509
Views
26
CrossRef citations to date
0
Altmetric
Reviews

Improving the prediction of drug disposition in the brain

, &
Pages 473-486 | Published online: 08 Jan 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Abubakar Wani, Sweilem B. Al Rihani, Ankita Sharma, Brenna Weadick, Rajgopal Govindarajan, Sameer U. Khan, Parduman R. Sharma, Ashish Dogra, Utpal Nandi, Chilakala N Reddy, Sonali S Bharate, Gurdarshan Singh, Sandip B. Bharate, Ram A. Vishwakarma, Amal Kaddoumi & Ajay Kumar. (2021) Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway. Autophagy 17:11, pages 3813-3832.
Read now
Antonin Dréan, Lauriane Goldwirt, Maïté Verreault, Michael Canney, Charlotte Schmitt, Jeremy Guehennec, Jean-Yves Delattre, Alexandre Carpentier & Ahmed Idbaih. (2016) Blood-brain barrier, cytotoxic chemotherapies and glioblastoma. Expert Review of Neurotherapeutics 16:11, pages 1285-1300.
Read now

Articles from other publishers (24)

Anish Gomatam, Blessy Joseph, Ulka Gawde, Kavita Raikuvar & Evans Coutinho. (2022) Predicting toxicity of endocrine disruptors and blood–brain barrier permeability using chirality-sensitive descriptors and machine learning. Computational Toxicology 24, pages 100240.
Crossref
Tzu-Hui Yu, Bo-Han Su, Leo Chander Battalora, Sin Liu & Yufeng Jane Tseng. (2022) Ensemble modeling with machine learning and deep learning to provide interpretable generalized rules for classifying CNS drugs with high prediction power. Briefings in Bioinformatics 23:1.
Crossref
Margareta Hammarlund-Udenaes. 2022. Drug Delivery to the Brain. Drug Delivery to the Brain 173 209 .
Lili Liu, Li Zhang, Huawei Feng, Shimeng Li, Miao Liu, Jian Zhao & Hongsheng Liu. (2021) Prediction of the Blood–Brain Barrier (BBB) Permeability of Chemicals Based on Machine-Learning and Ensemble Methods. Chemical Research in Toxicology 34:6, pages 1456-1467.
Crossref
Ashley Ghiaseddin, Lan B Hoang Minh, Michalina Janiszewska, David Shin, Wolfgang Wick, Duane A Mitchell, Patrick Y Wen & Stuart A Grossman. (2021) Adult precision medicine: learning from the past to enhance the future. Neuro-Oncology Advances 3:1.
Crossref
Eugene V. Radchenko, Alina S. Dyabina & Vladimir A. Palyulin. (2020) Towards Deep Neural Network Models for the Prediction of the Blood–Brain Barrier Permeability for Diverse Organic Compounds. Molecules 25:24, pages 5901.
Crossref
Mayuri Gupta, Thomas Bogdanowicz, Mark A. Reed, Christopher J. Barden & Donald F. Weaver. (2019) The Brain Exposure Efficiency (BEE) Score. ACS Chemical Neuroscience 11:2, pages 205-224.
Crossref
Amit Jayaswal, Hirdyesh Mishra, Ankita Mishra & Kavita Shah. (2019) Examining pharmacodynamic and pharmacokinetic properties of eleven analogues of saquinavir for HIV protease inhibition. Archives of Virology 164:4, pages 949-960.
Crossref
Bryan G. Harder, Mylan R. Blomquist, Junwen Wang, Anthony J. Kim, Graeme F. Woodworth, Jeffrey A. Winkles, Joseph C. Loftus & Nhan L. Tran. (2018) Developments in Blood-Brain Barrier Penetrance and Drug Repurposing for Improved Treatment of Glioblastoma. Frontiers in Oncology 8.
Crossref
Yaxia Yuan, Fang Zheng & Chang-Guo Zhan. (2018) Improved Prediction of Blood–Brain Barrier Permeability Through Machine Learning with Combined Use of Molecular Property-Based Descriptors and Fingerprints. The AAPS Journal 20:3.
