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Review

New insights in the biology of ABC transporters ABCC2 and ABCC3: impact on drug disposition

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Tsvetelin Lukanov, Milena Ivanova, Petya Yankova, Bushra Al Hadra, Anastasiya Mihaylova, Marianka Genova, Dobrin Svinarov & Elisaveta Naumova. (2022) Impact of CYP3A7, CYP2D6 and ABCC2/ABCC3 polymorphisms on tacrolimus steady state concentrations in Bulgarian kidney transplant recipients. Biotechnology & Biotechnological Equipment 36:1, pages 362-369.
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Henrike Bruckmueller & Ingolf Cascorbi. (2021) ABCB1, ABCG2, ABCC1, ABCC2, and ABCC3 drug transporter polymorphisms and their impact on drug bioavailability: what is our current understanding?. Expert Opinion on Drug Metabolism & Toxicology 17:4, pages 369-396.
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Cornelis Smit, Sjoerd De Hoogd, Roger J.M. Brüggemann & Catherijne A. J. Knibbe. (2018) Obesity and drug pharmacology: a review of the influence of obesity on pharmacokinetic and pharmacodynamic parameters. Expert Opinion on Drug Metabolism & Toxicology 14:3, pages 275-285.
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David E. Amacher. (2016) The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors. Expert Opinion on Drug Metabolism & Toxicology 12:12, pages 1463-1477.
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Valentin Tastet, Marc Le Vée, Arnaud Bruyère & Olivier Fardel. (2023) Interactions of human drug transporters with chemical additives present in plastics: Potential consequences for toxicokinetics and health. Environmental Pollution 331, pages 121882.
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EC Bernsen, LM Hanff, LM Haveman, BBJ Tops, M van der Lee, JJ Swen, ADR Huitema & MHM Diekstra. (2022) Genetic variants found in paediatric oncology patients with severe chemotherapy-induced toxicity: A case series. Journal of Oncology Pharmacy Practice 29:5, pages 1237-1245.
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Mariana B. Morais & Mariana Verdelho Machado. (2022) Benign inheritable disorders of bilirubin metabolism manifested by conjugated hyperbilirubinemia–A narrative review. United European Gastroenterology Journal 10:7, pages 745-753.
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Chenyu Zhao, Xiaoliu Shi, Yonghong Zhang & Hui Huang. (2022) Case Report: Three novel pathogenic ABCC2 mutations identified in two patients with Dubin–Johnson syndrome. Frontiers in Genetics 13.
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Karolina Seborova, Alzbeta Kloudova-Spalenkova, Kamila Koucka, Petr Holy, Marie Ehrlichova, Changwei Wang, Iwao Ojima, Iveta Voleska, Petr Daniel, Kamila Balusikova, Michael Jelinek, Jan Kovar, Lukas Rob, Martin Hruda, Marcela Mrhalova, Pavel Soucek & Radka Vaclavikova. (2021) The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes. International Journal of Molecular Sciences 23:1, pages 73.
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Thiago Dominguez Crespo Hirata, Carolina Dagli-Hernandez, Fabiana Dalla Vecchia Genvigir, Volker Martin Lauschke, Yitian Zhou, Mario Hiroyuki Hirata & Rosario Dominguez Crespo Hirata. (2021) Cardiovascular Pharmacogenomics: An Update on Clinical Studies of Antithrombotic Drugs in Brazilian Patients. Molecular Diagnosis & Therapy 25:6, pages 735-755.
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Alzbeta Kloudova‐Spalenkova, Petr Holy & Pavel Soucek. (2020) Oxysterols in cancer management: From therapy to biomarkers. British Journal of Pharmacology 178:16, pages 3235-3247.
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María Julia SeverinMaría Herminia HazelhoffRomina Paula BulacioMaría Eugenia MamprinAnabel BrandoniAdriana Mónica Torres. (2021) Erythropoietin alters the pharmacokinetics of organic anions mainly eliminated by the kidney in rats. Canadian Journal of Physiology and Pharmacology 99:4, pages 368-377.
