutkar, John Litchfield, David J. Edmonds, David A. Griffith & Manthena V. S. Varma. (2020) Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs. Journal of Medicinal Chemistry 63:20, pages 11831-11844.
Crossref
Mihwa Kwon, Ji-Hyeon Jeon, Min-Koo Choi & Im-Sook Song. (2020) The Development and Validation of a Novel “Dual Cocktail” Probe for Cytochrome P450s and Transporter Functions to Evaluate Pharmacokinetic Drug-Drug and Herb-Drug Interactions. Pharmaceutics 12:10, pages 938.
Crossref
Ze Wang, Haihua Shang, Yazhuo Li, Chen Zhang, Yan Dong, Tao Cui, Hongbing Zhang, Xiaoyan Ci, Xiulin Yi, Tiejun Zhang, Fengying Yan, Yaping Zhang, Xing Huang, Weidang Wu & Changxiao Liu. (2020) Transporters (OATs and OATPs) contribute to illustrate the mechanism of medicinal compatibility of ingredients with different properties in yuanhuzhitong prescription. Acta Pharmaceutica Sinica B 10:9, pages 1646-1657.
Crossref
Lyrialle W. Han, Lu Wang, Yuanyuan Shi, Joseph L. Dempsey, Olesya V. Pershutkina, Moumita Dutta, Theo K. Bammler, Julia Y. Cui & Qingcheng Mao. (2020) Impact of Microbiome on Hepatic Metabolizing Enzymes and Transporters in Mice during Pregnancy. Drug Metabolism and Disposition 48:8, pages 708-722.
Crossref
Hiromichi Yoshimatsu, Kunikazu Ishii & Shinji Yamashita. (2020) Extent and rate of oral drug absorption in minipigs: Comparison with mice, rats and humans. Journal of Drug Delivery Science and Technology 58, pages 101743.
Crossref
Ron C. Gaba, Lobna Elkhadragy, F. Edward Boas, Sulalita Chaki, Hanna H. Chen, Mohammed El-Kebir, Kelly D. Garcia, Eileena F. Giurini, Grace Guzman, Francesca V. LoBianco, Mario F. Neto, Jordan L. Newson, Aisha Qazi, Maureen Regan, Lauretta A. Rund, Regina M. Schwind, Matthew C. Stewart, Faith M. Thomas, Herbert E. Whiteley, Jiaqi Wu, Lawrence B. Schook & Kyle M. Schachtschneider. (2020) Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation. Oncotarget 11:28, pages 2686-2701.
Crossref
Duygu D. Corum, Orhan Corum, Orkun Atik, Hatice E. Faki, Feray Altan & Kamil Uney. (2020) Effect of benzylpenicillin on intravenous pharmacokinetics of acyclovir in red‐eared slider turtles ( Trachemys scripta elegans ) . Journal of Veterinary Pharmacology and Therapeutics 43:4, pages 319-324.
Crossref
Verena J. Herbener, Timo Burster, Alicia Goreth, Maximilian Pruss, Hélène von Bandemer, Tim Baisch, Rahel Fitzel, Markus D. Siegelin, Georg Karpel-Massler, Klaus-Michael Debatin, Mike-Andrew Westhoff & Hannah Strobel. (2020) Considering the Experimental Use of Temozolomide in Glioblastoma Research. Biomedicines 8:6, pages 151.
Crossref
Ni Lin, Xiaobing Zhou, Xingchao Geng, Christopher Drewell, Juliane Hübner, Zuogang Li, Yingli Zhang, Ming Xue, Uwe Marx & Bo Li. (2020) Repeated dose multi-drug testing using a microfluidic chip-based coculture of human liver and kidney proximal tubules equivalents. Scientific Reports 10:1.
Crossref
Mingqing Chen, Shuiying Hu, Yang Li, Alice A. Gibson, Qiang Fu, Sharyn D. Baker & Alex Sparreboom. (2020) Role of Oatp2b1 in Drug Absorption and Drug-Drug Interactions. Drug Metabolism and Disposition 48:5, pages 420-426.
Crossref
Derek Spieler, Christian Namendorf, Tamara Namendorf, Maja von Cube & Manfred Uhr. (2020) Donepezil, a cholinesterase inhibitor used in Alzheimer's disease therapy, is actively exported out of the brain by abcb1ab p-glycoproteins in mice. Journal of Psychiatric Research 124, pages 29-33.
Crossref
Menq-Rong Wu, Yi-You Huang & Jong-Kai Hsiao. (2019) Role of Sodium Taurocholate Cotransporting Polypeptide as a New Reporter and Drug-Screening Platform: Implications for Preventing Hepatitis B Virus Infections. Molecular Imaging and Biology 22:2, pages 313-323.
