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Blood–brain barrier models: in vitro to in vivo translation in preclinical development of CNS-targeting biotherapeutics

, MD PhD (Director, Translational Bioscience) , , PhD (Team Leader, Cellular Pharmacology) , , PhD & , PhD (Research Officer)

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Fabien Plisson & Andrew Piggott. (2019) Predicting Blood–Brain Barrier Permeability of Marine-Derived Kinase Inhibitors Using Ensemble Classifiers Reveals Potential Hits for Neurodegenerative Disorders. Marine Drugs 17:2, pages 81.
Crossref
Frederick R. Taylor. (2019) CGRP, Amylin, Immunology, and Headache Medicine. Headache: The Journal of Head and Face Pain 59:1, pages 131-150.
Crossref
Bhupesh Sharma, Kanishk Luhach & G.T. Kulkarni. 2019. Brain Targeted Drug Delivery System. Brain Targeted Drug Delivery System 53 101 .
Fernanda Rodriguez‐Otormin, Aroa Duro‐Castano, Inmaculada Conejos‐Sánchez & María J. Vicent. (2018) Envisioning the future of polymer therapeutics for brain disorders. WIREs Nanomedicine and Nanobiotechnology 11:1.
Crossref
Judie B. Alimonti, Maria Ribecco-Lutkiewicz, Caroline Sodja, Anna Jezierski, Danica B. Stanimirovic, Qing Liu, Arsalan S. Haqqani, Wayne Conlan & Mahmud Bani-Yaghoub. (2018) Zika virus crosses an in vitro human blood brain barrier model. Fluids and Barriers of the CNS 15:1.
Crossref
Qin Wang, Luisette Delva, Paul H. Weinreb, Robert B. Pepinsky, Danielle Graham, Elvana Veizaj, Anne E. Cheung, Weiping Chen, Ivan Nestorov, Ellen Rohde, Robin Caputo, Geoffrey M. Kuesters, Tonika Bohnert & Liang-Shang Gan. (2018) Monoclonal antibody exposure in rat and cynomolgus monkey cerebrospinal fluid following systemic administration. Fluids and Barriers of the CNS 15:1.
Crossref
Elena D. Osipova, Yulia K. Komleva, Andrey V. Morgun, Olga L. Lopatina, Yulia A. Panina, Raissa Ya. Olovyannikova, Elizaveta F. Vais, Vladimir V. Salmin & Alla B. Salmina. (2018) Designing in vitro Blood-Brain Barrier Models Reproducing Alterations in Brain Aging. Frontiers in Aging Neuroscience 10.
Crossref
Hassan Pezeshgi Modarres, Mohsen Janmaleki, Mana Novin, John Saliba, Fatima El-Hajj, Mahdi RezayatiCharan, Amir Seyfoori, Hamid Sadabadi, Milène Vandal, Minh Dang Nguyen, Anwarul Hasan & Amir Sanati-Nezhad. (2018) In vitro models and systems for evaluating the dynamics of drug delivery to the healthy and diseased brain. Journal of Controlled Release 273, pages 108-130.
Crossref
Maria Ribecco-Lutkiewicz, Caroline Sodja, Julie Haukenfrers, Arsalan S. Haqqani, Dao Ly, Peter Zachar, Ewa Baumann, Marguerite Ball, Jez Huang, Marina Rukhlova, Marzia Martina, Qing Liu, Danica Stanimirovic, Anna Jezierski & Mahmud Bani-Yaghoub. (2018) A novel human induced pluripotent stem cell blood-brain barrier model: Applicability to study antibody-triggered receptor-mediated transcytosis. Scientific Reports 8:1.
Crossref
Tori B. Terrell-Hall, Amanda G. Ammer, Jessica I. G. Griffith & Paul R. Lockman. (2017) Permeability across a novel microfluidic blood-tumor barrier model. Fluids and Barriers of the CNS 14:1.
Crossref
David E Watson, Rosemarie Hunziker & John P Wikswo. (2017) Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology. Experimental Biology and Medicine 242:16, pages 1559-1572.
Crossref
