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Review

Irregular gastrointestinal drug absorption in Parkinson's disease

, MD PhD & , PhD
Pages 193-203 | Published online: 05 Feb 2008

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Michael M. Lipp, Anthony J. Hickey, Robert Langer & Peter A. LeWitt. (2021) A technology evaluation of CVT-301 (Inbrija): an inhalable therapy for treatment of Parkinson’s disease. Expert Opinion on Drug Delivery 18:11, pages 1559-1569.
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Fabrizio Stocchi, Laura Vacca, Paola Stirpe & Margherita Torti. (2018) Pharmacokinetic drug evaluation of CVT-301 for the treatment of Parkinson’s disease. Expert Opinion on Drug Metabolism & Toxicology 14:12, pages 1189-1195.
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Nicola Tambasco, Simone Simoni, Pasquale Nigro, Federico Paolini Paoletti, Erica Marsili & Paolo Calabresi. (2016) Morning akinesia in Parkinson's disease: challenges and solutions. Journal of Parkinsonism and Restless Legs Syndrome 6, pages 57-63.
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David Salat-Foix & Oksana Suchowersky. (2012) The management of gastrointestinal symptoms in Parkinson’s disease. Expert Review of Neurotherapeutics 12:2, pages 239-248.
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S. Demartis, G. Rassu, V. Mazzarello, E. Larrañeta, A. Hutton, R.F. Donnelly, A. Dalpiaz, M. Roldo, A.J. Guillot, A. Melero, P. Giunchedi & E. Gavini. (2023) Delivering hydrosoluble compounds through the skin: what are the chances?. International Journal of Pharmaceutics 646, pages 123457.
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Yehuda Arav & Assaf Zohar. (2023) Model-based optimization of controlled release formulation of levodopa for Parkinson’s disease. Scientific Reports 13:1.
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Rajesh Pahwa, Fernando L. Pagan, Daniel E. Kremens & Marie Saint-Hilaire. (2023) Clinical Use of On-Demand Therapies for Patients with Parkinson’s Disease and OFF Periods. Neurology and Therapy 12:4, pages 1033-1049.
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Jacob E Earp, Cristina Colon-Semenza & Dara L LoBuono. (2023) Considerations for developing a targeted amino acid supplement for people with Parkinson’s disease that promotes health while accounting for pathophysiology and medication interference. Nutrition Reviews 81:8, pages 1063-1076.
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Zhe Zhong, Min Ye & Fuling Yan. (2023) A review of studies on gut microbiota and levodopa metabolism. Frontiers in Neurology 14.
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D. Woitalla, C. Buhmann, R. Hilker-Roggendorf, G. Höglinger, J. Koschel, T. Müller & D. Weise. (2023) Role of dopamine agonists in Parkinson's disease therapy. Journal of Neural Transmission 130:6, pages 863-873.
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Linda Molteni, Bruno Charlier, Viviana Izzo, Albino Coglianese, Valeria Conti, Roberto Eleopra, Roberto Cilia, Chiara Capelli, Annachiara D’Urso & Ugo de Grazia. (2023) Development and Validation of a New LC-MS/MS Bioanalytical Method for the Simultaneous Determination of Levodopa, Levodopa Methyl Ester, and Carbidopa in Human Plasma Samples. Molecules 28:11, pages 4264.
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Valentina Leta, Lisa Klingelhoefer, Katherine Longardner, Marta Campagnolo, Hafize Çotur Levent, Federico Aureli, Vinod Metta, Roongroj Bhidayasiri, Guy Chung‐Faye, Cristian Falup‐Pecurariu, Fabrizio Stocchi, Peter Jenner, Tobias Warnecke & K. Ray Chaudhuri. (2023) Gastrointestinal barriers to levodopa transport and absorption in Parkinson's disease. European Journal of Neurology 30:5, pages 1465-1480.
