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Drug Discovery Case History

The discovery and development of vandetanib for the treatment of thyroid cancer

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Ling Li, Jingkui Yu, Shuhong Jiao, Wei Wang, Fen Zhang & Shiqing Sun. (2018) Vandetanib (ZD6474) induces antiangiogenesis through mTOR–HIF-1 alpha–VEGF signaling axis in breast cancer cells. OncoTargets and Therapy 11, pages 8543-8553.
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Zijun Huo, Shuang Yu, Shubin Hong, Xiaopei Cao, Lingling Xiu, Zhihong Liao, Yanbing Li & Haipeng Xiao. (2016) A systematic review and meta-analysis of the risk of diarrhea associated with vandetanib treatment in carcinoma patients. OncoTargets and Therapy 9, pages 3621-3631.
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Shuang Zhang, Min Yu & Yuquan Wei. (2014) Do anti-angiogenic cancer therapies increase risk of significant weight loss?. Expert Opinion on Drug Safety 13:4, pages 473-482.
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Naga Rajiv Lakkaniga, Naresh Gunaganti, Lingtian Zhang, Binyam Belachew, Brendan Frett, Yuet-Kin Leung & Hong-yu Li. (2020) Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation. European Journal of Medicinal Chemistry 206, pages 112691.
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Vivek Subbiah & Gilbert J. Cote. (2020) Advances in Targeting RET-Dependent Cancers. Cancer Discovery 10:4, pages 498-505.
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Rania S.M. Ismail, Sahar M. Abou-Seri, Wagdy M. Eldehna, Nasser S.M. Ismail, Sara M. Elgazwi, Hazem A. Ghabbour, Mahmoud Salama Ahmed, Fathi T. Halaweish & Dalal A. Abou El Ella. (2018) Novel series of 6-(2-substitutedacetamido)-4-anilinoquinazolines as EGFR-ERK signal transduction inhibitors in MCF-7 breast cancer cells. European Journal of Medicinal Chemistry 155, pages 782-796.
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Qin Xie, Hui Chen, Jing Ai, Ying-lei Gao, Mei-yu Geng, Jian Ding & Yi Chen. (2017) Evaluation of in vitro and in vivo activity of a multityrosine kinase inhibitor, AL3810, against human thyroid cancer. Acta Pharmacologica Sinica 38:11, pages 1533-1542.
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Timothy P. Heffron. (2016) Small Molecule Kinase Inhibitors for the Treatment of Brain Cancer. Journal of Medicinal Chemistry 59:22, pages 10030-10066.
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Sandra Lassalle, Joséphine Zangari, Alexandra Popa, Marius Ilie, Véronique Hofman, Elodie Long, Martine Patey, Frédérique Tissier, Geneviève Belléannée, Hélène Trouette, Bogdan Catargi, Isabelle Peyrottes, Jean-Louis Sadoul, Olivier Bordone, Christelle Bonnetaud, Catherine Butori, Alexandre Bozec, Nicolas Guevara, José Santini, Imène Sarah Hénaoui, Géraldine Lemaire, Olivier Blanck, Philippe Vielh, Pascal Barbry, Bernard Mari, Patrick Brest & Paul Hofman. (2016) MicroRNA-375/SEC23A as biomarkers of the in vitro efficacy of vandetanib . Oncotarget 7:21, pages 30461-30478.
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Tuo Li, Jianguo Sheng, Weiqin Li, Xin Zhang, Hongyu Yu, Xueyun Chen, Jianquan Zhang, Quancai Cai, Yongquan Shi & Zhimin Liu. (2015) A new computational model for human thyroid cancer enhances the preoperative diagnostic efficacy. Oncotarget 6:29, pages 28463-28477.
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D. Hartl. (2015) Tumori del corpo della tiroide. EMC - Otorinolaringoiatria 14:3, pages 1-12.
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D. Hartl. (2015) Tumores de la gl?ndula tiroidea. EMC - Otorrinolaringolog?a 44:3, pages 1-14.
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Huan‐gao Zhu, Jun‐yu Zhao, Rui Zhang, Lin Liao & Jian‐jun Dong. (2015) New agent to treat advanced or metastasized thyroid cancer, its efficacy, safety, and mechanism. Thoracic Cancer 6:4, pages 539-543.
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Robert RoskoskiJr.Jr.. (2015) Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors. Pharmacological Research 94, pages 9-25.
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