Paul Curley, Marco Giardiello, Neill J. Liptrott, David Dickens, Darren M. Moss, James J. Hobson, Alison C. Savage, Tom O. McDonald, Marco Siccardi, Steve Rannard & Andrew Owen. (2017) In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line. Journal of Interdisciplinary Nanomedicine 2:3, pages 157-169.
Crossref
Mukta Agrawal, Ajazuddin, Dulal K. Tripathi, Swarnlata Saraf, Shailendra Saraf, Sophia G. Antimisiaris, Spyridon Mourtas, Margareta Hammarlund-Udenaes & Amit Alexander. (2017) Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease. Journal of Controlled Release 260, pages 61-77.
Crossref
Yumi Yamamoto, Meindert Danhof & Elizabeth C. M. de Lange. (2017) Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations. The AAPS Journal 19:4, pages 891-909.
Crossref
Asli Kara, Naile Ozturk & Imran Vural. 2017. Nanotechnology Methods for Neurological Diseases and Brain Tumors. Nanotechnology Methods for Neurological Diseases and Brain Tumors 151 185 .
Song Guo, Anne L.H. Vollesen, Jes Olesen & Messoud Ashina. (2016) Premonitory and nonheadache symptoms induced by CGRP and PACAP38 in patients with migraine. Pain 157:12, pages 2773-2781.
Crossref
Carla L. Esposito, Silvia Nuzzo, Swati A. Kumar, Anna Rienzo, Clare L. Lawrence, Roberto Pallini, Lisa Shaw, Jane E. Alder, Lucia Ricci-Vitiani, Silvia Catuogno & Vittorio de Franciscis. (2016) A combined microRNA-based targeted therapeutic approach to eradicate glioblastoma stem-like cells. Journal of Controlled Release 238, pages 43-57.
Crossref
Martin Raasch, Knut Rennert, Tobias Jahn, Claudia Gärtner, Gilbert Schönfelder, Otmar Huber, Andrea E. M. Seiler & Alexander S. Mosig. (2016) An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development . Biomicrofluidics 10:4.
Crossref
Ravi K Sajja, Shafiqur Rahman & Luca Cucullo. (2015) Drugs of abuse and blood-brain barrier endothelial dysfunction: A focus on the role of oxidative stress. Journal of Cerebral Blood Flow & Metabolism 36:3, pages 539-554.
Crossref
Norman R. Saunders, Mark D. Habgood, Kjeld Møllgård & Katarzyna M. Dziegielewska. (2016) The biological significance of brain barrier mechanisms: help or hindrance in drug delivery to the central nervous system?. F1000Research 5, pages 313.
Crossref
Marcelo E Bigal, David W Dodick, Alan M Rapoport, Stephen D Silberstein, Yuju Ma, Ronghua Yang, Pippa S Loupe, Rami Burstein, Lawrence C Newman & Richard B Lipton. (2015) Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of high-frequency episodic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study. The Lancet Neurology 14:11, pages 1081-1090.
Crossref
Marcelo E Bigal, Lars Edvinsson, Alan M Rapoport, Richard B Lipton, Egilius L H Spierings, Hans-Christoph Diener, Rami Burstein, Pippa S Loupe, Yuju Ma, Ronghua Yang & Stephen D Silberstein. (2015) Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study. The Lancet Neurology 14:11, pages 1091-1100.
Crossref
Jacquelyn A. Brown, Virginia Pensabene, Dmitry A. Markov, Vanessa Allwardt, M. Diana Neely, Mingjian Shi, Clayton M. Britt, Orlando S. Hoilett, Qing Yang, Bryson M. Brewer, Philip C. Samson, Lisa J. McCawley, James M. May, Donna J. Webb, Deyu Li, Aaron B. Bowman, Ronald S. Reiserer & John P. Wikswo. (2015) Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor. Biomicrofluidics 9:5.
Crossref

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