561
Views
25
CrossRef citations to date
0
Altmetric
Reviews

The TZD insulin sensitizer clue provides a new route into diabetes drug discovery

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Jerry R. Colca, William G McDonald & Wade J. Adams. (2018) MSDC-0602K, a metabolic modulator directed at the core pathology of non-alcoholic steatohepatitis. Expert Opinion on Investigational Drugs 27:7, pages 631-636.
Read now

Articles from other publishers (23)

Daria Schneider-Matyka, Anna Maria Cybulska, Małgorzata Szkup, Bogumiła Pilarczyk, Mariusz Panczyk, Agnieszka Tomza-Marciniak & Elżbieta Grochans. (2023) Selenium as a predictor of metabolic syndrome in middle age women. Aging 15:6, pages 1734-1747.
Crossref
Yue Qi & Xiaofei Wang. (2023) The Role of Gut Microbiota in High-Fat-Diet-Induced Diabetes: Lessons from Animal Models and Humans. Nutrients 15:4, pages 922.
Crossref
Sangeeta Ballav, Bini Biswas, Vishal Kumar Sahu, Amit Ranjan & Soumya Basu. (2022) PPAR-γ Partial Agonists in Disease-Fate Decision with Special Reference to Cancer. Cells 11:20, pages 3215.
Crossref
David Mallet, Raphael Goutaudier, Emmanuel L. Barbier, Sebastien Carnicella, Jerry R. Colca, Florence Fauvelle & Sabrina Boulet. (2022) Re-routing Metabolism by the Mitochondrial Pyruvate Carrier Inhibitor MSDC-0160 Attenuates Neurodegeneration in a Rat Model of Parkinson’s Disease. Molecular Neurobiology 59:10, pages 6170-6182.
Crossref
Jerry R. Colca & Brian N. Finck. (2022) Metabolic Mechanisms Connecting Alzheimer’s and Parkinson’s Diseases: Potential Avenues for Novel Therapeutic Approaches. Frontiers in Molecular Biosciences 9.
Crossref
Jerry R. Colca & Philipp E. Scherer. (2022) The metabolic syndrome, thiazolidinediones, and implications for intersection of chronic and inflammatory disease. Molecular Metabolism 55, pages 101409.
Crossref
Ahmed Olatunde, Manisha Nigam, Rahul Kunwar Singh, Abhaya Shikhar Panwar, Abdulwahab Lasisi, Fahad A. Alhumaydhi, Vijay Jyoti kumar, Abhay Prakash Mishra & Javad Sharifi-Rad. (2021) Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs. Cancer Cell International 21:1.
Crossref
Virender Kumar, Xiaofei Xin, Jingyi Ma, Chalet Tan, Natalia Osna & Ram I. Mahato. (2021) Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis. Advanced Drug Delivery Reviews 176, pages 113888.
Crossref
Navjot Singh Sethi, Deo Nandan Prasad & Rajesh Kumar Singh. (2020) An Insight into the Synthesis and SAR of 2,4-Thiazolidinediones (2,4-TZD) as Multifunctional Scaffold: A Review. Mini-Reviews in Medicinal Chemistry 20:4, pages 308-330.
Crossref
Yujie Shi, Yixin Zou, Ziyue Shen, Yonghong Xiong, Wenxiang Zhang, Chang Liu & Siyu Chen. (2020) Trace Elements, PPARs, and Metabolic Syndrome. International Journal of Molecular Sciences 21:7, pages 2612.
Crossref
Stephen A. Harrison, Naim Alkhouri, Beth A. Davison, Arun Sanyal, Christopher Edwards, Jerry R. Colca, Bo Hyun Lee, Rohit Loomba, Kenneth Cusi, Orville Kolterman, Gad Cotter & Howard C. Dittrich. (2020) Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study. Journal of Hepatology 72:4, pages 613-626.
Crossref
Steven P. Tanis, Jerry R. Colca, Timothy T. Parker, Gerald D. ArtmanIIIIII, Scott D. Larsen, Robert C. Gadwood & James R. Zeller. (2019) The development of improved syntheses of PPARγ-sparing, insulin sensitizing thiazolidinedione-ketones. Tetrahedron Letters 60:33, pages 150931.