Crossref
Rob C. van Wijk, Rami Ayoun Alsoud, Hans Lennernäs & Ulrika S. H. Simonsson. (2020) Model-Informed Drug Discovery and Development Strategy for the Rapid Development of Anti-Tuberculosis Drug Combinations. Applied Sciences 10:7, pages 2376.
Crossref
Hiroshi Kohara, Piyush Bajaj, Kazunori Yamanaka, Akimitsu Miyawaki, Kosuke Harada, Kazumasa Miyamoto, Toshikatsu Matsui, Yoshiko Okai, Matthew Wagoner & Tadahiro Shinozawa. (2020) High-Throughput Screening to Evaluate Inhibition of Bile Acid Transporters Using Human Hepatocytes Isolated From Chimeric Mice. Toxicological Sciences 173:2, pages 347-361.
Crossref
Yoshitane Nozaki & Saki Izumi. (2020) Recent advances in preclinical in vitro approaches towards quantitative prediction of hepatic clearance and drug-drug interactions involving organic anion transporting polypeptide (OATP) 1B transporters. Drug Metabolism and Pharmacokinetics 35:1, pages 56-70.
Crossref
Joanne X. Shen, Sonia Youhanna, Reza Zandi Shafagh, Julianna Kele & Volker M. Lauschke. (2019) Organotypic and Microphysiological Models of Liver, Gut, and Kidney for Studies of Drug Metabolism, Pharmacokinetics, and Toxicity. Chemical Research in Toxicology 33:1, pages 38-60.
Crossref
Jean-Marie Nicolas, Hugues Chanteux, Johan Nicolaï, Frédéric Brouta, Delphine Viot, Marie-Luce Rosseels, Eric Gillent, Pierre Bonnaillie, François-Xavier Mathy, Jeff Long & Eric Helmer. (2020) Role of P-glycoprotein in the brain disposition of seletalisib: Evaluation of the potential for drug-drug interactions. European Journal of Pharmaceutical Sciences 142, pages 105122.
Crossref
Filippo Zanetti. 2020. Organ-on-a-chip. Organ-on-a-chip 233 253 .
Jinpeng LiRaja S. SettivariMatthew J. LeBaronMary Sue Marty. (2019) Functional Comparison of HepaRG Cells and Primary Human Hepatocytes in Sandwich and Spheroid Culture as Repeated-Exposure Models for Hepatotoxicity. Applied In Vitro Toxicology 5:4, pages 187-195.
Crossref
Tobie D. Lee, Olivia W. Lee, Kyle R. Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G. Tebase, Carleen Klumpp-Thomas, Robert W. Robey, Suresh V. Ambudkar, Min Shen, Michael M. Gottesman & Matthew D. Hall. (2019) A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology 96:5, pages 629-640.
Crossref
Yi-Zhong Gu, Xiaoyan Chu, Robert Houle, Katerina Vlasakova, Kenneth A Koeplinger, Isabelle Bourgeois, Kiran Palyada, Kenneth D Anderson, Christopher Brynczka, Bhavana Bhatt, Feifei Chen, Roger Smith, Rupesh Amin, Warren E Glaab, Jose Lebron, Kathleen Cox & Frank D Sistare. (2019) Polyethlyene Glycol 200 Can Protect Rats Against Drug-Induced Kidney Toxicity Through Inhibition of the Renal Organic Anion Transporter 3. Toxicological Sciences 172:1, pages 155-166.
Crossref
Kit Wun Kathy Cheung, Bianca D. van Groen, Edwin Spaans, Marjolein D. van Borselen, Adrianus C.J.M. de Bruijn, Ytje Simons‐Oosterhuis, Dick Tibboel, Janneke N. Samsom, Robert M. Verdijk, Bart Smeets, Lei Zhang, Shiew‐Mei Huang, Kathleen M. Giacomini & Saskia N. de Wildt. (2019) A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization. Clinical Pharmacology & Therapeutics 106:5, pages 1083-1092.
Crossref
Izna Ali, Daniel Guidone, Joseph A. Nicolazzo & Kim L.R. Brouwer. (2019) Impact of reduced P‐glycoprotein function on digoxin concentrations in patients with dementia. British Journal of Clinical Pharmacology 85:10, pages 2351-2359.
