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Principles and applications of Raman spectroscopy in pharmaceutical drug discovery and development

, B Pharm (Graduate Student) & , PhD (Assistant Professor of Pharmaceutics)

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Gopal P. Jadhav, Pavan Kumar Prathipati & Harsh Chauhan. (2020) Surface plasmon resonance, Orbitrap mass spectrometry and Raman advancements: exciting new techniques in drug discovery. Expert Opinion on Drug Discovery 15:7, pages 739-743.
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Xiaoli Li, Ruiqing Zhou, Yifei Xu, Xuan Wei & Yong He. (2017) Spectral unmixing combined with Raman imaging, a preferable analytic technique for molecule visualization. Applied Spectroscopy Reviews 52:5, pages 417-438.
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Chia-Chi Huang. (2016) Applications of Raman spectroscopy in herbal medicine. Applied Spectroscopy Reviews 51:1, pages 1-11.
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Xixian Wang, Lihui Ren, Zhidian Diao, Yuehui He, Jiaping Zhang, Min Liu, Yuandong Li, Lijun Sun, Rongze Chen, Yuetong Ji, Jian Xu & Bo Ma. (2023) Robust Spontaneous Raman Flow Cytometry for Single‐Cell Metabolic Phenome Profiling via pDEP‐DLD‐RFC. Advanced Science 10:16.
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Gerard G. Dumancas, Lakshmi Viswanath, Arnold Lubguban, Beulah Solivio, Roberto Malaluan & Michael Waller. 2023. Spectroscopic and Chemometric Techniques for Pharmaceutical Applications. Spectroscopic and Chemometric Techniques for Pharmaceutical Applications.
Yali Song, Handan Bian, Tingting Zeng, Ting Lin, Yuxin Liu, Shanying Deng, Juan Liao, Zhigang Mao & Si Chen. (2023) Progress in the Detection of Cerebrospinal Fluid by Raman Spectroscopy. Current Nanoscience 19:3, pages 338-349.
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Kashvi C. Shah, Maitri B. Shah, Sakshi J. Solanki, Vikas D. Makwana, Dipen K. Sureja, Anuradha K. Gajjar, Kunjan B. Bodiwala & Tejas M. Dhameliya. (2023) Recent advancements and applications of Raman spectroscopy in pharmaceutical analysis. Journal of Molecular Structure 1278, pages 134914.
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Rongqin Chen, Fei Liu, Chu Zhang, Wei Wang, Rui Yang, Yiying Zhao, Jiyu Peng, Wenwen Kong & Jing Huang. (2023) Trends in digital detection for the quality and safety of herbs using infrared and Raman spectroscopy. Frontiers in Plant Science 14.
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Yanmei Xu, Xinyu Pan, Huan Li, Qiongfang Cao, Fan Xu & Jianshu Zhang. (2023) Accuracy of Raman spectroscopy in the diagnosis of Alzheimer's disease. Frontiers in Psychiatry 14.
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Hulya Yilmaz, Deniz Yilmaz, Irem Culha Taskin & Mustafa Culha. (2022) Pharmaceutical applications of a nanospectroscopic technique: Surface-enhanced Raman spectroscopy. Advanced Drug Delivery Reviews 184, pages 114184.
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Sana Inam, Muhammad Irfan, Noor ul ain Lali, Haroon Khalid Syed, Sajid Asghar, Ikram Ullah Khan, Salah-Ud-Din Khan, Muhammad Shahid Iqbal, Imran Zaheer, Ahmed Khames, Heba A. Abou-Taleb & Mohammad A. S. Abourehab. (2022) Development and Characterization of Eudragit® EPO-Based Solid Dispersion of Rosuvastatin Calcium to Foresee the Impact on Solubility, Dissolution and Antihyperlipidemic Activity. Pharmaceuticals 15:4, pages 492.
