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Competency of different cell models to predict human hepatotoxic drugs

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Lei Cao, Huicun Zhao, Mengyuan Qian, Chuxiao Shao, Yan Zhang & Jun Yang. (2022) Construction of polysaccharide scaffold-based perfusion bioreactor supporting liver cell aggregates for drug screening. Journal of Biomaterials Science, Polymer Edition 33:17, pages 2249-2269.
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Maryam Mirahmad, Reyhaneh Sabourian, Mohammad Mahdavi, Bagher Larijani & Maliheh Safavi. (2022) In vitro cell-based models of drug-induced hepatotoxicity screening: progress and limitation. Drug Metabolism Reviews 54:2, pages 161-193.
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Han Li, Yu-Guang Wang, Zeng-Chun Ma, Gao Yun-Hang, Song Ling, Chen Teng-Fei, Zhang Guang-Ping & Yue Gao. (2021) A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction. Xenobiotica 51:7, pages 752-763.
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Petar D. Petrov, M. Leonor Fernández-Murga, Mireia López-Riera, M. José Goméz-Lechón, Jose V. Castell & Ramiro Jover. (2018) Predicting drug-induced cholestasis: preclinical models. Expert Opinion on Drug Metabolism & Toxicology 14:7, pages 721-738.
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Otto Kučera, René Endlicher, David Rychtrmoc, Halka Lotková, Ondřej Sobotka & Zuzana Červinková. (2017) Acetaminophen toxicity in rat and mouse hepatocytes in vitro. Drug and Chemical Toxicology 40:4, pages 448-456.
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Richard J. Weaver, Catherine Betts, Eric A.G. Blomme, Helga H.J. Gerets, Klaus Gjervig Jensen, Philip G. Hewitt, Satu Juhila, Gilles Labbe, Michael J. Liguori, Natalie Mesens, Monday O. Ogese, Mikael Persson, Jan Snoeys, James L. Stevens, Tracy Walker & B. Kevin Park. (2017) Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology 13:7, pages 767-782.
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Maria Teresa Donato, Maria José Gómez-Lechón & Laia Tolosa. (2017) Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies. Expert Opinion on Drug Discovery 12:2, pages 201-211.
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M. José Gómez-Lechón, Laia Tolosa & M. Teresa Donato. (2017) Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing. Expert Opinion on Drug Metabolism & Toxicology 13:2, pages 137-148.
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Faiza Farhan, Manjari Trivedi, Priscilla Di Wu & Wei Cui. (2023) Extracellular matrix modulates the spatial hepatic features in hepatocyte-like cells derived from human embryonic stem cells. Stem Cell Research & Therapy 14:1.
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Eva Sanchez-Quant, Maria Lucia Richter, Maria Colomé-Tatché & Celia Pilar Martinez-Jimenez. (2023) Single-cell metabolic profiling reveals subgroups of primary human hepatocytes with heterogeneous responses to drug challenge. Genome Biology 24:1.
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V. N. Perfilova. (2023) Opportunities and Prospects for Preclinical Drug Safety Assessment Using Alternative Methods: Experience from the Toxicology in the 21st Century (Tox21) Programme in the USA. Safety and Risk of Pharmacotherapy.
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Kristin Beirow, Christian Schmidt, Britta Jürgen, Rabea Schlüter, Thomas Schweder & Patrick J. Bednarski. (2023) Investigation of TGF‐ α ‐overexpressing mouse hepatocytes (TAMH) cultured as spheroids for use in hepatotoxicity screening of drug candidates . Journal of Applied Toxicology.
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Tara J. Bowen, Andrew D. Southam, Andrew R. Hall, Ralf J. M. Weber, Gavin R. Lloyd, Ruth Macdonald, Amanda Wilson, Amy Pointon & Mark R. Viant. (2023) Simultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics. Nature Communications 14:1.
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Limei Li, Qingce Zang, Xinzhu Li, Ying Zhu, Shanjing Wen, Jiuming He, Ruiping Zhang & Zeper Abliz. (2023) Spatiotemporal pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids. Journal of Pharmaceutical Analysis 13:5, pages 483-493.
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Jingyu Fu, Hailong Qiu & Cherie S. Tan. (2023) Microfluidic Liver-on-a-Chip for Preclinical Drug Discovery. Pharmaceutics 15:4, pages 1300.
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