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Michele Leuenberger, Stephanie Häusler, Vera Höhn, Adriana Euler, Bruno Stieger & Martin Lochner. (2021) Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters. Journal of Pharmacology and Experimental Therapeutics, pages JPET-AR-2020-000449.
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Mitchell S. Cairo, Kenneth R. Cooke, Hillard M. Lazarus & Nelson Chao. (2020) Modified diagnostic criteria, grading classification and newly elucidated pathophysiology of hepatic SOS/VOD after haematopoietic cell transplantation. British Journal of Haematology 190:6, pages 822-836.
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Marek Droździk, Stefan Oswald & Agnieszka Droździk. (2020) Extrahepatic Drug Transporters in Liver Failure: Focus on Kidney and Gastrointestinal Tract. International Journal of Molecular Sciences 21:16, pages 5737.
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Christian Kropf, Karl Fent, Stephan Fischer, Ayako Casanova & Helmut Segner. (2020) ABC transporters in gills of rainbow trout ( Oncorhynchus mykiss ) . Journal of Experimental Biology 223:15.
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Cheng Zeng, Dong Fan, Ying Xu, Xiaoju Li, Jiani Yuan, Qian Yang, Xuanxuan Zhou, Jianguo Lu, Cun Zhang, Jun Han, Jintao Gu, Yuan Gao, Lijuan Sun & Siwang Wang. (2020) Curcumol enhances the sensitivity of doxorubicin in triple-negative breast cancer via regulating the miR-181b-2-3p-ABCC3 axis. Biochemical Pharmacology 174, pages 113795.
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Zelin Sun, Xiaoyuan Qi & Yan Zhang. (2020) Bioinformatics Analysis of the Expression of ATP binding cassette subfamily C member 3 (ABCC3) in Human Glioma. Open Medicine 15:1, pages 107-113.
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Oliver Bruhn, Marie Lindsay, Friederike Wiebel, Meike Kaehler, Inga Nagel, Ruwen Böhm, Christian Röder & Ingolf Cascorbi. (2020) Alternative Polyadenylation of ABC Transporters of the C-Family (ABCC1, ABCC2, ABCC3) and Implications on Posttranscriptional Micro-RNA Regulation. Molecular Pharmacology 97:2, pages 112-122.
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Christophe Corpechot, Véronique Barbu, Olivier Chazouillères, Pierre Broué, Muriel Girard, Bertrand Roquelaure, Yves Chrétien, Catherine Dong, Olivier Lascols, Chantal Housset & Isabelle Jéru. (2019) Genetic contribution of ABCC2 to Dubin‐Johnson syndrome and inherited cholestatic disorders . Liver International 40:1, pages 163-174.
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Sara Brin Rosenthal, Kevin T. Bush & Sanjay K. Nigam. (2019) A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis. Scientific Reports 9:1.
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Amit Kumar & Vikas Jaitak. (2019) Natural products as multidrug resistance modulators in cancer. European Journal of Medicinal Chemistry 176, pages 268-291.
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Timothy Ackerson, Alexander Amberg, Jens Atzrodt, Catherine Arabeyre, Elisabeth Defossa, Martina Dorau, Angela Dudda, Jacquelyn Dwyer, Wolfgang Holla, Thomas Kissner, Markus Kohlmann, Ulrich Kürzel, József Pánczél, Shibani Rajanna, Jens Riedel, Friedemann Schmidt, Kerstin Wäse, Dietmar Weitz & Volker Derdau. (2019) Mechanistic investigations of the liver toxicity of the free fatty acid receptor 1 agonist fasiglifam (TAK875) and its primary metabolites. Journal of Biochemical and Molecular Toxicology 33:8.
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Carolina I. Ghanem & Jose E. Manautou. (2019) Modulation of Hepatic MRP3/ABCC3 by Xenobiotics and Pathophysiological Conditions: Role in Drug Pharmacokinetics. Current Medicinal Chemistry 26:7, pages 1185-1223.
