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The multicellular tumor spheroid model for high-throughput cancer drug discovery

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Pages 819-830 | Published online: 12 Jul 2012

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Kamila Duś-Szachniewicz, Katarzyna Gdesz-Birula & Grzegorz Rymkiewicz. (2022) Development and Characterization of 3D Hybrid Spheroids for the Investigation of the Crosstalk Between B-Cell Non-Hodgkin Lymphomas and Mesenchymal Stromal Cells. OncoTargets and Therapy 15, pages 683-697.
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Blaise Calpe & Werner J. Kovacs. (2020) High-throughput screening in multicellular spheroids for target discovery in the tumor microenvironment. Expert Opinion on Drug Discovery 15:8, pages 955-967.
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Gerhard Hamilton & Barbara Rath. (2019) Applicability of tumor spheroids for in vitro chemosensitivity assays. Expert Opinion on Drug Metabolism & Toxicology 15:1, pages 15-23.
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Sabah Haq, Vanessa Samuel, Fiona Haxho, Roman Akasov, Maria Leko, Sergey V Burov, Elena Markvicheva & Myron R Szewczuk. (2017) Sialylation facilitates self-assembly of 3D multicellular prostaspheres by using cyclo-RGDfK(TPP) peptide. OncoTargets and Therapy 10, pages 2427-2447.
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Manpreet Sambi, Sabah Haq, Vanessa Samuel, Bessi Qorri, Fiona Haxho, Kelli Hill, William Harless & Myron R Szewczuk. (2017) Alternative therapies for metastatic breast cancer: multimodal approach targeting tumor cell heterogeneity. Breast Cancer: Targets and Therapy 9, pages 85-93.
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Melani A. Solomon, Jenkins Lemera & Gerard G. M. D’Souza. (2016) Development of an in vitro tumor spheroid culture model amenable to high-throughput testing of potential anticancer nanotherapeutics. Journal of Liposome Research 26:3, pages 246-260.
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Natalia J Martinez, Steven A Titus, Amanda K Wagner & Anton Simeonov. (2015) High-throughput fluorescence imaging approaches for drug discovery using in vitro and in vivo three-dimensional models. Expert Opinion on Drug Discovery 10:12, pages 1347-1361.
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Tim R Dargaville, Brett G Hollier, Ali Shokoohmand & Richard Hoogenboom. (2014) Poly(2-oxazoline) hydrogels as next generation three-dimensional cell supports. Cell Adhesion & Migration 8:2, pages 88-93.
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Keefe T. Chan, Stephen W. Jones, Hailey E. Brighton, Tao Bo, Shelly D. Cochran, Norman E. Sharpless & James E. Bear. (2013) Intravital imaging of a spheroid-based orthotopic model of melanoma in the mouse ear skin. IntraVital 2:2.
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