Crossref
Ying Kong, Yan Gao, Dongyi Lan, Ying Zhang, Rixin Zhan, Meiqi Liu, Zhouan Zhu, Guohua Zeng & Qiren Huang. (2019) Trans-repression of NFκB pathway mediated by PPARγ improves vascular endothelium insulin resistance. Journal of Cellular and Molecular Medicine 23:1, pages 216-226.
Crossref
Emmanuel Quansah, Wouter Peelaerts, J. William Langston, David K. Simon, Jerry Colca & Patrik Brundin. (2018) Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration. Molecular Neurodegeneration 13:1.
Crossref
Steven P. Tanis, Jerry R. Colca, Timothy T. Parker, Gerald D. ArtmanIIIIII, Scott D. Larsen, William G. McDonald, Robert C. Gadwood, Rolf F. Kletzien, James B. Zeller, Pil H. Lee & Wade J. Adams. (2018) PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development. Bioorganic & Medicinal Chemistry 26:22, pages 5870-5884.
Crossref
Domenica M. Corigliano, Riyaz Syed, Sebastiano Messineo, Antonio Lupia, Rahul Patel, Chittireddy Venkata Ramana Reddy, Pramod K. Dubey, Carmela Colica, Rosario Amato, Giovambattista De Sarro, Stefano Alcaro, Adisherla Indrasena & Antonio Brunetti. (2018) Indole and 2,4-Thiazolidinedione conjugates as potential anticancer modulators. PeerJ 6, pages e5386.
Crossref
A.J. Scheen. (2018) Perspectives dans le traitement pharmacologique du diabète de type 2 pour les 10 prochaines années. Médecine des Maladies Métaboliques 12:2, pages 174-181.
Crossref
Xun Chen, Steven Stout, Uwe Mueller, George Boykow, Richard Visconti, Phieng Siliphaivanh, Kerrie Spencer, Jeremy Presland, Michael Kavana, Andrea D. Basso, David G. McLaren & Robert W. Myers. (2017) Label-Free, LC-MS-Based Assays to Quantitate Small-Molecule Antagonist Binding to the Mammalian BLT1 Receptor. SLAS Discovery 22:9, pages 1131-1141.
Crossref
Xinni Xie, Wei Chen, Ning Zhang, Mei Yuan, Cheng Xu, Zhibing Zheng, Hua Li & Lili Wang. (2017) Selective Tissue Distribution Mediates Tissue-Dependent PPARγ Activation and Insulin Sensitization by INT131, a Selective PPARγ Modulator. Frontiers in Pharmacology 8.
Crossref
Jerry R. Colca, William G. McDonald, Kyle S. McCommis & Brian N. Finck. (2017) Treating fatty liver disease by modulating mitochondrial pyruvate metabolism. Hepatology Communications 1:3, pages 193-197.
Crossref
Kyle S. McCommis, Wesley T. Hodges, Elizabeth M. Brunt, Ilke Nalbantoglu, William G. McDonald, Christopher Holley, Hideji Fujiwara, Jean E. Schaffer, Jerry R. Colca & Brian N. Finck. (2017) Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis. Hepatology 65:5, pages 1543-1556.
Crossref
Clyde F. Phelix, Greg Villareal, Richard G. LeBaron & Dawnlee J. Roberson. (2017) Integrating -omics information with biosimulations to assist diagnosis and treatment of diabetes mellitus in silico. Integrating -omics information with biosimulations to assist diagnosis and treatment of diabetes mellitus in silico.
A. Ghosh, T. Tyson, S. George, E. N. Hildebrandt, J. A. Steiner, Z. Madaj, E. Schulz, E. Machiela, W. G. McDonald, M. L. Escobar Galvis, J. H. Kordower, J. M. Van Raamsdonk, J. R. Colca & P. Brundin. (2016) Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinsons disease. Science Translational Medicine 8:368, pages 368ra174-368ra174.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.