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Review

Abuse-deterrent formulations: part 1 – development of a formulation-based classification system

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Keep up to date with the latest research on this topic with citation updates for this article.

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David J. Mastropietro, Srinath Muppalaneni & Hossein Omidian. (2016) Deterred drug abuse using superabsorbent polymers. Expert Opinion on Drug Delivery 13:11, pages 1523-1531.
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Srinath Muppalaneni, David J. Mastropietro & Hossein Omidian. (2016) Crush resistance and insufflation potential of poly(ethylene oxide)-based abuse deterrent formulations. Expert Opinion on Drug Delivery 13:10, pages 1375-1382.
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Maciej Gasior, Mary Bond & Richard Malamut. (2016) Routes of abuse of prescription opioid analgesics: a review and assessment of the potential impact of abuse-deterrent formulations. Postgraduate Medicine 128:1, pages 85-96.
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Articles from other publishers (18)

Golam Kibria, Bandaranayake Bandaranayake, Jiwen Zheng, Sau Lee & Celia Cruz. (2023) Stability of Abuse-deterrent properties of PEO-based Abuse-deterrent formulation. International Journal of Pharmaceutics 631, pages 122430.
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Dhwani Rana, Sagar Salave & Derajram Benival. (2022) Emerging Trends in Abuse-Deterrent Formulations: Technological Insights and Regulatory Considerations. Current Drug Delivery 19:8, pages 846-859.
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Mori Dhaval, Shweta Sharma, Kiran Dudhat & Jayant Chavda. (2020) Twin-Screw Extruder in Pharmaceutical Industry: History, Working Principle, Applications, and Marketed Products: an In-depth Review. Journal of Pharmaceutical Innovation 17:2, pages 294-318.
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Parmita Phaugat, Suchitra Nishal & Rakhi Dhiman. (2022) Abuse-Deterrent Formulations in Constraining the Abuse Potential of Prescription Medicines: A Myth or Truth. Current Drug Delivery 19:4, pages 466-478.
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Ankit Soni, Anuja Paprikar & Senshang Lin. (2021) Effect of alkalizing agent on abuse deterrent potential of multiple-unit ingestion of bilayer abuse-deterrent extended-release tablets using propranolol as model drug for opioids overdose crisis. International Journal of Pharmaceutics 600, pages 120480.
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Siddhant Palekar, Pavan Kumar Nukala, Richa Vartak & Ketan Patel. (2020) Abuse deterrent immediate release film technology (ADRIFT): A novel bilayer film technology for limiting intentional drug abuse. International Journal of Pharmaceutics 590, pages 119944.
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Saikishore Meruva, Leyla Rezaei, Prajwal Thool & Maureen D. Donovan. (2020) Use of Drug Release Testing to Evaluate the Retention of Abuse-Deterrent Properties of Polyethylene Oxide Matrix Tablets. AAPS PharmSciTech 21:7.
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Jun Jie Ong, Atheer Awad, Annalisa Martorana, Simon Gaisford, Edmont Stoyanov, Abdul W. Basit & Alvaro Goyanes. (2020) 3D printed opioid medicines with alcohol-resistant and abuse-deterrent properties. International Journal of Pharmaceutics 579, pages 119169.
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Saikishore Meruva & Maureen D. Donovan. (2019) Effects of Drug-Polymer Interactions on Tablet Properties During the Development of Abuse-Deterrent Dosage Forms. AAPS PharmSciTech 20:3.
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Miroslav Veverka, Tibor Dubaj, Eva Veverková, Peter Šimon, Štefan Husár, Katarína Tomanová & Vladimír Jorík. (2019) Beta-glucan and arabinogalactan-based xerogels for abuse-deterrent opioid formulations. European Journal of Pharmaceutical Sciences 129, pages 132-139.
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Zhen Li & Xiangyu Gao. (2018) RETRACTED ARTICLE: Research on the Method of Music Content Analysis Based on Fuzzy Classification. Wireless Personal Communications 102:2, pages 1949-1962.
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Yogesh Joshi, Srinath Muppalaneni, Alborz Omidian, David Jude Mastropietro & Hamid Omidian. (2018) Determining Abuse Deterrence Performance of Poly (ethylene oxide) Using a Factorial Design. Advanced Pharmaceutical Bulletin 8:3, pages 495-505.
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Thien C. Pham, Courtney Kominek, Abigail Brooks & Jeffrey Fudin. 2018. The American Society of Addiction Medicine Handbook on Pain and Addiction. The American Society of Addiction Medicine Handbook on Pain and Addiction 163 173 .
Martin E Hale, Derek Moe, Mary Bond, Maciej Gasior & Richard Malamut. (2016) Abuse-deterrent formulations of prescription opioid analgesics in the management of chronic noncancer pain. Pain Management 6:5, pages 497-508.
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Carmen Walter, Claudia Knothe & Jörn Lötsch. (2015) Abuse-Deterrent Opioid Formulations: Pharmacokinetic and Pharmacodynamic Considerations. Clinical Pharmacokinetics 55:7, pages 751-767.
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Xiaoming Xu, Abhay Gupta, Manar Al-Ghabeish, Silvia N. Calderon & Mansoor A. Khan. (2016) Risk based in vitro performance assessment of extended release abuse deterrent formulations. International Journal of Pharmaceutics 500:1-2, pages 255-267.
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Icilio Cavero & Henry Holzgrefe. (2015) 14th Annual Meeting of the Safety Pharmacology Society: Threading through peripheral and central nervous system presentations. Journal of Pharmacological and Toxicological Methods 75, pages 143-157.
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Kaoru Toyama, Naoki Uchida, Hitoshi Ishizuka, Takehiko Sambe & Shinichi Kobayashi. (2015) Single-dose evaluation of safety, tolerability and pharmacokinetics of newly formulated hydromorphone immediate-release and hydrophilic matrix extended-release tablets in healthy Japanese subjects without co-administration of an opioid antagonist. The Journal of Clinical Pharmacology 55:9, pages 975-984.
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