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Masahiro NAGAI, Satoshi TADA, Yuki YAMANISHI, Noriyuki MIYAUE & Rina ANDO. (2023) Differing Patterns of Diurnal Variation and Impact of Antacids on Levodopa Pharmacokinetics in Patients with Parkinson's Disease. Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 54:1, pages 3-8.
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Jocelyn J. Chang, Sanjay R.V. Gadi, Aleksandar Videnovic, Braden Kuo & Trisha S. Pasricha. (2023) Impact of outpatient gastroenterology consult on pharmacotherapy and management of gastrointestinal symptoms in Parkinson’s Disease. Clinical Parkinsonism & Related Disorders 9, pages 100215.
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Erik Wollmer & Sandra Klein. (2022) Patient-specific in vitro drug release testing coupled with in silico PBPK modeling to forecast the in vivo performance of oral extended-release levodopa formulations in Parkinson’s disease patients. European Journal of Pharmaceutics and Biopharmaceutics 180, pages 101-118.
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Roongroj Bhidayasiri, Warongporn Phuenpathom, Ai Huey Tan, Valentina Leta, Saisamorn Phumphid, K. Ray Chaudhuri & Pramod Kumar Pal. (2022) Management of dysphagia and gastroparesis in Parkinson’s disease in real-world clinical practice – Balancing pharmacological and non-pharmacological approaches. Frontiers in Aging Neuroscience 14.
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Hellen Windolf, Rebecca Chamberlain, Jörg Breitkreutz & Julian Quodbach. (2022) 3D Printed Mini-Floating-Polypill for Parkinson’s Disease: Combination of Levodopa, Benserazide, and Pramipexole in Various Dosing for Personalized Therapy. Pharmaceutics 14:5, pages 931.
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Glenardi Glenardi, Tutwuri HandayaniJimmy BarusGhea Mangkuliguna. (2022) Inhaled Levodopa (CVT-301) for the Treatment of Parkinson Disease. Neurology Clinical Practice 12:2, pages 139-148.
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Joji Fujikawa, Ryoma Morigaki, Nobuaki Yamamoto, Teruo Oda, Hiroshi Nakanishi, Yuishin Izumi & Yasushi Takagi. (2022) Therapeutic Devices for Motor Symptoms in Parkinson’s Disease: Current Progress and a Systematic Review of Recent Randomized Controlled Trials. Frontiers in Aging Neuroscience 14.
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Arshad Mahmood, Alia Erum, Sophia Mumtaz, Ume Ruqia Tulain, Nadia Shamshad Malik & Mohammed S. Alqahtani. (2022) Preliminary Investigation of Linum usitatissimum Mucilage-Based Hydrogel as Possible Substitute to Synthetic Polymer-Based Hydrogels for Sustained Release Oral Drug Delivery. Gels 8:3, pages 170.
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Delaram Safarpour, Kaveh Sharzehi & Ronald F. Pfeiffer. (2022) Gastrointestinal Dysfunction in Parkinson’s Disease. Drugs 82:2, pages 169-197.
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Dag Nyholm & Wolfgang H. Jost. (2022) Levodopa–entacapone–carbidopa intestinal gel infusion in advanced Parkinson’s disease: real-world experience and practical guidance. Therapeutic Advances in Neurological Disorders 15, pages 175628642211080.
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Iryna Karaban, Nina Karasevych & Tetyana Hasiuk. (2021) Prospects of successful treatment of Parkinson's disease using apomorphine. Ageing & Longevity:4 2021, pages 1-26.
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Moslem Mansour Lakouraj, Masoume Rezaei & Vahid Hasantabar. (2021) Synthesis, characterization and in-vitro prolonged release of L-DOPA using a novel amphiphilic hydrogel based on sodium alginate-polypyrrole. International Journal of Biological Macromolecules 193, pages 609-618.
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I.M. Karaban, N.V. Karasevych & T.V. Hasiuk. (2021) Prospects for successful treatment of Parkinson’s disease with the use of apomorphine. INTERNATIONAL NEUROLOGICAL JOURNAL 17:4, pages 54-73.
