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Review

Tools for predicting the PK/PD of therapeutic proteins

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Rahul Khetan, Robin Curtis, Charlotte M. Deane, Johannes Thorling Hadsund, Uddipan Kar, Konrad Krawczyk, Daisuke Kuroda, Sarah A. Robinson, Pietro Sormanni, Kouhei Tsumoto, Jim Warwicker & Andrew C.R. Martin. (2022) Current advances in biopharmaceutical informatics: guidelines, impact and challenges in the computational developability assessment of antibody therapeutics. mAbs 14:1.
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Rachel H. Rose, Armin Sepp, Felix Stader, Katherine L. Gill, Cong Liu & Iain Gardner. (2022) Application of physiologically based pharmacokinetic models for therapeutic proteins and other novel modalities. Xenobiotica 52:8, pages 840-854.
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Miro J. Eigenmann, Ludivine Fronton, Hans Peter Grimm, Michael B. Otteneder & Ben-Fillippo Krippendorff. (2017) Quantification of IgG monoclonal antibody clearance in tissues. mAbs 9:6, pages 1007-1015.
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Ioannis P. Androulakis. (2022) Towards a comprehensive assessment of QSP models: what would it take?. Journal of Pharmacokinetics and Pharmacodynamics.
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Brendan T. Griffin, Jianfeng Guo, Elena Presas, Maria D. Donovan, Mar?a J. Alonso & Caitriona M. O'Driscoll. (2016) Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs. Advanced Drug Delivery Reviews 106, pages 367-380.
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Weirong Wang, Thomas S. McIntosh, Xiling Jiang, Rajitha Doddareddy, Elayne C. Dell & Honghui Zhou. (2015) Deciphering the In Vivo Performance of a Monoclonal Antibody to Neutralize Its Soluble Target at the Site of Action in a Mouse Collagen-Induced Arthritis Model. Pharmaceutical Research 33:4, pages 1040-1049.
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