1,506
Views
25
CrossRef citations to date
0
Altmetric
Reviews

Transporter assays as useful in vitro tools in drug discovery and development

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Donna A. Volpe & Hisham Qosa. (2018) Challenges with the precise prediction of ABC-transporter interactions for improved drug discovery. Expert Opinion on Drug Discovery 13:8, pages 697-707.
Read now

Articles from other publishers (23)

Valentin Tastet, Marc Le Vée, Arnaud Bruyère & Olivier Fardel. (2023) Interactions of human drug transporters with chemical additives present in plastics: Potential consequences for toxicokinetics and health. Environmental Pollution 331, pages 121882.
Crossref
Stefano Altomonte, Xuefeng Yan, Cheryl L. Morse, Jeih-San Liow, Madeline D. Jenkins, Jose A. Montero Santamaria, Sami S. Zoghbi, Robert B. Innis & Victor W. Pike. (2023) Discovery of a High-Affinity Fluoromethyl Analog of [ 11 C]5-Cyano- N -(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide ([ 11 C]CPPC) and Their Comparison in Mouse and Monkey as Colony-Stimulating Factor 1 Receptor Positron Emission Tomography Radioligands . ACS Pharmacology & Translational Science 6:4, pages 614-632.
Crossref
Ryuto Tomabechi, Miki Miyasato, Taeka Sato, Tappei Takada, Kei Higuchi, Hisanao Kishimoto, Yoshiyuki Shirasaka & Katsuhisa Inoue. (2022) Identification of 5-Carboxyfluorescein as a Probe Substrate of SLC46A3 and Its Application in a Fluorescence-Based In Vitro Assay Evaluating the Interaction with SLC46A3. Molecular Pharmaceutics 20:1, pages 491-499.
Crossref
Sarah Lazzaro, Mark A. West, Soraya Eatemadpour, Bo Feng, Manthena V.S. Varma, A. David Rodrigues, Csilla Temesszentandrási-Ambrus, Péter Kovács-Hajdu, Zsuzsanna Nerada, Zsuzsanna Gáborik & Chester Costales. (2023) Translatability of in vitro Inhibition Potency to in vivo P-Glycoprotein Mediated Drug Interaction Risk. Journal of Pharmaceutical Sciences.
Crossref
Dongyan Feng, Guorui Zhong, Qingxia Zuo, Yanbin Wan, Wanqing Xu, Changsheng He, Cailing Lin, Dongchao Huang, Feng Chen & Lizhen Huang. (2022) Knockout of ABC transporters by CRISPR/Cas9 contributes to reliable and accurate transporter substrate identification for drug discovery. Frontiers in Pharmacology 13.
Crossref
Sandra Barreiro, Bárbara Silva, Solida Long, Madalena Pinto, Fernando Remião, Emília Sousa & Renata Silva. (2022) Fiscalin Derivatives as Potential Neuroprotective Agents. Pharmaceutics 14:7, pages 1456.
Crossref
Joseph P. O'Shea, Patrick Augustijns, Martin Brandl, David J. Brayden, Joachim Brouwers, Brendan T. Griffin, René Holm, Ann-Christin Jacobsen, Hans Lennernäs, Zahari Vinarov & Caitriona M. O'Driscoll. (2022) Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review. European Journal of Pharmaceutical Sciences 170, pages 106098.
Crossref
Scott G. Summerfield, James W. T. Yates & David A. Fairman. (2022) Free Drug Theory – No Longer Just a Hypothesis?. Pharmaceutical Research 39:2, pages 213-222.
Crossref
Yoon-Jee Chae, Ji-Eun Chang, Mi-Kyung Lee, Juhee Lim, Kwang-Hee Shin & Kyeong-Ryoon Lee. (2021) Regulation of drug transporters by microRNA and implications in disease treatment. Journal of Pharmaceutical Investigation 52:1, pages 23-47.
Crossref
Yurie Chatzikyriakidou, Do-Hwan Ahn, Emmanuel Nji & David Drew. (2021) The GFP thermal shift assay for screening ligand and lipid interactions to solute carrier transporters. Nature Protocols 16:12, pages 5357-5376.
Crossref
Qasem Ramadan, Roa Saleem Fardous, Rana Hazaymeh, Sultan Alshmmari & Mohammed Zourob. (2021) Pharmacokinetics‐On‐a‐Chip: In Vitro Microphysiological Models for Emulating of Drugs ADME. Advanced Biology 5:9, pages 2100775.
Crossref
Hubert J. Sijben, Julie J. E. van den Berg, Jeremy D. Broekhuis, Adriaan P. IJzerman & Laura H. Heitman. (2021) A study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery. Scientific Reports 11:1.
Crossref
Sascha C.T. Nicklisch & Amro Hamdoun. (2020) Disruption of small molecule transporter systems by Transporter‐Interfering Chemicals (TICs). FEBS Letters 594:23, pages 4158-4185.
Crossref
Yu-Syuan Luo, Kyle C Ferguson, Ivan Rusyn & Weihsueh A Chiu. (2020) In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide Extracts of Petroleum Substances . Toxicological Sciences 174:2, pages 168-177.
Crossref
Chuang Lu & Li Di. (2020) In vitro and in vivo methods to assess pharmacokinetic drug– drug interactions in drug discovery and development . Biopharmaceutics & Drug Disposition 41:1-2, pages 3-31.
Crossref
Jean-Marie Nicolas, Hugues Chanteux, Johan Nicolaï, Frédéric Brouta, Delphine Viot, Marie-Luce Rosseels, Eric Gillent, Pierre Bonnaillie, François-Xavier Mathy, Jeff Long & Eric Helmer. (2020) Role of P-glycoprotein in the brain disposition of seletalisib: Evaluation of the potential for drug-drug interactions. European Journal of Pharmaceutical Sciences 142, pages 105122.
Crossref
Laure-Alix Clerbaux, Alicia Paini, Annie Lumen, Hanan Osman-Ponchet, Andrew P. Worth & Olivier Fardel. (2019) Membrane transporter data to support kinetically-informed chemical risk assessment using non-animal methods: Scientific and regulatory perspectives. Environment International 126, pages 659-671.
Crossref
Andréia C. K. Fontana. (2018) Protocols for Measuring Glutamate Uptake: Dose-Response and Kinetic Assays in In Vitro and Ex Vivo Systems. Current Protocols in Pharmacology 82:1, pages e45.
Crossref
Donna A Volpe & Praveen V Balimane. (2018) Application of in vitro CYP and transporter assays to predict clinical drug–drug interactions . Bioanalysis 10:9, pages 619-623.
Crossref
Rodney Rouse, Naomi Kruhlak, James Weaver, Keith Burkhart, Vikram Patel & David G. Strauss. (2018) Translating New Science Into the Drug Review Process: The US FDA’s Division of Applied Regulatory Science. Therapeutic Innovation & Regulatory Science 52:2, pages 244-255.
Crossref
Shaili Aggarwal & Ole V. Mortensen. (2018) In Vitro Assays for the Functional Characterization of the Dopamine Transporter (DAT). Current Protocols in Pharmacology 79:1.
Crossref
Sue-Chih Lee, Vikram Arya, Xinning Yang, Donna A. Volpe & Lei Zhang. (2017) Evaluation of transporters in drug development: Current status and contemporary issues. Advanced Drug Delivery Reviews 116, pages 100-118.
Crossref
Valérie Fessard. 2017. Recent Advances in the Analysis of Marine Toxins. Recent Advances in the Analysis of Marine Toxins 231 275 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.