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On the ‘micro’-pharmacodynamic and pharmacokinetic mechanisms that contribute to long-lasting drug action

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Rumin Zhang & Kenny Wong. (2017) High performance enzyme kinetics of turnover, activation and inhibition for translational drug discovery. Expert Opinion on Drug Discovery 12:1, pages 17-37.
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Alexander Heifetz, Peter V. Coveney, Dmitri G. Fedorov, Inaki Morao, Tim James, Michelle Southey, Kostas Papadopoulos, Mike J. Bodkin & Andrea Townsend-Nicholson. 2021. Recent Advances of the Fragment Molecular Orbital Method. Recent Advances of the Fragment Molecular Orbital Method 307 322 .
Oksana A. Lenina, Irina V. Zueva, Vladimir V. Zobov, Vyacheslav E. Semenov, Patrick Masson & Konstantin A. Petrov. (2020) Slow-binding reversible inhibitor of acetylcholinesterase with long-lasting action for prophylaxis of organophosphate poisoning. Scientific Reports 10:1.
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Esmée Vendel, Vivi Rottschäfer & Elizabeth C. M. de Lange. (2020) A 3D brain unit model to further improve prediction of local drug distribution within the brain. PLOS ONE 15:9, pages e0238397.
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Anna Vlachodimou, Konstantina Konstantinopoulou, Adriaan P. IJzerman & Laura H. Heitman. (2020) Affinity, binding kinetics and functional characterization of draflazine analogues for human equilibrative nucleoside transporter 1 (SLC29A1). Biochemical Pharmacology 172, pages 113747.
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Christopher T. Szlenk, Jeevan B. GC & Senthil Natesan. (2019) Does the Lipid Bilayer Orchestrate Access and Binding of Ligands to Transmembrane Orthosteric/Allosteric Sites of G Protein-Coupled Receptors?. Molecular Pharmacology 96:5, pages 527-541.
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Xiaojing Yuan, Stefano Raniolo, Vittorio Limongelli & Yechun Xu. (2018) The Molecular Mechanism Underlying Ligand Binding to the Membrane-Embedded Site of a G-Protein-Coupled Receptor. Journal of Chemical Theory and Computation 14:5, pages 2761-2770.
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Konstantin Petrov, Irina Zueva, Irina Kovyazina, Igor Sedov, Sofya Lushchekina, Alexandra Kharlamova, Oksana Lenina, Sergei Koshkin, Yurii Shtyrlin, Evgeny Nikolsky & Patrick Masson. (2018) C-547, a 6-methyluracil derivative with long-lasting binding and rebinding on acetylcholinesterase: Pharmacokinetic and pharmacodynamic studies. Neuropharmacology 131, pages 304-315.
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Stephen J. Briddon, Laura E. Kilpatrick & Stephen J. Hill. (2018) Studying GPCR Pharmacology in Membrane Microdomains: Fluorescence Correlation Spectroscopy Comes of Age. Trends in Pharmacological Sciences 39:2, pages 158-174.
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Peter J. Tonge. (2017) Drug–Target Kinetics in Drug Discovery. ACS Chemical Neuroscience 9:1, pages 29-39.
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Georges Vauquelin. (2018) Link between a high k on for drug binding and a fast clinical action: to be or not to be? . MedChemComm 9:9, pages 1426-1438.
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Rutger H.A. Folmer. (2018) Drug target residence time: a misleading concept. Drug Discovery Today 23:1, pages 12-16.
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Georges Vauquelin. (2017) Distinct in vivo target occupancy by bivalent- and induced-fit-like binding drugs . British Journal of Pharmacology 174:23, pages 4233-4246.
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Sara T. Gebre, Scott A. Cameron, Lei Li, Y.S. Babu & Vern L. Schramm. (2017) Intracellular rebinding of transition-state analogues provides extended in vivo inhibition lifetimes on human purine nucleoside phosphorylase. Journal of Biological Chemistry 292:38, pages 15907-15915.
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Si Yan, Duncan E. Shaw, Linhong Yang, David A. Sandham, Mark P. Healy, John Reilly & Bing Wang. (2017) Interactions between β2-Adrenoceptor Ligands and Membrane: Atomic-Level Insights from Magic-Angle Spinning NMR. Journal of Medicinal Chemistry 60:16, pages 6867-6879.
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Dong Guo, Laura H. Heitman & Adriaan P. IJzerman. (2016) Kinetic Aspects of the Interaction between Ligand and G Protein-Coupled Receptor: The Case of the Adenosine Receptors. Chemical Reviews 117:1, pages 38-66.
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Staffan Uhlén, Helgi B. Schiöth & Jan Anker Jahnsen. (2016) A new, simple and robust radioligand binding method used to determine kinetic off-rate constants for unlabeled ligands. Application at α 2A - and α 2C -adrenoceptors. European Journal of Pharmacology 788, pages 113-121.
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Georges Vauquelin. (2016) Cell membranes… and how long drugs may exert beneficial pharmacological activity in vivo . British Journal of Clinical Pharmacology 82:3, pages 673-682.
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Georges Vauquelin. (2016) Effects of target binding kinetics on in vivo drug efficacy: k off , k on and rebinding . British Journal of Pharmacology 173:15, pages 2319-2334.
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Callum J. Dickson, Viktor Hornak, Camilo Velez-Vega, Daniel J. J. McKay, John Reilly, David A. Sandham, Duncan Shaw, Robin A. Fairhurst, Steven J. CharltonDavid A. SykesRobert A. Pearlstein & Jose S. Duca. (2016) Uncoupling the Structure–Activity Relationships of β2 Adrenergic Receptor Ligands from Membrane Binding. Journal of Medicinal Chemistry 59:12, pages 5780-5789.
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