Crossref
Mariana Matias, Ana Fortuna, Joana Bicker, Samuel Silvestre, Amílcar Falcão & Gilberto Alves. (2017) Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)one derivatives using a combo of in vitro and in silico assays. European Journal of Pharmaceutical Sciences 109, pages 334-346.
Crossref
Didier Rognan. (2017) The impact of in silico screening in the discovery of novel and safer drug candidates. Pharmacology & Therapeutics 175, pages 47-66.
Crossref
E. V. Radchenko, G. F. Makhaeva, V. A. Palyulin & N. S. Zefirov. 2017. Computational Systems Pharmacology and Toxicology. Computational Systems Pharmacology and Toxicology 120 173 .
H. Tsui, Q. Zeng, K. Chen & X. Zhang. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 408 446 .
A. S. Dyabina, E. V. Radchenko, V. A. Palyulin & N. S. Zefirov. (2016) Prediction of blood-brain barrier permeability of organic compounds. Doklady Biochemistry and Biophysics 470:1, pages 371-374.
Crossref
Yan-Yan Zhang, Houfu Liu, Scott G. SummerfieldChristopher N. LuscombeJasminder Sahi. (2016) Integrating in Silico and in Vitro Approaches To Predict Drug Accessibility to the Central Nervous System . Molecular Pharmaceutics 13:5, pages 1540-1550.
Crossref
Yulan Wang, Jing Xing, Yuan Xu, Nannan Zhou, Jianlong Peng, Zhaoping Xiong, Xian Liu, Xiaomin Luo, Cheng Luo, Kaixian Chen, Mingyue Zheng & Hualiang Jiang. (2015) In silico ADME/T modelling for rational drug design . Quarterly Reviews of Biophysics 48:4, pages 488-515.
Crossref
Werner J Geldenhuys, Afroz S Mohammad, Chris E Adkins & Paul R Lockman. (2015) Molecular determinants of blood–brain barrier permeation. Therapeutic Delivery 6:8, pages 961-971.
Crossref
Michael D. Prados, Sara A. Byron, Nhan L. Tran, Joanna J. Phillips, Annette M. Molinaro, Keith L. Ligon, Patrick Y. Wen, John G. Kuhn, Ingo K. Mellinghoff, John F. de Groot, Howard Colman, Timothy F. Cloughesy, Susan M. Chang, Timothy C. Ryken, Waibhav D. Tembe, Jeffrey A. Kiefer, Michael E. Berens, David W. Craig, John D. Carpten & Jeffrey M. Trent. (2015) Toward precision medicine in glioblastoma: the promise and the challenges. Neuro-Oncology 17:8, pages 1051-1063.
Crossref
Timothy B. Durham & Maria-Jesus Blanco. (2015) Target Engagement in Lead Generation. Bioorganic & Medicinal Chemistry Letters 25:5, pages 998-1008.
Crossref
Daqing Zhang, Jianfeng Xiao, Nannan Zhou, Mingyue Zheng, Xiaomin Luo, Hualiang Jiang & Kaixian Chen. (2015) A Genetic Algorithm Based Support Vector Machine Model for Blood-Brain Barrier Penetration Prediction. BioMed Research International 2015, pages 1-13.
Crossref
Hee-Yeon Cho, Weijun Wang, Niyati Jhaveri, David Jungpa Lee, Natasha Sharma, Louis Dubeau, Axel H. Schönthal, Florence M. Hofman & Thomas C. Chen. (2014) NEO212, Temozolomide Conjugated to Perillyl Alcohol, Is a Novel Drug for Effective Treatment of a Broad Range of Temozolomide-Resistant Gliomas. Molecular Cancer Therapeutics 13:8, pages 2004-2017.
Crossref
Joana Bicker, Gilberto Alves, Ana Fortuna & Amílcar Falcão. (2014) Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review. European Journal of Pharmaceutics and Biopharmaceutics 87:3, pages 409-432.
Crossref
Margareta Hammarlund-Udenaes. 2014. Drug Delivery to the Brain. Drug Delivery to the Brain 127 161 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.