Crossref
Zhen Chen, Tuo Shao, Wei Gao, Hualong Fu, Thomas Lee Collier, Jian Rong, Xiaoyun Deng, Qingzhen Yu, Xiaofei Zhang, April T. Davenport, James B. Daunais, Hsiao‐Ying Wey, Yihan Shao, Lee Josephson, Wen‐Wei Qiu & Steven Liang. (2019) Synthesis and Preliminary Evaluation of [ 11 C]GNE‐1023 as a Potent PET Probe for Imaging Leucine‐Rich Repeat Kinase 2 (LRRK2) in Parkinson's Disease . ChemMedChem 14:17, pages 1580-1585.
Crossref
Lianne J. Stevens, Marola M.H. van Lipzig, Steven L.A. Erpelinck, Apollo Pronk, Joost van Gorp, Heleen M. Wortelboer & Evita van de Steeg. (2019) A higher throughput and physiologically relevant two-compartmental human ex vivo intestinal tissue system for studying gastrointestinal processes. European Journal of Pharmaceutical Sciences 137, pages 104989.
Crossref
Sadhana Jackson, Caitlin Meeks, Amélie Vézina, Robert W. Robey, Kandice Tanner & Michael M. Gottesman. (2019) Model systems for studying the blood-brain barrier: Applications and challenges. Biomaterials 214, pages 119217.
Crossref
Xin Zhou, Kenneth C. Cassidy, Loyd Hudson, Michael A. Mohutsky, Geri A. Sawada & Junliang Hao. (2019) Enterohepatic circulation of glucuronide metabolites of drugs in dog. Pharmacology Research & Perspectives 7:4.
Crossref
Po-Chang Chiang, Karthik Nagapudi, Jia Liu, James J. Crawford, Jason R. Zbieg, Emile Plise & Yuzhong Deng. (2019) An Integrated Analysis of Solid Form Change Impact on Solubility and Permeability: Case Study of Oral Exposure in Rats of an RAR Related Orphan Receptor C Inhibitor. Journal of Pharmaceutical Sciences 108:7, pages 2256-2263.
Crossref
Domenico Ventrella, Monica Forni, Maria Laura Bacci & Pieter Annaert. (2019) Non-clinical Models to Determine Drug Passage into Human Breast Milk. Current Pharmaceutical Design 25:5, pages 534-548.
Crossref
C.J. Henderson, Y. Kapelyukh, N. Scheer, A. Rode, AW. McLaren, A.K. MacLeod, D. Lin, J. Wright, L.A. Stanley & C.R. Wolf. (2019) An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials. Drug Metabolism and Disposition 47:6, pages 601-615.
Crossref
Yunpeng Zhang, Shuping Li, Youxu Wang, Gang Deng, Ning Cao, Chao Wu, Wenzheng Ding, Yuwen Wang, Xuemei Cheng & Changhong Wang. (2019) Potential Pharmacokinetic Drug–Drug Interaction Between Harmine, a Cholinesterase Inhibitor, and Memantine, a Non-Competitive N-Methyl-d-Aspartate Receptor Antagonist. Molecules 24:7, pages 1430.
Crossref
Charlotte J. Green, Thomas Marjot, Jeremy W. Tomlinson & Leanne Hodson. (2018) Of mice and men: Is there a future for metformin in the treatment of hepatic steatosis?. Diabetes, Obesity and Metabolism 21:4, pages 749-760.
Crossref
Dennis A. SmithKevin Beaumont, Tristan S. Maurer & Li Di. (2018) Clearance in Drug Design. Journal of Medicinal Chemistry 62:5, pages 2245-2255.
Crossref
Yongjun Hu & David E. Smith. (2019) In Silico Prediction of the Absorption and Disposition of Cefadroxil in Humans using an Intestinal Permeability Method Scaled from Humanized PepT1 Mice . Drug Metabolism and Disposition 47:3, pages 173-183.
Crossref
Tom T.G. Nieskens & Anna-Karin Sjögren. (2019) Emerging In Vitro Systems to Screen and Predict Drug-Induced Kidney Toxicity. Seminars in Nephrology 39:2, pages 215-226.
Crossref
Kendall S. Frazier, Anne M. Ryan, Richard A. Peterson & Leslie A. Obert. (2019) Kidney Pathology and Investigative Nephrotoxicology Strategies Across Species. Seminars in Nephrology 39:2, pages 190-201.
Crossref
Luke A. Wittenburg, Dominique Ramirez, Holly Conger & Daniel L. Gustafson. (2019) Simultaneous absolute quantitation of ATP-binding cassette transporters in normal dog tissues by signature peptide analysis using a LC/MS/MS method. Research in Veterinary Science 122, pages 93-101.
