Advanced search
Publication Cover
Expert Opinion on Drug Metabolism & Toxicology Volume 12, 2016 - Issue 5
Submit an article Journal homepage
880
Views
27
CrossRef citations to date
0
Altmetric
Drug Evaluation

Overview of elagolix for the treatment of endometriosis

Gian Benedetto MelisClinica Ostetrica e Ginecologica, Dipartimento di Scienze Chirurgiche, Università di Cagliari, Cagliari, Italy;Clinica Ostetrica e Ginecologica, Azienda Ospedaliero Universitaria di Cagliari, Policlinico Duilio Casula, Monserrato, ItalyCorrespondence[email protected]
,
Manuela NeriClinica Ostetrica e Ginecologica, Dipartimento di Scienze Chirurgiche, Università di Cagliari, Cagliari, Italy;Clinica Ostetrica e Ginecologica, Azienda Ospedaliero Universitaria di Cagliari, Policlinico Duilio Casula, Monserrato, Italy
,
Valentina CordaClinica Ostetrica e Ginecologica, Dipartimento di Scienze Chirurgiche, Università di Cagliari, Cagliari, Italy;Clinica Ostetrica e Ginecologica, Azienda Ospedaliero Universitaria di Cagliari, Policlinico Duilio Casula, Monserrato, Italy
,
Maria Elena MaluneClinica Ostetrica e Ginecologica, Dipartimento di Scienze Chirurgiche, Università di Cagliari, Cagliari, Italy;Clinica Ostetrica e Ginecologica, Azienda Ospedaliero Universitaria di Cagliari, Policlinico Duilio Casula, Monserrato, Italy
,
Bruno PirasClinica Ostetrica e Ginecologica, Dipartimento di Scienze Chirurgiche, Università di Cagliari, Cagliari, Italy;Clinica Ostetrica e Ginecologica, Azienda Ospedaliero Universitaria di Cagliari, Policlinico Duilio Casula, Monserrato, Italy
,
Silvia PirarbaClinica Ostetrica e Ginecologica, Dipartimento di Scienze Chirurgiche, Università di Cagliari, Cagliari, Italy;Clinica Ostetrica e Ginecologica, Azienda Ospedaliero Universitaria di Cagliari, Policlinico Duilio Casula, Monserrato, Italy
,
Stefano GuerrieroClinica Ostetrica e Ginecologica, Dipartimento di Scienze Chirurgiche, Università di Cagliari, Cagliari, Italy;Clinica Ostetrica e Ginecologica, Azienda Ospedaliero Universitaria di Cagliari, Policlinico Duilio Casula, Monserrato, Italy
,
Marisa OrrùClinica Ostetrica e Ginecologica, Dipartimento di Scienze Chirurgiche, Università di Cagliari, Cagliari, Italy;Clinica Ostetrica e Ginecologica, Azienda Ospedaliero Universitaria di Cagliari, Policlinico Duilio Casula, Monserrato, Italy
,
Maurizio Nicola D’AlterioClinica Ostetrica e Ginecologica, Dipartimento di Scienze Chirurgiche, Università di Cagliari, Cagliari, Italy;Clinica Ostetrica e Ginecologica, Azienda Ospedaliero Universitaria di Cagliari, Policlinico Duilio Casula, Monserrato, Italy
,
Stefano AngioniClinica Ostetrica e Ginecologica, Dipartimento di Scienze Chirurgiche, Università di Cagliari, Cagliari, Italy;Clinica Ostetrica e Ginecologica, Azienda Ospedaliero Universitaria di Cagliari, Policlinico Duilio Casula, Monserrato, Italy
&
Anna Maria PaolettiClinica Ostetrica e Ginecologica, Dipartimento di Scienze Chirurgiche, Università di Cagliari, Cagliari, Italy;Clinica Ostetrica e Ginecologica, Azienda Ospedaliero Universitaria di Cagliari, Policlinico Duilio Casula, Monserrato, Italy
 show all
Pages 581-588 | Received 28 Dec 2015, Accepted 23 Mar 2016, Published online: 25 Apr 2016

