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The dynamics of drug-target interactions: drug-target residence time and its impact on efficacy and safety

Pages 305-310 | Published online: 29 Mar 2010

Keep up to date with the latest research on this topic with citation updates for this article.

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Robert A. Copeland. (2021) Evolution of the drug-target residence time model. Expert Opinion on Drug Discovery 16:12, pages 1441-1451.
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Rumin Zhang & Kenny Wong. (2017) High performance enzyme kinetics of turnover, activation and inhibition for translational drug discovery. Expert Opinion on Drug Discovery 12:1, pages 17-37.
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Vadim Bernard-Gauthier & Ralf Schirrmacher. (2016) Evaluation of WO2015042088 A1 - a novel urea-based scaffold for TrkA inhibition. Expert Opinion on Therapeutic Patents 26:2, pages 291-295.
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Wilhelmus EA de Witte, Yin Cheong Wong, Indira Nederpelt, Laura H Heitman, Meindert Danhof, Piet H van der Graaf, Ron AHJ Gilissen & Elizabeth C.M. de Lange. (2016) Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients. Expert Opinion on Drug Discovery 11:1, pages 45-63.
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Georges Vauquelin. (2015) On the ‘micro’-pharmacodynamic and pharmacokinetic mechanisms that contribute to long-lasting drug action. Expert Opinion on Drug Discovery 10:10, pages 1085-1098.
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Rumin Zhang & Michael Kavana. (2015) Quantitative analysis of receptor allosterism and its implication for drug discovery. Expert Opinion on Drug Discovery 10:7, pages 763-780.
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Karim M ElSawy, Adelene Sim, David P Lane, Chandra S Verma & Leo SD Caves. (2015) A spatiotemporal characterization of the effect of p53 phosphorylation on its interaction with MDM2. Cell Cycle 14:2, pages 179-188.
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Karim ElSawy, Chandra S. Verma, David P. Lane & Leo Caves. (2013) On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein. Cell Cycle 12:24, pages 3727-3735.
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Karim ElSawy, Chandra S. Verma, Thomas Leonard Joseph, David P. Lane, Reidun Twarock & Leo Caves. (2013) On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: A Brownian dynamics study. Cell Cycle 12:3, pages 394-404.
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Ye Fang. (2012) Ligand–receptor interaction platforms and their applications for drug discovery. Expert Opinion on Drug Discovery 7:10, pages 969-988.
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Kun Bi, Connie S Lebakken & Kurt W Vogel. (2011) Transformation of in vitro tools for kinase profiling: keeping an eye over the off-target liabilities. Expert Opinion on Drug Discovery 6:7, pages 701-712.
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Rumin Zhang & Frederick Monsma. (2010) Binding kinetics and mechanism of action: toward the discovery and development of better and best in class drugs. Expert Opinion on Drug Discovery 5:11, pages 1023-1029.
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Georges Vauquelin. (2010) Rebinding: or why drugs may act longer in vivo than expected from their in vitro target residence time. Expert Opinion on Drug Discovery 5:10, pages 927-941.
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