Crossref
Derek Spieler, Christian Namendorf, Tamara Namendorf & Manfred Uhr. (2019) abcb1ab p-glycoprotein is involved in the uptake of the novel antidepressant vortioxetine into the brain of mice. Journal of Psychiatric Research 109, pages 48-51.
Crossref
Dianlei Wang. 2019. Drug Transporters in Drug Disposition, Effects and Toxicity. Drug Transporters in Drug Disposition, Effects and Toxicity 203 240 .
Weijia Han, Qiao Wu, Xiaohui Zhang & Zhongping Duan. (2018) Innovation for hepatotoxicity in vitro research models: A review. Journal of Applied Toxicology 39:1, pages 146-162.
Crossref
Shin‐ichiro Ogawa, Yoshihiko Tsunenari, Hiroyuki Kawai & Hiroshi Yamazaki. (2019) Pharmacokinetics and metabolism of pemafibrate, a novel selective peroxisome proliferator‐activated receptor‐ alpha modulator, in rats and monkeys . Biopharmaceutics & Drug Disposition 40:1, pages 12-17.
Crossref
Sean Tanzey, Xia Shao, Jenelle Stauff, Janna Arteaga, Phillip Sherman, Peter Scott & Andrew Mossine. (2018) Synthesis and Initial In Vivo Evaluation of [11C]AZ683—A Novel PET Radiotracer for Colony Stimulating Factor 1 Receptor (CSF1R). Pharmaceuticals 11:4, pages 136.
Crossref
Ru Yan, Ying Yang & Yijia Chen. (2018) Pharmacokinetics of Chinese medicines: strategies and perspectives. Chinese Medicine 13:1.
Crossref
Pedro Caetano-Pinto & Simone H. Stahl. (2018) Perspective on the Application of Microphysiological Systems to Drug Transporter Studies. Drug Metabolism and Disposition 46:11, pages 1647-1657.
Crossref
Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura & Yasuhiro Kazuki. (2018) Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans. Drug Metabolism and Disposition 46:11, pages 1756-1766.
Crossref
Yingying Guo, Xiaoyan Chu, Neil J. Parrott, Kim L.R. Brouwer, Vicky Hsu, Swati Nagar, Pär Matsson, Pradeep Sharma, Jan Snoeys, Yuichi Sugiyama, Daniel Tatosian, Jashvant D. Unadkat, Shiew‐Mei Huang & Aleksandra Galetin. (2018) Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro , Imaging and Physiologically Based Pharmacokinetic Modeling Approaches . Clinical Pharmacology & Therapeutics 104:5, pages 865-889.
Crossref
Paresh P. Chothe, Shu-Pei Wu, Zhengqi Ye & Niresh Hariparsad. (2018) Assessment of Transporter-Mediated and Passive Hepatic Uptake Clearance Using Rifamycin-SV as a Pan-Inhibitor of Active Uptake. Molecular Pharmaceutics 15:10, pages 4677-4688.
Crossref
Sungwoo Hyung, Yoo-Seong Jeong, Jungmin Yeo, Yoo-Kyung Song, Min-Soo Kim, Young-Jae Im, Han-Joo Maeng & Suk-Jae Chung. (2018) Identification of the primary determining factor(s) governing the oral absorption of edaravone in rats. European Journal of Pharmaceutical Sciences 123, pages 312-320.
Crossref
Rhishikesh Thakare, Jawaher Abdullah Alamoudi, Nagsen Gautam, A. David Rodrigues & Yazen Alnouti. (2018) Species differences in bile acids II. Bile acid metabolism. Journal of Applied Toxicology 38:10, pages 1336-1352.
Crossref
Kelsey RettingDwayne CarterCandace Crogan-GrundyChirag KhatiwalaLeah NoronaElizabeth PaffenrothUmesh HanumegowdaAlice ChenLisa HazelwoodLois Lehman-McKeemanSharon Presnell. (2018) Modeling Liver Biology and the Tissue Response to Injury in Bioprinted Human Liver Tissues. Applied In Vitro Toxicology 4:3, pages 288-303.
Crossref
Marcel M. Miyake, Angela Nocera & Michelle M. Miyake. (2018) P‐glycoprotein and chronic rhinosinusitis. World Journal of Otorhinolaryngology - Head and Neck Surgery 4:3, pages 169-174.
Crossref
Sankalp Jain, Melanie Grandits & Gerhard F. Ecker. (2018) Interspecies comparison of putative ligand binding sites of human, rat and mouse P-glycoprotein. European Journal of Pharmaceutical Sciences 122, pages 134-143.