Citations (27)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Vendy Zajec, Mislav Mikuš, Salvatore Giovanni Vitale, Maurizio Nicola D’alterio, Marija Gregov, Marko Jakov Šarić, Jose Carugno, Stefano Angioni & Mario Ćorić. (2022) Current status and challenges of drug development for hormonal treatment of endometriosis: a systematic review of randomized control trials. Gynecological Endocrinology 38:9, pages 713-720.
Read now
Mohamed Ali, Sara A.R.Ayman Al Hendy. (2021) Elagolix in the treatment of heavy menstrual bleeding associated with uterine fibroids in premenopausal women. Expert Review of Clinical Pharmacology 14:4, pages 427-437.
Read now
Manuela Neri, Gian Benedetto Melis, Elena Giancane, Valerio Vallerino, Monica Pilloni, Bruno Piras, Alessandro Loddo, Anna Maria Paoletti & Valerio Mais. (2019) Clinical Utility Of Elagolix As An Oral Treatment For Women With Uterine Fibroids: A Short Report On The Emerging Efficacy Data. International Journal of Women's Health 11, pages 535-546.
Read now
Mohamed Ali & Ayman Al-Hendy. (2018) Uterine fibroid therapy: the pharmacokinetic considerations. Expert Opinion on Drug Metabolism & Toxicology 14:9, pages 887-889.
Read now
Giuseppe Benagiano, Sun-Wei Guo, Paola Bianchi, Patrick Puttemans, Stephan Gordts, Felice Petraglia & Ivo Brosens. (2016) Pharmacologic treatment of the ovarian endometrioma. Expert Opinion on Pharmacotherapy 17:15, pages 2019-2031.
Read now

Articles from other publishers (22)