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Joshua Gini, Adeniyi Olagunju, Laura Dickinson, Catriona Waitt, Megan Neary, Laura J Else, Marco Siccardi & Saye Khoo. (2019) Impact of pharmacogenetics and pregnancy on tenofovir and emtricitabine pharmacokinetics. Pharmacogenomics 20:4, pages 217-223.
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Angelica Macauda, Eleonora Castelli, Gabriele Buda, Matteo Pelosini, Aleksandra Butrym, Marzena Watek, Marcin Kruszewski, Annette Juul Vangsted, Marcin Rymko, Krzysztof Jamroziak, Niels Abildgaard, Eva Kannik Haastrup, Grzegorz Mazur, Rafael Ríos, Artur Jurczyszyn, Daria Zawirska, Marek Dudziński, Małgorzata Raźny, Magdalena Dutka, Waldemar Tomczak, Anna Suska, Agnieszka Druzd-Sitek, Herlander Marques, Mario Petrini, Miroslaw Markiewicz, Joaquin Martinez-Lopez, Lene Hyldahl Ebbesen, Elżbieta Iskierka-Jażdżewska, Juan Sainz, Federico Canzian & Daniele Campa. (2018) Inherited variation in the xenobiotic transporter pathway and survival of multiple myeloma patients. British Journal of Haematology 183:3, pages 375-384.
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P. Holy, A. Kloudova & P. Soucek. (2018) Importance of genetic background of oxysterol signaling in cancer. Biochimie 153, pages 109-138.
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Izna Ali, Jason R. Slizgi, Josh D. Kaullen, Marija Ivanovic, Mikko Niemi, Paul W. Stewart, Alfred S. BarrittIVIV & Kim L.R. Brouwer. (2018) Transporter-Mediated Alterations in Patients With NASH Increase Systemic and Hepatic Exposure to an OATP and MRP2 Substrate. Clinical Pharmacology & Therapeutics 104:4, pages 749-756.
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Na Liu, Guihua Yang, Mei Hu, Yuyu Cai, Zhiying Hu, Chundi Jia & Man Zhang. (2018) Association of ABCC2   polymorphism and gender with high-density lipoprotein cholesterol response to simvastatin . Pharmacogenomics 19:14, pages 1125-1132.
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Sarah Allegra, Giovanna Fatiguso, Silvia De Francia, Elisa Pirro, Chiara Carcieri, Jessica Cusato, Amedeo De Nicolò, Valeria Avataneo, Giovanni Di Perri & Antonio D'Avolio. (2018) Pharmacogenetic of voriconazole antifungal agent in pediatric patients. Pharmacogenomics 19:11, pages 913-925.
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Monicah A Otieno, Jan Snoeys, Wing Lam, Avi Ghosh, Mark R Player, Alessandro Pocai, Rhys Salter, Damir Simic, Hollie Skaggs, Bhanu Singh & Heng-Keang Lim. (2018) Fasiglifam (TAK-875): Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver Injury. Toxicological Sciences 163:2, pages 374-384.
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Simon Chewchuk, Tyler Boorman, Derek Edwardson & Amadeo M. Parissenti. (2018) Bile Acids Increase Doxorubicin Sensitivity in ABCC1-expressing Tumour Cells. Scientific Reports 8:1.
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J.E. Manautou & C.I. Ghanem. 2018. Comprehensive Toxicology. Comprehensive Toxicology 215 276 .
Bruno Stieger & Zainab M. Mahdi. (2017) Model Systems for Studying the Role of Canalicular Efflux Transporters in Drug-Induced Cholestatic Liver Disease. Journal of Pharmaceutical Sciences 106:9, pages 2295-2301.
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Kienana Muhrez, Bérenger Largeau, Patrick Emond, Frédéric Montigny, Jean-Michel Halimi, Patrick Trouillas & Chantal Barin-Le Guellec. (2017) Single nucleotide polymorphisms of ABCC2 modulate renal secretion of endogenous organic anions. Biochemical Pharmacology 140, pages 124-138.