Crossref
Lukas Cerveny, Zuzana Ptackova, Marketa Durisova & Frantisek Staud. (2018) Interactions of protease inhibitors atazanavir and ritonavir with ABCB1, ABCG2, and ABCC2 transporters: Effect on transplacental disposition in rats. Reproductive Toxicology 79, pages 57-65.
Crossref
Tom De Bruyn, Ayşe Ufuk, Carina Cantrill, Rachel E. Kosa, Yi-an Bi, Mark Niosi, Sweta Modi, A. David Rodrigues, Larry M. Tremaine, Manthena V. S. Varma, Aleksandra Galetin & J. Brian Houston. (2018) Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance. Drug Metabolism and Disposition 46:7, pages 989-1000.
Crossref
Izabel Almeida Alves, Keli Jaqueline Staudt, Fernando Olinto Carreño, Graziela de Araujo Lock, Carolina de Miranda Silva, Stela Maris Kuze Rates, Teresa Dalla Costa & Bibiana Verlindo De Araujo. (2018) Population Pharmacokinetic Modeling to Describe the Total Plasma and Free Brain Levels of Fluconazole in Healthy and Cryptococcus neoformans Infected Rats: How Does the Infection Impact the Drug’s Levels on Biophase?. Pharmaceutical Research 35:7.
Crossref
Saki Izumi, Yoshitane Nozaki, Hiroyuki Kusuhara, Koichiro Hotta, Toshiki Mochizuki, Takafumi Komori, Kazuya Maeda & Yuichi Sugiyama. (2018) Relative Activity Factor (RAF)-Based Scaling of Uptake Clearance Mediated by Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 in Human Hepatocytes. Molecular Pharmaceutics 15:6, pages 2277-2288.
Crossref
Marco F. Taddio, Linjing Mu, Claudia Keller, Roger Schibli & Stefanie D. Krämer. (2018) Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice . Contrast Media & Molecular Imaging 2018, pages 1-11.
Crossref
Joanne Y.-C. Soo, Jitske Jansen, Rosalinde Masereeuw & Melissa H. Little. (2018) Advances in predictive in vitro models of drug-induced nephrotoxicity. Nature Reviews Nephrology 14:6, pages 378-393.
Crossref
Adjanie Patabendige, Benedict D. Michael, Alister G. Craig & Tom Solomon. (2018) Brain microvascular endothelial-astrocyte cell responses following Japanese encephalitis virus infection in an in vitro human blood-brain barrier model. Molecular and Cellular Neuroscience 89, pages 60-70.
Crossref
Ayman F. El-Kattan & Manthena V. S. Varma. (2018) Navigating Transporter Sciences in Pharmacokinetics Characterization Using the Extended Clearance Classification System. Drug Metabolism and Disposition 46:5, pages 729-739.
Crossref
Tom T. G. Nieskens, Janny G. P. Peters, Dina Dabaghie, Daphne Korte, Katja Jansen, Alexander H. Van Asbeck, Neslihan N. Tavraz, Thomas Friedrich, Frans G. M. Russel, Rosalinde Masereeuw & Martijn J. Wilmer. (2018) Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity. Drug Metabolism and Disposition 46:5, pages 592-599.
Crossref
Lin Chen, Haiying Yang, Chenchen Yu, Mei Yuan & Hua Li. (2018) High hepatic exposure of furanocoumarins in Radix Angelica dahuricae is associated with transporter mediated active uptake. Journal of Ethnopharmacology 212, pages 74-85.
Crossref
Lindsey H.M. te Brake, Gerjo J. de Knegt, Jurriaan E. de Steenwinkel, Teunis J.P. van Dam, David M. BurgerFrans G.M. Russel, Reinout van Crevel, Jan B. Koenderink & Rob E. Aarnoutse. (2018) The Role of Efflux Pumps in Tuberculosis Treatment and Their Promise as a Target in Drug Development: Unraveling the Black Box. Annual Review of Pharmacology and Toxicology 58:1, pages 271-291.
Crossref
Sanna Turunen, Susanna Kaisto, Ilya Skovorodkin, Vladimir Mironov, Tomi Kalpio, Seppo Vainio & Aleksandra Rak-Raszewska. (2018) 3D bioprinting of the kidney—hype or hope?. AIMS Cell and Tissue Engineering 2:3, pages 119-162.
Crossref
E.L. LeCluyse, L.M. Norona, J.A. Akingbasote, L.S. Howell, J.L. Woodhead, M.J. Cross, A.B. Roth & C.E. Goldring. 2018. Comprehensive Toxicology. Comprehensive Toxicology 651 712 .
KP. Van Ness & EJ. Kelly. 2018. Comprehensive Toxicology. Comprehensive Toxicology 143 164 .
