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Expert Opinion on Drug Discovery Volume 9, 2014 - Issue 3
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Current strategies for designing antidotes against botulinum neurotoxins

Kruti PatelUniversity of Massachusetts Dartmouth, Department of Chemistry and Biochemistry, North Dartmouth, MA 02747, USA
,
Shuowei CaiUniversity of Massachusetts Dartmouth, Department of Chemistry and Biochemistry, North Dartmouth, MA 02747, USA
&
Bal Ram SinghUniversity of Massachusetts Dartmouth, Department of Chemistry and Biochemistry, North Dartmouth, MA 02747, USA;Institute of Advanced Sciences and Prime Bio, Inc., Botulinum Research Center, 166 Chase Road, North Dartmouth, MA 02747, USA+1 508 992 2042; [email protected]
Pages 319-333 | Published online: 13 Feb 2014

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Fabrizio Anniballi, Davide Lonati, Alfonsina Fiore, Bruna Auricchio, Dario De Medici & Carlo Alessandro Locatelli. (2014) New targets in the search for preventive and therapeutic agents for botulism. Expert Review of Anti-infective Therapy 12:9, pages 1075-1086.
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Articles from other publishers (15)

Jia Liu, Shujing Xu, Chao Huang, Jingtao Shen, Shuo Yu, Yunzhou Yu, Qianyun Sun & Qiuyun Dai. (2022) Synthesis and activity evaluation of selenazole-coupled CPI-1 irreversible bifunctional inhibitors for botulinum toxin A light chain. Bioorganic & Medicinal Chemistry Letters 73, pages 128913.
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Shuowei Cai, Raj Kumar & Bal Ram Singh. (2021) Clostridial Neurotoxins: Structure, Function and Implications to Other Bacterial Toxins. Microorganisms 9:11, pages 2206.
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Kruti B. Patel, Olga Kononova, Shuowei Cai, Valeri Barsegov, Virinder S. Parmar, Raj Kumar & Bal Ram Singh. (2021) Botulinum neurotoxin inhibitor binding dynamics and kinetics relevant for drug design. Biochimica et Biophysica Acta (BBA) - General Subjects 1865:9, pages 129933.
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Raj Kumar, Farkhad Maksudov, Olga Kononova, Kenneth A. Marx, Valeri Barsegov & Bal Ram Singh. (2020) Botulinum Endopeptidase: SAXS Experiments and MD Simulations Reveal Extended Solution Structures That Account for Its Biochemical Properties. The Journal of Physical Chemistry B 124:28, pages 5801-5812.
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Ritika Chauhan, Vinita Chauhan, Priyanka Sonkar & Ram Kumar Dhaked. (2019) Identification of Inhibitors against Botulinum Neurotoxins: 8-Hydroxyquinolines Hold Promise. Mini-Reviews in Medicinal Chemistry 19:20, pages 1694-1706.
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Godakova, Noskov, Vinogradova, Ugriumova, Solovyev, Esmagambetov, Tukhvatulin, Logunov, Naroditsky, Shcheblyakov & Gintsburg. (2019) Camelid VHHs Fused to Human Fc Fragments Provide Long Term Protection Against Botulinum Neurotoxin A in Mice. Toxins 11:8, pages 464.
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Raj Kumar, Thomas M. Feltrup, Roshan V. Kukreja, Kruti B. Patel, Shuowei Cai & Bal Ram Singh. (2019) Evolutionary Features in the Structure and Function of Bacterial Toxins. Toxins 11:1, pages 15.
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Kruti B. Patel, Shuowei Cai, Michael Adler, Brajendra K. Singh, Virinder S. Parmar & Bal Ram Singh. (2018) Natural Compounds and Their Analogues as Potent Antidotes against the Most Poisonous Bacterial Toxin. Applied and Environmental Microbiology 84:24.
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Kruti Patel, Shmuel Halevi, Paul Melman, John Schwartz, Shuowei Cai & Bal Singh. (2017) A Novel Surface Plasmon Resonance Biosensor for the Rapid Detection of Botulinum Neurotoxins. Biosensors 7:4, pages 32.
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Casey C Fowler, Shu-Jung Chang, Xiang Gao, Tobias Geiger, Gabrielle Stack & Jorge E Galán. (2017) Emerging insights into the biology of typhoid toxin. Current Opinion in Microbiology 35, pages 70-77.
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Tzuu-Wang Chang, Pavithra Janardhanan, Charlene M. Mello, Bal Ram Singh & Shuowei Cai. (2016) Selection of RNA Aptamers Against Botulinum Neurotoxin Type A Light Chain Through a Non-Radioactive Approach. Applied Biochemistry and Biotechnology 180:1, pages 10-25.
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Shan Chang, Hong-Qiu He, Lin Shen & Hua Wan. (2015) Understanding peptide competitive inhibition of botulinum neurotoxin a binding to SV2 protein via molecular dynamics simulations. Biopolymers 103:10, pages 597-608.
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Erkan Kiris, James C. Burnett, Jonathan E. Nuss, Laura M. Wanner, Brian D. Peyser, Hao T. Du, Glenn Y. Gomba, Krishna P. Kota, Rekha G. Panchal, Rick Gussio, Christopher D. Kane, Lino Tessarollo & Sina Bavari. (2015) Src Family Kinase Inhibitors Antagonize the Toxicity of Multiple Serotypes of Botulinum Neurotoxin in Human Embryonic Stem Cell-Derived Motor Neurons. Neurotoxicity Research 27:4, pages 384-398.
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Chung-Yan Koh, Ulrich Y. Schaff, Matthew E. Piccini, Larry H. Stanker, Luisa W. Cheng, Easwaran Ravichandran, Bal-Ram Singh, Greg J. Sommer & Anup K. Singh. (2015) Centrifugal Microfluidic Platform for Ultrasensitive Detection of Botulinum Toxin. Analytical Chemistry 87:2, pages 922-928.
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Jean Mukherjee, Igor Dmitriev, Michelle Debatis, Jacqueline M. Tremblay, Gillian Beamer, Elena A. Kashentseva, David T. Curiel & Charles B. Shoemaker. (2014) Prolonged Prophylactic Protection from Botulism with a Single Adenovirus Treatment Promoting Serum Expression of a VHH-Based Antitoxin Protein. PLoS ONE 9:8, pages e106422.
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