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Manon Auffret, Vincent Meuric, Emile Boyer, Martine Bonnaure-Mallet & Marc Vérin. (2021) Oral Health Disorders in Parkinson’s Disease: More than Meets the Eye. Journal of Parkinson's Disease 11:4, pages 1507-1535.
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Angelo Antonini, Per Odin, Rajesh Pahwa, Jason Aldred, Ali Alobaidi, Yash J. Jalundhwala, Pavnit Kukreja, Lars Bergmann, Sushmitha Inguva, Yanjun Bao & K. Ray Chaudhuri. (2021) The Long-Term Impact of Levodopa/Carbidopa Intestinal Gel on ‘Off’-time in Patients with Advanced Parkinson’s Disease: A Systematic Review. Advances in Therapy 38:6, pages 2854-2890.
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Bart Hens, Patrick Augustijns, Hans Lennernäs, Mark McAllister & Bertil Abrahamsson. (2021) Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare. Frontiers in Medicine 8.
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Kathryn A. Chung & Ronald F. Pfeiffer. (2020) Gastrointestinal dysfunction in the synucleinopathies. Clinical Autonomic Research 31:1, pages 77-99.
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Emma McAlister, Bridie Dutton, Lalitkumar K. Vora, Li Zhao, Anastasia Ripolin, Dk Siti Zawanah Binti Pg Hj Zahari, Helen L. Quinn, Ismaiel A. Tekko, Aaron J. Courtenay, Stephen A. Kelly, Aoife M. Rodgers, Lilach Steiner, Galit Levin, Etgar Levy‐Nissenbaum, Nava Shterman, Helen O. McCarthy & Ryan F. Donnelly. (2020) Directly Compressed Tablets: A Novel Drug‐Containing Reservoir Combined with Hydrogel‐Forming Microneedle Arrays for Transdermal Drug Delivery. Advanced Healthcare Materials 10:3.
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Li-Fei Zheng, Sumei Liu, Li Zhou, Xiao-Li Zhang, Xiao Yu & Jin-Xia Zhu. 2021. Dopamine in the Gut. Dopamine in the Gut 133 202 .
R. Alberto Travagli, Kirsteen N. Browning & Michael Camilleri. (2020) Parkinson disease and the gut: new insights into pathogenesis and clinical relevance. Nature Reviews Gastroenterology & Hepatology 17:11, pages 673-685.
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M. Senek, D. Nyholm & E. I. Nielsen. (2020) Population pharmacokinetics of levodopa gel infusion in Parkinson’s disease: effects of entacapone infusion and genetic polymorphism. Scientific Reports 10:1.
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Hakan Runvik, Alexander Medvedev & Maria C. Kjellsson. (2020) Impulsive Feedback Modeling of Levodopa Pharmacokinetics Subject to Intermittently Interrupted Gastric Emptying * . Impulsive Feedback Modeling of Levodopa Pharmacokinetics Subject to Intermittently Interrupted Gastric Emptying * .
Ronald F. Pfeiffer, Stuart H. Isaacson & Rajesh Pahwa. (2020) Clinical implications of gastric complications on levodopa treatment in Parkinson's disease. Parkinsonism & Related Disorders 76, pages 63-71.
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Jade Kenna & Ryan S. Anderton. 2020. Genetics, Neurology, Behavior, and Diet in Parkinson's Disease. Genetics, Neurology, Behavior, and Diet in Parkinson's Disease 569 582 .
Peter A. LeWitt, Nir Giladi & Nadav Navon. (2019) Pharmacokinetics and efficacy of a novel formulation of carbidopa-levodopa (Accordion Pill®) in Parkinson's disease. Parkinsonism & Related Disorders 65, pages 131-138.
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Cheol Min Shin, Yoon Jin Lee, Jong-Min Kim, Jee Young Lee, Kyung-Joon Kim, Yoon Jin Choi, Nayoung Kim & Dong Ho Lee. (2018) DA-9701 on gastric motility in patients with Parkinson's disease: A randomized controlled trial. Parkinsonism & Related Disorders 54, pages 84-89.