David M. Burger, Lindsey H. M. te Brake & Rob E. Aarnoutse. 2018. Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions. Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions 15 47 .
Sungwoo Hyung, Wonji Pyeon, Ji Eun Park, Yoo-Kyung Song & Suk-Jae Chung. (2017) The conditional stimulation of rat organic cation transporter 2, but not its human ortholog, by mesoridazine: the possibility of the involvement of the high-affinity binding site of the transporter in the stimulation. Journal of Pharmacy and Pharmacology 69:11, pages 1513-1523.
Crossref
Louis Lin & Harvey Wong. (2017) Predicting Oral Drug Absorption: Mini Review on Physiologically-Based Pharmacokinetic Models. Pharmaceutics 9:4, pages 41.
Crossref
Noriko Okudaira. (2017) Evaluation of New Chemical Entities as Substrates of Liver Transporters in the Pharmaceutical Industry: Response to Regulatory Requirements and Future Steps. Journal of Pharmaceutical Sciences 106:9, pages 2251-2256.
Crossref
Emi Kimoto, Yi-An Bi, Rachel E. Kosa, Larry M. Tremaine & Manthena V.S. Varma. (2017) Hepatobiliary Clearance Prediction: Species Scaling From Monkey, Dog, and Rat, and In Vitro–In Vivo Extrapolation of Sandwich-Cultured Human Hepatocytes Using 17 Drugs. Journal of Pharmaceutical Sciences 106:9, pages 2795-2804.
Crossref
Solène Marie, Salvatore Cisternino, Irène Buvat, Xavier Declèves & Nicolas Tournier. (2017) Imaging Probes and Modalities for the Study of Solute Carrier O (SLCO)-Transport Function In Vivo. Journal of Pharmaceutical Sciences 106:9, pages 2335-2344.
Crossref
Xiaoyan Chu, Grace Hoyee Chan & Raymond Evers. (2017) Identification of Endogenous Biomarkers to Predict the Propensity of Drug Candidates to Cause Hepatic or Renal Transporter-Mediated Drug-Drug Interactions. Journal of Pharmaceutical Sciences 106:9, pages 2357-2367.
Crossref
Anton Ivanyuk, Françoise Livio, Jérôme Biollaz & Thierry Buclin. (2017) Renal Drug Transporters and Drug Interactions. Clinical Pharmacokinetics 56:8, pages 825-892.
Crossref
Huangyu Jiang, Jia Yu, Haihui Zheng, Jiamei Chen, Jinjun Wu, Xiaoxiao Qi, Ying Wang, Xinchun Wang, Ming Hu, Lijun Zhu & Zhongqiu Liu. (2017) Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Regulate the Disposition of Acacetin Glucuronides. Pharmaceutical Research 34:7, pages 1402-1415.
Crossref
Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment 35 76 .
Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment 1 34 .
Charles S. Venuto, Marianthi Markatou, Yvonne Woolwine-Cunningham, Rosemary Furlage, Andrew J. Ocque, Robin DiFrancesco, Emily O. Dumas, Paul K. Wallace, Gene D. Morse & Andrew H. Talal. (2017) Paritaprevir and Ritonavir Liver Concentrations in Rats as Assessed by Different Liver Sampling Techniques. Antimicrobial Agents and Chemotherapy 61:5.
Crossref
Viktoriia Starokozhko, Suresh Vatakuti, Bauke Schievink, Marjolijn T. Merema, Annika Asplund, Jane Synnergren, Anders Aspegren & Geny M. M. Groothuis. (2016) Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days. Archives of Toxicology 91:5, pages 2079-2092.
Crossref
Heli Savolainen, Albert D Windhorst, Philip H Elsinga, Mariangela Cantore, Nicola A Colabufo, Antoon TM Willemsen & Gert Luurtsema. (2016) Evaluation of [ 18 F]MC225 as a PET radiotracer for measuring P-glycoprotein function at the blood–brain barrier in rats: Kinetics, metabolism, and selectivity . Journal of Cerebral Blood Flow & Metabolism 37:4, pages 1286-1298.
Crossref
Sumathy Mathialagan, Mary A. Piotrowski, David A. Tess, Bo Feng, John Litchfield & Manthena V. Varma. (2017) Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach. Drug Metabolism and Disposition 45:4, pages 409-417.
Crossref
Natasha Walker, Panagiotis Filis, Ugo Soffientini, Michelle Bellingham, Peter J O’Shaughnessy & Paul A Fowler. (2017) Placental transporter localization and expression in the Human: the importance of species, sex, and gestational age differences†. Biology of Reproduction 96:4, pages 733-742.