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Wei Wang, Lorena Buitrago & Ying Wang. (2017) ABC transporters in megakaryopoiesis and platelet activity. Thrombosis Research 156, pages 126-133.
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Issey Takehara, Hanano Terashima, Takeshi Nakayama, Takashi Yoshikado, Miwa Yoshida, Kenichi Furihata, Nobuaki Watanabe, Kazuya Maeda, Osamu Ando, Yuichi Sugiyama & Hiroyuki Kusuhara. (2017) Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese Volunteers. Pharmaceutical Research 34:8, pages 1601-1614.
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Qiong-Ni Zhu, Wei-Yu Hou, Shang-Fu Xu, Yuan-Fu Lu & Jie Liu. (2017) Ontogeny, aging, and gender-related changes in hepatic multidrug resistant protein genes in rats. Life Sciences 170, pages 108-114.
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Barbara A. Roggenbeck, Mayukh Banerjee & Elaine M. Leslie. (2016) Cellular arsenic transport pathways in mammals. Journal of Environmental Sciences 49, pages 38-58.
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Tetsuhiro Yoshino, Haruka Nakamura, Megumi Sano, Yuko Horiba, Tomonori Nakamura & Kenji Watanabe. (2016) Elevated direct bilirubin: Possible predictors for pseudoaldosteronism: Case-control study. Traditional & Kampo Medicine 3:2, pages 174-176.
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Mingli Chen, Huancai Yin, Pengli Bai, Peng Miao, Xudong Deng, Yingxue Xu, Jun Hu & Jian Yin. (2016) ABC transporters affect the elimination and toxicity of CdTe quantum dots in liver and kidney cells. Toxicology and Applied Pharmacology 303, pages 11-20.
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K. Kato, Y. Hasegawa, K. Iwata, T. Ichikawa, T. Yahara, S. Tsuji, M. Sugiura & J.-i. Yamaguchi. (2016) Recommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion Studies. Drug Metabolism and Disposition 44:8, pages 1180-1183.
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Midrar AlHossiny, Linlin Luo, William R. Frazier, Noriko Steiner, Yuriy Gusev, Bhaskar Kallakury, Eric Glasgow, Karen Creswell, Subha Madhavan, Rakesh Kumar & Geeta Upadhyay. (2016) Ly6E/K Signaling to TGFβ Promotes Breast Cancer Progression, Immune Escape, and Drug Resistance. Cancer Research 76:11, pages 3376-3386.
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M. A. Csandl, G. Conseil & S. P. C. Cole. (2016) Cysteinyl Leukotriene Receptor 1/2 Antagonists Nonselectively Modulate Organic Anion Transport by Multidrug Resistance Proteins (MRP1-4). Drug Metabolism and Disposition 44:6, pages 857-866.
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Izabela Sadowska-Bartosz, Rafal Szewczyk, Lukasz Jaremko, Mariusz Jaremko & Grzegorz Bartosz. (2016) Anticancer agent 3-bromopyruvic acid forms a conjugate with glutathione. Pharmacological Reports 68:2, pages 502-505.
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Christoph G Dietrich. (2016) Molecular changes in hepatic metabolism and transport in cirrhosis and their functional importance. World Journal of Gastroenterology 22:1, pages 72.
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Shinya Matsuzaki, Kiyoshi Yoshino, Yutaka Ueda, Satoko Matsuzaki, Mamoru Kakuda, Akiko Okazawa, Tomomi Egawa-Takata, Eiji Kobayashi & Tadashi Kimura. (2015) Potential targets for ovarian clear cell carcinoma: a review of updates and future perspectives. Cancer Cell International 15:1.
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Elisabeta Baiceanu, Gianina Crisan, Felicia Loghin & Pierre Falson. (2015) Modulators of the human ABCC2: hope from natural sources?. Future Medicinal Chemistry 7:15, pages 2041-2063.
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