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The application of engineered liver tissues for novel drug discovery

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Wenjun Wang, Ying Xu, Chang Jiang & Yanhang Gao. (2019) Advances in the treatment of severe alcoholic hepatitis. Current Medical Research and Opinion 35:2, pages 261-273.
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Banumathi K. Cole, Ryan E. Feaver, Brian R. Wamhoff & Ajit Dash. (2018) Non-alcoholic fatty liver disease (NAFLD) models in drug discovery. Expert Opinion on Drug Discovery 13:2, pages 193-205.
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Richard J. Weaver, Catherine Betts, Eric A.G. Blomme, Helga H.J. Gerets, Klaus Gjervig Jensen, Philip G. Hewitt, Satu Juhila, Gilles Labbe, Michael J. Liguori, Natalie Mesens, Monday O. Ogese, Mikael Persson, Jan Snoeys, James L. Stevens, Tracy Walker & B. Kevin Park. (2017) Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology 13:7, pages 767-782.
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Paul A. Walker, Stephanie Ryder, Andrea Lavado, Clive Dilworth & Robert J. Riley. (2020) The evolution of strategies to minimise the risk of human drug-induced liver injury (DILI) in drug discovery and development. Archives of Toxicology 94:8, pages 2559-2585.
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David A. Kukla, Alexandra L. Crampton, David K. Wood & Salman R. Khetani. (2020) Microscale Collagen and Fibroblast Interactions Enhance Primary Human Hepatocyte Functions in Three-Dimensional Models. Gene Expression 20:1, pages 1-18.
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Richard J. Weaver, Eric A. Blomme, Amy E. Chadwick, Ian M. Copple, Helga H. J. Gerets, Christopher E. Goldring, Andre Guillouzo, Philip G. Hewitt, Magnus Ingelman-Sundberg, Klaus Gjervig Jensen, Satu Juhila, Ursula Klingmüller, Gilles Labbe, Michael J. Liguori, Cerys A. Lovatt, Paul Morgan, Dean J. Naisbitt, Raymond H. H. Pieters, Jan Snoeys, Bob van de Water, Dominic P. Williams & B. Kevin Park. (2019) Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models. Nature Reviews Drug Discovery 19:2, pages 131-148.
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Jason Wang, Alastair Khodabukus, Lingjun Rao, Keith Vandusen, Nadia Abutaleb & Nenad Bursac. (2019) Engineered skeletal muscles for disease modeling and drug discovery. Biomaterials 221, pages 119416.
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Sebastian Prill, Andrea Caddeo, Guido Baselli, Oveis Jamialahmadi, Paola Dongiovanni, Raffaela Rametta, Kajsa P. Kanebratt, Arturo Pujia, Piero Pingitore, Rosellina Margherita Mancina, Daniel Lindén, Carl Whatling, Annika Janefeldt, Mikael Kozyra, Magnus Ingelman-Sundberg, Luca Valenti, Tommy B. Andersson & Stefano Romeo. (2019) The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids. Scientific Reports 9:1.
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Richard J Weaver & Jean-Pierre Valentin. (2019) Today’s Challenges to De-Risk and Predict Drug Safety in Human “Mind-the-Gap”. Toxicological Sciences 167:2, pages 307-321.
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Julia Rogal, Aline Zbinden, Katja Schenke-Layland & Peter Loskill. (2019) Stem-cell based organ-on-a-chip models for diabetes research. Advanced Drug Delivery Reviews 140, pages 101-128.
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Anne F. Pihl, Anna F. Offersgaard, Christian K. Mathiesen, Jannick Prentoe, Ulrik Fahnøe, Henrik Krarup, Jens Bukh & Judith M. Gottwein. (2018) High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals. Scientific Reports 8:1.
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Hugues de Boussac, Claire Gondeau, Philippe Briolotti, Cédric Duret, Fridolin Treindl, Michael Römer, Jean-Michel Fabre, Astrid Herrero, Jeanne Ramos, Patrick Maurel, Markus Templin, Sabine Gerbal-Chaloin & Martine Daujat-Chavanieu. (2018) Epidermal Growth Factor Represses Constitutive Androstane Receptor Expression in Primary Human Hepatocytes and Favors Regulation by Pregnane X Receptor. Drug Metabolism and Disposition 46:3, pages 223-236.
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Aleksander Skardal, Sean V. Murphy, Mahesh Devarasetty, Ivy Mead, Hyun-Wook Kang, Young-Joon Seol, Yu Shrike Zhang, Su-Ryon Shin, Liang Zhao, Julio Aleman, Adam R. Hall, Thomas D. Shupe, Andre Kleensang, Mehmet R. Dokmeci, Sang Jin Lee, John D. Jackson, James J. Yoo, Thomas Hartung, Ali Khademhosseini, Shay Soker, Colin E. Bishop & Anthony Atala. (2017) Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform. Scientific Reports 7:1.
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Rami Mhanna & Anwarul Hasan. 2017. Tissue Engineering for Artificial Organs. Tissue Engineering for Artificial Organs 1 34 .
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Fatemeh Aleahmad, Tahereh Talaei-Khozani, Sareh Rajabi-Zeleti, Mahsa Sani, Sasan Jalili-Firoozinezhad, Shahin Bonakdar, Sanaz Heshmat-Azad, Mahnaz Azarnia & Mansoureh Jaberipour. (2017) Fabrication and Characterization of Heparin/Collagen Sponge for in Vitro Differentiation of Wharton’s Jelly-Derived Mesenchymal Stem Cells into Hepatocytes. Hepatitis Monthly 17:2.
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Tomasz Kostrzewski, Terri Cornforth, Sophie A Snow, Larissa Ouro-Gnao, Cliff Rowe, Emma M Large & David J Hughes. (2017) Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease. World Journal of Gastroenterology 23:2, pages 204.
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Megan J. Neufeld, Brenton R. Ware, Alec Lutzke, Salman R. Khetani & Melissa M. Reynolds. (2016) Water-Stable Metal–Organic Framework/Polymer Composites Compatible with Human Hepatocytes. ACS Applied Materials & Interfaces 8:30, pages 19343-19352.
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Zara Hannoun, Clara Steichen, Noushin Dianat, Anne Weber & Anne Dubart-Kupperschmitt. (2016) The potential of induced pluripotent stem cell derived hepatocytes. Journal of Hepatology 65:1, pages 182-199.
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Matthew D. Davidson, Kimberly R. Ballinger & Salman R. Khetani. (2016) Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes. Scientific Reports 6:1.
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Michaël Maes, Sara Crespo Yanguas, Joost Willebrords & Mathieu Vinken. (2015) Models and methods for in vitro testing of hepatic gap junctional communication. Toxicology in Vitro 30:1, pages 569-577.
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Mathieu Vinken. (2015) Adverse Outcome Pathways and Drug-Induced Liver Injury Testing. Chemical Research in Toxicology 28:7, pages 1391-1397.
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Joost Willebrords, Isabel Veloso Alves Pereira, Michaël Maes, Sara Crespo Yanguas, Isabelle Colle, Bert Van Den Bossche, Tereza Cristina Da Silva, Cláudia Pinto Marques Souza de Oliveira, Wellington Andraus, Venâncio Avancini Alves, Bruno Cogliati & Mathieu Vinken. (2015) Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research. Progress in Lipid Research 59, pages 106-125.
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Da Yoon No, Kwang-Ho Lee, Jaeseo Lee & Sang-Hoon Lee. (2015) 3D liver models on a microplatform: well-defined culture, engineering of liver tissue and liver-on-a-chip. Lab on a Chip 15:19, pages 3822-3837.
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