Crossref
Patrick E. Trapa, Kevin Beaumont, Karen Atkinson, Heather Eng, Amanda King-Ahmad, Dennis O. Scott, Tristan S. Maurer & Li Di. (2017) In Vitro – In Vivo Extrapolation of Intestinal Availability for Carboxylesterase Substrates Using Portal Vein–Cannulated Monkey. Journal of Pharmaceutical Sciences 106:3, pages 898-905.
Crossref
Charles S. Venuto & Andrew H. Talal. (2017) Intrahepatic Sampling for the Elucidation of Antiviral Clinical Pharmacology. Clinical Pharmacology in Drug Development 6:2, pages 169-175.
Crossref
Feifeng Song, Yongjun Hu, Huidi Jiang & David E. Smith. (2017) Species Differences in Human and Rodent PEPT2-Mediated Transport of Glycylsarcosine and Cefadroxil in Pichia Pastoris Transformants . Drug Metabolism and Disposition 45:2, pages 130-136.
Crossref
Janine C. Deddens, Amir Hossein Sadeghi, Jesper Hjortnaes, Linda W. van Laake, Marc Buijsrogge, Pieter A. Doevendans, Ali Khademhosseini & Joost P. G. Sluijter. (2017) Modeling the Human Scarred Heart In Vitro: Toward New Tissue Engineered Models. Advanced Healthcare Materials 6:3, pages 1600571.
Crossref
K. Samuelsson, N. Scheer, I. Wilson, C.R. Wolf & C.J. Henderson. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 130 149 .
M.P. Gleeson & D. Montanari. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 64 93 .
Giovanni Ugolini, Daniela Cruz-Moreira, Roberta Visone, Alberto Redaelli & Marco Rasponi. (2016) Microfabricated Physiological Models for In Vitro Drug Screening Applications. Micromachines 7:12, pages 233.
Crossref
Kevin A. Ford. (2017) Refinement, Reduction, and Replacement of Animal Toxicity Tests by Computational Methods. ILAR Journal 57:2, pages 226-233.
Crossref
Tom T.G. Nieskens & Martijn J. Wilmer. (2016) Kidney-on-a-chip technology for renal proximal tubule tissue reconstruction. European Journal of Pharmacology 790, pages 46-56.
Crossref
J. H. Chang, J. Chen, L. Liu, K. Messick & J. Ly. (2016) Rifampin-Mediated Induction of Tamoxifen Metabolism in a Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse Model. Drug Metabolism and Disposition 44:11, pages 1736-1741.
Crossref
Yoshiyuki Igawa, Seiya Fujiwara, Kayoko Ohura, Takatsugu Hirokawa, You Nishizawa, Shotaro Uehara, Yasuhiro Uno & Teruko Imai. (2016) Differences in Intestinal Hydrolytic Activities between Cynomolgus Monkeys and Humans: Evaluation of Substrate Specificities Using Recombinant Carboxylesterase 2 Isozymes. Molecular Pharmaceutics 13:9, pages 3176-3186.
Crossref
Douglas A. Grow, John R. McCarrey & Christopher S. Navara. (2016) Advantages of nonhuman primates as preclinical models for evaluating stem cell-based therapies for Parkinson's disease. Stem Cell Research 17:2, pages 352-366.
Crossref
John K. Fallon, Philip C. Smith, Cindy Q. Xia & Mi-Sook Kim. (2016) Quantification of Four Efflux Drug Transporters in Liver and Kidney Across Species Using Targeted Quantitative Proteomics by Isotope Dilution NanoLC-MS/MS. Pharmaceutical Research 33:9, pages 2280-2288.
Crossref
Annelaure Damont, Sébastien Goutal, Sylvain Auvity, Héric Valette, Bertrand Kuhnast, Wadad Saba & Nicolas Tournier. (2016) Imaging the impact of cyclosporin A and dipyridamole on P-glycoprotein (ABCB1) function at the blood-brain barrier: A [11C]-N-desmethyl-loperamide PET study in nonhuman primates. European Journal of Pharmaceutical Sciences 91, pages 98-104.
Crossref
Remigius U Agu. (2016) Challenges in nasal drug absorption: how far have we come?. Therapeutic Delivery 7:7, pages 495-510.
Crossref
João RibasHossein SadeghiAmir ManbachiJeroen LeijtenKatelyn BrinegarYu Shrike ZhangLino FerreiraAli Khademhosseini. (2016) Cardiovascular Organ-on-a-Chip Platforms for Drug Discovery and Development. Applied In Vitro Toxicology 2:2, pages 82-96.