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Hana You, Louise-Laure Mariani, Graziella Mangone, Delphine Le Febvre de Nailly, Fanny Charbonnier-Beaupel & Jean-Christophe Corvol. (2018) Molecular basis of dopamine replacement therapy and its side effects in Parkinson’s disease. Cell and Tissue Research 373:1, pages 111-135.
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Julia Staisch, Gene Bakis & John Nutt. (2018) A wrinkle in ON-time - A GI structural abnormality confounding levodopa therapy with Duodopa rescue; a case study. Parkinsonism & Related Disorders 50, pages 130-131.
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Ka Lun Lai, Yuan Fang, Hao Han, Qingqing Li, Shuai Zhang, Ho Yin Li, Shing Fung Chow, Tai Ning Lam & Wai Yip Thomas Lee. (2018) Orally-dissolving film for sublingual and buccal delivery of ropinirole. Colloids and Surfaces B: Biointerfaces 163, pages 9-18.
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Erik Wollmer & Sandra Klein. (2017) A review of patient-specific gastrointestinal parameters as a platform for developing in vitro models for predicting the in vivo performance of oral dosage forms in patients with Parkinson’s disease. International Journal of Pharmaceutics 533:1, pages 298-314.
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Aravind Mittur, Suneel Gupta & Nishit B. Modi. (2017) Pharmacokinetics of Rytary®, An Extended-Release Capsule Formulation of Carbidopa–Levodopa. Clinical Pharmacokinetics 56:9, pages 999-1014.
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Andrew Su, Rita Gandhy, Carrolee Barlow & George Triadafilopoulos. (2017) A practical review of gastrointestinal manifestations in Parkinson's disease. Parkinsonism & Related Disorders 39, pages 17-26.
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Harith Akram, Chengyuan Wu, Jonathan Hyam, Thomas Foltynie, Patricia Limousin, Enrico De Vita, Tarek Yousry, Marjan Jahanshahi, Marwan Hariz, Timothy Behrens, John Ashburner & Ludvic Zrinzo. (2017) l -Dopa responsiveness is associated with distinctive connectivity patterns in advanced Parkinson's disease . Movement Disorders 32:6, pages 874-883.
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Johan Virhammar & Dag Nyholm. (2016) Levodopa-carbidopa enteral suspension in advanced Parkinson’s disease: clinical evidence and experience. Therapeutic Advances in Neurological Disorders 10:3, pages 171-187.
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Louise Curley, Jordan Hinton, Cameron Marjoribanks, Ali Mirjalili, Julia Kennedy & Darren Svirskis. (2017) Magnetic Resonance Imaging to Visualize Disintegration of Oral Formulations. Journal of Pharmaceutical Sciences 106:3, pages 745-750.
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Stuart Isaacson, Mark Lew, William Ondo, Jean Hubble, Thomas Clinch & Fernando Pagan. (2016) Apomorphine Subcutaneous Injection for the Management of Morning Akinesia in Parkinson's Disease. Movement Disorders Clinical Practice 4:1, pages 78-83.
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Michael M. LippRichard BatyckyJerome MooreMika LeinonenMartin I. Freed. (2016) Preclinical and clinical assessment of inhaled levodopa for OFF episodes in Parkinson’s disease. Science Translational Medicine 8:360.
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Dee E. SilverRichard M. Trosch. (2016) Physicians' experience with RYTARY (carbidopa and levodopa) extended-release capsules in patients who have Parkinson disease. Neurology 86:14_supplement_1.
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Yasaman Kianirad & Tanya Simuni. (2016) Novel Approaches to Optimization of Levodopa Therapy for Parkinson’s Disease. Current Neurology and Neuroscience Reports 16:4.
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L. Epprecht, S. R. Schreglmann, O. Goetze, D. Woitalla, C. R. Baumann & D. Waldvogel. (2015) Unchanged gastric emptying and visceral perception in early Parkinson's disease after a high caloric test meal. Journal of Neurology 262:8, pages 1946-1953.
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