Cristina Huerga López, Alicia Gutiérrez Alagüero & Ignacio Cristóbal García. (2023) Abordaje de los miomas uterinos: aproximación al tratamiento médico. Medicina Clínica 161, pages S15-S21.
Crossref
Bahi ElbasuenyMaya Geerts, Emily C. Yang, Catherine Allaire, Paul J. Yong & Mohamed A. Bedaiwy. (2022) Medical treatments of endometriosis: a review. Reproductive and Developmental Medicine 7:3, pages 166-179.
Crossref
Yajie Hao, Zhong Feng, Xuhui Zhuang, Hao Teng & Guimin Zhang. (2023) UHPLC-MS/MS Method Development and Validation for the Genotoxic Impurities Trimethyl Phosphate and Triisopropyl Phosphate of Elagolix Sodium. Journal of Chromatographic Science.
Crossref
Pritesh Desai, Rohit Prajapati & Avani Chokshi. (2023) LC–MS-Compatible Chromatographic Method for Quantification of Potential Organic Impurities of Elagolix Sodium in Tablet Dosage Form with Identification of Major Degradation Products. Journal of AOAC International 106:3, pages 568-579.
Crossref
Xueni Zhong, Qianqian Lv, Qiyun Yong, Wenping Hu, Dan Li, Shuhui Ji, Liuyue Zhan, Wenbin Chen, Min Li, Jinsheng Lin & Cuirong Sun. (2023) Forced degradation studies of elagolix sodium with the implementation of high resolution LC-UV-PDA-MSn (n = 1,2,3…) and NMR structural elucidation. Journal of Pharmaceutical and Biomedical Analysis 224, pages 115198.
Crossref
Stefano Angioni, Francesca Congiu, Salvatore Giovanni Vitale, Maurizio Nicola D’Alterio, Antonio Noto, Giovanni Monni, Maria Laura Santoru, Vassilios Fanos, Federica Murgia & Luigi Atzori. (2023) Gas Chromatography–Mass Spectrometry (GC–MS) Metabolites Analysis in Endometriosis Patients: A Prospective Observational Translational Study. Journal of Clinical Medicine 12:3, pages 922.
Crossref
Angelos Daniilidis, Stefano Angioni, Stefano Di Michele, Konstantinos Dinas, Fani Gkrozou & Maurizio Nicola D’Alterio. (2022) Deep Endometriosis and Infertility: What Is the Impact of Surgery?. Journal of Clinical Medicine 11:22, pages 6727.
Crossref
Yue Li, Tongtong Xu, Mingdan Wang, Lili Jiang, Qifang Liu & Kuiran Liu. (2022) Concurrent Benign Metastasizing Leiomyoma in the Abdominal Wall and Pelvic Cavity: A Case Report and Review of the Literature. Frontiers in Surgery 9.
Crossref
Marilina Casais, Ana Sofia Zabala & Edgardo D. Rolla. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 125 138 .
Chiho Miyagawa, Kosuke Murakami, Takako Tobiume, Takafumi Nonogaki & Noriomi Matsumura. (2021) Characterization of patients that can continue conservative treatment for adenomyosis. BMC Women's Health 21:1.
Crossref
Maurizio Nicola D’Alterio, Stefania Saponara, Mirian Agus, Antonio Simone Laganà, Marco Noventa, Emanuela Stochino Loi, Anis Feki & Stefano Angioni. (2021) Medical and surgical interventions to improve the quality of life for endometriosis patients: a systematic review. Gynecological Surgery 18:1.
Crossref
Maurizio N. D’ALTERIO, Carlotta GIULIANI, Francesco SCICCHITANO, Antonio S. LAGANÀ, Noemi M. OLTOLINA, Felice SORRENTINO, Luigi NAPPI, Germano ORRÙ & Stefano ANGIONI. (2021) Possible role of microbiome in the pathogenesis of endometriosis. Minerva Obstetrics and Gynecology 73:2.
Crossref
Sonali S. Bharate. (2021) Recent developments in pharmaceutical salts: FDA approvals from 2015 to 2019. Drug Discovery Today 26:2, pages 384-398.
Crossref
Ahmed Samy, Ayman Taher, Sileem A. Sileem, Ahmed Mohamed Abdelhakim, Mohamed Fathi, Hisham Haggag, Khaled Ashour, Shady Abdelsattar Ahmed, Mohammad Abrar Shareef, Abdulhadi A. AlAmodi, Nawal Hamdy Ahmed Keshta, Hanan Barakat Abu Elyazid Shatat, Doaa M. Salah, Ahmed Said Ali, Eman Abdel Monem El Kattan & Moutaz Elsherbini. (2021) Medical therapy options for endometriosis related pain, which is better? A systematic review and network meta-analysis of randomized controlled trials. Journal of Gynecology Obstetrics and Human Reproduction 50:1, pages 101798.
Crossref
Serdar E Bulun, Bahar D Yilmaz, Christia Sison, Kaoru Miyazaki, Lia Bernardi, Shimeng Liu, Amanda Kohlmeier, Ping Yin, Magdy Milad & JianJun Wei. (2019) Endometriosis. Endocrine Reviews 40:4, pages 1048-1079.
Crossref
Paolo Vercellini, Paola Viganò, Giussy Barbara, Laura Buggio, Edgardo Somigliana, Giorgio Aimi, Daniela Alberico, Giussy Barbàra, Laura Benaglia, Nicola Berlanda, Alessandra Borghi, Laura Buggio, Andrea Busnelli, Olga De Giorgi, Agnese Donati, Dhouha Dridi, Marilena Farella, Maria Pina Frattaruolo, Umberto Gattei, Caterina Lazzari, Irma Marconi, Ermelinda Monti, Federica Ottolini, Elena Roncella, Edgardo Somigliana, Anna Uglietti, Vercellini Paolo & Paola Viganò. (2019) Elagolix for endometriosis: all that glitters is not gold. Human Reproduction 34:2, pages 193-199.
Crossref
Simone Ferrero, Fabio Barra & Umberto Leone Roberti Maggiore. (2018) Current and Emerging Therapeutics for the Management of Endometriosis. Drugs 78:10, pages 995-1012.
Crossref
Seon-Mi Kim, Minhee Lee, So Young Lee, Soo-Min Lee, Eun Jeong Kim, Jae Sun Kim, Jihyae Ann, Jiyoun Lee & Jeewoo Lee. (2018) Synthesis and biological evaluation of 3-(2-aminoethyl) uracil derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists. European Journal of Medicinal Chemistry 145, pages 413-424.
Crossref
Feng-Ling Tukun, Dag Olberg, Patrick Riss, Ira Haraldsen, Anita Kaass & Jo Klaveness. (2017) Recent Development of Non-Peptide GnRH Antagonists. Molecules 22:12, pages 2188.
Crossref
N. B. Watts. (2017) Adverse bone effects of medications used to treat non-skeletal disorders. Osteoporosis International 28:10, pages 2741-2746.
Crossref
Pontis Alessandro, Nappi Luigi, Sorrentino Felice, Paoletti Anna Maria, Melis Gian Benedetto & Angioni Stefano. (2017) Research development of a new GnRH antagonist (Elagolix) for the treatment of endometriosis: a review of the literature. Archives of Gynecology and Obstetrics 295:4, pages 827-832.
Crossref
Mohamed A. Bedaiwy, Sukinah Alfaraj, Paul Yong & Robert Casper. (2017) New developments in the medical treatment of endometriosis. Fertility and Sterility 107:3, pages 555-565.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.