Crossref
Shannon Dallas, Laurent Salphati, David Gomez-Zepeda, Thomas Wanek, Liangfu Chen, Xiaoyan Chu, Jeevan Kunta, Mario Mezler, Marie-Claude Menet, Stephanie Chasseigneaux, Xavier Declèves, Oliver Langer, Esaie Pierre, Karen DiLoreto, Carolin Hoft, Loic Laplanche, Jodie Pang, Tony Pereira, Clara Andonian, Damir Simic, Anja Rode, Jocelyn Yabut, Xiaolin Zhang & Nico Scheer. (2016) Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model. Molecular Pharmacology 89:5, pages 492-504.
Crossref
Yongjun Hu & David E. Smith. (2016) Species differences in the pharmacokinetics of cefadroxil as determined in wildtype and humanized PepT1 mice. Biochemical Pharmacology 107, pages 81-90.
Crossref
Christoffer Bundgaard, Elin Eneberg & Connie Sánchez. (2016) P-glycoprotein differentially affects escitalopram, levomilnacipran, vilazodone and vortioxetine transport at the mouse blood–brain barrier in vivo. Neuropharmacology 103, pages 104-111.
Crossref
Tom T. G. Nieskens, Janny G. P. Peters, Marieke J. Schreurs, Niels Smits, Rob Woestenenk, Katja Jansen, Thom K. van der Made, Melanie Röring, Constanze Hilgendorf, Martijn J Wilmer & Rosalinde Masereeuw. (2016) A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity. The AAPS Journal 18:2, pages 465-475.
Crossref
Ryan D. Sochol, Navin R. Gupta & Joseph V. Bonventre. (2016) A Role for 3D Printing in Kidney-on-a-Chip Platforms. Current Transplantation Reports 3:1, pages 82-92.
Crossref
Anaïs Michaut, Dounia Le Guillou, Caroline Moreau, Simon Bucher, Mitchell R. McGill, Sophie Martinais, Thomas Gicquel, Isabelle Morel, Marie-Anne Robin, Hartmut Jaeschke & Bernard Fromenty. (2016) A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen. Toxicology and Applied Pharmacology 292, pages 40-55.
Crossref
Nico Scheer & Ian D. Wilson. (2016) A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity. Drug Discovery Today 21:2, pages 250-263.
Crossref
J. Q. Dong, M. V. Varma, A. Wolford, T. Ryder, L. Di, B. Feng, S. G. Terra, K. Sagawa & A. S. Kalgutkar. (2015) Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans. Drug Metabolism and Disposition 44:2, pages 209-219.
Crossref
Yuan Feng, Changyuan Wang, Qi Liu, Qiang Meng, Xiaokui Huo, Zhihao Liu, Pengyuan Sun, Xiaobo Yang, Huijun Sun, Jianhua Qin & Kexin Liu. (2016) Bezafibrate–mizoribine interaction: Involvement of organic anion transporters OAT1 and OAT3 in rats. European Journal of Pharmaceutical Sciences 81, pages 119-128.
Crossref
Maria D. Donovan, Harriët Schellekens, Geraldine B. Boylan, John F. Cryan & Brendan T. Griffin. (2016) In vitro bidirectional permeability studies identify pharmacokinetic limitations of NKCC1 inhibitor bumetanide. European Journal of Pharmacology 770, pages 117-125.
Crossref
Li Di & Edward H. Kerns. 2016. Drug-Like Properties. Drug-Like Properties 113 140 .
Ivan Sabolić, Davorka Breljak & Tvrtko Smital. 2016. Organic Cation Transporters. Organic Cation Transporters 217 242 .
Selvi Durmus, Gloria Lozano-Mena, Anita van Esch, Els Wagenaar, Olaf van Tellingen & Alfred H. Schinkel. (2015) Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug–Drug Interactions in Vivo . Molecular Pharmaceutics 12:12, pages 4259-4269.
Crossref
Bridget L. Morse, Hong Cai, Jamus G. MacGuire, Maxine Fox, Lisa Zhang, Yueping Zhang, Xiaomei Gu, Hong Shen, Elizabeth A. Dierks, Hong Su, Chiuwa E. Luk, Punit Marathe, Yue-Zhong Shu, W. Griffith Humphreys & Yurong Lai. (2015) Rosuvastatin Liver Partitioning in Cynomolgus Monkeys: Measurement In Vivo and Prediction Using In Vitro Monkey Hepatocyte Uptake. Drug Metabolism and Disposition 43:11, pages 1788-1794.
Crossref

Displaying 200 of 228 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.