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T. Hermane Avohou, Pierre-Yves Sacré, Philippe Hubert & Eric Ziemons. (2022) Interpretable One-Class Classification of Raman Spectra Using Prediction Bands Estimated by Wavelet Regression. Analytical Chemistry 94:10, pages 4183-4191.
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SR Nivaz, Ramakrishnan Geethalakshmi, GS Lekshmi, Duraiarasan Surendhiran, Chaudhery Mustansar Hussain & Abdul Razack Sirajunnisa. 2022. Handbook of Microbial Nanotechnology. Handbook of Microbial Nanotechnology 145 156 .
Francesca Madonini & Federica Villa. (2021) Single Photon Avalanche Diode Arrays for Time-Resolved Raman Spectroscopy. Sensors 21:13, pages 4287.
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Asmaa Bouazza, Salah Bassaid, Bouabdallah Daho, Massimo Messori & Abdelkader Dehbi. (2020) Synthesis and characterization of a composite organic semiconductor (curcumin-paracetamol/TiO 2 ) . Polymers and Polymer Composites 29:5, pages 417-426.
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Jiaqi Hu, De Zhang, Hantao Zhao, Biao Sun, Pei Liang, Jiaming Ye, Zhi Yu & Shangzhong Jin. (2021) Intelligent spectral algorithm for pigments visualization, classification and identification based on Raman spectra. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 250, pages 119390.
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Junjie Zeng, Wenying Zhao & Shuhua Yue. (2021) Coherent Raman Scattering Microscopy in Oncology Pharmacokinetic Research. Frontiers in Pharmacology 12.
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Malinda Salim, Sara J. Fraser-Miller, Ka̅rlis Be̅rziņš, Joshua J. Sutton, Gisela Ramirez, Andrew J. Clulow, Adrian Hawley, Stéphane Beilles, Keith C. Gordon & Ben J. Boyd. (2020) Low-Frequency Raman Scattering Spectroscopy as an Accessible Approach to Understand Drug Solubilization in Milk-Based Formulations during Digestion. Molecular Pharmaceutics 17:3, pages 885-899.
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Abdullahi Garba USMAN, Umar Muhammad GHALİ & Selin IŞIK. (2020) APPLICATIONS OF MINIATURIZED AND PORTABLE NEAR INFRARED (NIR), FOURIER TRANSFORM INFRARED (FT-IR) AND RAMAN SPECTROMETERS FOR THE INSPECTION AND CONTROL OF PHARMACEUTICAL PRODUCTS. Ankara Universitesi Eczacilik Fakultesi Dergisi, pages 188-203.
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Pran Kishore Deb, Sara Nidal Abed, Hussam Maher, Amal Al-Aboudi, Anant Paradkar, Shantanu Bandopadhyay & Rakesh K. Tekade. 2020. Drug Delivery Systems. Drug Delivery Systems 521 577 .
Ahmed Ali, Yasmine Abouleila, Yoshihiro Shimizu, Eiso Hiyama, Tomonobu M. Watanabe, Toshio Yanagida & Arno Germond. (2019) Single-Cell Screening of Tamoxifen Abundance and Effect Using Mass Spectrometry and Raman-Spectroscopy. Analytical Chemistry 91:4, pages 2710-2718.
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Hugh J. Byrne, Franck Bonnier, Alan Casey, Marcus Maher, Jennifer McIntyre, Esen Efeoglu & Zeineb Farhane. (2018) Advancing Raman microspectroscopy for cellular and subcellular analysis: towards in vitro high-content spectralomic analysis. Applied Optics 57:22, pages E11.
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Barbara Lenz, Andreas Brink, Monira Siam, Anne De Paepe, Simon Bassett, Anne Eichinger-Chapelon, Pierre Maliver, Rachel Neff, Urs Niederhauser, Bernd Steinhuber, Raphael Zurbach, Thomas Singer, Christoph Funk, Franz Schuler, Mudher Albassam & Simone Schadt. (2018) Application of Imaging Techniques to Cases of Drug-Induced Crystal Nephropathy in Preclinical Studies. Toxicological Sciences 163:2, pages 409-419.
