Expert Opinion on Drug Discovery, Volume 10, Issue 12 (2015)

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Expert Opinion on Drug Discovery, Volume 10, Issue 12 (2015)

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Reviews

The TZD insulin sensitizer clue provides a new route into diabetes drug discovery
Jerry R. Colca
Pages: 1259-1270
Published online: 19 Oct 2015
AbstractforThe TZD insulin sensitizer clue provides a new route into diabetes drug discovery | Full Text | References | PDF (656.8 KB)
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Fragment-based approaches to anti-HIV drug discovery: state of the art and future opportunities
Boshi Huang, Dongwei Kang, Peng Zhan & Xinyong Liu
Pages: 1271-1281
Published online: 15 Sep 2015
AbstractforFragment-based approaches to anti-HIV drug discovery: state of the art and future opportunities | Full Text | References | PDF (1.9 MB)
  • 473 Views
  • 9 CrossRef citations
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Quantitative structure–activity relationship: promising advances in drug discovery platforms
Tao Wang, Mian-Bin Wu, Jian-Ping Lin & Li-Rong Yang
Pages: 1283-1300
Published online: 11 Sep 2015
AbstractforQuantitative structure–activity relationship: promising advances in drug discovery platforms | Full Text | References | PDF (2.5 MB)
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Understanding the challenges of protein flexibility in drug design
Dinler A Antunes (Postdoctoral Research Associate) , Didier Devaurs & Lydia E Kavraki (Professor)
Pages: 1301-1313
Published online: 28 Sep 2015
AbstractforUnderstanding the challenges of protein flexibility in drug design | Full Text | References | PDF (884.7 KB)
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Using quantitative systems pharmacology for novel drug discovery
Violeta I Pérez-Nueno
Pages: 1315-1331
Published online: 25 Aug 2015
AbstractforUsing quantitative systems pharmacology for novel drug discovery | Full Text | References | PDF (1.5 MB)
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Identification of drug candidates and repurposing opportunities through compound–target interaction networks
Anna Cichonska (HIIT/FIMM-EMBL PhD student) MSc, Juho Rousu (Professor at Aalto University) PhD & Tero Aittokallio (EMBL-FIMM Group Leader) (Professor) PhD
Pages: 1333-1345
Published online: 01 Oct 2015
AbstractforIdentification of drug candidates and repurposing opportunities through compound–target interaction networks | Full Text | References | PDF (1.1 MB)
  • 1062 Views
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High-throughput fluorescence imaging approaches for drug discovery using in vitro and in vivo three-dimensional models
Natalia J Martinez, Steven A Titus, Amanda K Wagner & Anton Simeonov
Pages: 1347-1361
Published online: 22 Sep 2015
AbstractforHigh-throughput fluorescence imaging approaches for drug discovery using in vitro and in vivo three-dimensional models | Full Text | References | PDF (1.2 MB)
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Drug Discovery Case History

The discovery of sofosbuvir: a revolution for therapy of chronic hepatitis C
Ivan Gentile, Alberto Enrico Maraolo, Antonio Riccardo Buonomo, Emanuela Zappulo & Guglielmo Borgia
Pages: 1363-1377
Published online: 12 Nov 2015
AbstractforThe discovery of sofosbuvir: a revolution for therapy of chronic hepatitis C | Full Text | References | PDF (411.9 KB)
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