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Fragment-based approaches to anti-HIV drug discovery: state of the art and future opportunities

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Xiaofang Zuo, Zhipeng Huo, Dongwei Kang, Gaochan Wu, Zhongxia Zhou, Xinyong Liu & Peng Zhan. (2018) Current insights into anti-HIV drug discovery and development: a review of recent patent literature (2014–2017). Expert Opinion on Therapeutic Patents 28:4, pages 299-316.
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Boshi Huang, Zhongxia Zhou, Dongwei Kang, Wanzhuo Li, Zihui Chen, Peng Zhan & Xinyong Liu. (2017) Novel diaryltriazines with a picolinonitrile moiety as potent HIV-1 RT inhibitors: a patent evaluation of WO2016059647(A2). Expert Opinion on Therapeutic Patents 27:1, pages 9-15.
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Lu Sun, Peng Nie, Li Luan, Piet Herdewijn & Ya-Tao Wang. (2023) Synthetic approaches and application of clinically approved small-molecule Anti-HIV drugs: An update. European Journal of Medicinal Chemistry 261, pages 115847.
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Xiaoyu Shao, Shujing Xu, Xufeng Wan, Yang Zhou, Shuo Wang, Shuo Wu, Yuhuan Li, Xinyong Liu & Peng Zhan. (2023) Medicinal chemistry strategies in the discovery and optimization of HBV core protein allosteric modulators (2018–2022 update). Chinese Chemical Letters 34:11, pages 108349.
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Lingxin Hou, Ying Zhang, Han Ju, Srinivasulu Cherukupalli, Ruifang Jia, Jian Zhang, Bing Huang, Arianna Loregian, Xinyong Liu & Peng Zhan. (2022) Contemporary medicinal chemistry strategies for the discovery and optimization of influenza inhibitors targeting vRNP constituent proteins. Acta Pharmaceutica Sinica B 12:4, pages 1805-1824.
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Gaochan Wu, Tong Zhao, Dongwei Kang, Jian Zhang, Yuning Song, Vigneshwaran Namasivayam, Jacob Kongsted, Christophe Pannecouque, Erik De Clercq, Vasanthanathan Poongavanam, Xinyong Liu & Peng Zhan. (2019) Overview of Recent Strategic Advances in Medicinal Chemistry. Journal of Medicinal Chemistry 62:21, pages 9375-9414.
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KaiJun Jin, YaLi Sang, Sheng Han, Erik De Clercq, Christophe Pannecouque, Ge Meng & FenEr Chen. (2019) Synthesis and biological evaluation of dihydroquinazoline-2-amines as potent non-nucleoside reverse transcriptase inhibitors of wild-type and mutant HIV-1 strains. European Journal of Medicinal Chemistry 176, pages 11-20.
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Boshi Huang, Xueshun Wang, Xinhao Liu, Zihui Chen, Wanzhuo Li, Songkai Sun, Huiqing Liu, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan & Xinyong Liu. (2017) Discovery of novel DAPY-IAS hybrid derivatives as potential HIV-1 inhibitors using molecular hybridization based on crystallographic overlays. Bioorganic & Medicinal Chemistry 25:16, pages 4397-4406.
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Han Ju, Jian Zhang, Boshi Huang, Dongwei Kang, Bing Huang, Xinyong Liu & Peng Zhan. (2017) Inhibitors of Influenza Virus Polymerase Acidic (PA) Endonuclease: Contemporary Developments and Perspectives. Journal of Medicinal Chemistry 60:9, pages 3533-3551.
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