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Michael A. Repka, Suresh Bandari, Venkata Raman Kallakunta, Anh Q. Vo, Haley McFall, Manjeet B. Pimparade & Ajinkya M. Bhagurkar. (2018) Melt extrusion with poorly soluble drugs – An integrated review. International Journal of Pharmaceutics 535:1-2, pages 68-85.
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Vivek S. Dave, Hend I. Shahin, Susanne R. Youngren-Ortiz, Mahavir B. Chougule & Rahul V. Haware. (2017) Emerging technologies for the non-invasive characterization of physical-mechanical properties of tablets. International Journal of Pharmaceutics 532:1, pages 299-312.
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Edyta Pindelska, Agnieszka Sokal & Waclaw Kolodziejski. (2017) Pharmaceutical cocrystals, salts and polymorphs: Advanced characterization techniques. Advanced Drug Delivery Reviews 117, pages 111-146.
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Patrick Hitzer, Tim Bäuerle, Tobias Drieschner, Edwin Ostertag, Katharina Paulsen, Holger van Lishaut, Günter Lorenz & Karsten Rebner. (2017) Process analytical techniques for hot-melt extrusion and their application to amorphous solid dispersions. Analytical and Bioanalytical Chemistry 409:18, pages 4321-4333.
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Dan-Dan Chen, Xiao-Fang Xie, Hui Ao, Ji-Lei Liu & Cheng Peng. (2017) Raman spectroscopy in quality control of Chinese herbal medicine. Journal of the Chinese Medical Association 80:5, pages 288-296.
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Zeineb Farhane, Franck Bonnier & Hugh J. Byrne. (2016) Monitoring doxorubicin cellular uptake and trafficking using in vitro Raman microspectroscopy: short and long time exposure effects on lung cancer cell lines. Analytical and Bioanalytical Chemistry 409:5, pages 1333-1346.
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Di An, Yan Shen, Jinxiu Wen, Zebo Zheng, Jun Chen, Juncong She, Huanjun Chen, Shaozhi Deng & Ningsheng Xu. (2016) Molybdenum Nanoscrews: A Novel Non-coinage-Metal Substrate for Surface-Enhanced Raman Scattering. Nano-Micro Letters 9:1.
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Karin Kogermann, Marta Putrinš & Tanel Tenson. (2016) Single-cell level methods for studying the effect of antibiotics on bacteria during infection. European Journal of Pharmaceutical Sciences 95, pages 2-16.
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Tuan Anh Nguyen, Quan Duoc Tang, Duc Chanh Tin Doan & Mau Chien Dang. (2016) Micro and nano liposome vesicles containing curcumin for a drug delivery system. Advances in Natural Sciences: Nanoscience and Nanotechnology 7:3, pages 035003.
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W. Rudolf Seitz. 2016. Handbook of Measurement in Science and Engineering. Handbook of Measurement in Science and Engineering 2707 2725 .
L. E. Jones, A. Stewart, K. L. Peters, M. McNaul, S. J. Speers, N. C. Fletcher & S. E. J. Bell. (2016) Infrared and Raman screening of seized novel psychoactive substances: a large scale study of >200 samples. The Analyst 141:3, pages 902-909.
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R Krishna, T.J. Unsworth & R. Edge. 2016. Reference Module in Materials Science and Materials Engineering. Reference Module in Materials Science and Materials Engineering.
Kyle C. Doty, Claire K. Muro, Justin Bueno, Lenka Halámková & Igor K. Lednev. (2015) What can Raman spectroscopy do for criminalistics?. Journal of Raman Spectroscopy 47:1, pages 39-50.
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Jagadeesh Babu Nanubolu & Jonathan C. Burley. (2015) In situ Raman mapping for identifying transient solid forms. CrystEngComm 17:28, pages 5280-5287.
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