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Review

Intestinal UGTs as potential modifiers of pharmacokinetics and biological responses to drugs and xenobiotics

Pages 93-107 | Published online: 01 Feb 2007

Keep up to date with the latest research on this topic with citation updates for this article.

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Saeed Alqahtani, Ishfaq Bukhari, Ahmed Albassam & Maha Alenazi. (2018) An update on the potential role of intestinal first-pass metabolism for the prediction of drug–drug interactions: the role of PBPK modeling. Expert Opinion on Drug Metabolism & Toxicology 14:6, pages 625-634.
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Takako Furukawa, Yoichi Naritomi, Kazuhiro Tetsuka, Fumihiro Nakamori, Hiroyuki Moriguchi, Katsuhiro Yamano, Shigeyuki Terashita, Kenji Tabata & Toshio Teramura. (2014) Species differences in intestinal glucuronidation activities between humans, rats, dogs and monkeys. Xenobiotica 44:3, pages 205-216.
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Satya Prakash Tripathi, Anuseema Bhadauriya, Abhijeet Patil & Abhay T. Sangamwar. (2013) Substrate selectivity of human intestinal UDP-glucuronosyltransferases (UGTs): in silico and in vitro insights. Drug Metabolism Reviews 45:2, pages 231-252.
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Takako Furukawa, Katsuhiro Yamano, Yoichi Naritomi, Kohichiro Tanaka, Shigeyuki Terashita & Toshio Teramura. (2012) Method for predicting human intestinal first-pass metabolism of UGT substrate compounds. Xenobiotica 42:10, pages 980-988.
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Chantal Guillemette, Eric Lévesque, Mario Harvey, Judith Bellemare & Vincent Menard. (2010) UGT genomic diversity: beyond gene duplication. Drug Metabolism Reviews 42:1, pages 24-44.
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Xin-Fang Zhai, Jing-Jing Fan, Yang Yi, Meng Zhang, Xia Yuan, Xue Qiao, Lei Liang & Min Ye. (2023) Collaborative modification strategy to develop a highly selective fluorescent probe for human UDP-glucuronosyltransferase 1A10. Chemical Engineering Journal 463, pages 142382.
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Zhe Wang, Lili Jiang, Xiaoyu Wang, Hang Yin, Zhen Wang, Xin Lv & Yong Liu. (2022) Cabozantinib Carries the Risk of Drug-Drug Interactions via Inhibition of UDPglucuronosyltransferase (UGT) 1A9 . Current Drug Metabolism 23:11, pages 912-919.
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Adam S. Darwich, Oliver J. Hatley, Andrés Olivares‐Morales, Farzaneh Salem, Alison Margolskee & Amin Rostami‐Hodjegan. 2022. Oral Drug Delivery for Modified Release Formulations. Oral Drug Delivery for Modified Release Formulations 65 86 .
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Zhe Wang, Xiaoyu Wang, Zhen Wang, Yaqin Jia, Yuyi Feng, Lili Jiang, Yangliu Xia, Jun Cao & Yong Liu. (2021) In vitro inhibition of human UDP-glucuronosyltransferase (UGT) 1A1 by osimertinib, and prediction of in vivo drug-drug interactions. Toxicology Letters 348, pages 10-17.
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Sheila Annie Peters. 2021. Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations. Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations 263 292 .
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Yi Kuang, Yue Chai, Lulu Xu, Zilong Wang, Lei Liang, Xue Qiao & Min Ye. (2021) Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin. European Journal of Pharmaceutical Sciences 161, pages 105786.
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Wamidh H. Talib, Ahmad Riyad Alsayed, Faten Farhan & Lina T. Al Kury. (2020) Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets. Molecules 25:18, pages 4282.
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Michael S. LittleSamuel J. PellockWilliam G. WaltonAshutosh TripathyMatthew R. Redinbo. (2017) Structural basis for the regulation of β-glucuronidase expression by human gut Enterobacteriaceae. Proceedings of the National Academy of Sciences 115:2.
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Takanori Akazawa, Yasuo Uchida, Eisuke Miyauchi, Masanori Tachikawa, Sumio Ohtsuki & Tetsuya Terasaki. (2017) High Expression of UGT1A1/1A6 in Monkey Small Intestine: Comparison of Protein Expression Levels of Cytochromes P450, UDP-Glucuronosyltransferases, and Transporters in Small Intestine of Cynomolgus Monkey and Human. Molecular Pharmaceutics 15:1, pages 127-140.
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Shingo Oda, Tatsuki Fukami, Tsuyoshi Yokoi & Miki Nakajima. (2015) A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development. Drug Metabolism and Pharmacokinetics 30:1, pages 30-51.
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Yoichi Naritomi, Fumihiro Nakamori, Takako Furukawa & Kenji Tabata. (2015) Prediction of hepatic and intestinal glucuronidation using in vitro–in vivo extrapolation. Drug Metabolism and Pharmacokinetics 30:1, pages 21-29.
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Brandon T. Gufford, Gang Chen, Philip Lazarus, Tyler N. Graf, Nicholas H. Oberlies & Mary F. Paine. (2014) Identification of Diet-Derived Constituents as Potent Inhibitors of Intestinal Glucuronidation. Drug Metabolism and Disposition 42:10, pages 1675-1683.
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Irene Pereira de Sousa & Andreas Bernkop-Schnürch. (2014) Pre-systemic metabolism of orally administered drugs and strategies to overcome it. Journal of Controlled Release 192, pages 301-309.
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